Article
Genetics & Heredity
Irene Peral-Sanchez, Batoul Hojeij, Diego A. Ojeda, Regine P. M. Steegers-Theunissen, Sandrine Willaime-Morawek
Summary: This review examines the relationship between non-communicable diseases, environmental exposures, and lifestyle behaviors, focusing on the impact of poor maternal diet on embryonic development and epigenetic modifications. Various types of nutritional stressors and their effects on target genes and outcomes are discussed, as well as the relationship between maternal diets and assisted reproductive technology.
Article
Nutrition & Dietetics
Junki Imaizumi, Shuhei Kamada, Miyu Taniguchi, Tatsuro Sugimoto, Takaaki Maeda, Ryosuke Arakaki, Shota Yamamoto, Aya Shirakawa, Ayuka Mineda, Atsuko Yoshida, Takeshi Iwasa, Takashi Kaji
Summary: Changes in oxytocin levels and oxytocin receptor mRNA expression were observed in rats with intrauterine undernutrition. These changes could potentially affect nutritional and metabolic regulation systems and contribute to the mechanisms underlying DOHaD.
Article
Nutrition & Dietetics
Pierre Hofstee, Anthony V. Perkins, James S. M. Cuffe
Summary: Selenium deficiency during the perinatal period reduces exercise behavior and leads to glucose intolerance in offspring. Exercise may not be the optimal intervention for metabolic disease in offspring affected by selenium deficiency in early life.
Review
Gastroenterology & Hepatology
Dax Humberto Galvan-Martinez, Victor Manuel Bosquez-Mendoza, Yeniley Ruiz-Noa, Lorena del Rocio Ibarra-Reynoso, Gloria Barbosa-Sabanero, Maria-Luisa Lazo-de-la-Vega-Monroy
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global liver disease with increasing prevalence in children and adolescents. This article reviews the potential maternal and paternal conditions that may contribute to the early-life programming of NAFLD. Maternal factors such as obesogenic diet, overweight/obesity, and altered lipogenesis, as well as certain vitamin supplementation and drug use during pregnancy, are discussed. Additionally, maternal-fetal pathologies, exposure to environmental contaminants, microbiome changes, and paternal preconceptional conditions like exercise and diet are examined. Understanding these conditions is crucial for comprehending the mechanisms involved in NAFLD and developing preventive strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Environmental Sciences
Undarmaa Enkhbat, Enkhjargal Gombojav, Chimeglkham Banzrai, Sarangerel Batsukh, Buyantushig Boldbaatar, Enkhtuul Enkhtuya, Chimedsuren Ochir, David C. Bellinger, Bruce P. Lanphear, Lawrence C. McCandless, Ryan W. Allen
Summary: Reducing indoor particulate air pollution during pregnancy using air purifiers did not show benefits on children's behaviors. Associations between indoor PM2.5 concentrations in the first trimester and behavioral problems among 4-year old children suggest the need for early interventions to protect children.
ENVIRONMENTAL HEALTH
(2021)
Article
Obstetrics & Gynecology
Juan J. Fraire-Zamora, Meritxell Martinez, Marc Torra-Massana, Irene Miguel-Escalada, Rita Vassena
Summary: This study found no significant differences in morphokinetic parameters between male and female preimplantation embryos.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Obstetrics & Gynecology
Md Wasim Bari, Shiori Ishiyama, Sachi Matsumoto, Kazuki Mochizuki, Satoshi Kishigami
Summary: This study provides a brief history of assisted reproductive technology (ART) and its outcomes on subsequent development. It introduces a novel mouse model of diabetes generated through in vitro culture of preimplantation embryos. The findings suggest a close association between the preimplantation environment and postnatal health.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Shiori Ishiyama, Mayu Kimura, Takao Nakagawa, Yuka Fujimoto, Kohei Uchimura, Satoshi Kishigami, Kazuki Mochizuki
Summary: The study established a mouse model of diabetic kidney disease (DKD) through manipulating the embryonic environment, showing significant pathologies such as glomerulosclerosis and renal arteriolar changes, which were ameliorated by barley intake. This suggests that the MEM mouse model is effective for studying DKD, and dietary intervention with barley can improve the pathologies observed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Diego Halabi, Hans G. Richter, Natalia Mendez, Thilo Kahne, Carlos Spichiger, Esteban Salazar, Fabiola Torres, Karina Vergara, Maria Seron-Ferre, Claudia Torres-Farfan
Summary: The study demonstrated that gestational chronodisruption in rats can lead to major changes in maternal circadian rhythms and fetal development, impacting adult life at multiple physiological levels. These disruptions resulted in detrimental effects on adipose tissue recruitment and function, suggesting that the programming of adipose tissue function during gestational chronodisruption may lead to deficient metabolic responses persisting into adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Romina Via y Rada, Nathalie Daniel, Catherine Archilla, Anne Frambourg, Luc Jouneau, Yan Jaszczyszyn, Gilles Charpigny, Veronique Duranthon, Sophie Calderari
Summary: This study investigates the effect of a hyperglycemic and/or hyperinsulinemic environment on the development of preimplantation embryos, and finds that exposure to high glucose and high insulin can result in different transcriptional responses in the inner cell mass and trophectoderm, potentially compromising the development of future individuals and placenta.
Article
Environmental Sciences
Undarmaa Enkhbat, Enkhjargal Gombojav, Chimeglkham Banzrai, Sarangerel Batsukh, Buyantushig Boldbaatar, Enkhtuul Enkhtuya, David C. Bellinger, Bruce P. Lanphear, Lawrence C. McCandless, Ryan W. Allen
Summary: Exposure to indoor PM2.5 during pregnancy may increase the risk of developing autism spectrum disorder in children, while reducing indoor PM during pregnancy has little impact on mean autism-related behavior scores in children.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Akhgar Ghassabian, Laura Vandenberg, Kurunthachalam Kannan, Leonardo Trasande
Summary: This article discusses the unique vulnerability of children to endocrine-disrupting chemicals (EDCs) and the programming effects of EDCs on neuronal, metabolic, immune, endocrine, reproductive, and renal systems. By dispelling myths and providing a list of actions to reduce exposure and harm, it aims to address the health effects of EDCs on child health.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Review
Medicine, General & Internal
Romualdo Sciorio, Claudio Manna, Patricia Fauque, Paolo Rinaudo
Summary: Since the birth of Louise Brown in 1978, over nine million children have been conceived using assisted reproductive technologies (ARTs). The potential epigenetic consequences of gametes and embryo manipulation during the preimplantation period have raised concerns. This review examines the evidence on oocytes and embryo cryopreservation and their potential impact on epigenetic regulation. Overall, the stress induced by vitrification procedures may lead to epigenetic and transcriptomic changes in oocytes and embryos, but it is unclear whether these changes will affect the health of future offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Patricia C. Lisboa, Rosiane A. Miranda, Luana L. Souza, Egberto G. Moura
Summary: Breastfeeding period is crucial for development as it impacts child's health and may lead to metabolic disorders, with nutrients and environmental changes in breast milk playing a significant role.
Article
Medicine, General & Internal
Wanglong Gou, Huijun Wang, Xin-yi Tang, Yan He, Chang Su, Jiguo Zhang, Ting-yu Sun, Zengliang Jiang, Zelei Miao, Yuanqing Fu, Hui Zhao, Yu-ming Chen, Bing Zhang, Hongwei Zhou, Ju-Sheng Zheng
Summary: This study investigated the lifelong impact of famine exposure during early life on the adult gut microbial ecosystem and found associations between famine-induced disturbance in gut microbiota and type 2 diabetes.