Review
Oncology
Christine Greil, Monika Engelhardt, Juergen Finke, Ralph Waesch
Summary: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a controversial treatment for multiple myeloma (MM) due to its associated toxicity. However, recent data suggests that it should be considered in young patients without comorbidities, particularly in high-risk cases as part of a tandem approach. Prospective studies, especially those involving new immunotherapeutic approaches, are needed to further evaluate its efficacy.
Review
Oncology
Lu Tang, Zhigang Liu, Tao Li, Tian Dong, Qiuhui Wu, Ting Niu, Ting Liu, Jie Ji
Summary: Through investigating 1091 articles, it was found that the PTCy prophylaxis regimen can reduce the incidence of aGVHD, decrease NRM and EBV-related complications, and achieve better OS compared to the ATG-based regimen. There was no significant difference between the two groups in cGVHD, RI, CMV reactivation, and BKV-related HC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pediatrics
Yuhua Qu, Hao Liu, Likun Wei, Shushan Nie, Wenjiao Ding, Sha Liu, Haiyan Liu, Hua Jiang
Summary: This study examined the efficacy of hematopoietic stem cell transplantation (HSCT) for mucopolysaccharidosis (MPS) IV and VI. The results showed that HSCT can restore lysosomal enzyme levels, improve organ function, and increase overall survival rate. Umbilical cord blood (UCB) is a suitable donor source, and using a specific conditioning regimen can achieve better treatment outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Review
Oncology
Muhammad Umair Mushtaq, Moazzam Shahzad, Ezza Tariq, Qamar Iqbal, Sibgha Gull Chaudhary, Muhammad U. Zafar, Iqra Anwar, Nausheen Ahmed, Rajat Bansal, Anurag K. Singh, Sunil H. Abhyankar, Natalie S. Callander, Peiman Hematti, Joseph P. McGuirk
Summary: A systematic review and meta-analysis evaluated the outcomes of mismatched unrelated donor hematopoietic stem cell transplantation (MMUD-HSCT). The results showed that MMUD-HSCT had favorable treatment outcomes and an acceptable toxicity profile in patients lacking HLA-matched or haploidentical donors, thus expanding the accessibility of HSCT to underrepresented populations.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Walker M. Schmidt, Nirosha D. Perera, Francis K. Buadi, Suzanne R. Hayman, Shaji K. Kumar, Angela Dispenzieri, David Dingli, Joselle Cook, Martha Q. Lacy, Prashant Kapoor, Nelson Leung, Eli Muchtar, Rahma M. Warsame, Taxiarchis Kourelis, Moritz Binder, Wilson I. Gonsalves, William J. Hogan, Morie A. Gertz
Summary: This study retrospectively analyzed the outcomes and prognostic markers of 85 multiple myeloma patients who underwent allogeneic stem cell transplant. The overall survival and progression free survival were 1.7 years and 0.71 years, respectively. The five-year survival rates were 22.2% and 15.1%, respectively. The majority of patients relapsed or died within 2 years.
BLOOD CANCER JOURNAL
(2023)
Article
Hematology
Sara Butera, Marco Cerrano, Lucia Brunello, Chiara Maria Dellacasa, Danilo Giuseppe Faraci, Sara Vassallo, Nicola Mordini, Roberto Sorasio, Francesco Zallio, Alessandro Busca, Benedetto Bruno, Luisa Giaccone
Summary: The study suggests that lower doses of ATG may be beneficial in adult patients receiving allo-HCT from matched unrelated donors, leading to prolonged overall survival and disease-free survival, reduced infection-related mortality, and improved graft and relapse-free survival.
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Guru Subramanian Guru Murthy, Soyoung Kim, Zhen-Huan Hu, Noel Estrada-Merly, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Sherif M. Badawy, Amer Beitinjaneh, Chris Bredeson, Jean-Yves Cahn, Jan Cerny, Miguel Angel Diaz Perez, Nosha Farhadfar, Robert Peter Gale, Siddhartha Ganguly, Usama Gergis, Gerhard C. Hildebrandt, Michael R. Grunwald, Shahrukh Hashmi, Nasheed M. Hossain, Matt Kalaycio, Rammurti T. Kamble, Mohamed A. Kharfan-Dabaja, Betty Ky Hamilton, Hillard M. Lazarus, Jane Liesveld, Mark Litzow, David Marks, Hemant S. Murthy, Sunita Nathan, Aziz Nazha, Taiga Nishihori, Sagar S. Patel, Attaphol Pawarode, David Rizzieri, Bipin Savani, Sachiko Seo, Melhem Solh, Celalettin Ustun, Marjolein van der Poel, Leo F. Verdonck, Ravi Vij, Baldeep Wirk, Betul Oran, Ryotaro Nakamura, Bart Scott, Wael Saber
Summary: This retrospective cohort study of 1761 adult patients aged 50 and older with myelodysplastic syndrome found that using younger unrelated donors for allogeneic hematopoietic cell transplantation resulted in higher disease-free survival and lower relapse rates compared to using older sibling donors.
Article
Oncology
Eileen Danaher Hacker, Rae Lee Richards, Mohammad Abu Zaid, Shu-Yu Chung, Susan Perkins, Sherif Shafik Farag
Summary: This pilot study tested the acceptability, feasibility, and preliminary effects of a free-living physical activity intervention for MM patients after HCT. The results showed that the intervention was acceptable and feasible, but there were some declines in symptoms and physical performance. This study provides implications for nurses to help patients increase physical activity.
Article
Oncology
Bhagirathbhai Dholaria, Myriam Labopin, Jaime Sanz, Annalisa Ruggeri, Jan Cornelissen, Helene Labussiere-Wallet, Didier Blaise, Edouard Forcade, Patrice Chevallier, Anna Grassi, Ludmila Zubarovskaya, Jurgen Kuball, Patrice Ceballos, Fabio Ciceri, Frederic Baron, Bipin N. Savani, Arnon Nagler, Mohamad Mohty
Summary: This study compared the outcomes of CBT and single-allele-mismatched MMUD allo-HCT with PTCy in acute myeloid leukemia. The results showed that CBT was associated with higher incidence of graft failure and non-relapse mortality compared to MMUD, leading to lower leukemia-free survival, overall survival, and GVHD-free, relapse-free survival. In conclusion, MMUD allo-HCT with PTCy may be a preferred choice over CBT for patients without a fully matched donor.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Hematology
Lindsay Hammons, Shabi Haider, Andrew J. Portuguese, Rahul Banerjee, Aniko Szabo, Marcelo Pasquini, Saurabh Chhabra, Sabarinath Radhakrishnan, Meera Mohan, Ravi Narra, Jing Dong, Siegfried Janz, Nirav N. Shah, Mehdi Hamadani, Anita D'Souza, Parameswaran Hari, Binod Dhakal
Summary: CAR-T and BsAb therapies are feasible, safe, and provide deep and durable responses in MM patients with a prior history of allo-HCT.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Vera Portillo, Stavroula Masouridi-Levrat, Lena Royston, Sabine Yerly, Manuel Schibler, Maria Mappoura, Sarah Morin, Federica Giannotti, Anne-Claire Mamez, Christian van Delden, Yves Chalandon, Dionysios Neofytos
Summary: Positive CMV serology in allogeneic hematopoietic cell transplant recipients (allo-HCTRs) may be false-positive due to transfusion-associated passive immunity. Reclassifying CMV status can help accurately assess the risk of CMV infection in these patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Pashna N. Munshi, David H. Vesole, Andrew St Martin, Omar Davila, Shaji Kumar, Muzaffar Qazilbash, Nina Shah, Parameswaran N. Hari, Anita D'Souza
Summary: Autologous hematopoietic stem cell transplantation in multiple myeloma patients aged 75 years and above has shown excellent 2-year outcomes, but remains underutilized in this age group with significant racial and gender disparities.
Article
Biophysics
Sherilyn A. Tuazon, Brenda M. Sandmaier, Theodore A. Gooley, Darrell R. Fisher, Leona A. Holmberg, Pamela S. Becker, Sally J. Lundberg, Johnnie J. Orozco, Ajay K. Gopal, Brian G. Till, David G. Coffey, Margaret E. Nartea, Manuela C. Matesan, John M. Pagel, Joseph G. Rajendran, Oliver W. Press, William Bensinger, Damian J. Green
Summary: The study shows that incorporating CD45-targeted radioimmunotherapy (RIT) into reduced-intensity allogeneic HCT is well-tolerated and may induce long-term remissions in high-risk multiple myeloma patients.
BONE MARROW TRANSPLANTATION
(2021)
Article
Hematology
Sini Luoma, Raija Silvennoinen, Auvo Rauhala, Riitta Niittyvuopio, Eeva Martelin, Vesa Lindstrom, Jouni Heiskanen, Liisa Volin, Tapani Ruutu, Anne Nihtinen
Summary: The study explored the role of allogeneic hematopoietic stem cell transplantation in multiple myeloma, showing that this approach can lead to long-term survival in a small subgroup of patients, and auto-allo-SCT may be considered for younger patients.
ANNALS OF HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Patrizio Panelli, Elisabetta De Santis, Mattia Colucci, Francesco Tamiro, Francesca Sansico, Mattia Miroballo, Emanuele Murgo, Costanzo Padovano, Sam Gusscott, Michele Ciavarella, Elizabeth A. Chavez, Fabrizio Bianchi, Giovanni Rossi, Angelo M. Carella, Christian Steidl, Andrew P. Weng, Vincenzo Giambra
Article
Biophysics
Ryszard Swoboda, Myriam Labopin, Sebastian Giebel, Thomas Schroeder, Nicolaus Kroeger, Mutlu Arat, Bipin Savani, Alexandros Spyridonidis, Rose-Marie Hamladji, Victoria Potter, Ana Berceanu, Ibrahim Yakoub-Agha, Alessandro Rambaldi, Hakan Ozdogu, Jaime Sanz, Arnon Nagler, Mohamad Mohty
Summary: This study compared two different myeloablative conditioning regimens, FluTBI12 and FB4, before allo-HCT in AML patients. The results showed no significant differences in leukemia-free survival, overall survival, relapse incidence, and non-relapse mortality between the two groups. The incidence of acute and chronic GVHD also showed no statistical differences. In conclusion, FluTBI12 and FB4 are comparable myeloablative regimens for AML patients transplanted in CR1 and CR2.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Alberto Biggi, Stephane Chauvie, Federico Fallanca, Luca Guerra, Fabrizio Bergesio, Massimo Menga, Andrea Bianchi, Michele Gregianin, Agostino Chiaravalloti, Orazio Schillaci, Chiara Pavoni, Caterina Patti, Marco Picardi, Alessandra Romano, Corrado Schiavotto, Roberto Sorasio, Simonetta Viviani, Giorgio La Nasa, Livio Trentin, Alessandro Rambaldi, Andrea Gallamini
Summary: This study demonstrates the accuracy of end-of-treatment FDG-PET/CT in predicting treatment outcome in lymphoma patients, and confirms the appropriateness of the Lugano classification for evaluation.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Oncology
Nicolas Boissel, Sabina Chiaretti, Cristina Papayannidis, Josep-Maria Ribera, Renato Bassan, Andrey N. Sokolov, Naufil Alam, Alessandra Brescianini, Isabella Pezzani, Georg Kreuzbauer, Gerhard Zugmaier, Robin Foa, Alessandro Rambaldi
Summary: This retrospective study included adult patients with B-cell ALL who were treated with blinatumomab for MRD+ or R/R B-cell ALL. The results showed significant treatment responses and survival benefits in both groups of patients.
BLOOD CANCER JOURNAL
(2023)
Article
Medicine, General & Internal
Andrea Duminuco, Alessandra Cupri, Rosario Massimino, Salvatore Leotta, Giulio Antonio Milone, Bruno Garibaldi, Giulia Giuffrida, Orazio Garretto, Giuseppe Milone
Summary: A study was conducted to validate the use of portable ultrasound devices in hematopoietic stem cell transplant. The results showed a close correlation and substantial agreement between the conventional and handheld ultrasound devices in measuring various parameters, which can assist in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrea Duminuco, Salvatore Scarso, Alessandra Cupri, Nunziatina Laura Parrinello, Loredana Villari, Grazia Scuderi, Giuliana Giunta, Salvatore Leotta, Giulio Antonio Milone, Giulia Giuffrida, Giuseppe Alberto Palumbo, Giuseppe Milone
Summary: Ruxolitinib, a JAK1/2 inhibitor, has revolutionized the treatment of myelofibrosis by improving symptoms but also increasing the risk of immunosuppression-related infections. Limited information is available regarding parasitic infections, particularly leishmaniasis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Federico Lussana, Gianluca Cavallaro, Pantaleo De Simone, Alessandro Rambaldi
Summary: In this review, the impact of novel immune therapies on the treatment of acute lymphoblastic leukemia (ALL) in children and adults was discussed. Results from trials evaluating the incorporation of these new drugs into frontline treatments show promising clinical benefit. Clinical conditions, such as high tumor burden or extra medullary relapse, still have poor clinical outcome despite the promising results. Combination of immunotherapies with chemotherapy in frontline treatment is being evaluated to increase the rate and depth of molecular remission. The use of tyrosine kinase inhibitors and immunotherapy in Ph-positive ALL has shown unprecedented rates of remission and long-term cure. The development of potentially curative treatment modalities for older ALL patients who cannot receive intensive chemotherapy is also highlighted.
Article
Pharmacology & Pharmacy
Chun Liu, Pier Giorgio Cojutti, Maddalena Giannella, Marcello Roberto, Beatrice Casadei, Gianluca Cristiano, Cristina Papayannidis, Nicola Vianelli, Pier Luigi Zinzani, Pierluigi Viale, Francesca Bonifazi, Federico Pea
Summary: CAR T-cell therapy may cause cytokine release syndrome (CRS) and acute kidney injury, potentially affecting the pharmacokinetics of beta-lactam drugs. This study found that the clearance of meropenem and piperacillin did not need to be reduced in CAR T-cell patients experiencing CRS.
Article
Biochemistry & Molecular Biology
Beatrice Campanella, Stefano Legnaioli, Massimo Onor, Edoardo Benedetti, Emilia Bramanti
Summary: Saliva is a sample that can be easily collected and contains a wealth of biochemical information related to an individual's health status. The fast and straightforward analysis of saliva using vibrational spectroscopy provides a good basis for large-scale preclinical studies. This study explored the effects of saliva collection (spitting/swab) and processing (deproteinization procedures) and found that special care is needed when using swabs due to the significant interaction between the polymeric material and saliva components. Additionally, analyzing saliva before and after deproteinization by FTIR and Raman spectroscopy provides complementary biological information.
Article
Biology
Alberto Magi, Gianluca Mattei, Alessandra Mingrino, Chiara Caprioli, Chiara Ronchini, GianMaria Frige, Roberto Semeraro, Davide Bolognini, Alessandro Rambaldi, Anna Candoni, Emanuela Colombo, Luca Mazzarella, Pier Giuseppe Pelicci
Summary: DNA methylation patterns in sparse CpG regions drive chemoresistance in Acute Myeloid Leukemia patients.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biophysics
Giuseppe Milone, Salvatore Leotta, Giulia Giuffrida, Giulio Antonio Milone, Gabriele Sapuppo, Giuliana Giunta, Benedetta Esposito, Dario Leotta, Sebastiano Fiore, Chiara Pennisi, Linda Longo, Alessandra Cupri
Summary: This study investigated the prognostic value of the dynamic progression of cutaneous to visceral involvement in acute graft-versus-host disease (a-GVHD). The results showed that the dynamic of skin GVHD could be used to classify a-GVHD and guide treatment for skin-only Grade 1 GVHD.
BONE MARROW TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed Salah Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B. Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz, Jarrod A. Marto, Danilo Pellin, Daniel E. Bauer, Scott A. Armstrong, Pietro Genovese
Summary: Epitope engineering of donor haematopoietic stem/progenitor cells endows haematopoietic lineages with selective resistance to CAR T cells or monoclonal antibodies, without affecting protein function or regulation, enabling the targeting of genes that are essential for leukaemia survival and reducing the risk of tumour immune escape.
Letter
Oncology
Alessandra Carobbio, Alessandro Maria Vannucchi, Elisa Rumi, Valerio De Stefano, Alessandro Rambaldi, Giuseppe Carli, Maria Luigia Randi, Heinz Gisslinger, Francesco Passamonti, Juergen Thiele, Naseema Gangat, Ayalew Tefferi, Tiziano Barbui
BLOOD CANCER JOURNAL
(2023)
Article
Medicine, Research & Experimental
Ilaria Laurenzana, Luciana De Luca, Pietro Zoppoli, Giovanni Calice, Alessandro Sgambato, Angelo Michele Carella, Antonella Caivano, Stefania Trino
Summary: The methylation profile of HSPCs following AHSCT was analyzed and found to undergo changes that may be useful in transplant diagnostics. The methylation signature was also found to be related to patient outcome. This study suggests that the methylation profile of HSPCs can provide prognostic information for engraftment success and graft failure prediction in AHSCT.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ceilan Apaza, Washington Cuna, Froilan Branez, Roberto Passera, Celeste Rodriguez
Summary: The study revealed that children in the rural regions of Bolivia, particularly in the highlands, are more susceptible to gastrointestinal parasite infections and anemia. Parasitic infections such as Ascaris lumbricoides and Giardia lamblia are more prevalent in the highlands, while the risk of wasting is lower. Efforts to control parasites and improve nutrition will greatly enhance the health of children in the highlands.
JOURNAL OF TROPICAL MEDICINE
(2023)