Tanshinone IIA Prevents Rat Basilar Artery Smooth Muscle Cells Proliferation by Inactivation of PDK1 During the Development of Hypertension

The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: Possible role of metalloproteinases

(2014) Rocío Alcántara-Hernández et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endothelin ETA receptor antagonism in cardiovascular disease

(2014) Suzanne A. Nasser et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway

(2014) Francesco Maione et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-Inflammatory Effects of Danshen on Human Vascular Endothelial Cells in Culture

(2013) Christian Stumpf et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Role of the PI3K/AKT Pathway in Modulating Cytoskeleton Rearrangements and Phenotype Switching in Rat Pulmonary Arterial Vascular Smooth Muscle Cells

(2013) Zhiyu Fan et al.   DNA AND CELL BIOLOGY

Tanshinone IIA and Cryptotanshinone Prevent Mitochondrial Dysfunction in Hypoxia-Induced H9c2 Cells: Association to Mitochondrial ROS, Intracellular Nitric Oxide, and Calcium Levels

(2013) Hyou-Ju Jin et al.   Evidence-based Complementary and Alternative Medicine

Inhibition of Phosphatidylinositol 3-kinase/Akt Signaling Attenuates Hypoxia-induced Pulmonary Artery Remodeling and Suppresses CREB Depletion in Arterial Smooth Muscle Cells

(2013) Chrystelle V. Garat et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation

(2012) Mi Wang et al.   CIRCULATION

Simvastatin Attenuated Cerebrovascular Cell Proliferation in the Development of Hypertension Through Rho/Rho-kinase Pathway

(2012) Ming-Ming Ma et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926 cells

(2012) Lian-qun Jia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

(2011) Alexandra Hofler et al.   ANALYTICAL BIOCHEMISTRY

Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways

(2011) Min Huan Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats

(2010) Jing Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PDK1 Recruitment to the SHPS-1 Signaling Complex Enhances Insulin-like Growth Factor-I-stimulated AKT Activation and Vascular Smooth Muscle Cell Survival

(2010) Xinchun Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide

(2010) Wei Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Extracellular matrix alterations in hypertensive vascular remodeling

(2009) Catherine A. Lemarié et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY