Article
Chemistry, Multidisciplinary
Liu Tan, Jinling Fan, Yuqing Zhou, Di Xiong, Manzhen Duan, Ding Hu, Zhimin Wu
Summary: A new type of reversible cross-linked and pH-responsive polymeric micelle was synthesized for targeted delivery of curcumin. The micelle exhibited excellent stability and reversibility of pH-responsiveness in solutions with different pH values. Simulation methods were employed to investigate the self-assembly process and pH-responsive behavior of the micelle.
Article
Chemistry, Multidisciplinary
Chenggang Song, Fan Yang, Ruixuan Ji, Yin Lv, Zhong Wei
Summary: A newly prepared amphiphilic block copolymer nanomicelle successfully delivered the anticancer drug DOX to tumor sites, demonstrating good drug release performance and anticancer effects. Furthermore, these nanomicelles showed significantly improved therapeutic effects in treating tumor cells with the introduction of ferrocene.
Article
Chemistry, Multidisciplinary
Zhengmin Tang, Liang Gao, Jiaping Lin, Chunhua Cai, Yuan Yao, Gerald Guerin, Xiaohui Tian, Shaoliang Lin
Summary: This study reports the controlled growth of elongated micelles with a liquid crystalline core onto a hydrophobic substrate via synergistic interactions between the substrate and dispersed aggregates in solution. Seed formation is a transient phenomenon induced by the adsorption and rearrangement of core-swollen aggregates.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Kunlun Zhang, Mingheng Xiao, Li Zhang, Ying Chen, Jianbo Tan
Summary: This study reports a strategy for preparing surface-functional polymeric microspheres using photoinitiated reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization and subsequent photografting under different wavelengths of light. The method allows for the preparation of uniform-sized photoreactive polymeric microspheres and enables photografting polymerizations with various monomers. Furthermore, the technique allows for the preparation of carboxyl-functionalized polymeric microspheres, which can be extensively used for surface bioconjugation reactions.
Review
Materials Science, Multidisciplinary
Duy Toan Pham, Athittaya Chokamonsirikun, Vipasiri Phattaravorakarn, Waree Tiyaboonchai
Summary: Polymeric micelles serve as an effective approach in pulmonary drug delivery, enhancing drug targeting to the lung, reducing side effects, and improving drug efficacy. Their importance lies in rational design and ideal properties for pulmonary route delivery.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Biochemical Research Methods
Jinxuan He, Zhixiang Mou, Yuchen Tian, Yiyan Zhang, Tianjun Guan, Qixian Chen, Lan Chen
Summary: A polymeric siRNA conjugate was developed to overcome biological barriers for delivering siRNA into cells, showing potential for cancer treatment and hyperparathyroidism. The conjugate exhibited efficient release of active siRNA in the cytosol, providing a promising platform for RNA interference therapeutics and biomimetic materials.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zikang Li, Mei-Tung Lau, Jiahua Li, Feng Qiu, Zhengong Meng, Wai-Yeung Wong
Summary: A new bimetallic complex with a palladium core containing a 4'-ferrocenyl-(2,2':6',2''-terpyridine) and a polyethylene glycol-based pyridine ligand is applied for the first time in seeded-growth self-assembled supramolecular polymerization, resulting in nanoribbons with controllable lengths following a first-order reaction kinetics.
CHEMICAL COMMUNICATIONS
(2022)
Article
Polymer Science
Haohui Huo, Jie Liu, Senthil Kannan, Long Chen, Yimin Zhao, Lei Zhang, Gang Chang, Qilu Zhang, Feng Liu
Summary: This study presents the first example of protein-like multicompartment nanoparticles formed via self-assembly of a specifically designed 21-arm star polymer, PEG(PAA-b-PS)(20). The morphology of the MCNs is determined by the volume ratio of PS to PAA, and unique string structures composed of one-dimensional alignment of single-star polymers were observed for the first time. A new mechanism for the assembly of star polymers was proposed based on investigations under different conditions, suggesting potential applications in drug delivery and catalysis.
Review
Chemistry, Multidisciplinary
Ramya Kumar, Cristiam F. Santa Chalarca, Matthew R. Bockman, Craig Van Bruggen, Christian J. Grimme, Rishad J. Dalal, Mckenna G. Hanson, Joseph K. Hexum, Theresa M. Reineke
Summary: The development of genome editing has revolutionized the treatment of various debilitating diseases, with promising clinical prospects for gene therapy. While polymeric vectors offer great potential in efficient nucleic acid delivery, their clinical translation still faces significant challenges. Interdisciplinary approaches and fundamental question-driven methodologies are essential for designing high-performing polymeric vehicles for gene therapy.
Article
Chemistry, Multidisciplinary
Yufei Cao, Jiale Si, Moujiang Zheng, Qinghao Zhou, Zhishen Ge
Summary: Radiotherapy is widely used in the treatment of various cancers and has the advantages of precise controllability and deep tissue penetration. However, it is limited by side effects and tumor hypoxia. The combination of radiotherapy and other modalities can improve therapeutic efficacy and reduce toxicity.
CHEMICAL COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Irrum Mushtaq, Zareen Akhter, Muhammad Farooq, Farukh Jabeen, Ashfaq Ur Rehman, Sadia Rehman, Sidra Ayub, Bushra Mirza, Muhammad Siddiq, Farasat Zaman
Summary: A tunable amphiphilic ABA-type triblock copolymer, named P2L, was synthesized successfully. It is non-toxic to human blood cells and can encapsulate and release dexamethasone drug.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Fei Deng, Menglin Yang, Yanli Zhang, Xiaohui Wu, Rujiang Ma, Feihe Ma, Linqi Shi
Summary: By developing a one-pot strategy to synthesize high-concentration MSPMs, it is possible to mass produce nanochaperones for refolding denatured proteins and stabilizing the structure of native proteins. This simple method provides a way to promote the practical applications of functional nanochaperones.
Review
Polymer Science
Sam Russell, Nico Bruns
Summary: Fragrances are widely used in various applications and encapsulation is an effective method to limit their loss and sustain their release. This review provides an overview of different materials and techniques for fragrance encapsulation, with a focus on cyclodextrins, polymer microcapsules, inorganic microcapsules, block copolymer micelles, and polymersomes.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Franka Gruschwitz, Franziska Hausig, Philipp Schueler, Julian Kimmig, Stephanie Hoeppener, David Pretzel, Ulrich S. Schubert, Sylvain Catrouillet, Johannes C. Brendel
Summary: This study demonstrates the formation of shear-thinning hydrogels by amphiphilic polymers, which assemble into supramolecular polymer nanofibers through additional hydrogen bonds. The addition of bifunctional cross-linkers results in robust gels that exhibit strong shear-thinning behavior and can fully recover in the absence of shear stress. The low viscosity under shear load and rapid recovery make these gels suitable for easy extrusion and printing processes. Furthermore, the polymer-covered fiber structure provides excellent stability and biocompatibility to the gels.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yu Tong Tam, Lauren Repp, Zhi-Xiong Ma, John B. Feltenberger, Glen S. Kwon
PHARMACEUTICAL RESEARCH
(2019)
Article
Engineering, Biomedical
Libor Kostka, Lenka Kotrchova, Vladimir Subr, Alena Libanska, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Todd E. Barnhart, Jonathan W. Engle, Weibo Cai, Milada Sirova, Tomas Etrych
Article
Radiology, Nuclear Medicine & Medical Imaging
Weijun Wei, Dawei Jiang, Hye Jin Lee, Miao Li, Christopher J. Kutyreff, Jonathan W. Engle, Jianjun Liu, Weibo Cai
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Review
Chemistry, Multidisciplinary
Zhaoting Li, Yixin Wang, Yingyue Ding, Lauren Repp, Glen S. Kwon, Quanyin Hu
Summary: Immunotherapy plays a crucial role in treating diseases, but its application is hindered by limited response rates and systemic side effects. Using natural cells as carriers can reduce immunogenicity and toxicity, while controlling their spatiotemporal distribution can enhance treatment efficacy and minimize side effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Jianxin Wang, Adam J. Drelich, Caroline M. Hopkins, Sandro Mecozzi, Lingjun Li, Glen Kwon, Seungpyo Hong
Summary: In the midst of the COVID-19 pandemic, virus diagnostics have become crucial, with gold nanoparticle (AuNP) applications showing great potential in viral detection. Designing AuNP-based SARS-CoV-2 testing requires consideration of multiple factors, with the development of effective AuNP testing methods being critical for the future.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lauren Repp, Christopher J. Unterberger, Zhengqing Ye, John B. Feltenberger, Steven M. Swanson, Paul C. Marker, Glen S. Kwon
Summary: This study aimed to improve the stability of micelles by synthesizing an ester prodrug, successfully loading it within the micelle, solubilizing it in aqueous media, and delaying drug release. The prodrug rapidly converted to the parent drug post-release, showing efficacy and reduced toxicity compared to the traditional drug in a preclinical mouse model of prostate cancer.
Article
Chemistry, Multidisciplinary
Hye Jin Lee, Metti K. Gari, David R. Inman, Zachary T. Rosenkrans, Brian M. Burkel, Aeli P. Olson, Jonathan W. Engle, Reinier Hernandez, Suzanne M. Ponik, Glen S. Kwon
Summary: The study demonstrates that PEGylated FUD peptide has improved tumor exposure in a murine breast cancer model compared to non-PEGylated FUD. PEG-FUD maintains nanomolar binding affinity for FN in vitro and stability for up to 48 hours, showing potential as a therapeutic and imaging agent for breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Morteza Rasoulianboroujeni, Lauren Repp, Hye Jin Lee, Glen S. Kwon
Summary: A new method named PEG-assist is introduced for the production of drug-loaded polymeric micelles. The method utilizes PEG as a solvent and shows significant improvement in the encapsulation efficiency of drugs in the micelles. It is a promising approach for large scale production due to its simplicity, cost-effectiveness, and efficiency.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovar, Weibo Cai, Milada Sirova, Tomas Etrych
Summary: nanomedicines are being developed as an improved therapeutic option with reduced side effects, and this study introduces tailored nanosystems for the treatment of solid tumors or hematological malignancies. The relationship between the structure of the nanosystem and its distribution in the body was evaluated through independent assessments of the polymer carrier and drug pharmacokinetics. The results showed enhanced tumor accumulation of the polymer carriers in mice with solid tumors, as well as significant accumulation of doxorubicin bound to the polymer carriers in specific tumor types.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Lauren Repp, Sarah L. Skoczen, Morteza Rasoulianboroujeni, Stephan T. Stern, Glen S. Kwon
Summary: PTX is a commonly used chemotherapy drug for treating various solid tumors. o(LA)(8)-PTX prodrug-loaded PEG-b-PLA micelles have higher loading, slower release, and greater antitumor efficacy compared to PTX-loaded PEG-b-PLA micelles. This study investigates the plasma stability and pharmacokinetics of o(LA)(8)-PTX-loaded PEG-b-PLA micelles in rats. The prodrug is metabolized into o(LA)(1)-PTX and PTX in rat plasma, while in human plasma, it is metabolized into o(LA)(2)-PTX, o(LA)(1)-PTX, and PTX. The abundance of metabolites in rat plasma after IV injection follows the order: o(LA)(1)-PTX > o(LA)(2)-PTX > o(LA)(4)-PTX > o(LA)(6)-PTX. Bile metabolite profiles are similar to plasma metabolite profiles. Compared to Abraxane, plasma exposure to PTX is 100 times higher for Abraxane, and plasma exposure to o(LA)(1)-PTX is five times higher, indicating enhanced antitumor efficacy.
Article
Pharmacology & Pharmacy
Weijun Wei, Dawei Jiang, Hye Jin Lee, Jonathan W. Engle, Hisaya Akiba, Jianjun Liu, Weibo Cai
ADVANCED THERAPEUTICS
(2020)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
