Article
Biology
Muhammad Hamza Bokhari, Carina Halleskog, Alice Aslund, Nathalie Boulet, Eva Casadesus Rendos, Jasper Martin Anton de Jong, Robert Csikasz, Ez-Zoubir Amri, Irina Shabalina, Tore Bengtsson
Summary: The study demonstrates the crucial role of UCP1 protein in the thermogenesis of murine brown and brite adipocytes. The use of isothermal microcalorimetry is established as a sensitive and accurate technique for measuring this heat-producing response.
COMMUNICATIONS BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Riccardo Cavalieri, Marlou Klein Hazebroek, Camila A. Cotrim, Yang Lee, Edmund R. S. Kunji, Martin Jastroch, Susanne Keipert, Paul G. Crichton
Summary: This study elucidates the interaction between activators and UCP1, and demonstrates the potential of targeting UCP1 in cells as a therapeutic avenue using approved drugs, but requires variants with more effective delivery in brown adipocytes.
MOLECULAR METABOLISM
(2022)
Article
Environmental Sciences
Stephanie Kim, Eric Reed, Stefano Monti, Jennifer J. Schlezinger
Summary: This study aimed to establish a novel classification method for predicting PPAR gamma ligands and modifying chemicals, and to group chemicals based on their effects on the PPAR gamma transcriptome and downstream metabolic functions. The research developed a classification system using lipid accumulation and RNA-Seq data to identify PPAR gamma agonists and sort chemicals into potential white or brite adipogens. Environmental contaminants were accurately identified as PPAR gamma ligands distinct from therapeutic activators, demonstrating the general applicability of the computational and experimental framework to classify chemicals.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Biochemistry & Molecular Biology
Ching-Fang Chang, Amanda L. Gunawan, Irene Liparulo, Peter-James H. Zushin, Ambre M. Bertholet, Yuriy Kirichok, Andreas Stahl
Summary: Coenzyme Q deficiency affects respiration in brown adipose tissue by regulating UCP1 expression, leading to increased mitochondrial membrane potential and decreased ADP/ATP ratios. This deficiency also enhances cold sensitivity.
Article
Neurosciences
Spyridon Sideromenos, Anna Gundacker, Maria Nikou, Raimund Oberle, Orsolya Horvath, Peter Stoehrmann, Timo Partonen, Daniela D. Pollak
Summary: This study investigates the role of brown adipose tissue (BAT) in the bidirectional link between metabolic and psychiatric disorders. It suggests that uncoupling protein 1 (UCP-1), a key metabolic regulator highly expressed in BAT, plays a inhibitory role in anxiety-related behavior, particularly under thermogenic conditions. This function of UCP-1 may be mediated through its central role in brain regions involved in energy and emotional control.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Dufang Ma, Tao Wu, Yiwei Qu, Jinlong Yang, Lu Cai, Xiao Li, Yong Wang
Summary: This study found that astragalus polysaccharide (APS) can prevent lipid metabolism disorder and cardiac cachexia caused by heart failure (HF). APS can improve cardiac function, increase adipose weight, and inhibit lipolysis and brown adipogenesis. Additionally, APS can also suppress sympathetic activity and inflammation.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Hui Wang, Monja Willershaeuser, Yongguo Li, Tobias Fromme, Katharina Schnabl, Andrea Bast-Habersbrunner, Samira Ramisch, Sabine Mocek, Martin Klingenspor
Summary: While UCP1 is essential for cold-induced thermogenesis, its presence alone does not protect mice from diet-induced obesity. A new mouse model with low UCP1 levels demonstrates that impaired cold-induced thermogenic capacity does not increase susceptibility to diet-induced obesity. Pharmacological activation of brown fat is necessary to promote negative energy balance in diet-induced obese mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Katalin Gyurina, Mariia Yarmak, Laszlo Sasi-Szabo, Sarolta Molnar, Gabor Mehes, Tamas Roeszer
Summary: Studying subcutaneous adipose tissues in fetuses, infants, and children, we found that UCP1-positive adipocytes are mainly located in the deep layer of adipose tissue, particularly in the abdominal wall. These UCP1-positive adipocytes develop in late fetal stage and persist throughout childhood, expressing genes related to mitochondrial biogenesis and thermogenesis. The absence of UCP1 expression in adipose tissue during the early childhood adiposity rebound phase is associated with an obesity-related gene expression signature. UCP1 expression is negatively correlated with BMI z-score and adipocyte size in infants and children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Scott A. Jones, Prerana Gogoi, Jonathan J. Ruprecht, Martin S. King, Yang Lee, Thomas Zogg, Els Pardon, Deepak Chand, Stefan Steimle, Danielle M. Copeman, Camila A. Cotrim, Jan Steyaert, Paul G. Crichton, Vera Moiseenkova-Bell, Edmund R. S. Kunji
Summary: Mitochondrial uncoupling protein 1 (UCP1) is responsible for the ability of brown adipose tissue in mammals to burn calories as heat for thermoregulation. UCP1 can be activated by fatty acids to generate heat by catalyzing the leakage of protons across the mitochondrial inner membrane. However, purine nucleotides can bind and inhibit UCP1, regulating proton leak through an unknown molecular mechanism. The cryo-electron microscopy structure of the GTP-inhibited state of UCP1 provides insights into the specific interactions and pH dependency of the regulatory mechanism, indicating that inhibitor binding prevents the conformational changes necessary for proton leak.
Article
Biochemistry & Molecular Biology
Alessandra Gentile, Nunzia Magnacca, Rita Matteis, Maria Moreno, Federica Cioffi, Antonia Giacco, Antonia Lanni, Pieter Lange, Rosalba Senese, Fernando Goglia, Elena Silvestri, Assunta Lombardi
Summary: This study investigated the physiological role of uncoupling protein 3 (UCP3) in white adipose tissue (WAT). The absence of UCP3 was found to impair the ability of WAT to store triglycerides, reduce oxidative capacity, decrease response to insulin, increase inflammation, and alter adipokine production. These findings highlight the importance of UCP3 in regulating the metabolic functionality of WAT and provide insights into the association between metabolic disorders and low UCP3 levels.
Article
Multidisciplinary Sciences
Ping Gu, Xiaoyan Hui, Qiantao Zheng, Yuan Gao, Leigang Jin, Weimin Jiang, Changsheng Zhou, Tianxia Liu, Yu Huang, Qing Liu, Tao Nie, Yanfang Wang, Yu Wang, Jianguo Zhao, Aimin Xu
Summary: UCP1 plays a crucial role in maintaining vascular health and protecting against cardiovascular diseases by inhibiting the activation of the NLRP3 inflammasome and production of IL-1 beta.
Article
Cell Biology
Lovisa I. Lyngfelt, Malin C. Erlandsson, Mitra Nadali, Shahram Hedjazifar, Rille Pullerits, Karin M. Andersson, Petra Brembeck, Sofia Toyra Silfversward, Ulf Smith, Maria I. Bokarewa
Summary: This study investigated the relationship between UCP1 expression and cardiovascular health in female RA patients. The results showed that high UCP1 transcription in adipose tissue was associated with active RA disease, high IL6 levels, and overweight status. Patients with high UCP1 levels displayed unfavorable metabolic profiles but had no significant difference in new cardiovascular and metabolic events compared to other RA patients.
Article
Biochemistry & Molecular Biology
Yu Li, Dongmei Wang, Xiaodan Ping, Yankang Zhang, Ting Zhang, Li Wang, Li Jin, Wenjun Zhao, Mingwei Guo, Fei Shen, Meiyao Meng, Xin Chen, Ying Zheng, Jiqiu Wang, Dali Li, Qiang Zhang, Cheng Hu, Lingyan Xu, Xinran Ma
Summary: This study discovered that local hyperthermia therapy promotes the activation of beige fat and offers a promising strategy against obesity via the HSF1-A2B1 transcriptional axis.
Review
Cell Biology
Sarmed Al-Samerria, Sally Radovick
Summary: The neuroendocrine system in mammals plays a crucial role in regulating body growth and cellular metabolism through the communication between the hypothalamus and pituitary. Growth hormone (GH) is considered the master regulator of somatic development and is involved in carbohydrate and lipid metabolism via well-defined signaling pathways. The role of IGF-1 in regulating the GH-axis for somatic growth and metabolic homeostasis is essential for maintaining physiological functions.
Article
Immunology
IkRak Jung, Becky Tu-Sekine, Sunghee Jin, Frederick Anokye-Danso, Rexford S. Ahima, Todd T. Brown, Sangwon F. Kim
Summary: The study found that DTG targets UCP1 and mitochondrial functions in brown and beige adipocytes, disrupting thermogenic functions in preclinical models.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Areti K. Kapnia, Constantinos N. Dallas, Vassilis Gerodimos, Andreas D. Flouris
Summary: These two studies show that a 20-min warm-up routine increases muscle temperature but this benefit is lost after a typical post-warm-up inactivity period in high-level basketball, leading to reductions in certain aspects of athletic performance.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Review
Biochemistry & Molecular Biology
Maria Vliora, Cosetta Ravelli, Elisabetta Grillo, Michela Corsini, Andreas D. Flouris, Stefania Mitola
Summary: Adipose tissue is an active endocrine organ, which secretes adipokines that have various functions in the body. The plasticity of adipose tissue is associated with angiogenesis, which supports tissue expansion. Abnormal production or loss of certain adipokines can lead to metabolic dysfunction related to obesity. Understanding the role of adipokines in angiogenesis may offer new therapeutic approaches for treating obesity and metabolic diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Green & Sustainable Science & Technology
Pedro G. Alves, Joao P. Vale, Lars Nybo, Andreas D. Flouris, Tiago S. Mayor
Summary: Heavy-duty trucks emit a significant amount of CO2 despite their low fleet percentage. The use of air-conditioning will further increase their fuel consumption and emissions. Therefore, sustainable solutions are necessary to reduce thermal loads, minimize AC usage, and decrease costs and environmental impact.
INTERNATIONAL JOURNAL OF SUSTAINABLE TRANSPORTATION
(2023)
Article
Biochemistry & Molecular Biology
Maria Kourti, Maria V. V. Alvanou, Zoi Skaperda, Fotis Tekos, Georgios Papaefstathiou, Panagiotis Stathopoulos, Demetrios Kouretas
Summary: An extract from brine samples obtained through the Greek style debittering process of Kalamon olive fruits showed strong antioxidant capacity and DNA-protective activity. The extract consisted mainly of hydroxytyrosol, verbascoside, and tyrosol. In cell-free assays, the extract demonstrated radical scavenging ability, while in cell cultures, it exhibited cell type specific responses and protected against H2O2-induced DNA damage. Overall, this study highlights the potential of table olive wastewaters as a valuable source of bioactive compounds for various industries.
Article
Biochemistry & Molecular Biology
Fotios Tekos, Zoi Skaperda, Periklis Vardakas, Despina Kyriazi, Georgios C. C. Maravelis, Konstantinos Poulas, Ioannis A. A. Taitzoglou, Charitini Nepka, Demetrios Kouretas
Summary: Wine and its by-products, such as grape stems, contain bioactive polyphenolic compounds that can potentially benefit animal and human health. However, there are limited studies on the safety and toxicological risks of these compounds in vivo. This study examined the effects of oral administration of grape stem and wine extracts on redox biomarkers in mice and rats. The results showed that grape stem extract improved redox homeostasis in mice, while wine extract had both beneficial and harmful effects on rat redox status, indicating the complexity of biological systems.
Article
Biochemistry & Molecular Biology
Emmanouil Karampinis, Athina-Maria Aloizou, Efterpi Zafiriou, Alexandra Bargiota, Zoi Skaperda, Demetrios Kouretas, Angeliki-Viktoria Roussaki-Schulze
Summary: UV radiation has both harmful and beneficial effects on skin health. It can cause oxidative stress, leading to skin cancer and photoaging. However, it is also necessary for the production of vitamin D, which has important antioxidant and anticancer properties. This study found that skin cancer patients have lower levels of vitamin D and increased oxidative stress.
Article
Public, Environmental & Occupational Health
Leonidas G. Ioannou, Davide J. Testa, Lydia Tsoutsoubi, Konstantinos Mantzios, Giorgos Gkikas, Gerasimos Agaliotis, Lars Nybo, Zahra Babar, Andreas D. Flouris
Summary: This observational study aimed to compare the risk of experiencing high occupational heat strain during agriculture work between migrants and native coworkers. The study monitored 124 individuals from different income countries from 2016 to 2019. Video recordings were used to estimate workers' clothing insulation, body surface area, body posture, walking speed, activities, and unplanned breaks. The results showed that migrant workers from lower-middle- and low-income countries experienced higher physiological heat strain compared to migrant workers from upper-middle-income countries and native workers from high-income countries.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2023)
Article
Sport Sciences
Yanan Dang, Yiannis Koutedakis, Ruoling Chen, Matthew Wyon
Summary: This study aimed to examine the efficacy of a remote weekly self-report injury incidence and etiology tool. Two online questionnaires were developed, one for complete injury history information and the other for weekly reports on new injuries and causes. Results showed a 70.1% dropout rate among 756 respondents, with slightly lower rates for under 18-year-old students. It is concluded that a reminder system and teacher engagement can increase response rates.
JOURNAL OF DANCE MEDICINE & SCIENCE
(2023)
Article
Sport Sciences
Konstantinos Mantzios, Aggelos Pappas, Georgios-Ioannis Tsianos, Andreas D. Flouris
Summary: This case report demonstrates that sleeping at altitudes above 5500m results in reduced heart rate variability, increased awakenings, and deteriorated sleep duration and subjective sleep quality. These findings provide further insight into the effects of high altitude on cardiac autonomic function and sleep quality and may have implications for individuals who frequently spend time at high altitudes, such as climbers.
Article
Physiology
Andreas D. Flouris, Sean R. Notley, Rebecca L. Stearns, Douglas J. Casa, Glen P. Kenny
Summary: The recommended treatment for exertional heat stroke is immediate, whole-body immersion in water of <10°C until the rectal temperature reaches ≤ 38.6°C. Real-time T-re assessment may not always be possible in field settings or emergency situations. This study defines and validates immersion durations for treating exertional heat stroke at water temperatures of 2-26°C.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Leonidas G. Ioannou, Lydia Tsoutsoubi, Paraskevi Gkiata, Harry A. Brown, Julien D. Periard, Igor B. Mekjavic, Glen P. Kenny, Lars Nybo, Andreas D. Flouris
Summary: This study found no significant differences in performance, physiological heat strain, and perceptual responses among well-trained and national-level endurance athletes wearing different upper-torso sportswear technologies during prolonged running in moderately hot conditions.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Chemistry, Multidisciplinary
Leonidas G. Ioannou, Ursa Ciuha, Jason T. T. Fisher, Lydia Tsoutsoubi, Kunihito Tobita, Ana Bonell, James D. Cotter, Glen P. P. Kenny, Andreas D. Flouris, Igor B. Mekjavic
Summary: This study developed and validated a mobile phone application that predicts the physiological heat strain experienced by individuals during physical activity in adverse environmental conditions. The application accurately predicted 93% of elevated physiological heat strain occurrences and had an overall accuracy of 92%.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Claire Chrysanthi Karpodini, Themistoklis Tsatalas, Ioannis Giannakopoulos, Mattias Romare, Giannis Giakas, Panagiotis V. Tsaklis, Petros C. Dinas, Aline Nogueira Haas, Sokratis G. Papageorgiou, Efthalia Angelopoulou, Matthew A. Wyon, Yiannis Koutedakis
Summary: The aim of this study is to investigate the acute effects of a specially designed musicokinetic program on patients with Parkinson's disease, including anxiety levels, kinematic and kinetic parameters, and frontal cortex hemodynamic responses during gait initiation and walking. The study will be conducted as a blind cross-over randomized control trial with 13 volunteers attending a 45-minute musicokinetic program in synchronous and asynchronous formats. Gait biomechanics and frontal cortex hemodynamic responses will be measured using motion analysis and near-infrared spectroscopy, respectively, while anxiety levels will be assessed with the Hamilton Anxiety Rating Scale.
MEDICINA-LITHUANIA
(2023)
Article
Sport Sciences
Juergen M. Steinacker, Willem van Mechelen, Wilhelm Bloch, Mats Boerjesson, Maurizio Casasco, Bernd Wolfarth, Carolin Knoke, Theodora Papadopoulou, Janine Wendt, Hashel Al Tunaiji, Dietrich Andresen, Olena Andrieieva, Norbert Bachl, Victoriya Badtieva, Friedhelm J. Beucher, Cheri A. Blauwet, Jose-Antonio Casajus Mallen, Ju-Ho Chang, German Clenin, Naama Constantini, Demitri Constantinou, Luigi Di Luigi, Lukas Declercq, Stephane Doutreleau, Svitlana Drozdovska, Martine Duclos, Andrea Ermolao, Thomas Fischbach, Anastasia N. Fischer, Chiara Fossati, Jeorge Franchella, Mark Fulcher, Jan C. Galle, Christian Gerloff, Evelina Georgiades, Boris Gojanovic, Marcela Gonzalez Gross, Andy Grote, Martin Halle, Hans Hauner, Matthew Payton Herring, Mikio Hiura, Kerstin Holze, Gerhard Huber, David Hughes, Mark R. Hutchinson, Anca Ionescu, Dina Christina Janse van Rensburg, Anna Jegier, Natasha Jones, Kirsten Kappert-Gonther, Monika Kellerer, Yutaka Kimura, Agrita Kiopa, Bernd Kladny, Gerhard Koch, Elin Kolle, Greg Kolt, Yiannis Koutedakis, Stephan Kress, Susi Kriemler, Jens Kroeger, Christian Kuhn, Roman Laszlo, Ralph Lehnert, Francois J. Lhuissier, Kerstin Luedtke, Shigeru Makita, Pedro Manonelles Marqueta, Winfried Maerz, Kirill Micallef-Stafrace, Mike Miller, Melita Moore, Erich Mueller, Danie Neunhaeuserer, I. Renay Onur, Vahur Oeoepik, Malgorzata Perl, Anastassios Philippou, Hans-Georg Predel, Sebastien Racinais, Algirdas Raslanas, Ruediger Reer, Klaus Reinhardt, Claus Reinsberger, Sandra Rozenstoka, Robert Sallis, Luis B. Sardinha, Martin Scherer, Jasper Schipperijn, Romain Seil, Benedict Tan, Arno Schmidt-Trucksaess, Nils Schumacher, Bernhard Schwaab, Ansgar Schwirtz, Masato Suzuki, Jeroen Swart, Ralph Tiesler, Ulf Tippelt, Eleanor Tillet, Jane Thornton, Bulent Ulkar, Eve Unt, Evert Verhagen, Thomas Weikert, Roberto Vettor, Sheng Zeng, Richard Budgett, Lars Engebretsen, Ugur Erdener, Fabio Pigozzi, Yannis P. Pitsiladis
Summary: Non-communicable diseases, such as coronary heart disease and diabetes, are increasing worldwide due to a lack of physical activity. This leads to negative health outcomes and economic burdens. To address this issue, the 'Hamburg Declaration' was signed, aiming to promote physical activity and improve individual and community health.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Review
Medicine, General & Internal
Efthalia Angelopoulou, Evangelia Stanitsa, Claire Chrysanthi Karpodini, Anastasia Bougea, Dionysia Kontaxopoulou, Stella Fragkiadaki, Christos Koros, Vasiliki Epameinondas Georgakopoulou, George Fotakopoulos, Yiannis Koutedakis, Christina Piperi, Sokratis G. Papageorgiou
Summary: Depression is a common non-motor disorder in Parkinson's disease, affecting both patients and their caregivers. Pharmacological and non-pharmacological treatments are available, but the optimal approach for managing PD depression remains uncertain and challenging.
MEDICINA-LITHUANIA
(2023)