Nutritional, pharmacological, and environmental programming of NAFLD in early life

Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome

(2022) Marine Baptissart et al.   HEPATOLOGY

Maternal Blood Levels of Toxic and Essential Elements and Birth Outcomes in Argentina: The EMASAR Study

(2022) Shanshan Xu et al.   International Journal of Environmental Research and Public Health

Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function

(2022) Kassidy Lundy et al.   Frontiers in Endocrinology

Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study

(2022) Jing Lin et al.   Frontiers in Endocrinology

Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity

(2022) Juan-Antonio Garcia-Santillan et al.   Frontiers in Cell and Developmental Biology

Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction

(2022) Mark D. Simmers et al.   Epigenetics

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children

(2022) Vishal Midya et al.   JAMA Network Open

Gestational Diabetes Mellitus and Developmental Programming

(2021) Anne H.Y. Chu et al.   ANNALS OF NUTRITION AND METABOLISM

Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review

(2021) Claudia Eberle et al.   PLoS One

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood

(2021) Nikos Stratakis et al.   HEPATOLOGY

Associations of Sleep Duration and Screen Time with Incidence of Overweight in European Children: The IDEFICS/I.Family Cohort

(2021) Viveka Guzmán et al.   Obesity Facts

Sleep Duration, Sleep Quality, and the Development of Nonalcoholic Fatty Liver Disease: A Cohort Study

(2021) Yoo Jin Um et al.   Clinical and Translational Gastroenterology

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

(2020) Keisaku Sato et al.   JOURNAL OF PINEAL RESEARCH

Early-life programming of adipose tissue

(2020) Ericka Moreno-Mendez et al.   NUTRITION RESEARCH REVIEWS

Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγ

(2020) Zi Long et al.   CELL BIOLOGY AND TOXICOLOGY

Prenatal Exposure to Perfluoroalkyl Substances Associated with Increased Susceptibility to Liver Injury in Children

(2020) Nikos Stratakis et al.   HEPATOLOGY

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Implications for prenatal cadmium exposure and adverse health outcomes in adulthood

(2020) Jamie L. Young et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming

(2020) Inga Bae-Gartz et al.   Scientific Reports

Impact of Early Nutrition, Physical Activity and Sleep on the Fetal Programming of Disease in the Pregnancy: A Narrative Review

(2020) Jorge Moreno-Fernandez et al.   Nutrients

Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes

(2020) Sara Parrettini et al.   Frontiers in Endocrinology

Genetic and epigenetic factors determining NAFLD risk

(2020) Wenke Jonas et al.   Molecular Metabolism

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

(2019) Folami Y Ideraabdullah et al.   JOURNAL OF ENDOCRINOLOGY

Direct toxicity of insulin on the human placenta and protection by metformin

(2019) Mario Vega et al.   FERTILITY AND STERILITY

Paternal high-fat diet transgenerationally impacts hepatic immunometabolism

(2019) Thais de Castro Barbosa et al.   FASEB JOURNAL

The Role of Genetic Predisposition, Programing During Fetal Life, Family Conditions, and Post-natal Diet in the Development of Pediatric Fatty Liver Disease

(2019) Antonella Mosca et al.   JOURNAL OF PEDIATRICS

Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway

(2019) Shuwei Hu et al.   TOXICOLOGY

Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats

(2019) Shuwei Hu et al.   TOXICOLOGY

The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease

(2019) Hsu et al.   Nutrients

Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

(2019) Sine Knorr et al.   DIABETES CARE

The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

(2019) Shanshan Zhu et al.   Biomed Research International

The adverse health effects of bisphenol A and related toxicity mechanisms

(2019) Ya Ma et al.   ENVIRONMENTAL RESEARCH

Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time

(2019) Ronald McCarthy et al.   Frontiers in Endocrinology

Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine

(2019) Giancotti et al.   Cells

The use of medication in pregnancy

(2019) Katarina Dathe et al.   Deutsches Arzteblatt International

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

(2019) Ran Jin et al.   ENVIRONMENT INTERNATIONAL

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood

(2019) Ellis Voerman et al.   Pediatric Obesity

Prescription and Other Medication Use in Pregnancy

(2018) David M. Haas et al.   OBSTETRICS AND GYNECOLOGY

Liver metabolism in adult male mice offspring: consequences of a maternal, paternal or both maternal and paternal high-fructose diet

(2018) P. V. Carapeto et al.   Journal of Developmental Origins of Health and Disease

Ambient air pollution, H19/DMR methylation in cord blood and newborn size: A pilot study in Zhengzhou City, China

(2018) Tongkun He et al.   CHEMOSPHERE

Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific

(2018) Ouma Cissé et al.   EUROPEAN JOURNAL OF NUTRITION

High fat diet affects pre-gestational adiposity and glucose tolerance perturbing gestational placental macronutrient transporters culminating in an obese offspring in wild type and glucose transporter isoform 3 heterozygous null mice

(2018) Amit Ganguly et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice

(2018) Adam J. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human placental glucose transport in fetoplacental growth and metabolism

(2018) Nicholas P. Illsley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

(2018) Taylor K. Soderborg et al.   Nature Communications

Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

(2018) Umesh D. Wankhade et al.   Scientific Reports

Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease

(2017) Prajakta C. Shimpi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Smoking-Induced Changes in the Maternal Immune, Endocrine, and Metabolic Pathways and Their Impact on Fetal Growth: A Topical Review

(2017) Sally Sabra et al.   FETAL DIAGNOSIS AND THERAPY

Maternal Dietary Patterns during Pregnancy Are Associated with Newborn Body Composition

(2017) Anne P Starling et al.   JOURNAL OF NUTRITION

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

(2017) Kimberly P. Newton et al.   JOURNAL OF PEDIATRICS

Vitamin D and Chronic Diseases

(2017) Hanmin Wang et al.   Aging and Disease

Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations

(2017) Umesh D. Wankhade et al.   PLoS One

High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

(2016) Antonio F. Saad et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Association of maternal diabetes/glycosuria and pre-pregnancy body mass index with offspring indicators of non-alcoholic fatty liver disease

(2016) Sumaiya Patel et al.   BMC Pediatrics

Association Between Maternal Prepregnancy Body Mass Index and Plasma Folate Concentrations With Child Metabolic Health

(2016) Guoying Wang et al.   JAMA Pediatrics

Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring

(2016) Julia A. Sabet et al.   PLoS One

Foetal programming by methyl donor deficiency produces steato-hepatitis in rats exposed to high fat diet

(2016) Anaïs Bison et al.   Scientific Reports

Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression

(2015) Minoru Terashima et al.   Epigenetics

Maternal obesity programs offspring non-alcoholic fatty liver disease through disruption of 24-h rhythms in mice

(2015) A Mouralidarane et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepatic Steatosis Is Prevalent in Stillborns Delivered to Women With Diabetes Mellitus

(2015) Kalyani R. Patel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Programming of Obesity and Comorbidities in the Progeny: Lessons from a Model of Diet-Induced Obese Parents

(2015) Fernanda Ornellas et al.   PLoS One

Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK

(2015) Antonysunil Adaikalakoteswari et al.   Nutrients

In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model

(2014) Melissa A. Suter et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity

(2014) Maria Z. Alfaradhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Lipid Metabolism During Pregnancy and its Implications for Fetal Growth

(2014) Emilio Herrera et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates

(2014) S. R. Thorn et al.   DIABETES

Accelerated Infant Weight Gain and Risk for Nonalcoholic Fatty Liver Disease in Early Adulthood

(2014) Laura M. Breij et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model

(2014) Jun Ma et al.   Nature Communications

Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring

(2013) M. G. M. Pruis et al.   Acta Physiologica

High folate and low vitamin B-12 intakes during pregnancy are associated with small-for-gestational age infants in South Indian women: a prospective observational cohort study

(2013) Pratibha Dwarkanath et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Early growth and non-alcoholic fatty liver disease in adulthood—the NAFLD liver fat score and equation applied on the Helsinki Birth Cohort Study

(2013) Samuel Sandboge et al.   ANNALS OF MEDICINE

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring

(2013) M. Dahlhoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

(2013) E. Isganaitis et al.   DIABETES

Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

(2013) Angelina Mouralidarane et al.   HEPATOLOGY

Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease?

(2013) Ning Ding et al.   Expert Review of Clinical Pharmacology

Nutrient sensor–mediated programmed nonalcoholic fatty liver disease in low birthweight offspring

(2012) Diana Wolfe et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function in aged female offspring

(2012) Lindsey A. George et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hepatic Insulin Signaling Changes: Possible Mechanism in Prenatal Hypoxia-Increased Susceptibility of Fatty Liver in Adulthood

(2012) Li Cao et al.   ENDOCRINOLOGY

Maternal dietary folate and/or vitamin B12 restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring

(2012) Kalle Anand Kumar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A

(2012) Adriana Laura Burgueño et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Intrahepatic Fat Is Increased in the Neonatal Offspring of Obese Women with Gestational Diabetes

(2012) David E. Brumbaugh et al.   JOURNAL OF PEDIATRICS

Relation between serum folate status and blood mercury concentrations in pregnant women

(2012) Hyesook Kim et al.   NUTRITION

Early onset of fatty liver in growth-restricted rat fetuses and newborns

(2011) Makiko Yamada et al.   CONGENITAL ANOMALIES

Hypoxia-Induced Intrauterine Growth Restriction Increases the Susceptibility of Rats to High-Fat Diet-Induced Metabolic Syndrome

(2011) C. F. Rueda-Clausen et al.   DIABETES

Continuous Glucose Profiles in Obese and Normal-Weight Pregnant Women on a Controlled Diet: Metabolic determinants of fetal growth

(2011) K. A. Harmon et al.   DIABETES CARE

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

(2011) Rita S. Strakovsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Influence of Maternal Body Mass Index on Infant Adiposity and Hepatic Lipid Content

(2011) Neena Modi et al.   PEDIATRIC RESEARCH

Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates

(2011) Wilmon F. Grant et al.   PLoS One

Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats

(2011) Nisha S. Wadhwani et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring

(2010) Bianca M. Gregorio et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Prenatal Dexamethasone Programs Expression of Genes in Liver and Adipose Tissue and Increased Hepatic Lipid Accumulation But Not Obesity on a High-Fat Diet

(2010) Amanda J. Drake et al.   ENDOCRINOLOGY

A Maternal “Junk Food” Diet in Pregnancy and Lactation Promotes Nonalcoholic Fatty Liver Disease in Rat Offspring

(2010) Stéphanie A. Bayol et al.   ENDOCRINOLOGY

Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates

(2010) Melissa Suter et al.   FASEB JOURNAL

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

(2010) Jude A. Oben et al.   JOURNAL OF HEPATOLOGY

Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring

(2010) M A Hyatt et al.   REPRODUCTION

Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice

(2009) Maqsood M. Elahi et al.   BRITISH JOURNAL OF NUTRITION

Newborns’ cord blood plasma cotinine concentrations are similar to that of their delivering smoking mothers☆

(2009) Ivan Berlin et al.   DRUG AND ALCOHOL DEPENDENCE

Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat

(2009) Emmanuel Somm et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

(2009) Kimberley D. Bruce et al.   HEPATOLOGY

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

(2009) Carrie E. McCurdy et al.   JOURNAL OF CLINICAL INVESTIGATION

Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1

(2009) Hongwei Yuan et al.   JOURNAL OF HEPATOLOGY

Maternal Pregestational BMI Is Associated With Methylation of thePPARGC1APromoter in Newborns

(2009) Carolina Gemma et al.   Obesity

Excretion of biliary compounds during intrauterine life

(2009) Rocio IR Macias et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth–restricted offspring

(2008) Thomas R. Magee et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

(2008) Kjersti M Aagaard-Tillery et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hyperglycemia and Adverse Pregnancy Outcomes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Alterations in Hepatic Mitochondrial Compartment in a Model of Obesity and Insulin Resistance

(2008) Crescenzo Raffaella et al.   Obesity