Article
Nutrition & Dietetics
Haofeng Hong, Longting Chen, Yiming Zhong, Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: This study used a Mendelian randomization approach to investigate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific osteoarthritis (OA). The results showed that genetically predicted homocysteine had adverse effects on OA, while genetically predicted folate and vitamin B12 had protective effects on OA.
Article
Nutrition & Dietetics
Ziva Lavrisa, Hristo Hristov, Masa Hribar, Katja Zmitek, Anita Kusar, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Igor Pravst
Summary: Vitamin B12 deficiency is a common issue in the Slovenian population, especially among the elderly. Lower intake is observed in females, and meat and milk are the main contributors to vitamin B12 intake across all age groups. Serum vitamin B12 levels have a significant impact on the health of the elderly.
Review
Endocrinology & Metabolism
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Juan C. Cabrera-Guzman, Percy Herrera-Anazco, Vicente A. Benites-Zapata
Summary: This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and homocysteine (Hcy) levels with MetS. The results showed that higher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were positively associated with MetS. Folate levels were not associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Winner Kucha, Daniel Seifu, Abenezer Tirsit, Mahlet Yigeremu, Markos Abebe, Dawit Hailu, Dareskedar Tsehay, Solomon Genet
Summary: The study found that deficiency in folate and vitamin B12 in the blood of pregnant women may be associated with neural tube defects. There is a correlation between the use of folate/multivitamins and neural tube defects.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Li Li, Qi Huang, Linjian Yang, Rui Zhang, Leili Gao, Xueyao Han, Linong Ji, Xiantong Zou
Summary: There is an association between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) with levels of vitamin B12 and associated metabolites, while MMA and HCY may be associated with an increased risk for advanced fibrosis.
Article
Nutrition & Dietetics
Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W. V. Jaddoe
Summary: The study found associations between circulating vitamin B12, folate, and homocysteine concentrations during fetal life and early signs of atherosclerosis in school-age children, but only certain biochemical markers showed impact.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Panpan Zhang, Xia Xie, Yurong Zhang
Summary: This study investigated the associations between plasma homocysteine (Hcy), vitamin B12, and folate levels and the risk of all-cause mortality in American adults with stroke. The results showed a significant positive association between plasma Hcy levels and all-cause mortality in stroke patients, while no significant associations were found between plasma folate and vitamin B12 levels and all-cause mortality.
FRONTIERS IN NUTRITION
(2023)
Review
Hematology
Jean-Louis Gueant, Rosa-Maria Gueant-Rodriguez, Abderrahim Oussalah, Stephane Zuily, Irwin Rosenberg
Summary: Thromboembolic manifestations are common in patients with severe hyperhomocysteinemia related to inherited disorders and deficiencies in vitamin B12 and folate. However, moderate hyperhomocysteinemia is only a modest predictor of cardiovascular risk. The recognition of homocysteine as a cardiovascular risk factor has been challenged by some studies, but not all randomized clinical trials have reached the same conclusion.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Babak Hooshmand, Franziska Appold, Patrick Fissler, Robert Perneczky, Markus Otto, Hayrettin Tumani, Miia Kivipelto, Christine A. F. von Arnim
Summary: This study investigated the association between vitamin B12 status and biomarkers of Alzheimer's disease. The results suggest that vitamin B12-related markers are associated with AD biomarkers and cognitive performance. Vitamin B12 supplementation may be important in slowing down brain changes and cognitive decline.
ANNALS OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
L. Nalder, B. Zheng, G. Chiandet, L. T. Middleton, Celeste A. De Jager
Summary: The study found that older men and women are prone to vitamin B12 deficiency, which may have different negative effects on cognitive domains such as memory and attention. In addition, high BMI was also associated with poorer cognitive performance.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Geriatrics & Gerontology
Yuxin Quan, Jisen Xu, Qing Xu, Zhiqing Guo, Ruwei Ou, Huifang Shang, Qianqian Wei
Summary: This meta-analysis summarizes the relationship between homocysteine, vitamin B12, folate, and Parkinson's disease (PD). The results show that PD patients have lower folate and vitamin B12 levels, but higher homocysteine levels compared to healthy individuals. PD is also significantly associated with hyperhomocysteinemia. Various factors are linked to homocysteine levels in PD patients. Further research is needed to fully understand their roles in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Lijuan Ma, Jing Li, Yuan Yuan, Wenwen Chen, Jun Zhao
Summary: The MTHFR 677TT variant, gender, folate, and Vit B12 were identified as risk factors for the occurrence of H-type hypertension. Folate level decreased with the C to T substitution of the MTFHR C677T gene, while Vit B12 level was not associated with the gene. These factors should be considered in the prevention and treatment of hypertension.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Yang Song, Meina Quan, Tingting Li, Jianping Jia
Summary: This study investigates the changes of homocysteine, vitamin B12, and folate levels in different subtypes of dementia and their associations with cognitive function and MRI markers. The results show that elevated homocysteine levels and lower vitamin B12 levels are associated with various types of dementia. Homocysteine levels are correlated with temporal lobe atrophy in Alzheimer's disease, while vitamin B12 levels are associated with general cognition in vascular dementia. Hyperhomocysteinemia may increase the risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Gastroenterology & Hepatology
Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen
Summary: The study reveals that hyperhomocysteinemia (HHcy) plays a key role in the pathogenesis of non-alcoholic steatohepatitis (NASH) through homocysteinylation of proteins, leading to autophagy blockage. Vitamin B-12 and folate may serve as a novel first-line therapy for NASH by reducing homocysteine levels and promoting autophagy, thus improving liver histology.
JOURNAL OF HEPATOLOGY
(2022)
Article
Geriatrics & Gerontology
Guili Zhang, Shuai Liu, Zhichao Chen, Zhihong Shi, Wenzheng Hu, Lingyun Ma, Xiaodan Wang, Xudong Li, Yong Ji
Summary: Elevated plasma total homocysteine (tHcy) levels were independently associated with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The association was stronger for DLB than for AD, and future longitudinal studies are needed to confirm the causative role of tHcy in DLB.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Food Science & Technology
Dana Philip, Smadar Hod-Ovadia, Aron M. Troen
FOOD AND NUTRITION BULLETIN
(2017)
Article
Endocrinology & Metabolism
Katie L. Stone, Li-Yung Lui, William G. Christen, Aron M. Troen, Douglas C. Bauer, Deborah Kado, Christopher Schambach, Steven R. Cummings, JoAnn E. Manson
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Endocrinology & Metabolism
Yaniv S. Ovadia, Dov Gefel, Nathalie Weizmann, Merav Raizman, Rebecca Goldsmith, Sameer J. Mabjeesh, Lisbeth Dahl, Aron M. Troen
Article
Biochemistry & Molecular Biology
Nur Abu Ahmad, Merav Raizman, Nathalie Weizmann, Brandi Wasek, Erland Arning, Teodoro Bottiglieri, Oren Tirosh, Aron M. Troen
Article
Biochemistry & Molecular Biology
Noemi Monti, Rosaria A. Cavallaro, Andrea Stoccoro, Vincenzina Nicolia, Sigfrido Scarpa, Gabor G. Kovacs, Maria Teresa Fiorenza, Marco Lucarelli, Eleonora Aronica, Isidre Ferrer, Fabio Coppede, Aron M. Troen, Andrea Fuso
Article
Nutrition & Dietetics
Roni Lotan, Ithamar Ganmore, Shahar Shelly, Moran Zacharia, Jaime Uribarri, Paul Beisswenger, Weijing Cai, Aron M. Troen, Michal Schnaider Beeri
Article
Nutrition & Dietetics
Roni Lotan, Ithamar Ganmore, Abigail Livny, Shahar Shelly, Moran Zacharia, Jaime Uribarri, Paul Beisswenger, Weijing Cai, Michal Schnaider Beeri, Aron M. Troen
Summary: In this pilot trial, researchers found that reducing dietary intake of AGEs in elderly individuals with diabetes can lower the level of AGEs in the serum and potentially have a beneficial effect on metabolic biomarkers. This suggests that feasible lifestyle modifications targeting AGEs may help prevent cognitive decline in high-risk populations.
FRONTIERS IN NUTRITION
(2021)
Article
Neurosciences
Roni Lotan, Ithamar Ganmore, Abigail Livny, Nofar Itzhaki, Mark Waserman, Shahar Shelly, Moran Zacharia, Erin Moshier, Jaime Uribarri, Paul Beisswenger, Weijing Cai, Aron M. Troen, Michal Schnaider Beeri
Summary: This pilot trial focused on reducing dietary AGEs in older adults with type 2 diabetes to examine its effect on cognition and cerebral blood flow. The results suggest that intervention targeting AGEs may improve cognitive function, especially in participants with mild cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Nutrition & Dietetics
Jacob Selhub, Joshua W. Miller, Aron M. Troen, Joel B. Mason, Paul F. Jacques
Summary: This article proposes a hypothesis that excessive intake of folic acid depletes serum holotranscobalamin, decreasing active vitamin B-12 in the circulation and limiting its availability for tissues. The study provides evidence from observational and intervention studies, and suggests that further research is needed to elucidate the biochemical and physiological mechanisms underlying this interaction.
ADVANCES IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Line Tang Mollehave, Marie Holm Eliasen, Ieva Strele, Allan Linneberg, Rodrigo Moreno-Reyes, Ludmila B. Ivanova, Zvonko Kusic, Iris Erlund, Till Ittermann, Endre Nagy, Ingibjorg Gunnarsdottir, Jonathan Eli Arbelle, Aaron Milton Troen, Valdis Pirigs, Lisbeth Dahl, Alicja Hubalewska-Dydejczyk, Malgorzata Trofimiuk-Muldner, Joao Jacome de Castro, Mafalda Marcelino, Simona Gaberscek, Katja Zaltel, Manuel Puig-Domingo, Lluis Vila, Sofia Manousou, Helena Filipsson Nystrom, Michael Bruce Zimmermann, Karen R. Mullan, Jayne Valerie Woodside, Henry Voelzke, Betina Heinsbaek Thuesen
Summary: The study aimed to collect European register data on thyroid outcomes and compare the rates between countries/regions with different iodine status and prevention programs. Results indicated a relationship between iodine intake and rates of treatments for hyper- and hypothyroid disorders.
ENDOCRINE CONNECTIONS
(2022)
Article
Health Policy & Services
Janetta Azarieva, Elliot M. Berry, Aron M. Troen
Summary: Even in high-income countries like Israel, children are vulnerable to food insecurity caused by the COVID-19 pandemic. The national School Feeding Programs (SFPs) faced challenges during the pandemic, resulting in a loss of feeding days and revealing policy flaws.
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2022)
Article
Health Policy & Services
Zohar Barnett-Itzhaki, Daniel Ehrlich, Aron M. Troen, Efrat Rorman, Luda Groismann, Moran Blaychfeld-Magnazi, Ronit Endevelt, Tamar Berman
Summary: The lack of mandatory salt fortification policy in Israel, heavy reliance on desalination and low iodine intake from dairy products and seafood have led to iodine deficiency in the population. Despite the inadequacy identified in the 2016 iodine survey, there has been no improvement in the population's iodine status in the past five years. Compared to other countries, Israel and Lebanon are the only ones with median urinary iodine concentrations (UIC) below the WHO adequacy range. Therefore, there is an urgent need for mandatory salt fortification in Israel.
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Oren Heller, Yung Chun, Stav Shapira, Aron Troen, Yaniv Shlomo, Mary Acri, Phillip Marotta, Saneel Kulkarni, Brendan Kinnison, Michal Grinstein-Weiss
Summary: The study found that low-income and marginalized groups are more likely to experience long-COVID symptoms, and individuals with moderate/severe acute COVID are more likely to have long-term symptoms with a higher symptom count compared to those who have not been infected.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Dana Efrati Philip, Ghada Baransi, Danit R. Shahar, Aron M. Troen
FRONTIERS IN NUTRITION
(2018)
Review
Medicine, General & Internal
Atticus H. Hainsworth, Stuart M. Allan, Johannes Boltze, Catriona Cunningham, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D. Isaacs, Raj N. Kalaria, Saskia A. M. J. Lesnik Oberstein, Mark B. Moss, Bjoern Nitzsche, Gary A. Rosenberg, Julie W. Rutten, Melita Salkovic-Petrisic, Aron M. Troen