Article
Biotechnology & Applied Microbiology
Jiangkang Xu, Xiaoye Yang, Jianbo Ji, Yuan Gao, Na Qiu, Yanwei Xi, Anchang Liu, Guangxi Zhai
Summary: The study demonstrated that RVG-modified nanomicelles can enhance drug accumulation in the brain and inhibit tumor growth effectively, leading to significantly improved survival rate with minimal systemic toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhen Shi, Yuhan Yang, Ziyang Guo, Shun Feng, Yu Wan
Summary: In this study, a novel redox- and enzyme-responsive fluorinated polyarginine (PFC-PR) was developed as an anti-cancer siRNA carrier. The PFC-PR showed efficient binding with siRNA and enhanced stability, serum tolerance, cellular uptake, and endosome escape. It also exhibited responsiveness to cancer cell-specific conditions, leading to enhanced siRNA release and cancer-targeting ability. Overall, the PFC-PR demonstrated good biocompatibility and high gene silencing efficiency, making it a potential candidate for anti-cancer gene therapy applications.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Qinghua Wang, Shang Cheng, Fen Qin, Ailing Fu, Chen Fu
Summary: With the increasing incidence of central nervous system diseases due to the aging population, delivering drugs into the CNS remains challenging because of the blood-brain barrier. Targeted delivery systems utilizing RVG peptide modified carriers can encapsulate a wide range of drugs to effectively treat various CNS diseases.
Article
Biotechnology & Applied Microbiology
Qinqin Cheng, Zhefu Dai, Goar Smbatyan, Alan L. Epstein, Heinz-Josef Lenz, Yong Zhang
Summary: Researchers designed genetically engineered exosomes with displayed antibodies and immunomodulatory proteins for immunotherapy of breast cancer. These exosomes can redirect and activate T cells to kill cancer cells and induce potent anti-tumor immune responses.
Article
Pharmacology & Pharmacy
Shogo Nishida, Yuuki Takashima, Ryotaro Udagawa, Hisako Ibaraki, Yasuo Seta, Hiroshi Ishihara
Summary: This study aimed to develop a nanocarrier for the non-invasive delivery of siRNA to the retina by eyedrops. A hybrid nanocarrier based on a multifunctional peptide and liposomes was prepared and optimized. The results showed that the nanocarrier significantly enhanced siRNA transfection efficiency and effectively suppressed vascular endothelial growth factor expression in rat retinal pigment epithelium cells.
Article
Multidisciplinary Sciences
Ye Cao, Yang Fei Tan, Yee Shan Wong, Muhammad Aminuddin, Bhuthalingam Ramya, Melvin Wen Jie Liew, Jiaxin Liu, Subbu S. Venkatraman
Summary: Despite the challenges, this study presents a new nanogel system that can encapsulate and sustainably release siRNA, enhancing its efficiency and prolonging the gene silencing effect. This system shows promise for both fundamental biological studies and clinical applications in siRNA-based therapies.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Ramzi Mukred Saeed, Mohammed Abdullah, Mamoun Ahram, Mutasem Omar Taha
Summary: The study developed novel ellipsoid non-cytotoxic NPs crosslinked with TPP, utilizing the advantages of CSP and LC to efficiently deliver siRNA into cancer cells. The NPs showed excellent stability and cellular penetration, achieving significant silencing efficiency against SLUG protein.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Ye Liang, Yonghua Wang, Liping Wang, Zhijuan Liang, Dan Li, Xiaoyu Xu, Yuanbin Chen, Xuecheng Yang, Hongbo Zhang, Haitao Niu
Summary: This study developed a CD44 targeted gene delivery system based on natural macromolecules for effective bladder cancer treatment, which could be more conducive to clinical application due to its simple preparation and high biological safety.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Melissa L. Jagrosse, Uday K. Baliga, Christopher W. Jones, Jade J. Russell, Claudia I. Garcia, Rauf Ahmad Najar, Arshad Rahman, David A. Dean, Bradley L. Nilsson
Summary: In this study, a series of modified cyclic amphipathic cell-penetrating peptides (CAPs) were used to investigate their effects on siRNA-binding efficiency, cellular delivery and knockdown efficiency, and endocytic uptake mechanism. The results show that CAP sequences with strong cationic character and aromatic residues can interact most effectively with siRNA. Cationic charge and disulfide-constrained cyclization of CAPs improve the uptake of siRNA, while net neutral CAPs and an acyclic peptide show less-efficient siRNA translocation. All tested CAPs facilitate efficient siRNA target gene knockdown, and the best CAPs enable more than 80% knockdown. There is a moderate correlation between gene knockdown efficiency and CAP-siRNA-binding affinity. Most CAP-siRNA nanoparticles deliver siRNA through clathrin- and caveolin-mediated endocytosis. These findings provide valuable insights into the design of CAPs for siRNA delivery and the mechanism of siRNA translocation.
MOLECULAR PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Bettina Gabold, Friederike Adams, Sophie Brameyer, Kirsten Jung, Christian L. Ried, Thomas Merdan, Olivia M. Merkel
Summary: Nose-to-brain delivery is a promising alternative for delivering high molecular weight drugs. Transferrin-decorated chitosan nanoparticles can efficiently cross the nasal epithelial barrier and enhance cellular uptake in tumor cells. This approach offers a potential improvement in drug bioavailability through targeted ligand binding.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Roja Hadianamrei, Jiqian Wang, Stephen Brown, Xiubo Zhao
Summary: Gene therapy as an alternative to pharmacotherapy has gained attention, requiring the use of gene vectors for delivery. The development of short cationic amphiphilic peptides with anticancer activity for selective delivery of siRNA and ODNs to cancer cells shows potential for highly selective gene delivery to cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Javad Zavar Reza, Mohammad Hossein Modarressi, Davood Tofighi, Bibi Fatemeh Haghiralsadat, Fatemeh Oroojalian
Summary: This study developed a nanoparticle-based delivery system consisting of selenium nanoparticles modified by chitosan and hyaluronic acid, which successfully delivered PLK1 siRNAs to bladder cancer cells. These findings suggest that hyaluronic acid-chitosan-selenium nanoparticles may provide a good vehicle for targeted gene therapy for bladder cancer.
Article
Chemistry, Organic
Alexander Pontarelli, Jiang Tian Liu, Hourieh Movasat, Sarah Menard, Jung Kwon Oh, Christopher J. Wilds
Summary: The synthesis and incorporation of a tosylated phosphoramidite linker containing a disulfide bond is described. This linker was efficiently incorporated into short DNA and RNA oligomers using automated solid phase synthesis, allowing for the expansion of strategies for bifunctional modification of synthetic oligonucleotides for conjugation applications.
Article
Pharmacology & Pharmacy
Hejian Guo, Xuehui Yan, Hao Tang, Xiaoyan Zhang
Summary: In this study, biotinylated trimethylated chitosan nanoparticles were developed to improve the oral absorption of exenatide. The results showed that the nanoparticles had enteric characteristics and led to a better hypoglycemic effect compared to unmodified ones.
CURRENT DRUG DELIVERY
(2022)
Article
Food Science & Technology
Leila Ramezanzade, Seyed Fakhreddin Hosseini, Behrouz Akbari-Adergani, Anan Yaghmur
Summary: The study aimed to develop novel hybrid nanocarriers for fish-purified antioxidant peptide, utilizing liposomes coated with chitosan cross-linked with sodium tripolyphosphate. The produced nanodispersion demonstrated good stability and retained antioxidant activity, presenting a promising approach for delivering protein hydrolysates and peptide fractions in nutraceutical and functional foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Immunology
Pu Wang, Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Yan Zhang, Hang Zhao, Zhan-You Wang
CELLULAR & MOLECULAR IMMUNOLOGY
(2017)
Article
Cell Biology
Pu Wang, Pei-Pei Guan, Jing-Wen Guo, Long-Long Cao, Guo-Biao Xu, Xin Yu, Yue Wang, Zhan-You Wang
Article
Neurosciences
Yin Li, Ze-Xu Li, Tan Jin, Zhan-You Wang, Pu Zhao
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Ni Zong, Shi-Xin Ma, Zhan-You Wang
JOURNAL OF CHEMICAL NEUROANATOMY
(2017)
Article
Biochemistry & Molecular Biology
Xiaoxu Bi, Pu Wang, Qingjuan Ma, Li Han, Xingbo Wang, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Biochemistry & Molecular Biology
Xiaoxu Bi, Li Han, Tiange Qu, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Neurosciences
Chuang Guo, Zhao-Hui Yang, Shuai Zhang, Rui Chai, Han Xue, Yan-Hui Zhang, Jia-Yi Li, Zhan-You Wang
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Oncology
Yue Wang, Pei-Pei Guan, Xin Yu, Yan-Su Guo, Ying-Jie Zhang, Zhan-You Wang, Pu Wang
Article
Oncology
Shuai Zhang, Rui Chai, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Shuang-Feng Xu, Yan-Hui Zhang, Zhan-You Wang, Chuang Guo
Article
Geriatrics & Gerontology
Dan-Dan Li, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Geriatrics & Gerontology
Zhuo Wang, Ya-Hong Zhang, Chuang Guo, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Na-Na Liu, Rui-Fang Guo, Tian Lan, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Article
Engineering, Biomedical
Jing-Wen Guo, Pei-Pei Guan, Wei-Yan Ding, Si-Ling Wang, Xue-Shi Huang, Zhan-You Wang, Pu Wang
Article
Chemistry, Medicinal
Qing-juan Ma, Li Han, Yu Mu, Pei-pei Guan, Hui Lei, Zhan-you Wang, Xue-shi Huang
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)
Article
Cell Biology
Pu Wang, Zhan-You Wang
AGEING RESEARCH REVIEWS
(2017)