Review
Engineering, Biomedical
Xiao Xu, Limei Xu, Jiang Xia, Caining Wen, Yujie Liang, Yuanmin Zhang
Summary: Osteoarthritis (OA) is a common disease characterized by cartilage degeneration in middle-aged and elderly people. Currently, there is no effective treatment for OA apart from total joint replacement in advanced stages. Mesenchymal stem cells (MSCs) have shown great potential in regulating the cartilage microenvironment, promoting cartilage regeneration, and alleviating OA symptoms, making them a promising source of cells for OA therapy.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Narmadaa Raman, Siti A. M. Imran, Khairul Bariah Ahmad Amin Noordin, Wan Safwani Wan Kamarul Zaman, Fazlina Nordin
Summary: This review highlights the process of mechanotransduction, the effects of mechanical forces on cells and tissues, and the regulation of mesenchymal stem cell differentiation by mechanical factors. Research has shown that mechanical forces play a crucial role in cell sensing and adaptation to the environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vadym Burchak, Fritz Koch, Leonard Siebler, Sonja Haase, Verena K. Horner, Xenia Kempter, G. Bjoern Stark, Ute Schepers, Alisa Grimm, Stefan Zimmermann, Peter Koltay, Sandra Strassburg, Gunter Finkenzeller, Filip Simunovic, Florian Lampert
Summary: This study evaluated the printability and biocompatibility of a semi-synthetic hydrogel system (GelNB/GelS) for bioprinting of adipose-tissue-derived mesenchymal stem cells (ASCs). The results showed that GelNB/GelS hydrogels supported ASCs viability, proliferation and differentiation. The mechanical properties of GelNB/GelS system influenced the differentiation fate of ASCs. The hydrogel system may have potential applications in in vivo tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Asma Sepahdar, Abolfazl Nazbar, Saeed Bahadorikhalili, Ghassem Rezaei, Mohammad Ali Shokrgozar, Mohammad Mehdi Dehghan, Hamid Akbari Javar, Shahin Bonakdar
Summary: This paper presents a novel composite scaffold for the regeneration of cartilage tissue. The scaffold is made of a combination of a hydrogel and a controlled release drug delivery system. The release of kartogenin, a chondrogenic-inducing drug, from the scaffold is successfully controlled. The scaffold also demonstrates a porous structure and shows good performance in inducing chondrogenic differentiation of stem cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Review
Multidisciplinary Sciences
Narmadaa Raman, Siti A. M. Imran, Khairul Bariah Ahmad Amin Noordin, Wan Safwani Wan Kamarul Zaman, Fazlina Nordin
Summary: Cardiac muscle cells have the ability to perceive and respond to mechanical strain through mechanotransduction, which can lead to structural and functional changes in the heart. Prolonged or abnormal loading may cause maladaptive remodeling and heart failure. Mesenchymal stem cells offer potential for treating cardiovascular diseases through their immunomodulatory properties and ability to differentiate into cardiomyocytes.
Review
Biochemistry & Molecular Biology
Alexandra Roi, Ciprian Roi, Meda Lavinia Negrutiu, Laura Cristina Rusu, Mircea Rivis
Summary: Dental stem cells, such as human periapical cyst mesenchymal stem cells (hPCy-MSCs), derived from the oral cavity, possess multilineage differentiation potential, immunomodulatory activity, and repair capacity. These cells exhibit similar characteristics to mesenchymal stem cells (MSCs) and hold great significance for the development of clinical applications in dentistry.
Review
Biotechnology & Applied Microbiology
Marcin Szustak, Edyta Gendaszewska-Darmach
Summary: Nanocellulose is a promising biocompatible biomaterial with good mechanical properties for use as a scaffold in cartilage tissue engineering. The limited regenerative capacity of cartilage due to its lack of vascularization and sparsely distributed chondrocytes poses challenges for cell infiltration, making nanocellulose scaffolds a potential solution. The scaffolds have been shown to induce stem cell differentiation into chondrocyte phenotypes, offering opportunities for cartilage tissue development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Mingjing Zhu, Wenchao Zhong, Wei Cao, Qingbin Zhang, Gang Wu
Summary: This review summarizes the current knowledge on the design, molecular mechanisms, and applications of peptides in cartilage tissue engineering. Peptides, which can be chemically synthesized and mimic the functions of cartilaginous extracellular matrix and growth factors, show better stability and modifiability compared to natural biomaterials and recombinant growth factors. Studies have shown that peptides have a good efficacy in inducing chondrogenesis.
BIOACTIVE MATERIALS
(2022)
Review
Cell Biology
Xueqi Wang, Yiming Guan, Shiyu Xiang, Karen L. Clark, Peter G. Alexander, Lauren E. Simonian, Yuhao Deng, Hang Lin
Summary: This review examines the potential of mesenchymal stromal cells (MSCs) in cartilage repair based on animal studies conducted in the past three decades. However, the cartilage tissue derived from MSCs does not possess the same characteristics as native hyaline cartilage, especially in terms of chondrocytic hypertrophy. This undesired phenotype needs to be controlled before MSCs can be effectively used for cartilage repair in clinical settings. Current research focuses on suppressing hypertrophy and modulating the Wnt/β-catenin pathway to inhibit hypertrophy, along with exploring the potential crosstalk between Wnt/β-catenin and other pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Polymer Science
Mike Wagenbrenner, Susanne Mayer-Wagner, Maximilian Rudert, Boris Michael Holzapfel, Manuel Weissenberger
Summary: Cartilage has limited regenerative capacity, and cell-based approaches are a promising alternative for the treatment of cartilage defects and osteoarthritis, with MSCs being an attractive cell source often combined with hydrogels. This review focused on the advantages and disadvantages of various hydrogels, as well as different combinations of MSC subpopulations and hydrogels used in cartilage engineering.
Review
Biochemistry & Molecular Biology
Parisa Khayambashi, Janaki Iyer, Sangeeth Pillai, Akshaya Upadhyay, Yuli Zhang, Simon D. Tran
Summary: Tissue engineering has a long history in regenerative medicine, and methods such as cell-encapsulated hydrogels and exosomes can enhance the regenerative potential of various tissues, with hydrogels being the most user-friendly, economical, and accessible material for encapsulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Gollahalli Shivashankar Prajwal, Naveen Jeyaraman, Krishna Kanth, Madhan Jeyaraman, Sathish Muthu, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Manish Khanna, Eun Jung Oh, Kang Young Choi, Ho Yun Chung, Byeong-Cheol Ahn, Prakash Gangadaran
Summary: Tissue engineering and regenerative medicine provide a new approach for treating musculoskeletal diseases, utilizing MSCs and growth factors to improve the regenerative environment. However, the selection of MSCs source and the long-term and short-term effects of MSCs treatment remain uncertain.
Article
Materials Science, Ceramics
Patricia Ros-Tarraga, Carlos M. Martinez, Miguel A. Rodriguez, Piedad N. De Aza
Summary: The elderly population is increasing, leading to an increase in bone and joint problems. Scaffold for bone tissue regeneration can solve these problems, and material selection is crucial for satisfactory results. This study designed a three-dimensional porous ceramic scaffold and analyzed its biocompatibility and osteoinductive capacity. The results suggest that it has potential applications as bone substitutes.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Biomaterials
Galit Katarivas Levy, Yvonne Ventura, Jeremy Goldman, Razi Vago, Eli Aghion
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Materials Science, Biomaterials
O. Hakimi, Y. Ventura, J. Goldman, R. Vago, E. Aghion
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Engineering, Biomedical
Galit Katarivas Levy, Avi Leon, Alon Kafri, Yvonne Ventura, Jaroslaw W. Drelich, Jeremy Goldman, Razi Vago, Eli Aghion
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Liliana Astachov, Zvi Nevo, Moran Aviv, Razi Vago
FRONTIERS IN BIOSCIENCE-LANDMARK
(2011)
Article
Biochemistry & Molecular Biology
Liliana Astachov, Razi Vago, Moran Aviv, Zvi Nevo
FRONTIERS IN BIOSCIENCE-LANDMARK
(2011)
Article
Microscopy
Rina Jeger, Yona Lichtenfeld, Hagit Peretz, Boaz Shany, Razi Vago, Danny Baranes
JOURNAL OF ELECTRON MICROSCOPY
(2009)
Article
Biochemistry & Molecular Biology
Liliana Astachov, Zvi Nevo, Tamar Brosh, Razi Vago
JOURNAL OF STRUCTURAL BIOLOGY
(2011)
Article
Polymer Science
Liliana Astachov, Zvi Nevo, Razi Vago
Article
Materials Science, Multidisciplinary
Galit Katarivas Levy, Alon Kafri, Yvonne Ventura, Avi Leon, Razi Vago, Jeremy Goldman, Eli Aghion
Article
Chemistry, Multidisciplinary
Paulina X. Medina Rangel, Elena Moroni, Franck Merlier, Levi A. Gheber, Razi Vago, Bernadette Tse Sum Bui, Karsten Haupt
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Pharmacology & Pharmacy
Noa Ben Ghedalia-Peled, Ifat Cohen-Erez, Hanna Rapaport, Razi Vago
Summary: Polymeric nanoparticles can deliver drugs with lower systemic toxicity to solid tumors, and a new strategy using nanoparticles loaded with Wnt inhibitor IWP-2 significantly reduces tumorigenic capacities in aggressive breast cancer cells through improved solubility and efficacy of the drug.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
Orit Avior, Noa Ben Ghedalia-Peled, Tomer Ron, Razi Vago, Eli Aghion
Article
Materials Science, Ceramics
Ipek Karacan, Nathan Cox, Annette Dowd, Razi Vago, Bruce Milthorpe, Sophie Cazalbou, Besim Ben-Nissan
Summary: Artificially grown coral species, such as Millepora dichotoma, can be used to produce hydroxyapatite bioceramics for drug delivery systems and tissue engineering. Analysis showed that the hydrothermally treated coral was completely converted to hydroxyapatite, with a nanocrystalline structure suitable for biomedical applications like bone growth and repair.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2021)
Article
Chemistry, Physical
Noa Gabay, Tomer Ron, Razi Vago, Amnon Shirizly, Eli Aghion
Summary: This study evaluated a novel osseointegrated implant system based on a Ti-6Al-4V lattice infiltrated with a biodegradable Zn2%Fe alloy. The results demonstrate that this implant system exhibits good mechanical properties and corrosion resistance.
Article
Materials Science, Biomaterials
Tohar Perets, Noa Ben Ghedalia-Peled, Razi Vago, Jeremy Goldman, Amnon Shirizly, Eli Aghion
Summary: The study developed a novel bioactive hybrid metallic implant by combining a permanent matrix with a biodegradable substance, resulting in a porous structure that forms strong interfacial bonding and osseointegration in vivo. Benefits included the ability to produce complex implant structures and high strength with non-cytotoxic effects.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
