Article
Physiology
Leandro A. Oliveira, Taciana R. S. Pollo, Elineia A. Rosa, Josiane O. Duarte, Carlos H. Xavier, Carlos C. Crestani
Summary: The study investigates the role of adrenoceptors in the medial prefrontal cortex subareas in cardiovascular responses during emotional stress. Microinjection of selective adrenoceptor antagonists reduced the pressor response and tachycardia during restraint stress. Noradrenergic neurotransmission in both PL and IL mediates cardiovascular responses to aversive threats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Xi Zhu, Benjamin Suarez-Jimenez, Amit Lazarov, Sara Such, Caroline Marohasy, Scott S. Small, Tor D. Wager, Martin A. Lindquist, Shmuel Lissek, Yuval Neria
Summary: Comparison between resilient, trauma-exposed healthy participants and trauma-exposed individuals with psychopathology reveals a resilience network connectivity signature in the right executive control network during generalization learning. The study highlights the deficient fear generalization and neural abnormalities resulting from trauma exposure, as well as the intact fear generalization in trauma-exposed individuals without significant psychopathology. These findings have important implications for developing innovative treatments targeting specific neural dysfunctions among trauma-exposed individuals across different psychopathologies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Clinical Neurology
Ann W. Nguyen, Weidi Qin, Wenxing Wei, Verna M. Keith, Uchechi A. Mitchell
Summary: This study aimed to examine the associations between racial discrimination and 12-month and lifetime DSM-IV anxiety disorders in African American men and women. The results showed that racial discrimination was associated with increased odds of anxiety disorders, agoraphobia, and panic disorder among men. Among women, racial discrimination was associated with increased odds of anxiety disorders, posttraumatic stress disorder, social anxiety disorder, and panic disorder. These findings suggest the need for interventions to address gender disparities in anxiety disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
David F. Tolin, Eric Lee, Hannah C. Levy, Akanksha Das, Liya Mammo, Benjamin W. Katz, Gretchen J. Diefenbach
Summary: The study found that patients with social anxiety disorder showed heightened psychophysiological reactivity, while those with panic disorder and generalized anxiety disorder exhibited attenuated reactivity. Physiological recovery was slower in patients with generalized anxiety disorder and panic disorder compared to healthy controls. Patients with all anxiety disorders had diminished change in high frequency heart rate variability compared to healthy controls.
JOURNAL OF ANXIETY DISORDERS
(2021)
Article
Psychiatry
Tianhong Zhang, Linlin Zhou, Yanyan Wei, Xiaochen Tang, Yuqing Gao, Yegang Hu, Lihua Xu, Tao Chen, Haichun Liu, Chunbo Li, Zheng Lu, Jijun Wang
Summary: Age is associated with a decrease in heart rate variability in patients with psychiatric disorders, and this relationship remains significant after controlling for sex, heart rate, and diagnoses.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Arron T. L. Correia, Gosia Lipinska, H. G. Laurie Rauch, Philippa E. Forshaw, Laura C. Roden, Dale E. Rae
Summary: There is a bidirectional relationship between poor sleep and mood-and anxiety-related disorders, and both are independently associated with altered autonomic nervous system (ANS) function. Heart rate variability (HRV) can reflect ANS dysregulation during sleep, which may play a mediating role in the association between poor sleep and mood-and anxiety-related disorders.
Review
Clinical Neurology
Zuxing Wang, Yuanyuan Luo, Yuan Zhang, Lili Chen, Yazhu Zou, Jun Xiao, Wenjiao Min, Cui Yuan, Yu Ye, Mingmei Li, Mengtian Tu, Jiangli Hu, Zhili Zou
Summary: This study conducted a network meta-analysis to compare heart rate variability (HRV) between patients with generalized anxiety disorder (GAD), major depressive disorder (MDD), panic disorder (PD) and healthy controls (HCs). The results showed that GAD, PD and MDD patients exhibited significantly reduced HRV compared to controls, and GAD patients had lower HRV than PD patients. This study provides a potential objective biological marker to distinguish between GAD and PD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinha
Summary: Chronic cocaine use leads to adaptations in stress biology and the neuroactive steroid system. The study found that pregnenolone, a precursor to neuroactive steroids, decreases cocaine craving and anxiety, as well as reduces stress-induced autonomic arousal in individuals with cocaine use disorder.
Article
Medicine, General & Internal
Cynthia A. LeardMann, Hope Seib McMaster, Steven Warner, Alejandro P. Esquivel, Ben Porter, Teresa M. Powell, Xin M. Tu, William W. Lee, Rudolph P. Rull, Charles W. Hoge
Summary: The study evaluated the ability to compare and assess PTSD based on DSM-IV and DSM-5 criteria using PTSD Checklists (PCLs), with findings suggesting successful assessment and comparison of PTSD over time with either PCL instrument in veteran and military populations.
Article
Neurosciences
Robert S. Talay, Yaling Liu, Matthew Michael, Anna Li, Isabel D. Friesner, Fei Zeng, Guanghao Sun, Zhe Sage Chen, Qiaosheng Zhang, Jing Wang
Summary: The study found that AMPAkines can restore endogenous anti-nociceptive functions in the PL-PFC region, providing a successful strategy for treating chronic neuropathic pain.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lukasz Szeleszczuk, Dawid Fraczkowski
Summary: Propranolol, a non-selective beta blocker, is commonly used in the treatment of cardiovascular diseases and has potential applications in treating mental disorders such as stage fright and post-traumatic stress disorder (PTSD). This review provides information on its mechanisms of action, comparisons with other therapies, and aims to assist in decision-making regarding the use of propranolol for these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Leticia Leite, Nathalia Bianchini Esper, Jose Roberto M. Lopes Junior, Diogo Rizzato Lara, Augusto Buchweitz
Summary: This exploratory study identified differences in resting-state functional connectivity for the amygdala and its subregions in patients with PTSD compared to controls. The results showed a weaker functional connectivity between the superficial amygdala and posterior brain regions in PTSD patients, suggesting sensory and perceptual processes may be affected. Additionally, early traumatic experiences were associated with negative connectivity between the centromedial amygdala and sensory and perceptual regions.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Sema G. Quadir, Gillian M. Arleth, Meredith G. Cone, Margaret W. High, Maria C. Ramage, Devin P. Effinger, Maria Echeveste Sanchez, Melissa A. Herman
Summary: Despite the well-known consequences of alcohol consumption, a large number of adult Americans reported drinking alcohol in 2021, with no clear understanding of the relationship between alcohol drinking and affective and nociceptive behaviors. This study explored the effects of alcohol drinking on CRF1+ cells and found a complex interplay between alcohol drinking, affective state, and the role of prefrontal CRF1+ neurons in mediating these behaviors. The results showed that alcohol drinking decreased mechanical sensitivity and correlated with affe-ctive behavior, suggesting the involvement of CRF1 in these processes.
Article
Psychology, Multidisciplinary
Liran Kalderon, Moshe Chaimoff, Michal Katz-Leurer
Summary: This study aims to assess both state and trait anxiety levels in patients with BPPV in comparison with healthy controls, and their relations with cardiac autonomic parameters. The results showed that patients with BPPV had higher levels of state anxiety compared to healthy controls, while no differences were found in trait anxiety or total STAI scores. Among BPPV patients, there was a positive-moderate correlation between state anxiety and heart rate, and a negative moderate-strong correlation between state anxiety and heart rate variability.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Taylor A. Teckchandani, J. Patrick Neary, Katie L. Andrews, Kirby Q. Maguire, Laleh Jamshidi, Jolan Nisbet, Robyn E. Shields, Tracie O. Afifi, Shannon Sauer-Zavala, Lisa M. Lix, Rachel L. Krakauer, Gordon J. G. Asmundson, Gregory P. Kratzig, R. Nicholas Carleton
Summary: The current study examined variations in cardioautonomic lability during the Royal Canadian Mounted Police (RCMP) Cadet Training Program (CTP) between cadets starting their training who did or did not screen positive for one or more mental health disorders. The results indicated that cadets who endorsed clinically significant anxiety symptoms on the GAD-7 showed less variability in the LF:HF ratio over the course of the CTP.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Madalyn Hafenbreidel, Robert C. Twining, Carolynn Rafa Todd, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Behavioral Sciences
Michael K. Fitzgerald, James M. Otis, Devin Mueller
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Madalyn Hafenbreidel, Carolynn Rafa Todd, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
James M. Otis, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Behavioral Sciences
James M. Otis, Michael K. Fitzgerald, Hanna Yousuf, Jake L. Burkard, Matthew Drake, Devin Mueller
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Neurosciences
James M. Otis, Kidane B. Dashew, Devin Mueller
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
James M. Otis, Michael K. Fitzgerald, Devin Mueller
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Christian Bravo-Rivera, Ciorana Roman-Ortiz, Edith Brignoni-Perez, Francisco Sotres-Bayon, Gregory J. Quirk
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
James M. Otis, Michael K. Fitzgerald, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2014)
Review
Neurosciences
James M. Otis, Craig T. Werner, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Luis E. Rosas-Vidal, Fabricio H. Do-Monte, Francisco Sotres-Bayon, Gregory J. Quirk
NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Neurosciences
Madalyn Hafenbreidel, Carolynn Rafa Todd, Robert C. Twining, Jennifer J. Tuscher, Devin Mueller
PSYCHOPHARMACOLOGY
(2014)
Article
Behavioral Sciences
Hanna Yousuf, Chad W. Smies, Madalyn Hafenbreidel, Jennifer J. Tuscher, Ashley M. Fortress, Karyn M. Frick, Devin Mueller
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Anesthesiology
Keri R. Hainsworth, Michelle L. Czarnecki, Pippa M. Simpson, Liyun Zhang, William H. Davies, Devin Mueller, Steven J. Weisman
Summary: The study found that light cues can increase opioid consumption in pediatric patients, indicating that their PCA behavior is influenced more by operant factors than by pain.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Neurosciences
Elizabeth M. Doncheck, Madalyn Hafenbreidel, Sarah A. Ruder, Michael K. Fitzgerald, Lilith Torres, Devin Mueller
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)