Article
Multidisciplinary Sciences
Irrum Mushtaq, Zareen Akhter, Muhammad Farooq, Farukh Jabeen, Ashfaq Ur Rehman, Sadia Rehman, Sidra Ayub, Bushra Mirza, Muhammad Siddiq, Farasat Zaman
Summary: A tunable amphiphilic ABA-type triblock copolymer, named P2L, was synthesized successfully. It is non-toxic to human blood cells and can encapsulate and release dexamethasone drug.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Dimitrios Selianitis, Stergios Pispas
Summary: We synthesized a new series of thermo- and pH-responsive hyperbranched copolymers and studied their self-assembly in aqueous media. The copolymers showed the formation of nano-aggregates responsive to changes in temperature and pH. Encapsulation experiments with a hydrophobic drug also showed promising results. These hyperbranched copolymers have potential as nanocarrier systems for medicinal applications.
Article
Chemistry, Inorganic & Nuclear
Aeli P. Olson, Li Ma, Yutian Feng, Firouzeh Najafi Khosroshahi, Steven P. Kelley, Eduardo Aluicio-Sarduy, Todd E. Barnhart, Heather M. Hennkens, Paul A. Ellison, Silvia S. Jurisson, Jonathan W. Engle
Summary: A new trithiol chelate was developed in this study to successfully complex with Sb-119, which can be purified by HPLC. This method provides a solution to the challenge of incorporating Sb-119 into biologically targeted compounds.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Lauren Repp, Morteza Rasoulianboroujeni, Hye Jin Lee, Glen S. Kwon
Summary: The use of PEG-b-PLA and PEG-b-PCL nano-assemblies can enhance the water solubility of anticancer drugs, have lower toxicity compared to traditional organic solvents or solubilizers, and the prodrugs combined in the nano-assemblies significantly enhance the anticancer efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Chufen Yang, Delin Wang, Wenyao Liu, Zexiong Yang, Teng He, Fang Chen, Wenjing Lin
Summary: In this study, folate (FA) modified dual pH/reduction-responsive mixed polymeric micelles were successfully assembled for high loading, controlled release, and active targeted delivery. The micelles showed excellent drug loading capacity and encapsulation efficiency, and demonstrated well-controlled release performance in neutral and acidic environments. Cytotoxicity assays further revealed the superior inhibitory effect of FA-modified micelles on cancer cells. These findings suggest that the developed micelles have great potential for anticancer drug delivery.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Bixin Jin, Qin Li, Lingjuan Hu, Qianwei Liu, Yiqi Chen, Yunjun Luo, Shumeng Chi, Xiaoyu Li
Summary: By incorporating additional polymers into liquid crystalline block copolymers, controllable supramolecular polymerization driven by mesogenic ordering effect can be achieved. The length of the resulting supramolecular polymers is controlled by tuning the ratio between nucleating and growing components.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Rini Sharma, Ujjal Haldar, Hyung-il Lee
Summary: A block copolymer probe with dual-detection capacity of cysteine and glucose was synthesized in this study, demonstrating colorimetric detection by altering the hydrophilicity of the probe in response to the presence of the target molecules.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Chan-Jin Kim, Ga-Hyun Kim, Eun Hye Jeong, Hyukjin Lee, So-Jung Park
Summary: This study investigates how the nature of the hydrophobic core affects the molecular interactions of DNA block copolymer assemblies. Results show that DNA block copolymer micelles with different hydrophobic cores exhibit markedly different molecular and biological interactions, with DNA-b-PS displaying superior properties. The type of hydrophobic core polymer has a profound impact on the molecular and biological interactions of the DNA shell.
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Zikang Li, Mei-Tung Lau, Jiahua Li, Feng Qiu, Zhengong Meng, Wai-Yeung Wong
Summary: A new bimetallic complex with a palladium core containing a 4'-ferrocenyl-(2,2':6',2''-terpyridine) and a polyethylene glycol-based pyridine ligand is applied for the first time in seeded-growth self-assembled supramolecular polymerization, resulting in nanoribbons with controllable lengths following a first-order reaction kinetics.
CHEMICAL COMMUNICATIONS
(2022)
Article
Polymer Science
Haohui Huo, Jie Liu, Senthil Kannan, Long Chen, Yimin Zhao, Lei Zhang, Gang Chang, Qilu Zhang, Feng Liu
Summary: This study presents the first example of protein-like multicompartment nanoparticles formed via self-assembly of a specifically designed 21-arm star polymer, PEG(PAA-b-PS)(20). The morphology of the MCNs is determined by the volume ratio of PS to PAA, and unique string structures composed of one-dimensional alignment of single-star polymers were observed for the first time. A new mechanism for the assembly of star polymers was proposed based on investigations under different conditions, suggesting potential applications in drug delivery and catalysis.
Article
Chemistry, Physical
Alberto Scacchi, Maria Sammalkorpi, Tapio Ala-Nissila
Summary: This study demonstrates how intrinsic length scales and interspecies molecular interactions can be used to control self-assembly in soft matter systems using classical density functional theory. The results show that tuning intermolecular interactions and system composition can influence concentration gradients within the assemblies.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Polymer Science
Bishnu Prasad Bastakoti, Nischal Bhattarai, Moses D. Ashie, Felix Tettey, Shin-ichi Yusa, Kenichi Nakashima
Summary: A laboratory-synthesized triblock copolymer was used as a template to synthesize hollow BaCO3 nanoparticles. The formation of spherical micelles with a PEG corona, PAA shell, and PS core in an aqueous solution was confirmed. The controlled precipitation of BaCO3 around the polymeric micelles allowed for the synthesis of hollow BC-NPs with specific properties.
Article
Polymer Science
Anastasiia A. Elistratova, Alexander S. Gubarev, Alexey A. Lezov, Petr S. Vlasov, Anastasia Solomatina, Yu-Chan Liao, Pi-Tai Chou, Sergey P. Tunik, Pavel S. Chelushkin, Nikolai Tsvetkov
Summary: In this paper, a detailed hydrodynamic study of six commercial diblock copolymers was conducted. The study found that the block copolymers exhibited bimodal particle distributions in both organic solvent and water micellar dispersions. The micelles were stable and showed low critical micelle concentration values, with low toxicity towards cells.
Article
Chemistry, Multidisciplinary
Shaofei Song, Hang Zhou, Shuyang Ye, Jason Tam, Jane Y. Howe, Ian Manners, Mitchell A. Winnik
Summary: By crystallization-driven self-assembly, a BCP containing an amphiphilic ferrocenyldimethylsilane can form 3D structures similar to spherulites in decane, with externally spherical symmetry but asymmetric core structure consisting of sheaf-like leaves. The amount of added unimer determines the growth stoppage at different stages of the seeded growth experiment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Editorial Material
Chemistry, Multidisciplinary
Christine Allen, Michael Dunne
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemistry & Molecular Biology
Megan G. Roberts, Qing Yu, Rachel Keunen, Jieyi Liu, Edmond Chi Ngae Wong, Chandresh Kumar Rastogi, Raymond M. Reilly, Christine Allen, Mitchell A. Winnik
Review
Pharmacology & Pharmacy
Yen Ting Shen, Rashi Asthana, Casper Peeters, Christine Allen, Carlo DeAngelis, Micheline Piquette-Miller
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Michael Dunne, Maximilian Regenold, Christine Allen
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Multidisciplinary Sciences
Marc A. Santos, Sheng-Kai Wu, Maximilian Regenold, Christine Allen, David E. Goertz, Kullervo Hynynen
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Jessica Steigenberger, Elisa Siniscalchi, Michael Dunne, Luca Casettari, Heiko Heerklotz, Christine Allen
JOURNAL OF CONTROLLED RELEASE
(2020)
Editorial Material
Chemistry, Multidisciplinary
Christine Allen
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Nanoscience & Nanotechnology
Nidal Muhanna, Donovan Eu, Harley H. L. Chan, Michael Daly, Inga B. Fricke, Catriona M. Douglas, Jason L. Townson, Jinzi Zheng, Christine Allen, David A. Jaffray, Jonathan C. Irish
Summary: This study evaluated the use of CF800 in enhancing intraoperative tumor demarcation in head and neck cancer. The results showed significant enhancement in fluorescence imaging and CBCT, indicating CF800 as a promising candidate for image-guided surgery. Further investigation is needed to determine its sensitivity and specificity in detecting nodal involvement.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Pauric Bannigan, Matteo Aldeghi, Zeqing Bao, Florian Hase, Alan Aspuru-Guzik, Christine Allen
Summary: Machine learning has made significant advances in the healthcare and pharmaceutical sectors, especially in drug formulation development. Traditional approaches to drug formulation development are time-consuming and limited, while machine learning can help accelerate drug formulation development, improve the bioavailability and targeted delivery of new drugs.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Medicinal
Zeqing Bao, Sungmin Jung, Jack Bufton, James C. Evans, Dean J. Aguiar, Christine Allen
Summary: A novel polymeric material, PVL-co-PAVL, was used to manufacture microparticles for sustained drug delivery. In vitro evaluation showed sustained release of drug with first-order release kinetics, while in vivo release was slightly lower than expected. Further studies will continue to investigate the distribution of drug in this new polymer-based microparticle system.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jack Bufton, Sungmin Jung, James C. Evans, Zeqing Bao, Dean Aguiar, Christine Allen
Summary: The study synthesized two novel cross-linkable copolymers for preparing disc-shaped implants, and the manipulation of composition and drug loading conditions was found to influence system performance. The results support further development of cross-linkable matrices for sustained drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Brittany Epp-Ducharme, Michael Dunne, Linyu Fan, James C. Evans, Lubabah Ahmed, Pauric Bannigan, Christine Allen
Summary: The heat shock protein 90 inhibitor luminespib has shown promising preclinical activity against various cancers, with potential for even greater efficacy through reformulation using advanced drug delivery strategies. Specifically, the use of thermosensitive liposomes for drug delivery in combination with other chemotherapeutic agents has shown synergistic activity in lung cancer, offering hope for the resuscitation of this promising anticancer agent in clinical settings.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Qing Yu, Megan G. Roberts, Loujin Houdaihed, Yang Liu, Kuan Ho, Gilbert Walker, Christine Allen, Raymond M. Reilly, Ian Manners, Mitchell A. Winnik
Summary: The physicochemical properties of drug nanocarriers, such as size, shape, and surface chemistry, play a crucial role in their efficient penetration into tumor tissues. Rigid rod-like micelles with uniform width and varied lengths were found to exhibit significant cell uptake and penetration into multicellular tumor spheroids, with elongated micelles showing deeper penetration. However, the extent and depth of tumor penetration decreased with increasing aspect ratio of the rod-like micelles, indicating a shape-dependent effect on cellular uptake and penetration.
Review
Medicine, Research & Experimental
Hoda Soleymani Abyaneh, Maximilian Regenold, Trevor D. McKee, Christine Allen, Marc A. Gauthier
Article
Pharmacology & Pharmacy
Victor Passos Gibson, Rabeb Mouna Derbali, Huu Trong Phan, Houda Tahiri, Christine Allen, Pierre Hard, Jeanne Leblond Chain
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)