Article
Neurosciences
Jessica A. Higginbotham, Rong Wang, Ben D. Richardson, Hiroko Shiina, Shi Min Tan, Mark A. Presker, David J. Rossi, Rita A. Fuchs
Summary: Systemic CB1R antagonism during cocaine-memory reconsolidation reduced drug context-induced cocaine-seeking behavior and inhibited cellular adaptations and synaptic physiology changes in the basolateral amygdala. These findings suggest that CB1R signaling modulates cellular and synaptic mechanisms in the BLA, potentially playing a crucial role in preventing relapse.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Thatiane De Oliveira Sergio, Kelly Lei, Claudina Kwok, Shahbaj Ghotra, Scott A. Wegner, Margaret Walsh, Jaclyn Waal, David Darevsky, Frederic W. Hopf
Summary: Specific brain connections and neural receptors play crucial roles in regulating compulsion-like drinking and alcohol-only drinking. Inhibition methods can reduce both types of drinking, suggesting potential different pathways in the brain for compulsion-like drinking versus alcohol-only drinking. Further research is required to definitively address the different pathways' roles in these behaviors.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liangpei Chen, Shihao Huang, Chang Yang, Feilong Wu, Qiuyao Zheng, He Yan, Jie Yan, Yixiao Luo, Ewa Galaj
Summary: Propranolol may reduce relapse by interfering with the reconsolidation of heroin memory, holding potential therapeutic value in opioid addiction treatment and relapse prevention.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Houri Hintiryan, Ian Bowman, David L. Johnson, Laura Korobkova, Muye Zhu, Neda Khanjani, Lin Gou, Lei Gao, Seita Yamashita, Michael S. Bienkowski, Luis Garcia, Nicholas N. Foster, Nora L. Benavidez, Monica Y. Song, Darrick Lo, Kaelan Cotter, Marlene Becerra, Sarvia Aquino, Chunru Cao, Ryan P. Cabeen, Jim Stanis, Marina Fayzullina, Sarah Ustrell, Tyler Boesen, Amanda J. Tugangui, Zheng-Gang Zhang, Bo Peng, Michael S. Fanselow, Peyman Golshani, Joel D. Hahn, Ian R. Wickersham, Giorgio A. Ascoli, Li Zhang, Hong-Wei Dong
Summary: The authors used machine-learning based computational techniques to map the connectivity of the basolateral amygdalar complex, identifying distinct domains within the anterior BLA with target-specific projection neurons and morphological features. This study provides insights into the circuitry of BLA projection neurons and their connections to behavior networks within the brain.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Myrto Panopoulou, Oliver M. Schlueter
Summary: Frequent relapse hinders successful treatment of substance use disorders by triggering the retrieval of drug-associated memories. This study investigates the cellular and molecular mechanisms underlying drug-induced memory retrieval using a conditioned place preference (CPP) procedure in mice. The results suggest that Ca2+-permeable AMPA receptors (CP-AMPARs) in the nucleus accumbens (NAc) play a key role in regulating the threshold for drug-induced retrieval and behavioral expression of drug memories.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Maged M. Harraz, Adarsha P. Malla, Evan R. Semenza, Maria Shishikura, Manisha Singh, Yun Hwang, In Guk Kang, Young Jun Song, Adele M. Snowman, Pedro Cortes, Senthilkumar S. Karuppagounder, Ted M. Dawson, Valina L. Dawson, Solomon H. Snyder
Summary: Cocaine exerts its stimulant effect by inhibiting dopamine reuptake, and recent research suggests the existence of a high-affinity receptor for cocaine, which is considered to be the pharmacologically relevant receptor for the drug.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Tainara Boareto Capelari, Jhessica de Cassia Mendonca, Luana Rianne da Rocha, Maiyara Carolyne Prete, Pedro Nunes Angelis, Luan Pereira Camargo, Luiz Henrique Dall'Antonia, Cesar Ricardo Teixeira Tarley
Summary: A novel electrochemical sensing platform based on multi-walled carbon nanotubes grafted with poly(methacrylic acid) and beta-cyclodextrin was developed for highly sensitive and selective cocaine determination in seized samples. The nanocomposite modified electrode showed improved selectivity and sensitivity in cocaine determination due to the synergistic effect of MWCNT, poly(MAA), and beta-CD. The proposed method demonstrated outstanding selectivity towards cocaine even in the presence of common adulterants in seized samples, providing accurate detection results confirmed by HPLC-DAD.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yanjun Sun, Lisa M. Giocomo
Summary: This study reveals that a subset of neurons in the hippocampus of mice encode drug-associated contextual information, providing insight into how drug abuse alters hippocampal circuitry to encode drug-context associations.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Dong-oh Seo, Eric T. Zhang, Sean C. Piantadosi, David J. Marcus, Laura E. Motard, Bryce K. Kan, Adrian M. Gomez, Tammy K. Nguyen, Li Xia, Michael R. Bruchas
Summary: The study found that the activation of noradrenergic neurons can lead to contextual generalization, which requires b-adrenergic-mediated modulation to promote aversive generalization. This suggests that disruption of noradrenergic tone may be an important avenue for treating stress-induced disorders.
Article
Medicine, Legal
Julio de Carvalho Ponce, Luiz Ferreira Neves Neves Junior, Ana Carolina Stosch da Silva, Luiz Carlos Liberatori, Priscila Vieira de Medeiros
Summary: This case report discusses an uncommon drug seizure case where cocaine was found in herbs that are typically used to deliver synthetic cannabinoids, rather than the usual powder or crack form. The report also includes a comparison of the physical appearance and chemical results of genuine coca leaves.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Neurosciences
Ramiro Comas Mutis, Pablo Javier Espejo, Irene Delia Martijena, Victor Alejandro Molina, Gaston Diego Calfa
Summary: The reconsolidation of fear memory is a protein synthesis-dependent process wherein destabilized memory returns to a stable state, attracting extensive studies for its implications in memory processing and potential therapeutic applications. This study focused on the interaction between the BLA and DH, showing changes in structural plasticity in the DH's CA1 region during the destabilization/reconsolidation process. Additionally, the modulatory role of BLA in structural plasticity was demonstrated through drug infusions, offering insights into the underlying mechanisms of memory storage and potential medical applications.
Article
Behavioral Sciences
Prableen K. Singh, Kabirullah Lutfy
Summary: The study found differences in cocaine-induced conditioned place preference (CPP) between male and female mice lacking beta-endorphin, with gender-related distinctions in CPP reinstatement. The results suggest a functional role for beta-endorphin in cocaine-induced CPP and reinstatement.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Matthew B. Pomrenze, Daniel F. Cardozo Pinto, Peter A. Neumann, Pierre Llorach, Jason M. Tucciarone, Wade Morishita, Neir Eshel, Boris D. Heifets, Robert C. Malenka
Summary: Social isolation plays a major role in the current opioid addiction crisis. Research shows that sociability deficits during opioid withdrawal are linked to the activation of kappa opioid receptors in the nucleus accumbens. Blocking the release of dynorphin from dorsal raphe neurons prevents these deficits, while optogenetic activation of these neurons reproduces sociability decreases. Deleting KORs from serotonin neurons prevents sociability deficits, but not from NAc neurons or dopamine neurons.
Article
Substance Abuse
Robert W. Seaman, Kenner C. Rice, Gregory T. Collins
Summary: Recent evidence suggests that polysubstance use is common, emphasizing the need for a better understanding of interactions between commonly co-abused drugs. The study found that synthetic cathinones and cocaine can act as economic substitutes, and that the reinforcing effects determined under a progressive ratio schedule of reinforcement can predict drug choice.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Behavioral Sciences
Martin J. Dahl, Agnieszka Kulesza, Markus Werkle-Bergner, Mara Mather
Summary: Memory is crucial for defining our identity and guiding behavior based on past experiences. However, as we age, memory declines and disrupts the lives of older adults. Recent research suggests that degeneration of the locus coeruleus, a brain region responsible for dopamine and noradrenaline production, results in deficient modulation of hippocampal plasticity, leading to memory decline.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Madalyn Hafenbreidel, Robert C. Twining, Carolynn Rafa Todd, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Behavioral Sciences
Michael K. Fitzgerald, James M. Otis, Devin Mueller
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Madalyn Hafenbreidel, Carolynn Rafa Todd, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
James M. Otis, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Behavioral Sciences
James M. Otis, Michael K. Fitzgerald, Hanna Yousuf, Jake L. Burkard, Matthew Drake, Devin Mueller
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Neurosciences
James M. Otis, Kidane B. Dashew, Devin Mueller
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
James M. Otis, Michael K. Fitzgerald, Devin Mueller
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Robert C. Twining, Jennifer J. Tuscher, Elizabeth M. Doncheck, Karyn M. Frick, Devin Mueller
Article
Neurosciences
James M. Otis, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2011)
Review
Neurosciences
James M. Otis, Craig T. Werner, Devin Mueller
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Madalyn Hafenbreidel, Carolynn Rafa Todd, Robert C. Twining, Jennifer J. Tuscher, Devin Mueller
PSYCHOPHARMACOLOGY
(2014)
Article
Behavioral Sciences
Hanna Yousuf, Chad W. Smies, Madalyn Hafenbreidel, Jennifer J. Tuscher, Ashley M. Fortress, Karyn M. Frick, Devin Mueller
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Anesthesiology
Keri R. Hainsworth, Michelle L. Czarnecki, Pippa M. Simpson, Liyun Zhang, William H. Davies, Devin Mueller, Steven J. Weisman
Summary: The study found that light cues can increase opioid consumption in pediatric patients, indicating that their PCA behavior is influenced more by operant factors than by pain.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Neurosciences
Elizabeth M. Doncheck, Madalyn Hafenbreidel, Sarah A. Ruder, Michael K. Fitzgerald, Lilith Torres, Devin Mueller