Article
Biochemistry & Molecular Biology
Die Hu, Qian Ren, Zhongcheng Li, Sili Han, Longjiang Ding, Ziqian Lu, Linglin Zhang
Summary: The mechanism of amelogenin-derived peptide QP5 in regulating enamel biomimetic remineralization is uncovered for the first time using a combination of experiments and computer simulation. QP5 inhibits spontaneous nucleation by adsorbing onto minerals through its two domains. The C-tail domain plays a significant role in the formation of enamel-like crystals. QP5 adsorbs onto enamel and captures Ca2+ from solution to promote enamel remineralization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Ceramics
Marta Kalbarczyk, Aleksandra Szczes
Summary: Polyphasic calcium phosphates were synthesized using raw non-calcined eggshells as a source of calcium via low-cost precipitation method. The material composition, morphology, calcium release profile, and enamel remineralization potential were influenced by the initial pH value.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Sandra Diez-Garcia, Maria-Jesus Sanchez-Martin, Jose Manuel Amigo, Manuel Valiente
Summary: By combining synchrotron radiation-based techniques, such as infrared microspectroscopy and micro X-ray diffraction, with specific data mining, the limitations of assessing dental enamel remineralization have been overcome. A controlled ion release of structural ions, including Ca2+, PO43-, F-, and Zn2+, for fluorapatite, in the presence of amelogenin, has been proposed to remineralize the surface of etched teeth.
ANALYTICAL CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jiarong Yan, Lingyun Cao, Ting Luo, Danchen Qin, Fang Hua, Hong He
Summary: The study investigated the antibacterial and enamel remineralization performances, as well as physicochemical properties and biocompatibility of a fluoride-coated clear aligner plastic (FCAP). The results showed that FCAP had uniformly distributed fluoride and exhibited stronger antibacterial activity compared to normal clear aligner plastic (CAP). FCAP could release fluoride continuously for 14 days and induce the formation of hydroxyapatite. Additionally, FCAP reduced enamel damage without compromising biocompatibility. Therefore, FCAP has the potential to prevent enamel demineralization during clear aligner treatment.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Engineering, Biomedical
Yinghui Wang, Shuting Zhang, Peiwen Liu, Fan Li, Xu Chen, Haorong Wang, Zhangyi Li, Xi Zhang, Xiangyu Zhang, Xu Zhang
Summary: The aim of this study was to develop a stable calcium-phosphorus system for remineralizing early enamel caries lesions. A nanocomplex solution of carboxymethyl chitosan/L-serine/amorphous calcium phosphate (CMC-Ser-ACP) was synthesized and transformed into hydroxyapatite (HAP) crystals using sodium hypochlorite (NaClO). The CMC-Ser-ACP nanocomplexes preserved their stability for 45 days and regenerated aprismatic enamel-like crystals. This novel remineralization system has great solution stability and shows promising therapeutic effects against early enamel caries.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Review
Engineering, Biomedical
Jue Wang, Zhihui Liu, Bingyu Ren, Qian Wang, Jia Wu, Nan Yang, Xin Sui, Lingfeng Li, Meihui Li, Xiao Zhang, Xinyue Li, Bowei Wang
Summary: Caries and dental erosion are common oral diseases. Biomimetic mineralisation is an ideal approach for restoring enamel, forming a new mineral layer that is tightly attached to the surface. This review highlights the application of various techniques in biomimetic mineralisation for enamel restoration.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nayara Goncalves Emerenciano, Alberto Carlos Botazzo Delbem, Francyenne Maira Castro Goncalves, Julia Paiao Quinterio, Emerson Rodrigues de Camargo, Yara Teresinha Correa Silva-Sousa, Marcelle Danelon
Summary: The addition of 0.25% nano-sized beta-CaGPn to 1100F formulation increased the bioavailability of calcium and phosphate, promoting a higher level of remineralization.
JOURNAL OF DENTISTRY
(2023)
Article
Physiology
Yaru Li, Yiwei Li, Qinghua Bai, Mingzhu Wen, Dandan Ma, Yisha Lin, Jinpu Chu
Summary: The study explored the regulatory effect of recombinant amelogenin peptide TRAP on the remineralization of early enamel carious lesions. The results showed that TRAP can promote the remineralization of enamel lesions and reduce mineral loss. This study provides a promising biomaterial for the treatment of early enamel carious lesions.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Jiarong Yan, Hongye Yang, Ting Luo, Fang Hua, Hong He
Summary: Enamel demineralization, a common dental problem, is a concern for dental professionals and patients due to its impact on both health and aesthetics. Amorphous calcium phosphate (ACP) has gained attention as a potential agent for preventing or treating enamel demineralization. This article briefly reviews ACP stabilizers and their mechanisms, as well as the scientific evidence supporting the remineralization ability of these agents. The limitations of current research and future prospects for clinical translation of ACP agents are also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jiarong Xu, Hui Shi, Jun Luo, Haiyan Yao, Pei Wang, Zhihua Li, Junchao Wei
Summary: This article discusses the importance of enamel remineralization and the application of advanced materials, pointing out that remineralization treatment can effectively control the progression of caries and restore the structure and hardness of the enamel.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Andrea Butera, Simone Gallo, Maurizio Pascadopoli, Mona A. Montasser, Mohammad H. Abd El Latief, Gioia Giada Modica, Andrea Scribante
Summary: This study compared the efficacy of toothpaste containing biomimetic hydroxyapatite and toothpaste containing 1450 ppm fluoride in promoting the remineralization and desensitization of white spot lesions. The results showed that the hydroxyapatite-based toothpaste resulted in a greater reduction in sensitivity and pain compared to the conventional fluoride toothpaste.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Chemistry, Multidisciplinary
Hewei Zhao, Shaojia Liu, Junfeng Lu, Xiuyi Yang, Zhao Yang, Fengshi Li, Lin Guo
Summary: This study focuses on analyzing the structure-property relationship of tooth enamel and summarizes the tooth-enamel analogs based on detailed mimicking of their hierarchy. The design concept of enamel analogs is explained by introducing the underlying principles relating to the formation process and hierarchical structure to excellent mechanical properties. The synthesis of enamel analogs by biomimetic remineralization and physical-chemical processes-assisted assembly are discussed, and the promising applications of these enamel analogs are exhibited.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lin Lu Dai, May Lei Mei, Chun Hung Chu, Edward Chin Man Lo
Summary: The study found that the combined use of HX-BGC and fluoride can reduce mineral loss and promote remineralization of demineralized enamel and dentine through the precipitation of newly formed apatite. Adjunctive use of HX-BGC may enhance the remineralization effect of fluoride in the management of early dental caries lesions.
JOURNAL OF DENTISTRY
(2021)
Article
Biochemistry & Molecular Biology
Alexander L. Danesi, Dimitra Athanasiadou, Ahmad Mansouri, Alina Phen, Mehrnoosh Neshatian, James Holcroft, Johan Bonde, Bernhard Ganss, Karina M. M. Carneiro
Summary: Biomineralization is a crucial process in which organisms produce mineralized tissues, such as teeth, bones, and shells, composed of hierarchically organized hydroxyapatite crystals. Developing protein-based materials as artificial scaffolds for guiding hydroxyapatite growth is an attractive goal for designing ordered nanomaterials and tissue regeneration. Uniaxial hydroxyapatite growth on a nanoengineered amelogenin scaffold combined with amelotin may provide insights into the molecular mechanism of hydroxyapatite formation and mineralized tissue formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Multidisciplinary
Andrea Butera, Carolina Maiorani, Simone Gallo, Maurizio Pascadopoli, Martina Quintini, Marco Lelli, Fabrizio Tarterini, Ismaela Foltran, Andrea Scribante
Summary: Biomimetic zinc-carbonate hydroxyapatite technology was developed to mimic the natural hydroxyapatite of enamel and dentin and possess strong affinity to adhere to these biological tissues. The literature review showed that oral care products with this technology provide benefits such as remineralization, prevention of enamel demineralization, and reduction of dentinal hypersensitivity.
Article
Biochemical Research Methods
Renee M. Huval, Oliver H. Miller, J. Lowry Curley, Yuwei Fan, Benjamin J. Hall, Michael J. Moore
Article
Chemistry, Analytical
Alan Campion, Kenneth J. Smith, Alexey V. Fedulov, David Z. Gregory, Yuwei Fan, John J. Godleski
ANALYTICAL CHEMISTRY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Ivana Parcina Amizic, Ivana Miletic, Anja Baraba, Yuwei Fan, Dan Nathanson
JOURNAL OF PROSTHETIC DENTISTRY
(2018)
Article
Microbiology
Sumei Liao, Marlise I. Klein, Kyle P. Heim, Yuwei Fan, Jacob P. Bitoun, San-Joon Ahn, Robert A. Burne, Hyun Koo, L. Jeannine Brady, Zezhang T. Wen
JOURNAL OF BACTERIOLOGY
(2014)
Article
Dentistry, Oral Surgery & Medicine
J. F. Zhang, R. Wu, Y. Fan, S. Liao, Y. Wang, Z. T. Wen, X. Xu
JOURNAL OF DENTAL RESEARCH
(2014)
Article
Materials Science, Biomaterials
Mobin Yahyazadehfar, George Huyang, Xiaohong Wang, Yuwei Fan, Dwayne Arola, Jirun Sun
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Microscopy
Sandra A. McDonald, Yuwei Fan, William R. Welch, Daniel W. Cramer, Rebecca C. Stearns, Liam Sheedy, Marshall Katler, John J. Godleski
ULTRASTRUCTURAL PATHOLOGY
(2019)
Review
Dentistry, Oral Surgery & Medicine
Peixi Liao, Yuwei Fan, Dan Nathanson
JOURNAL OF PROSTHETIC DENTISTRY
(2019)
Article
Pathology
Sandra A. McDonald, Yuwei Fan, William R. Welch, Daniel W. Cramer, John J. Godleski
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2019)
Article
Microscopy
Sandra A. McDonald, Yuwei Fan, Rick A. Rogers, John J. Godleski
ULTRASTRUCTURAL PATHOLOGY
(2019)
Article
Toxicology
Erika Sato, Sandra A. McDonald, Yuwei Fan, Shaina Peterson, Joseph D. Brain, John J. Godleski
PARTICLE AND FIBRE TOXICOLOGY
(2020)
Article
Crystallography
Supontep Teerakanok, Minglei Zhao, Russell Giordano, Yuwei Fan
Summary: The study showed that increasing fluoride concentration affected the size and shape of hydroxyapatite crystals in enamel remineralization, while magnesium ions did not directly impact crystal morphology. However, a combination of fluoride and magnesium ions resulted in the formation of small needle-like crystals with a greater density.
JOURNAL OF CRYSTAL GROWTH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nadav Bashary, Marina R. Kaizer, Abeer Tashkandi, Yuwei Fan, Mutlu Ozcan, Nadin Al Haj Husain, Yu Zhang
Summary: This study evaluated the bond-strength of a polymer-infiltrated-ceramic-network with zirconia, showing that it is the favorable choice for CAD-milled veneers and crowns due to its comparable bond strength with reference materials and superior resistance to fatigue fracture.
EUROPEAN JOURNAL OF PROSTHODONTICS AND RESTORATIVE DENTISTRY
(2021)
Article
Public, Environmental & Occupational Health
Sarah Bahammam, Dan Nathanson, Yuwei Fan
Article
Oncology
Kurt E. Johnson, Anastas Popratiloff, Yuwei Fan, Sandra McDonald, John J. Godleski
GYNECOLOGIC ONCOLOGY
(2020)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.