Article
Cell & Tissue Engineering
Tomoyasu Jo, Yasuyuki Arai, Kazuo Hatanaka, Hiroyuki Ishii, Akiko Ono, Nobuki Matsuyama, Jumpei Mori, Yangsook Koh, Fumihiro Azuma, Takafumi Kimura
Summary: This study examined the impact of anti-HLA antibodies against HLA-DP and -DQ on cord-blood transplantation outcomes. The presence of DSAs against HLA-DP and -DQ was associated with lower engraftment rates, longer engraftment time, increased risk of bacterial infection, and reduced survival after transplantation.
Article
Immunology
Ding-Ping Chen, Tang-Her Jaing, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu
Summary: This study identified specific SNPs in non-HLA genes associated with the effectiveness of unrelated CBT, which can aid in selecting the best donor and predicting the risk of CBT adverse reactions, further suggesting the important role of SNPs in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mailin Gan, Lin Liu, Shunhua Zhang, Zongyi Guo, Ya Tan, Jia Luo, Qiong Yang, Hongmei Pan, Xuewei Li, Jinyong Wang, Linyuan Shen, Li Zhu
Summary: Differential expression of porcine umbilical cord blood miRNA may have differences in immunity and angiogenesis, with great potential in the treatment of human diseases due to their ability for cross-species transmission. miRNA in cord blood may be beneficial for muscle-related diseases and liver- and brain-related diseases, providing insights for potential applications in mother-fetal communication.
Review
Hematology
Andrea P. Ho, Bethany E. Ho, Mary P. Berg, Jonathan A. Gutman, Nicole L. Draper
Summary: This case describes a rare occurrence of late reversal of dominance chimerism pattern following double umbilical cord blood transplantation, which contradicts previous data on predicting long-term cord dominance.
Article
Cell & Tissue Engineering
Joanie Hare, Paulina Garcia DeLeon, Krystle Pool, Donna Reioux, Milford Fontenot, Richard E. Champlin, Erin N. Eaton, David Marin, Katayoun Rezvani, Elizabeth J. Shpall, Jeffrey M. Wilson, Chitra Hosing
Summary: The success of umbilical cord blood transplant depends on the dose of total nucleated and CD34+ cells infused, highlighting the importance of collecting high-quality cord blood units with high cell doses. Maternal gestational age and race, and neonatal weight and sex were found to correlate with the total nucleated cell dose, emphasizing the impact of these factors on cell dose. Optimized collection of umbilical cord blood is crucial for its use as a source of stem cells for transplantation.
Article
Cell & Tissue Engineering
Jessica M. Sun, Laura E. Case, Mohamad A. Mikati, Joan M. Jasien, Colleen McLaughlin, Barbara Waters-Pick, Gordon Worley, Jesse Troy, Joanne Kurtzberg
Summary: Studies suggest that appropriately dosed allogeneic sibling HLA-matched umbilical cord blood infusion has the potential to improve motor function in young children with cerebral palsy. This treatment is well tolerated and shows no adverse events related to the infusion.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Xin-Yu Li, Li-Ping Zhan, Dian-Dian Liu, Xia-Wei Han, Han Chen, Zheng-Zhou Wu, Yin Wang, Li-Ping Que, Xiao-Jun Wu, Su Liu, Kai-Mei Wang, Shao-Liang Huang, Jian-Pei Fang, Ke Huang, Hong-Gui Xu
Summary: Using posttransplant cyclophosphamide (PTCY) as a method for controlling peri-engraftment syndrome (PES) and prophylaxis against graft-versus-host disease (GvHD) in single-unit umbilical cord blood transplantation (UCBT) for children with acute leukemia is safe and effective. Higher doses of PTCY may be more suitable for GvHD prophylaxis in UCBT patients.
Article
Cell Biology
Pei Tian, Andrew Elefanty, Edouard G. Stanley, Jennifer C. Durnall, Lachlan H. Thompson, Ngaire J. Elwood
Summary: Clinical-grade induced pluripotent stem cells (iPSCs) can be efficiently created using small volumes of thawed cord blood from public cord blood banks. This study presents a protocol that involves ex-vivo expansion and reprogramming of erythroid progenitor cells derived from cord blood, resulting in iPSC lines that are tested for pluripotency, genomic integrity, and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Romy Mosch, Henk-Jan Guchelaar
Summary: This review discusses ADA formation of mAbs and its clinical impact, as well as proposes the use of HLA haplotypes as biomarkers to predict patients' susceptibility to ADA formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Helen Latsoudis, Emmanouil Stylianakis, Irene Mavroudi, Alexandros Kanterakis, Pavlos Pavlidis, Anthie Georgopoulou, Aristea Batsali, Ioanna Gontika, Irene Fragiadaki, Maria Zamanakou, Anastasios E. Germenis, Helen A. Papadaki
Summary: This study provides an in-depth characterization of the HLA immunogenetic profile in the population of Crete and highlights the importance of regional public cord blood banks (PCBBs) in fulfilling the needs for hematopoietic stem cell transplantation (HSCT). The study compares the HLA distribution in Crete with the Deutsche Knochenmarkspenderdatei (DKMS) donor registry and reveals significant differences between the populations. The findings emphasize the role of demographic history and regional diversity in HLA heterogeneity and donor selection.
Article
Cell Biology
Sureka Rajendran, Alagupandian Murugan, Yogesh Nandakumar, Ankur Chaturvedi, Nagaraja M. Phani, Chirayu Padhiar, Pardhasaradhi Goditala, Prakash Sadashiv Gambhir
Summary: Forty novel HLA class I and class II alleles were discovered in umbilical cord blood samples and classified into different types of mutations. This study identified 14 new HLA-A alleles, 9 new HLA-B alleles, 4 new HLA-C alleles, 3 new HLA-DRB1 alleles, and 10 new HLA-DQB1 alleles. Comparison with the most similar sequence revealed that 60% of the novel alleles had non-synonymous substitution, 32.5% had synonymous substitution, 5% had premature stop codon, and 2.5% had frameshift mutation. The majority of the new alleles had a single nucleotide variation compared to the most similar sequence.
Article
Biophysics
Alice Pievani, Valentina Granata, Giacomo Desantis, Laura Antolini, Sara Ornaghi, Antonio Galleu, Andrea Biondi, Bernhard Gentner, Francesco Dazzi, Marta Serafini
Summary: Monocytes are effective at improving engraftment in HSPC transplantation, particularly in cases of limited cell doses such as CB transplantation and HSC gene therapy. Co-culturing monocytes increases survival and stemness of CB-CD34(+) cells. Soluble factors and direct-cell contact interactions play critical roles in the HSC-monocyte crosstalk.
BONE MARROW TRANSPLANTATION
(2022)
Review
Biophysics
Yarui Huang, Chengxin Luo, Guixian Wu, Xiangtao Huang, Yaqun Ding, Zhen Huang, Jieping Chen, Xi Li, Shuangnian Xu
Summary: The presence of donor-specific antibodies (DSAs) has been associated with an increased risk of primary graft failure after allo-HSCT, but its effects on engraftment time and long-term outcomes remain unclear.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Attya Omer-Javed, Gabriele Pedrazzani, Luisa Albano, Sherash Ghaus, Claire Latroche, Maura Manzi, Samuele Ferrari, Martina Fiumara, Aurelien Jacob, Valentina Vavassori, Alessandro Nonis, Daniele Canarutto, Luigi Naldini
Summary: Hematopoietic stem/progenitor cell gene therapy has been successful in treating genetic diseases. Mobilizers provide an opportunity for exogenous cells to efficiently replace depleted bone marrow through competition. This competitive advantage is achieved by rescuing the detrimental effects of mobilization on hematopoietic stem/progenitor cells during ex vivo culture, and can be further enhanced by transient overexpression of engraftment effectors.
Review
Cell & Tissue Engineering
Gabriela Sanchez-Petitto, Katayoun Rezvani, May Daher, Hind Rafei, Partow Kebriaei, Elizabeth J. Shpall, Amanda Olson
Summary: Umbilical cord blood transplantation is an attractive alternative source of hematopoietic stem cells, with unique immune tolerance and engraftment kinetics. It has a lower risk of GvHD and comparable clinical outcomes to bone marrow transplantation. However, limitations in cell numbers and delayed engraftment pose challenges for its wider application. Research is being conducted to address these limitations and explore the potential of cord blood in treating various disorders.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)