Review
Chemistry, Multidisciplinary
Zhengrong Yin, Yaxi Liu, Annikaer Anniwaer, Yuan You, Jingmei Guo, Ying Tang, Lei Fu, Luyao Yi, Cui Huang
Summary: Oral biofilms, also known as dental plaque, are the main cause of oral and systemic diseases, posing serious health risks. Novel antimicrobial biomaterials with controllable fabrication and functionalization have shown promise. However, previous reviews have focused on the properties and effectiveness of these biomaterials, lacking attention to the design rationales tailored to different infection types and application scenarios. This review provides guidance on the design and application of antibiofilm biomaterials, discussing core strategies, advanced antibiofilm biomaterials, and future improvements.
ADVANCED MATERIALS
(2023)
Review
Engineering, Biomedical
Jamie L. Hernandez, Kim A. Woodrow
Summary: Porosity is an important material feature that is commonly used in medical devices. It promotes cell infiltration and drug diffusion, and is beneficial for tissue responses. However, it can also lead to negative effects such as biofilm formation and calcification. The host responses to porous biomaterials depend on tissue location and specific microenvironment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Medicine, General & Internal
Yue Qu, Anton Y. Peleg, David McGiffin
Summary: Ventricular assist device (VAD)-specific infections, particularly driveline infections, are a concerning complication of VAD implantation due to biofilm formation and migration. Despite multiple preventative strategies, driveline infections still have a high prevalence and unsatisfactory treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Enea Gino Di Domenico, Alessandra Oliva, Maria Guembe
Summary: Biofilm-related infections pose a significant challenge to healthcare professionals due to the ability of microorganisms to form biofilm, which leads to treatment resistance and reduced susceptibility to antibiotics. Current microbiological diagnosis and antibiotic susceptibility testing methods are often inadequate for accurately assessing biofilm-related infections. Timely identification of these infections is crucial for guiding appropriate treatment strategies.
Review
Materials Science, Multidisciplinary
Annabel Braem, Nur Hidayatul Nazirah Kamarudin, Nitu Bhaskar, Zoya Hadzhieva, Andrea Mele, Jeremy Soulie, Denver P. Linklater, Linda Bonilla-Gameros, Aldo R. Boccaccini, Ipsita Roy, Christophe Drouet, Elena P. Ivanova, Diego Mantovani, Bikramjit Basu
Summary: Peri-implant infection is a significant challenge in the clinical field. Researchers are developing biomaterial and bioengineering-based antimicrobial strategies to tackle this issue. However, the development of these approaches is hindered by challenges like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues, and antibiotic resistance development. This review provides insights into current state-of-the-art biomaterial-based antimicrobial approaches and highlights the importance of translational research strategies and regulatory frameworks for clinical implementation. The integration of computational tools and experimental databases using artificial intelligence (AI) is proposed as a vision to accelerate the development of next-generation biomaterial-based antimicrobial strategies.
INTERNATIONAL MATERIALS REVIEWS
(2023)
Article
Multidisciplinary Sciences
Chuang Yang, Yao Luo, Hao Shen, Min Ge, Jin Tang, Qiaojie Wang, Han Lin, Jianlin Shi, Xianlong Zhang
Summary: By modulating antigen presentation and co-stimulatory molecule expression, the use of PVP-modified MPS nanosheets can trigger a strong immune response against bacterial biofilm infections, reducing residual and recurrent infections.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Zheng Su, Lingtong Kong, Yong Dai, Jin Tang, Jiawei Mei, Zhengzheng Qian, Yuanyuan Ma, Qianming Li, Shenghong Ju, Jiaxing Wang, Wenpei Fan, Chen Zhu
Summary: There is a growing demand for nonantibiotic strategies to overcome drug resistance in bacterial biofilm infections. This study proposes a gas-sensitized hyperthermia strategy using a metal-organic framework (MOF)-sealed Prussian blue-based nanocarrier for efficient elimination of biofilms through H2S-induced thermal eradiation.
Review
Biochemistry & Molecular Biology
Joana Barros, Fernando Jorge Monteiro, Maria Pia Ferraz
Summary: One of the most serious complications following orthopedic biomaterial implantation is infection, which not only causes clinical problems and patient suffering, but also burdens healthcare systems. Microorganisms can form biofilms on implant surfaces, leading to tissue destruction, infection development, and implant failure. Biofilms provide protection to bacteria and increase the pathogenesis of infection. The emergence of antibiotic-resistant strains has prompted the development of new approaches to prevent and control implant-related infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Carla L. Vidal, Izabela Ferreira, Paulo S. Ferreira, Mariana L. C. Valente, Ana B. V. Teixeira, Andrea C. Reis
Summary: The incorporation of beta-AgVO3 into dental porcelains promoted antimicrobial activity and fracture toughness, reduced biofilm formation, but did not affect P. aeruginosa viability and increased surface roughness.
Article
Chemistry, Physical
Lin Chen, Dan Fang, Junyue Zhang, Xiangyu Xiao, Nan Li, Yue Li, Mimi Wan, Chun Mao
Summary: A microneedle patch is designed to penetrate bacterial biofilms and deliver bacterial quorum sensing inhibitors and nanomotors with antibacterial properties. The results of in vitro and in vivo experiments show that the microneedle patches have good biosafety and antibacterial properties. The nanomotors, under near-infrared irradiation, can effectively remove biofilms and promote wound healing through photothermal and photodynamic therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Acoustics
Ryan Morse, Christopher Childers, Elizabeth Nowak, Jayasimha Rao, Eli Vlaisavljevich
Summary: Biofilm formation in medical catheters is a major concern for hospital-acquired infections. This study investigates the potential of using histotripsy to remove biofilms from catheters at increased speeds and efficiency. The results show significant improvements in biofilm removal and bacterial killing speeds compared to previous methods, indicating the promise of histotripsy for clinically relevant treatment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Review
Oncology
George M. Viola, Ariel D. Szvalb, Alexandre E. Malek, Anne-Marie Chaftari, Ray Hachem, Issam I. Raad
Summary: The article comprehensively reviews evidence-based recommendations and best practices for the prevention of device-related infections. It emphasizes the importance of collaboration between various entities and the need for sustained reduction in infection rates.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Infectious Diseases
Audrey Courdurie, Romain Lotte, Raymond Ruimy, Vincent Cauhape, Michel Carles, Marc-Olivier Gauci, Pascal Boileau, Johan Courjon
Summary: The study aimed to evaluate the efficacy of clindamycin in treating C. acnes shoulder implant joint infections, showing that patients treated with clindamycin had a higher cure rate, indicating that a 6-week treatment regimen seemed to be effective.
Article
Multidisciplinary Sciences
Joel A. Finbloom, Preethi Raghavan, Michael Kwon, Bhushan N. Kharbikar, Michelle A. Yu, Tejal A. Desai
Summary: Researchers have developed a nanoscale drug carrier that can deliver both antibiotics and antimicrobial silver nanoparticles to bacterial infections, showing synergistic antimicrobial effects against Pseudomonas aeruginosa. The carrier has also demonstrated positive outcomes in reducing bacterial burden and improving survival outcomes in a mouse model of lung infection.
Article
Biotechnology & Applied Microbiology
Karina Sampaio Caiaffa, Vanessa Rodrigues dos Santos, Gabriel Flores Abuna, Norival Alves Santos-Filho, Eduardo Maffud Cilli, Vivien Thiemy Sakai, Luciano Tavares Angelo Cintra, Cristiane Duque
Summary: This study demonstrated the excellent antibacterial effects of the combination of EGCG and KR-12-a5 against oral pathogens, showing significant efficacy in eliminating bacteria such as Streptococcus mutans and Actinomyces israelii.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
