Article
Polymer Science
Meirong Zhao, Weiwei Jiang, Xinrong Xie, Yogini Jaiswal, Leonard Williams, Mei Wei, Ying Mo, Yifu Guan, Hua Yang
Summary: In this paper, a new drug carrier was synthesized using self-assembled polymeric micelles to load paclitaxel. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The results indicate that the developed carrier has good pH sensitivity and potential for increased solubility and clinical efficacy of paclitaxel.
Article
Pharmacology & Pharmacy
Jin Sil Lee, Hyeryeon Oh, Daekyung Sung, Jin Hyung Lee, Won Il Choi
Summary: The use of thermosponge nanoparticles loaded with paclitaxel can improve its anticancer effects by increasing drug release rate, leading to significant anticancer activity against multidrug resistance-related colorectal cancer cells.
Article
Biochemistry & Molecular Biology
Yujia Dong, Yanhui He, Daidi Fan, Zhansheng Wu
Summary: In this study, ginsenoside loaded nanoparticles were prepared using an ionic cross-linking method, which provided a sustained slow release effect of ginsenoside Rb1 in the intestinal fluid through intelligent response. The nanoparticles exhibited good pH sensitivity and controlled release properties in buffer solutions of different pH's. The results showed that CDA3.6-NPs can effectively control release and intelligently deliver ginsenoside Rb1, which could be a promising alternative for oral delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Waixiang Yang, Lei Yang, Fanjie Li, Yulin Zhao, Xiali Liao, Chuanzhu Gao, Jing Yang, Bo Yang
Summary: A novel tumor-targeting drug delivery system was designed by encapsulating PPT in CD derivatives, significantly increasing its water solubility. The system showed effective proliferation inhibition on cancer cells while reducing cytotoxicity to normal cells.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Agricultural Engineering
Fuyuan Lu, Shuzhen Ni, Xiangxi Meng, Chuanling Si, Menghua Qin, Yan Wang, Yingjuan Fu, Xiaoqian Chen
Summary: The majority of current oral drugs are hydrophobic and have gastrointestinal toxic side effects, limiting their therapeutic efficacy. Lignin nanoparticles (LNPs) with antimicrobial and antioxidant properties show great potential for application in pharmaceuticals. This study prepared LNPs by modifying and self-assembling alkali lignin, and evaluated their application in a hydrophobic oral drug delivery system using Ibuprofen. The IBU-loaded LNPs showed controlled release in the intestine rather than the stomach and improved the bioavailability of Ibuprofen drugs. The research proposes a method for preparing smart lignin nanoparticles and demonstrates their promising application in pharmaceuticals industry.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Yang Cao, Xuwen Yuan, Xuan Wang, Wentao Li, Huaiyu Yang
Summary: This study successfully synthesized inhibitor-encapsuled polyaniline hollow microspheres with pH sensitive response and controlled release function. The pH sensitive controlled release behavior and kinetic mechanism of the microspheres in 3.5% NaCl solutions were systematically investigated, showing promising potential for practical applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Bianca Andrade de Campos, Natalia Cristina Borges da Silva, Lucas Szmgel Moda, Pedro Vidinha, Ligia Passos Maia-Obi
Summary: pH-sensitive degradable hydrogels are smart materials that degrade upon pH variation. This study focused on the development of a hydrogel using HPG and OA, and investigated its formation process, as well as drug release for oral administration.
Article
Pharmacology & Pharmacy
Vahideh Mohammadzadeh, Mohammad Reza Zirak, Seyedeh Maryam Hosseini Khah, Hossein Kamali, Mahmoud Reza Jaafari
Summary: Nanotechnology has shown great potential in cancer treatment, especially with pH-responsive nanocarriers delivering natural anticancer compounds like curcumin to tumor cells efficiently.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Wenjing Li, Qi Wang, Fang Zhang, Hui Shang, Shiyang Bai, Jihong Sun
Summary: In this study, pH-sensitive thiamethoxam-loaded bimodal mesoporous silica nanoparticles were synthesized and demonstrated to have excellent controlled-release capabilities and enhanced toxicity against peach aphids compared to commercial thiamethoxam, showing promising prospects for effective insect control and environmental protection.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Feng Fan, Lijun Jin, Lihua Yang
Summary: A new approach using long-circulating, pH-sensitive nanoparticles composed solely of cellular membrane-disruptive molecules has been proposed for treating pancreatic cancer. These nanoparticles effectively permeabilized the stromal barrier and eradicated pancreatic cancer cells without promoting tumor metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Roya Sedghi, Somayeh Ashrafzadeh, Bahareh Heidari
Summary: A new pH responsive CUR imprinted polymer GO@CUR-MIP was synthesized and showed high adsorption capacity and selectivity for CUR, with controlled and sustained release in response to environmental pH changes. The pH responsiveness of the system led to targeted drug delivery potential, while the inclusion complex improved drug interaction with the nanocomposite. The novel system has potential in separation and drug delivery processes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Jinzhong Hu, Zhiguo Gao, Kai Sun, Min Liu, Zining Wang, Jiaying Yu, Wanying Wei, Xiaofan He, Senlin Wang, Yaojia Li, Baiwang Sun
Summary: A redox-triggered PTX liposome system (PTX-SS-CP) based on PTX disulfide CP conjugates (PTX-SS-CP) has been developed. This system exhibits rapid release, high cellular uptake capacity, and improved anticancer efficiency under reductive conditions (GSH). It shows strong tumor targeting efficacy and growth inhibition in in vivo studies.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Sidra Kanwal, Muhammad Naveed, Ali Arshad, Azka Arshad, Farhat Firdous, Amir Faisal, Basit Yameen
Summary: Novel reduction-sensitive polymer-drug conjugate (PDC) nanoparticles with precise drug release control exhibit significant cytotoxicity against cancer cells in vitro, highlighting their potential in tumor therapy.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jinzhong Hu, Zhiguo Gao, Kai Sun, Min Liu, Zining Wang, Jiaying Yu, Wanying Wei, Xiaofan He, Senlin Wang, Yaojia Li, Baiwang Sun
Summary: A new PTX liposome system based on PTX disulfide CP conjugates has been studied, which exhibits rapid release, high cellular uptake capacity, and improved anticancer efficiency. In vivo studies showed significantly stronger tumor targeting efficacy and growth inhibition compared to other PTX-SS-CP groups.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
B. Khodashenas, M. Ardjmand, A. S. Rad, M. R. Esfahani
Summary: This study investigated the synthesis and effectiveness of gold/gelatin nanoparticles as a carrier for methotrexate drug. The size and shape of AuNPs were found to affect the entrapment efficiency, drug release rate, and cellular uptake, with AuNPs showing higher EE than AuNRs. MTX loaded AuNR2-gelatin exhibited the highest cytotoxic effect on MCF-7 breast cancer cells.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.