Article
Pharmacology & Pharmacy
Malihe Karimi, Hossein Kamali, Marzieh Mohammadi, Mohsen Tafaghodi
Summary: Therapeutic proteins and peptides have gained attention for chronic diseases, and pulmonary drug administration is a promising alternative with acceptable bioavailability and stability. Stabilizing proteins through drying techniques is critical, and various methods have been used to prepare inhalable powders.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Azin Jahangiri, Ali Nokhodchi, Kofi Asare-Addo, Erfan Salehzadeh, Shahram Emami, Shadi Yaqoubi, Hamed Hamishehkar
Summary: The study aimed to develop carrier-free inhalable CLX microparticles for dry powder inhalation (DPI) using electrospraying. The results showed that electrosprayed particles prepared from the ethanol-acetone solvent mixture at a drug concentration of 3% exhibited the best in vitro aerosolization properties.
Article
Pharmacology & Pharmacy
Bhavya Vishwa, Afrasim Moin, D. V. Gowda, Syed M. D. Rizvi, Wael A. H. Hegazy, Amr S. Abu Lila, El-Sayed Khafagy, Ahmed N. Allam
Summary: The study aimed to achieve localized lung delivery of the anti-tubercular drug moxifloxacin targeting alveolar macrophages through inhalable microspheres as a dry powder inhaler method. The optimized microspheres showed preferential accumulation in lung tissue and sustained drug residence in the lung, suggesting a promising therapeutic approach for effective tuberculosis eradication and improved patient adherence to treatment.
Article
Chemistry, Multidisciplinary
Clarinda Costa, Beatriz Nobre, Ana Sofia Matos, Ana Sofia Silva, Teresa Casimiro, Maria Luisa Corvo, Ana Aguiar-Ricardo
Summary: Liposomes are a promising drug delivery system for biopharmaceuticals, however, they can destabilize during storage. Converting liposomal suspension into solid form can overcome this issue, as shown in this study utilizing pharmaceutical and supercritical carbon dioxide technologies. The dry powder formulations demonstrated stability at specific relative humidities, showing potential for long-term storage.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Medicine, Research & Experimental
Varsha V. V. Nair, Hugh D. C. Smyth
Summary: This study explores the feasibility of engineering an inhaled powder formulation of the broad-spectrum antibiotic Tigecycline (TIG) for the treatment of respiratory tract infections. Micronized TIG showed excellent aerosolization efficiency and maintained stability in different inhaler devices. The results suggest that micronized TIG can be delivered via the pulmonary route for the treatment of lung infections.
MOLECULAR PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Ashish Sarode, Priyal Patel, Natalia Vargas-Montoya, Ayed Allawzi, Alisa Zhilin-Roth, Saswata Karmakar, Lianne Boeglin, Hongfeng Deng, Shrirang Karve, Frank DeRosa
Summary: Pulmonary delivery of mRNA via inhalation is a promising approach for RNA-based therapy for lung diseases. In this study, a successful mRNA-lipid nanoparticle (LNP) dry powder product (DPP) was developed. Formulation optimization of mRNA LNPs in DPP form resulted in efficient and functional delivery of mRNA for treatment of lung diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hairui Zhang, Yajie Zhang, Robert O. Williams, Hugh D. C. Smyth
Summary: The study focuses on using thin-film freeze-drying (TFFD) to prepare gene editing dry powder formulations containing PEGylated chitosan/CRISPR-Cas9 nanocomplexes. Six potential DPI formulations were identified and characterized, with two formulations containing 3% mannitol found to be suitable for inhalation with desired aerodynamic performance. The flow rate and inhaler dependency of these formulations were also evaluated at different conditions, demonstrating the suitability of TFFD-processed CRISPR-Cas9 polymer nanocomplexes for dry powder inhalation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
Kristen D. Popowski, Adele Moatti, Grant Scull, Dylan Silkstone, Halle Lutz, Blanca Lopez de Juan Abad, Arianna George, Elizabeth Belcher, Dashuai Zhu, Xuan Mei, Xiao Cheng, Megan Cislo, Asma Ghodsi, Yuheng Cai, Ke Huang, Junlang Li, Ashley C. Brown, Alon Greenbaum, Phuong-Uyen C. Dinh, Ke Cheng
Summary: Respiratory diseases are a major global burden, and the development of effective therapeutics is limited. Researchers have developed a stable inhalable form of extracellular vesicles that can effectively deliver drugs to the lungs and have shown promising results in vaccine applications.
Article
Pharmacology & Pharmacy
Ho Wan Chan, Hok Wai Lee, Stephanie Chow, David Chi Leung Lam, Shing Fung Chow
Summary: This study developed a continuous process for fabricating inhalable nanoagglomerate dry powder formulations of remdesivir (RDV). The optimized formulation showed good redispersibility and aerosol performance, and the RDV nanoparticles displayed enhanced cell uptake and low cytotoxicity in vitro. Moreover, the continuous manufacturing process showed no significant differences in the quality attributes compared to the standalone batch mode.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Bishal Raj Adhikari, Shyamal C. Das
Summary: This study investigated the aerosol performance of spray-dried powders based on Soluplus polymer for pulmonary drug delivery. The potential use of leucine to improve aerosolization was also explored. The results showed that Soluplus powder without leucine exhibited good performance for pulmonary drug delivery, and the addition of 20% leucine further enhanced aerosolization of the particles.
Article
Pharmacology & Pharmacy
Tushar Saha, Shubhra Sinha, Rhodri Harfoot, Miguel E. Quinones-Mateu, Shyamal C. Das
Summary: This study developed an inhalable dry powder formulation of ivermectin through spray-drying conditions, which could ensure sufficient drug concentrations in the respiratory tract. The ivermectin dry powder showed similar potency to inhibit SARS-CoV-2 replication compared to the solution form.
Review
Materials Science, Biomaterials
M. Munir, L. Jena, V. L. Kett, N. J. Dunne, H. O. McCarthy
Summary: Gene therapy shows promise in the treatment of lung pathologies. Pulmonary delivery through inhalation allows for localized treatment, and the large surface area of the lungs promotes drug absorption. Dry powder inhalers (DPIs) offer advantages in stability, ease of use, and minimal physical stress. Spray drying can be used to produce nucleic acid-containing DPIs, with the right parameters, delivery system, and excipients improving cargo stability and functionality.
BIOMATERIALS ADVANCES
(2022)
Article
Instruments & Instrumentation
Linxia Jiang, Yijun Li, Jiaqi Yu, Jianhong Wang, Jiarui Ju, Jundong Dai
Summary: The new dry powder inhalable formulation of SAL developed in this study, with the addition of L-arginine and lecithin, showed improved biocompatibility and enhanced drug delivery to the lung, resulting in increased drug concentration and bioavailability. This formulation presents a promising strategy for the treatment of pulmonary fibrosis.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Applied
Beatriz Arauzo, M. Pilar Lobera, Antonio Monzon, Jesus Santamaria
Summary: Electrospray technique was utilized to produce inhalable ciprofloxacin-loaded chitosan sub-micron particles, which had small sizes and high surface charge for enhanced mucoadhesive properties and antimicrobial activity against common respiratory pathogens. The particles showed biocompatibility with alveolar cell line (A549) and promising results in antimicrobial efficacy.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Sagar Dhoble, Vinod Ghodake, Vaibhavi Peshattiwar, Vandana Patravale
Summary: Pulmonary Hypertension (PH) is a condition with high mortality rate and non-reversible pathogenesis, currently managed with symptomatic relief medications. Research shows that anti-angiogenic Erlotinib liposomal formulation in inhalable dry powder form has the potential to improve physiological parameters and reverse pathological mechanisms in PH patients.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tomoyuki Okuda, Patricia Tang, Jiaqi Yu, Warren H. Finlay, Hak-Kim Chan
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Review
Pharmacology & Pharmacy
Tomoyuki Okuda
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2017)
Article
Pharmacology & Pharmacy
Takehiro Noda, Tomoyuki Okuda, Ryota Mizuno, Tetsuya Ozeki, Hirokazu Okamoto
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Chemistry, Multidisciplinary
Tomoyuki Okuda, Masaki Morishita, Kimiyasu Mizutani, Ayumi Shibayama, Maki Okazaki, Hirokazu Okamoto
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Chemistry, Medicinal
Daiki Hira, Tomoyuki Okuda, Ayano Mizutani, Nao Tomida, Hirokazu Okamoto
JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Medicine, Research & Experimental
Kei Miwata, Hirokazu Okamoto, Taku Nakashima, Daisuke Ihara, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Ayumi Shibata, Takaaki Ito, Tomoyuki Okuda, Noboru Hattori
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Medicine, Research & Experimental
Takaaki Ito, Tomoyuki Okuda, Yoshimasa Takashima, Hirokazu Okamoto
MOLECULAR PHARMACEUTICS
(2019)
Article
Multidisciplinary Sciences
Tomohiro Mizuno, Kengo Yoshioka, Masashi Mizuno, Mie Shimizu, Fumihiko Nagano, Tomoyuki Okuda, Naotake Tsuboi, Shoichi Maruyama, Tadashi Nagamatsu, Masaki Imai
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Medicinal
Takaaki Ito, Tomoyuki Okuda, Ryo Takayama, Hirokazu Okamoto
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Tomoyuki Okuda, Yoko Toyoda, Takashi Murakami, Hirokazu Okamoto
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Takaaki Ito, Maino Fukuhara, Tomoyuki Okuda, Hirokazu Okamoto
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Chemistry, Medicinal
Tomoyuki Okuda, Hirokazu Okamoto
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Kana Suenaga, Daiki Hira, Eri Ishido, Hiroyoshi Koide, Satoshi Ueshima, Tomoyuki Okuda, Masafumi Yamaguchi, Shin-ya Morita, Hirokazu Okamoto, Tomonobu Okano, Yasutaka Nakano, Tomohiro Terada, Mikio Kakumoto
Summary: The study revealed that 33.3% of participants held the inhaler at an incorrect angle during the drug-loading step. In vitro experiments showed that holding the inhaler at an incorrect angle significantly decreased OE (an index of the loaded dose) by 73.3%, while St2 (an index of the deagglomerating efficiency) remained stable regardless of the holding angle. OE x St2, indicating the bronchial and pulmonary drug delivery amount, decreased by 76.9%. Holding the inhaler at an incorrect angle reduces the loaded dose, leading to decreased pulmonary delivery.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Misa Ichikawa, Naomi Muramatsu, Wataru Matsunaga, Takahiro Ishikawa, Tomoyuki Okuda, Hirokazu Okamoto, Akinobu Gotoh
Summary: This study developed an orally inhalable gene therapy drug for the treatment of lung cancer. The drug effectively decreased cell proliferation and directly impacted the lungs. It provides a novel gene therapy option that patients can self-administer.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Takehiro Noda, Tomoyuki Okuda, Kousuke Ban, Ryota Mizuno, Tatsuaki Tagami, Tetsuya Ozeki, Hirokazu Okamoto
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2017)