New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance

Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation

(2012) Ravi Murumalla et al.   Journal of Inflammation-London

Cannabinoids Induce Pancreatic  -Cell Death by Directly Inhibiting Insulin Receptor Activation

(2012) W. Kim et al.   Science Signaling

The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications

(2011) Béla Horváth et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-obesity efficacy of LH-21, a cannabinoid CB1 receptor antagonist with poor brain penetration, in diet-induced obese rats

(2011) Mónica Alonso et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

(2011) D Vara et al.   CELL DEATH AND DIFFERENTIATION

The L- -Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity

(2011) J. M. Moreno-Navarrete et al.   DIABETES

The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats

(2011) A. Díaz-Arteaga et al.   DIABETES OBESITY & METABOLISM

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans

(2011) C. Li et al.   DIABETES OBESITY & METABOLISM

Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice

(2011) M. Bajzer et al.   DIABETOLOGIA

CNS Opioid Signaling Separates Cannabinoid Receptor 1-Mediated Effects on Body Weight and Mood-Related Behavior in Mice

(2011) Sarah Haas Lockie et al.   ENDOCRINOLOGY

Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice

(2011) K S Bell-Anderson et al.   INTERNATIONAL JOURNAL OF OBESITY

Cannabinoid Receptor Type 1 (CB1R) Signaling Regulates Hepatic Gluconeogenesis via Induction of Endoplasmic Reticulum-bound Transcription Factor cAMP-responsive Element-binding Protein H (CREBH) in Primary Hepatocytes

(2011) Dipanjan Chanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans

(2011) Silvana Y Romero-Zerbo et al.   JOURNAL OF ENDOCRINOLOGY

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

(2011) Sebastiano Banni et al.   Nutrition & Metabolism

Acute Overactive Endocannabinoid Signaling Induces Glucose Intolerance, Hepatic Steatosis, and Novel Cannabinoid Receptor 1 Responsive Genes

(2011) Maxwell A. Ruby et al.   PLoS One

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

G1359A Polymorphism in the Cannabinoid Receptor-1 Gene Is Associated with Metabolic Syndrome in the Chinese Han Population

(2010) Wen-Chao Hu et al.   ARCHIVES OF MEDICAL RESEARCH

Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells

(2010) Chen Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver: The Role of eNOS, p38 MAPK, and AMPK Pathways

(2010) L. Tedesco et al.   DIABETES

Effects of in vitro antagonism of endocannabinoid-1 receptors on the glucose transport system in normal and insulin-resistant rat skeletal muscle

(2010) K. A. Lindborg et al.   DIABETES OBESITY & METABOLISM

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age

(2010) J. Agudo et al.   DIABETOLOGIA

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma

(2010) JodiAnne T. Wood et al.   JOURNAL OF LIPID RESEARCH

Modulation of Adipocyte Biology by Δ9-Tetrahydrocannabinol

(2010) Diana Teixeira et al.   Obesity

Reversal of Inflammation-Induced Impairment of Glucose Uptake in Adipocytes by Direct Effect of CB1 Antagonism on Adipose Tissue Macrophages

(2010) Alexandra Miranville et al.   Obesity

Cannabinoids and the gut: New developments and emerging concepts

(2010) Angelo A. Izzo et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

(2009) C. Lipina et al.   DIABETES

Involvement of hypothalamic peptides in the anorectic action of the CB1receptor antagonist rimonabant (SR 141716)

(2009) Aaron N. A. Verty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Endocannabinoids May Mediate the Ability of (n-3) Fatty Acids to Reduce Ectopic Fat and Inflammatory Mediators in Obese Zucker Rats

(2009) Barbara Batetta et al.   JOURNAL OF NUTRITION

Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes

(2009) Rukiyah T. Van Dross   MOLECULAR CARCINOGENESIS

Anandamide Increases the Differentiation of Rat Adipocytes and Causes PPARγ and CB1 Receptor Upregulation

(2009) Sevasti Karaliota et al.   Obesity

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis

(2009) Vanessa Deveaux et al.   PLoS One

Effect of Rimonabant on the High-Triglyceride/ Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat

(2008) Jean-Pierre Després et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

Activated Endocannabinoid System in Coronary Artery Disease and Antiinflammatory Effects of Cannabinoid 1 Receptor Blockade on Macrophages

(2008) Koichi Sugamura et al.   CIRCULATION

Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors

(2008) V. Di Marzo et al.   DIABETOLOGIA

Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

(2008) K. Eckardt et al.   DIABETOLOGIA

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Temporal and Site-Specific Brain Alterations in CB1 Receptor Binding in High Fat Diet-Induced Obesity in C57Bl/6 Mice

(2008) T. South et al.   JOURNAL OF NEUROENDOCRINOLOGY

The Cannabinoid CB1 Receptor Antagonist Rimonabant Stimulates 2-Deoxyglucose Uptake in Skeletal Muscle Cells by Regulating the Expression of Phosphatidylinositol-3-kinase

(2008) I. Esposito et al.   MOLECULAR PHARMACOLOGY

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet

(2008) Katarzyna M. Starowicz et al.   Obesity

Cannabinoid CB2receptors in the gastrointestinal tract: a regulatory system in states of inflammation

(2007) K L Wright et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions

(2007) V E Mendizábal et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet β-cells via CB1 receptors

(2007) Masanori Nakata et al.   REGULATORY PEPTIDES