Article
Chemistry, Applied
Seul Gi Park, Mei-Xian Li, Woo Kyung Cho, Yoon Ki Joung, Kang Moo Huh
Summary: A novel synthetic tissue adhesive material with adjustable properties was developed in this study, showing excellent biocompatibility, wound healing effects, and promotion of tissue regeneration.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Mingyu Zou, Jinhua Chi, Zhiwen Jiang, Wei Zhang, Huiwen Hu, Ruibao Ju, Chenqi Liu, Tianjiao Xu, Shuo Wang, Zhilong Feng, Wanshun Liu, Baoqin Han
Summary: In this study, a thermosensitive hydroxypropyl chitin (HPCT) hydrogel was prepared and its biocompatibility and functionality were evaluated in cell culture and animal models. The results showed that the HPCT hydrogel could serve as a carrier for RIN-m5F cells, maintaining cell viability and insulin secretion, thus providing a potential strategy for the treatment of diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lucas Del Coli B. Araujo, Henrique K. de Matos, Debora P. Facchi, Debora A. de Almeida, Bruna M. G. Goncalves, Johny P. Monteiro, Alessandro F. Martins, Elton G. Bonafe
Summary: In this study, a natural carbohydrate-based CS/Pec hydrogel adsorbent was developed for efficient removal of Pb(II) from aqueous solutions, showing high adsorption capacities. However, the hydrogel adsorbent exhibited limited potential for reuse, indicating the need for further research to improve its reusability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Xueping Liu, Hui Wu, Peng Pan, Mengmeng Wang, Wenjing Zhang, Cheng Hu, Shenzhou Lu, Mingzhong Li, Yu Liu
Summary: In this study, thermosensitive hydroxybutyl chitosan (HBC)/silk fibroin (SF) hybrid hydrogels were prepared by physical interaction. The HBC/SF hybrids showed rapid sol-gel transition at physiological temperature and had the potential to be used as injectable tissue engineering scaffolds and soft tissue fillers. The introduction of SF component effectively reduced the cytotoxicity of HBC hydrogel.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Materials Science, Ceramics
Nga H. N. Do, Thinh H. Pham, Phung K. Le, Anh C. Ha
Summary: In this study, thermo-sensitive hydrogels made from chitosan and beta-glycerophosphate (GP) were used to post-load diclofenac sodium (DS) for temperature-controlled-release at inflammatory sites. The hydrogels showed sol-gel and swelling behaviors in response to temperature changes. The developed chitosan hydrogels had specific surface area, pore size, and pore volume within certain ranges. The hydrogels exhibited adaptive swelling to temperature changes and showed significantly improved DS loading capacity compared to previous studies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Franco Furlani, Arianna Rossi, Maria Aurora Grimaudo, Giada Bassi, Elena Giusto, Filippo Molinari, Florigio Lista, Monica Montesi, Silvia Panseri
Summary: This work presents the development of an injectable nanocomposite system for regenerative medicine, combining chitosan thermosensitive hydrogel and liposomes. The system allows controlled release, enhances cellular uptake, and can form a hydrogel at physiological temperature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ali Fatehi Hassanabad, Anna N. Zarzycki, Kristina Jeon, Justin F. Deniset, Paul W. M. Fedak
Summary: Post-surgical adhesions are common complications with significant morbidity, mortality, and increased healthcare costs. Despite extensive research, a prevailing mechanism driving adhesion formation has not been identified, leading to challenges in consistently demonstrating the safety and efficacy of therapeutic options. Translation of research findings into robust clinical trials has also proven to be elusive.
Article
Biochemistry & Molecular Biology
Chengkun Liu, Chang Liu, Zhiyuan Liu, Zhuang Shi, Shihai Liu, Xiaojuan Wang, Xiaoqiang Wang, Fang Huang
Summary: A thermogelling chitosan/glycerophosphate formulation was developed by incorporating dihydrocaffeic acid (DHCA), which significantly enhanced gel-forming capacity and tissue adherence. The thermosensitive hydrogels showed improved hemostasis and reduced blood loss in both in vitro and in vivo models. The results demonstrated the potential of enhancing thermogelling and bioadhesion of chitosan-based hydrogels through noncovalent supramolecular mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Yi Wang, Weijie Zhai, Lan Yang, Shujie Cheng, Wenguo Cui, Jinghua Li
Summary: After abdominopelvic surgery, 90-93% of patients develop postoperative adhesions, which can lead to complications and increased financial burden. This review systematically examines the occurrence mechanism of post-operative adhesion, summarizes the construction methods of animal adhesion models, and lists common evaluation indicators such as adhesion scores and histological characterization. It serves as a reference for the in vivo characterization of anti-adhesive materials.
ADVANCED THERAPEUTICS
(2023)
Article
Engineering, Environmental
Xuemin Liu, Huihui Wang, Jiajie She, Qiang Zhang, Qingyu Hu, Dongdong Li, Hongliang Wu, Xiaofeng Ye, Ruiying Diao, Xuetao Shi, Liping Wang
Summary: Intrauterine adhesions (IUA) can cause menstrual irregularities, infertility, and repeated pregnancy loss. This study developed a hydrophilic hydrogel film with a negative surface potential that can absorb proinflammatory cytokines to alleviate inflammation and limit fibrosis in the uterus. The hydrogel film exhibited good biocompatibility and anti-fibroblast adhesion properties in vitro and reduced inflammation and fibrosis in vivo. By loading the film with vascular endothelial growth factor (VEGF) and implanting it into injured rat endometrial cavities, improved endometrial regeneration was observed during IUA treatment. Overall, this hydrogel film provides a promising strategy for treating and preventing IUA difficulties with broad clinical application potential.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Medicinal
Luke J. Tucker, Christine S. Grant, Malley A. Gautreaux, Dhanush L. Amarasekara, Nicholas C. Fitzkee, Amol Janorkar, Anandavalli Varadarajan, Santanu Kundu, Lauren B. Priddy
Summary: This study investigated the interactions between fosfomycin and chitosan hydrogel systems, revealing a concentration-dependent inhibition of Staphylococcus aureus by fosfomycin, as well as the rheological effects of varying beta-glycerol phosphate concentration on the hydrogel. The study provides insight into the physicochemical interactions between fosfomycin and chitosan hydrogel systems, which can help in improving infection treatment by informing the selection of biomaterial components.
Review
Surgery
Morgan A. Hill, O. Agata Walkowiak, William T. Head, Jennie H. Kwon, Minoo N. Kavarana, Taufiek Konrad Rajab
Summary: The study highlighted the importance of inducing post-operative pericardial adhesions in animal models for research purposes. It found that combining autologous blood introduction into the pericardial cavity with physical abrasion of the epicardium led to more severe adhesion formation. The analysis also emphasized that the time frame allowed for adhesion development, ranging from 10 days to 12 months, plays a crucial role in the research outcomes.
FRONTIERS IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Panxianzhi Ni, Sheng Ye, Renpeng Li, Jing Shan, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
Summary: This study developed novel thermosensitive hydrogels based on lyophilizate powders for use in ESD procedures, which exhibited excellent properties such as injectability, mechanical strength, and cell compatibility. Submucosal injection experiments demonstrated that the cushions created by these hydrogels lasted longer, indicating potential clinical applications in ESD and other digestive tract procedures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Yu Godeau, Freddy Jocelyne R. Andrianandrasana, Olga Volkova, Caroline R. Szczepanski, Arnaud Zenerino, Olivier Montreuil, Rene-Paul Godeau, Pavel Kuzhir, Guilhem Godeau
Summary: Biopolymers and their derivatives, such as chitosan, are materials that are gaining increasing interest in industry and sustainable engineering development. This study focuses on the extraction and characterization of chitosan from giant dung beetles, as well as its application in hydrogel formation and 3D printing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Naiwen Tan, Maja Sabalic-Schoener, Linh Nguyen, Francesco D'Aiuto
Summary: Injectable biomaterials have great potential in dental tissue regeneration. This study successfully prepared an injectable thermosensitive beta-TCP and chitosan hydrogel, and demonstrated its feasibility and biocompatibility in periodontal tissue regeneration.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
