Article
Chemistry, Physical
Caroline A. S. Ribeiro, Lindomar J. C. Albuquerque, Carlos E. de Castro, Rodrigo M. Pereira, Brunno L. Albuquerque, Ewa Pavlova, Luiza Gabriela Schluter, Bruno L. Batista, Ismael C. Bellettini, Fernando C. Giacomelli
Summary: In this study, a facile and fast method was reported for the synthesis of surface-decorated gold nanoparticles with enhanced biological responses. The gold ions were reduced using polyethyleneimine (PEI) derivatives, which acted as both reducing and stabilizing agents. The resulting nanoparticles exhibited low cytotoxicity and were rapidly uptaken by specific cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Mehmet Can, Nurettin Sahiner
Summary: Laminarin (LAM), a marine polysaccharide with various bioactivities, shows great potential in biomedical applications. A facile method was developed to prepare poly(laminarin) (p(LAM)) particles, which exhibited excellent blood compatibility and chemical modifiability. The synthesized p(LAM) particles hold promise as natural alternative surrogates in drug delivery and other biomedical applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Mathilde Guerin, Aurelien Lebrun, Liisa Kuhn, Thierry Azais, Guillaume Laurent, Olivier Marsan, Christophe Drouet, Gilles Subra
Summary: This study reports the one-pot synthesis of hybrid organic-inorganic apatite nanoparticles with well-defined bioactive properties. The nanoparticles consist of a mineral core and an organic corona composed of bioactive peptides. The synthesis process involves the use of dual stabilizing-bioactive agents to form the organic corona and expose the peptide moieties on the nanoparticle surface. The success of this approach is demonstrated through various characterization techniques and the nanoparticles show a synergistic proliferative effect on fibroblast cells.
Article
Chemistry, Multidisciplinary
Anjana Anandan Vannathan, Tatinaidu Kella, Debaprasad Shee, Sib Sankar Mal
Summary: A simple method of using two polyoxomolybdate-doped polyindole composites as electrodes for electrochemical supercapacitors is reported. The composites exhibit higher capacitance, faster charge/discharge rates, and greater cycle stability, making them promising candidates for supercapacitor applications.
Article
Chemistry, Physical
Zhao Shijie, Li Na, Sun Liping, Li Qiang, Huo Lihua, Zhao Hui
Summary: This paper investigates the synthesis of Pr2CuO4-Pr6O11 composites using a one-pot method and characterizes their phase evolution and oxygen reduction reaction properties. The decoration of Pr6O11 effectively enhances the oxygen adsorption capability of the composite cathode. The composite exhibits promising performance as a cathode material for solid oxide fuel cells.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Agricultural Engineering
Xiaohong Hu, Linxin Dai, Qianli Ma, Jianying Xu, Jianfeng Ma, Xing'e Liu
Summary: A novel codeposition strategy was developed to synthesize magnetic porous char (MPC) using bamboo hydrochar as precursors. The synthesized MPC demonstrated excellent adsorption capacities and rapid adsorption rate for Cu(II) and Pb(II). The study proposed a synergistic mechanism of chemical complexation and physical adsorption for the higher adsorption capabilities of MPC. Furthermore, the regeneration investigation revealed that the sorption efficiencies of MPC remained high after multiple cycles.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Physical
Ahmed S. Yasin, Dong Hyun Kim, Kyubock Lee
Summary: A ZnO nanoparticles-decorated activated carbon (ACZn) nanocomposite was successfully prepared for efficient capacitive deionization. The ACZn nanocomposite showed higher specific capacitance and improved desalination performance compared to activated carbon alone.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Pengchong Wang, Hongrui Ji, Shiyan Guo, Ying Zhang, Yan Yan, Ke Wang, Jianfeng Xing, Yalin Dong
Summary: By controlling reaction conditions, the properties of CDs can be greatly enhanced, improving fluorescence quantum yield, and showing potential applications in areas such as bioimaging and ion detection.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Heba M. Abdallah, Mahmoud H. Abu Elella, Marwa M. Abdel-Aziz
Summary: Tuberculosis (TB) is a highly lethal infectious disease. Traditional anti-TB drugs have limitations in terms of toxicity and treatment efficacy. In recent years, the development of new anti-TB drugs using natural biopolymers has gained attention due to their biodegradability, biocompatibility, and non-toxicity. This study successfully engineered chitosan biguanidine (ChBG) nanoparticles as a safe and effective anti-TB drug. The nanoparticles showed uniform distribution and a small particle size of approximately 38 nm. They exhibited significant inhibitory activity against different M. tuberculosis strains, including drug-resistant strains, with minimal inhibitory concentrations (MIC) lower than that of isoniazid. Furthermore, the ChBG nanoparticles showed no cytotoxicity against normal lung cells in the tested concentration range.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Zi-Qi Geng, Chunhui Zhao, Hao-Dong Qian, Si-Jia Li, Hao Peng, Hao Xu
Summary: A Cu/Ag relay catalyzed cascade reaction was used to synthesize chiral triazole-fused pyrazine scaffolds. This method utilized a novel N,N,P-ligand and showed high efficiency, functional group tolerance, excellent enantioselectivities, and a broad substrate scope using readily available starting materials.
Article
Chemistry, Physical
Ganesh Sunil More, Nidhi Kushwaha, Rajaram Bal, Rajendra Srivastava
Summary: In this study, a Pd-decorated MOF-derived CeO2 catalyst was successfully used for the cascade one-pot synthesis of secondary amines through thermal and photocatalytic routes. Pd(0.5%)/CeO2-300 exhibited the best activity and demonstrated excellent stability and recyclability under thermal and photocatalytic conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Jasvir Dalal, Sanket Malik, Sajjan Dahiya, Rajesh Punia, Kuldeep Singh, A. S. Maan, S. K. Dhawan, Anil Ohlan
Summary: This study presents a facile method for synthesizing Ni0.5Co0.5Fe2O4 nanoparticles decorated reduced graphene oxide (RGO) nanocomposites, which exhibit enhanced shielding effectiveness and absorption performance. The findings suggest that the interface linkages and synergy between Ni0.5Co0.5Fe2O4 and RGO play a crucial role in improving the microwave absorbing properties, thereby advancing the design of lightweight microwave absorbers.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Energy & Fuels
Sadananda Muduli, Subir K. Pati, Tapan K. Pani, Surendra K. Martha
Summary: In this work, a simple one-pot hydrothermal synthesis method was used to prepare NiO nanorods followed by carbon framework decorated NiO nanorods (NiO@C). The NiO@C electrode exhibited an excellent specific capacitance of 1360 F g-1 compared to pristine NiO of 890 F g-1. The NiO@C electrodes also showed excellent cycle stability over 10,000 cycles with 90% capacitance retention. Moreover, asymmetric supercapacitors fabricated using corncob-derived activated carbon anode and NiO@C cathode delivered a power density of 4574 W kg-1 at an energy density of 21.6 Wh kg-1. The enhanced capacitance of NiO@C material was attributed to the synergistic effect of the pseudocapacitive of NiO nanorods and the electric double-layer capacitance of the carbon matrix. The carbon framework also facilitated quick charge acceptance, improved cycling stability, and rate capability. The cost-effective one-pot synthesis and eco-friendly NiO nanorods with easy electrode fabrication provide opportunities for developing high-energy-density NiO-based supercapacitors.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Chemistry, Multidisciplinary
Ahmed M. Khalil, Laurent Michely, Remy Pires, Stephane Bastide, Khouloud Jlassi, Souad Ammar, Mohamed Jaziri, Mohamed M. Chehimi
Summary: This study focuses on valorizing agrowaste into biochar to serve as a support for bimetallic nanocatalysts, which have shown to be efficient in environmental remediation. The one-pot method devised in this work provides unique CuNi-decorated biochar and broadens the horizons of biochar-supported nanocatalysts.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Chenchen Liu, Shuning Liu, Lingling Wang, Zhongxiang Bai, Guo Lin, Xiaofang Feng, Kun Jia, Xiaobo Liu
Summary: This work presents the facile synthesis of PAE@Fe3O4 hybrid nanospheres using a reactive polymer as the structure-directing agent. The obtained hybrid nanospheres exhibit diverse electromagnetic loss pathways due to the metalligand bonding between Fe3O4 and the polymer. The optimized PAE@Fe3O4 hybrid nanospheres display enhanced reflection loss and effective absorption bandwidth, making them promising candidates for flexible electromagnetic radiation controlling devices.
Article
Chemistry, Multidisciplinary
Seok Jeong, Youjung Sim, Jin Kyun Kim, Sunyoung Shin, Jaewoong Lim, Junmo Seong, Seonghwan Lee, Dohyun Moon, Seung Bin Baek, Chae Un Kim, Ja-Hyoung Ryu, Myoung Soo Lah
Summary: A new synthetic approach for tunable mesoporous metal-organic frameworks (MeMs) is developed, where mesopores are created by heat conversion of high-density nanocrystallites. The pore size can be controlled by adjusting heat treatment conditions, and immobilized enzymes in MeMs exhibit catalytic activity.
Review
Materials Science, Biomaterials
Jun Yong Oh, Gyeongseok Yang, Eunshil Choi, Ja-Hyoung Ryu
Summary: The review highlights the recent research on mesoporous silica nanoparticle-supported nanocarriers for efficient cancer treatment. These nanocarriers possess a high drug loading capacity, encapsulation stability, and targeting capability, making them promising for drug delivery applications.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Sangpil Kim, Nam Gu Yoon, Batakrishna Jana, Byoung Heon Kang, Ja-Hyoung Ryu
Summary: Novel mitochondria targeting agents with high water solubility were designed by introducing quaternary ammonium, which effectively inhibit mitochondrial respiratory chain and induce apoptosis in cancer cells. These agents have the potential to be developed as anticancer drugs.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Eun-Koung An, Juyoung Hwang, So-Jung Kim, Hae-Bin Park, Wei Zhang, Ja-Hyoung Ryu, SangGuan You, Jun-O Jin
Summary: This study found that fucoidan from Laminaria japonica can stimulate immune cell activation and enhance anti-cancer immunity, while laminarin showed weaker immune activation ability. In addition, fucoidan enhanced the anticancer efficacy of immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Youngdo Jeong, Soyeong Jin, L. Palanikumar, Huyeon Choi, Eunhye Shin, Eun Min Go, Changjoon Keum, Seunghwan Bang, Dongkap Kim, Seungho Lee, Minsoo Kim, Hojun Kim, Kwan Hyi Lee, Batakrishna Jana, Myoung-Hwan Park, Sang Kyu Kwak, Chaekyu Kim, Ja-Hyoung Ryu
Summary: The dynamic behavior of biological nanomachines, controlled by supramolecular recognition, has led to the development of potential therapeutic artificial nanomachines. This study integrates actuatable molecular components into a hierarchical nanomaterial to regulate biological functions in response to external stimuli, providing a strategy for designing biomimetic nanotoxins.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Correction
Geriatrics & Gerontology
Jae-Byoung Chae, Hyoik Jang, Chanok Son, Chul-Woo Park, Huyeon Choi, Seongeon Jin, Ho-Yeon Lee, Hyungwoo Lee, Ja-Hyoung Ryu, Namshin Kim, Chaekyu Kim, Hyewon Chung
Article
Biology
Hyungwoo Lee, Ho-Yeon Lee, Jae-Byoung Chae, Chul-Woo Park, Chaekyu Kim, Ja-Hyoung Ryu, Jiwon Jang, Namshin Kim, Hyewon Chung
Summary: Single cell transcriptomics has identified a cell subpopulation that may induce cellular senescence of the retinal pigment epithelium, which could contribute to retinal degenerative diseases. The study analyzed the single-cell RNA profiles of control and senescent retinal pigment epithelium tissue, revealing four main subpopulations with distinct biological activities. Cellular senescence predominantly occurred in a specific cluster characterized by catalytic activity. Additionally, several genes not previously associated with senescence showed altered expression in the senescent tissue. These findings provide valuable insights for understanding control and senescent retinal pigment epithelium.
COMMUNICATIONS BIOLOGY
(2022)
Article
Engineering, Environmental
Jun Yong Oh, Eun-Koung An, Batakrishna Jana, Hansol Kim, Seongeon Jin, Gyeongseok Yang, Jinsoo Kim, Eunshil Choi, Jun-O Jin, Ja-Hyoung Ryu
Summary: In order to improve drug delivery with nanoparticles, antibodies are used due to their high affinity to the target site. However, the traditional method of conjugating antibodies to nanoparticles can damage the antibody's ability to recognize its target. This study presents a simple approach to create a targeted delivery platform by coating the nanoparticle surface with a fusion protein consisting of glutathione-S-transferase (GST) and the antibody-binding domain (ABD) called Z domain. The antibody-plugged nanoparticle exhibits excellent stability and target-specific behavior, significantly enhancing drug delivery efficiency in various therapeutic applications both in vitro and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jun Yong Oh, Eunshil Choi, Batakrishna Jana, Eun Min Go, Eunji Jin, Seongeon Jin, Jinhyu Lee, Jong-hoon Bae, Gyeongseok Yang, Sang Kyu Kwak, Wonyoung Choe, Ja-Hyoung Ryu
Summary: In this study, protein corona-blocked Zr-6-based MOF (PCN-224) nanoparticles are used for targeted cancer therapy. The PCN-224 surface is precoated with GST-fused targetable affibody (GST-Afb) proteins to prevent unwanted interactions with external proteins. The effectiveness of the particles in inducing cell death in cancer cells is demonstrated both in vitro and in vivo using two different affibodies targeting HER2 and EGFR receptors. This study provides insights into regulating the protein-adhesive surface of MOF nanoparticles for the design of more effective targeted delivery systems.
Article
Nanoscience & Nanotechnology
Youjung Sim, Junmo Seong, Seonghwan Lee, Dohyun Kim, Eunshil Choi, Myoung Soo Lah, Ja-Hyoung Ryu
Summary: The integration of catalase (CAT) into metal-organic framework (MOF) nanoparticles (NPs) through supramolecular interactions enhances its cellular entry and improves the effectiveness of photodynamic therapy (PDT). This study demonstrates the potential of the protein-MOF integration strategy in overcoming tumor hypoxia and efficiently delivering biomolecular cargos.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Gyeongseok Yang, Sangpil Kim, Jun Yong Oh, Dohyun Kim, Seongeon Jin, Eunshil Choi, Ja-Hyoung Ryu
Summary: In this paper, a strategy for targeted delivery and controlled drug release using disulfide-incorporated mesoporous organosilica nanoparticles (MONs) was presented. The MONs were loaded with the chemodrug doxorubicin (DOX) and conjugated with a cell-specific affibody (Afb) fused with glutathione-S-transferase (GST). The particles exhibited prompt responsivity to the SS bond-dissociating glutathione (GSH), resulting in significant degradation of the particles and release of DOX, thereby enhancing cancer-therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Batakrishna Jana, Seongeon Jin, Eun Min Go, Yumi Cho, Dohyun Kim, Sangpil Kim, Sang Kyu Kwak, Ja-Hyoung Ryu
Summary: Lysosomes are important organelles and targets for cancer therapy. Recent studies have shown that lysosomal membrane permeabilization can induce cell death, providing an effective way to treat cancer. However, most lysosome-targeted anticancer drugs lack selectivity for cancer cells. This study demonstrates the use of intra-lysosomal self-assembly of a peptide amphiphile as a powerful technique to overcome this problem. The peptide amphiphile localizes in the cancer lysosome and undergoes enzyme-instructed supramolecular assembly, leading to lysosomal damage and caspase-independent apoptotic death of cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Eun Seong Choi, Sangpil Kim, Dohyun Kim, Eunshil Choi, Ja-Hyoung Ryu
Summary: This study presents a nanogel system for co-delivery of an anticancer drug and mitochondria-targeting monomer, which can cooperatively activate cell death mechanisms and enhance cancer therapy.
Article
Chemistry, Multidisciplinary
Sangpil Kim, Huyeon Choi, Seongeon Jin, Sehee Son, Yeji Lee, Kibeom Kim, Ja-Hyoung Ryu
Summary: Self-assembly is a process of constructing three-dimensional structures through non-covalent interactions between building blocks of different sizes. It has attracted attention in cancer treatment due to its advantages in targeted therapy and overcoming the side effects of traditional chemotherapy. However, precise control of self-assembly in intracellular environments is challenging, prompting researchers to focus on self-assembly inside cellular organelles.
Article
Chemistry, Multidisciplinary
Huyeon Choi, Gaeun Park, Eunhye Shin, Seon Woo Shin, Batakrishna Jana, Seongeon Jin, Sangpil Kim, Huaimin Wang, Sang Kyu Kwak, Bing Xu, Ja-Hyoung Ryu
Summary: Mitochondria-targeting nucleopeptide can sequester ATP by self-assembling, leading to apoptosis of cancer cells.