Article
Pharmacology & Pharmacy
Kwadwo Mfoafo, Young Kwon, Yadollah Omidi, Hossein Omidian
Summary: Poloxamers, also known as Pluronic(R), are amphiphilic polymers with thermo-responsive properties. They have been widely used in the pharmaceutical field for prolonging drug release, improving solubility, enhancing stability, and improving bioavailability. Their unique thermogelling property has also led to biomedical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
G. Landazuri, V. V. A. Fernandez, J. F. A. Soltero, Y. Rharbi
Summary: The study utilizes fluorescence technique to quantify fusion and fission processes in triblock copolymer micelles in aqueous solutions, revealing that fusion and fission rates decrease sharply with increasing core block length (NPPO). Fission is primarily controlled by core interfacial tension, while fusion follows the same dependence on temperature and NPPO as fission.
Article
Chemistry, Multidisciplinary
Saugata Sahu, Pulak Karan, Ashok Kumar Mishra
Summary: FDAPT is an efficient environment-sensitive fluorescent probe that can sense the alteration of its microenvironment with six different fluorescent parameters. The study investigates the saccharide-induced dehydration of a F127 polymeric micelle using multiparametric fluorescence approach, revealing that saccharide molecules not only decrease the critical micellization temperature of the F127 solution but also strongly alter the physical properties inside the micellar structures. The dehydration efficiency order of different saccharide molecules is found to be trisaccharide (raffinose) > disaccharide (sucrose) > monosaccharide (glucose and fructose), with dehydration occurring more significantly in the core region than in the corona region.
Article
Chemistry, Multidisciplinary
Hongjun Jin, Ziyan Wu, Weilin Lin, Yinye Chen, Jingran Zhang, Ruyi Zheng, Haibing Wei, Qinghua Chen, Qingrong Qian, Jianbin Huang, Jie Zhang, Yun Yan
Summary: In this study, size-controllable tetragonal nanoprisms were formed through crystallization-directed ionic self-assembly (CDISA) by evaporating a micellar solution on solid substrates. The length and width of the nanoprisms can be easily tuned by varying the initial concentration. This precise size-control strategy is expected to provide new possibilities for designing advanced materials with size-controllable anisotropic nanostructures.
Article
Chemistry, Physical
Nitumani Tripathi, Debes Ray, Vinod K. Aswal, Ketan Kuperkar, Pratap Bahadur
Summary: This study investigates the nanoscale self-assembly behavior of ethylene oxide and propylene oxide-based block copolymers in aqueous solution, as well as the influence of sodium salts on the self-assembly process. The results show that at low temperatures, the copolymers exist as molecularly dissolved units, and at higher concentrations or in the presence of salt or elevated temperatures, the micellar structures exhibit a higher degree of organization.
Article
Chemistry, Physical
Nitumani Tripathi, Debes Ray, Vinod K. Aswal, Ketan Kuperkar, Pratap Bahadur
Summary: This article investigates the nanoscale self-assembly behavior of commercially available Pluronics L44 and F77 (ethylene oxide and propylene oxide-based block copolymers) in aqueous solution and their interaction with sodium salts. The results show that at low temperatures, the Pluronics solutions exist as individual units called unimers, while at higher concentrations and in the presence of salt or elevated temperatures, the micellar structures become more organized. Additionally, the study also explores the effect of various salts on the structural morphology changes of the block copolymers.
Article
Polymer Science
Aristeidis Papagiannopoulos, Natassa Pippa, Costas Demetzos, Stergios Pispas, Aurel Radulescu
Summary: The study demonstrates that amphiphilic block copolymers can be effectively used to prepare mixed lipid-block copolymer vesicles with controlled lamellarity and significant potential for drug delivery.
Article
Polymer Science
Ioannis Moutsios, Konstantinos Ntetsikas, Gkreti-Maria Manesi, George Liontos, Evgeniia A. Nikitina, Cheng-Yen Chang, Loic Vidal, Nikos Hadjichristidis, Rong-Ming Ho, Dimitri A. Ivanov, Apostolos Avgeropoulos
Summary: This study comprehensively examines structured diblock copolymer liquids composed of soft segments with low glass-transition temperatures, and finds that they have the ability to form well-ordered structures at low temperatures. By manipulating monomer ratios, the molecular and thermal characteristics of the copolymers were studied, and the limits of phase stability were assessed. The diverse molecular characteristics and the ability to design block copolymers with well-ordered phases have great potential for applications in soft electronics.
Article
Polymer Science
Bingbing Zhao, Yuting Yan, Junmei Zhang, Enping Chen, Ke Wang, Changshun Zhao, Yinan Zhong, Dechun Huang, Zhiqin Cui, Dawei Deng, Congying Gu, Wei Chen
Summary: A novel zwitterionic triblock copolymer was designed and synthesized, showing well-defined structure and controlled molecular weight; the copolymer could self-assemble into polymersomes with good biocompatibility and cell transmembrane ability; cytochrome c-loaded polymersomes exhibited potent cancer inhibitory activity and apoptosis-inducing ability against HeLa cells.
Article
Chemistry, Multidisciplinary
Nicholas J. Van Zee, Amanda S. Peroutka, Marc A. Hillmyer, Timothy P. Lodge
Summary: Poloxamers, also known as Pluronics, have been found to alleviate cellular membrane damage, but the underlying protection mechanism is still unclear. This study investigated the impact of poloxamer molar mass, hydrophobicity, and concentration on the mechanical properties of lipid vesicles, revealing that poloxamers tend to decrease the stretching modulus. The study provides important insights into how poloxamers interact with lipid membranes and protect cells from various stresses.
Article
Polymer Science
Rasika Dahanayake, Elena E. Dormidontova
Summary: The structure and properties of micelles formed by diblock and triblock copolymers are influenced by chain architecture. The addition of co-solvents affects the shape of micelles, water content in the core, and co-solvent accumulation at the core-corona interface.
Article
Biochemistry & Molecular Biology
Obed Andres Solis-Gonzalez, Juan Ramon Avendano-Gomez, Aaron Rojas-Aguilar
Summary: The study on the interaction between poloxamers and lipid bilayers found that F127 had stronger affinity than F108, leading to an increase in vesicle size and formation of bilayer discs at low concentrations. The results demonstrated a close association between the copolymers and the membrane, rather than just absorption onto the bilayer surface. These findings highlight the importance of temperature, copolymer concentration, and hydrophobic chain length in the interactions and stability of liposomes.
JOURNAL OF LIPOSOME RESEARCH
(2022)
Article
Polymer Science
Eider Matxinandiarena, Agurtzane Mugica, Agnieszka Tercjak, Viko Ladelta, George Zapsas, Nikos Hadjichristidis, Dario Cavallo, Araceli Flores, Alejandro J. Muller
Summary: Two novel tetrablock quarterpolymers were studied for the first time, revealing different crystallization behaviors and mechanical properties. One of the polymers self-assembled into tetracrystalline banded spherulites during crystallization, impacting its mechanical properties significantly. Additionally, the crystallization sequence of the blocks varied between the two polymers, with different blocks exhibiting distinct characteristics during the process.
Article
Chemistry, Multidisciplinary
Pratik S. Gotad, Navin Kafle, Toshikazu Miyoshi, Sadhan C. Jana
Summary: This study evaluates the surfactant adsorption abilities of polymer gels with high surface area and high porosity. It is found that below the critical micelle concentration, the surfactant adsorbs as a monolayer on the polymer strands and the adsorbed amount increases with the specific surface area of the gel. Above the critical micelle concentration, the gel shows strong surfactant adsorption.
Article
Polymer Science
Joseph F. Hassler, Nicholas J. Van Zee, Adelyn A. Crabtree, Frank S. Bates, Benjamin J. Hackel, Timothy P. Lodge
Summary: This work presents a synthetic strategy for making grafted block polymers with poly(propylene oxide) and poly(ethylene oxide) side chains, known as bottlebrush analogues of poloxamers. The bottlebrush architecture results in higher critical micelle concentration compared to linear analogues, allowing the polymers to exist as unimers at higher molecular weights and concentrations in solution.
Article
Clinical Neurology
C. Peyton, E. Yang, M. E. Msall, L. Adde, R. Stoen, T. Fjortoft, A. F. Bos, C. Einspieler, Y. Zhou, M. D. Schreiber, J. D. Marks, A. Drobyshevsky
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)
Article
Neurosciences
Jyothsna Suresh, Mihailo Radojicic, Lorenzo L. Pesce, Anita Bhansali, Janice Wang, Andrew K. Tryba, Jeremy D. Marks, Wim van Drongelen
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Oncology
Alexandre Chlenski, Marija Dobratic, Helen R. Salwen, Mark Applebaum, Lisa J. Guerrero, Ryan Miller, Gillian DeWane, Elena Solomaha, Jeremy D. Marks, Susan L. Cohn
Article
Biology
Leigh D. Plant, Jeremy D. Marks, Steve A. N. Goldstein
Article
Biochemistry & Molecular Biology
Janice C. Wang, Vytautas P. Bindokas, Matthew Skinner, Todd Emrick, Jeremy D. Marks
NEUROCHEMISTRY INTERNATIONAL
(2017)
Editorial Material
Medicine, General & Internal
Michael D. Schreiber, Jeremy D. Marks
NEW ENGLAND JOURNAL OF MEDICINE
(2017)
Article
Neurosciences
Jacob J. Riehm, Lijun Wang, Ghanashyam Ghadge, Michael Teng, Ana M. Correa, Jeremy D. Marks, Raymond P. Roos, Michael J. Allen
NEUROBIOLOGY OF DISEASE
(2018)
Article
Critical Care Medicine
Gregory B. Waypa, Jeremy D. Marks, Robert D. Guzy, Paul T. Mungai, Jacqueline M. Schriewer, Danijela Dokic, Molly K. Ball, Paul T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2013)
Article
Biochemistry & Molecular Biology
Gregory B. Waypa, Scott W. Osborne, Jeremy D. Marks, Sara K. Berkelhamer, Jyothisri Kondapalli, Paul T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Simran S. Sabharwal, Gregory B. Waypa, Jeremy D. Marks, Paul T. Schumacker
BIOCHEMICAL JOURNAL
(2013)
Meeting Abstract
Biophysics
Jia-yu Wang, Chi-Yuan Cheng, Ravinath Kausik, Jaemin Chin, Jeremy D. Marks, Song-I Han, Ka Yee C. Lee
BIOPHYSICAL JOURNAL
(2013)
Article
Neurosciences
Phullara B. Shelat, Leigh D. Plant, Janice C. Wang, Elizabeth Lee, Jeremy D. Marks
JOURNAL OF NEUROSCIENCE
(2013)
Article
Medicine, General & Internal
Colleen Peyton, Christa Einspieler, Toril Fjortoft, Lars Adde, Michael D. Schreiber, Alexander Drobyshevsky, Jeremy D. Marks
JOURNAL OF CLINICAL MEDICINE
(2020)
Meeting Abstract
Biophysics
Leigh D. Plant, Jeremy D. Marks, Steve A. N. Goldstein
BIOPHYSICAL JOURNAL
(2017)
Meeting Abstract
Critical Care Medicine
G. B. Waypa, J. D. Marks, R. D. Guzy, P. T. Mungai, J. Schriewer, D. Dokic, M. K. Ball, P. T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2013)