Article
Biochemistry & Molecular Biology
Menno Hoekstra, Amber B. Ouweneel, Juliet Price, Rick van der Geest, Ronald J. van der Sluis, Janine J. Geerling, Joya E. Nahon, Miranda Van Eck
Summary: SR-BI deficiency in mice fed a high-fat diet was associated with increased weight gain but better glucose handling. Only SR-BI knockout mice developed atherosclerotic lesions in the aortic root, while showing decreased hepatic steatosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Md. Raihan Uzzaman Prince, S. M. Neamul Kabir Zihad, Puja Ghosh, Nazifa Sifat, Razina Rouf, Gazi Mohammad Al Shajib, Md. Ashraful Alam, Jamil A. Shilpi, Shaikh J. Uddin
Summary: The study evaluated the effects of Amaranthus spinosus on obesity induced by high-carbohydrate-high-fat diet, showing that it significantly reduced weight gain and fat deposition while improving glucose and lipid parameters. This medicinal herb also normalized liver biomarkers and boosted hepatic antioxidant levels, suggesting its potential as a food supplement for managing obesity and metabolic disorders.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Simeng Wang, Qingzhang Zhu, Guosheng Liang, Tania Franks, Magalie Boucher, Kendra K. Bence, Mingjian Lu, Carlos M. Castorena, Shangang Zhao, Joel K. Elmquist, Philipp E. Scherer, Jay D. Horton
Summary: Studies using mice lacking CB-1 in hepatocytes or stellate cells suggest that CB-1 signaling does not directly contribute to the development of NAFLD or liver fibrosis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Kendrick Lee, Daniel B. Hardy
Summary: Consumption of cannabis during pregnancy by 18-24-year-old pregnant women can lead to fetal growth restriction and increased risk of obesity, type II diabetes, and cardiovascular disease in the offspring. The doubling concentration of Δ9-THC in cannabis over the past decade can readily cross the placenta and negatively impact fetal development via the eCB system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qiuchi Chen, Wei Fang, Kun Cui, Qiang Chen, Xiaojun Xiang, Junzhi Zhang, Yunqiang Zhang, Kangsen Mai, Qinghui Ai
Summary: The study revealed that ER stress can promote lipid droplets accumulation and inhibit lipoprotein transport by transcriptionally upregulating PLIN2 in the liver, providing insight into a novel mechanism for ER stress-induced hepatic steatosis.
Article
Food Science & Technology
Jhih-Wei Hsu, Chung-Yi Nien, Hsin-Wei Chen, Feng-Yuan Tsai, Szu-Ching Yeh, Yung-Hsi Kao, Tsui-Chun Tsou
Summary: This study found that DEHP exposure exacerbated metabolic disorders in obese mice, but not in lean mice. The synergistic effects of obesity and DEHP regulated carbohydrate uptake, lipolysis, and abnormal adipose tissue, while obesity and DEHP differentially modulated transcriptomic changes in hepatic tissue.Obesity and DEHP exposure together caused early onset of metabolic disorders in obese mice through a potential mechanism involving Pparg, Lipe, Cd44, and Irs1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Zheng-yu Yang, Yi-ying Wu, Yi Zhou, Yun-qi Yang, Jia-hui Zhang, Tao He, Sha Liu
Summary: NITyr reduced lipid accumulation by improving lipid and glucose metabolism involving CB1 and CB2 receptors, without affecting appetite-related indexes and other organ functions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Chung-Hao Li, Chung-Teng Wang, Ying-Ju Lin, Hsin-Yu Kuo, Juei-Seng Wu, Tzu-Chun Hong, Chih-Jen Chang, Hung-Tsung Wu
Summary: Long-term consumption of sorbitol may alter gut microbiome composition and potentially induce glucose intolerance.
Article
Endocrinology & Metabolism
Valentina S. Klaus, Sonja C. Schriever, Jose Manuel Monroy Kuhn, Andreas Peter, Martin Irmler, Janina Tokarz, Cornelia Prehn, Gabi Kastenmueller, Johannes Beckers, Jerzy Adamski, Alfred Koenigsrainer, Timo D. Mueller, Martin Heni, Matthias H. Tschoep, Paul T. Pfluger, Dominik Lutter
Summary: The study introduced a correlation-based method for integrating multi-omics data to identify effective modulators of metabolism. By applying the method to murine liver data, several genes with potential regulatory effects on hepatic metabolism were successfully identified.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Mohammad Irshad Reza, Anees A. Syed, Pragati Singh, Athar Husain, Jiaur R. Gayen
Summary: Mitochondrial dysfunction induced by PST is responsible for hepatic steatosis in T2D, and protection from these abnormalities can be achieved by knockdown of Chga gene or administration of PST inhibitor.
Article
Endocrinology & Metabolism
Yi Zeng, Zhen Zhang, SiTing Liang, XinMiao Chang, RuiJie Qin, Hong Chen, LiXin Guo
Summary: Sleep insufficiency may lead to metabolic dysregulation and increase the risk of diabetes. Research has found that paternal sleep deprivation can affect the metabolic phenotype of offspring, and this is believed to be due to epigenetic inheritance. Male offspring of sleep-deprived fathers show glucose intolerance, insulin resistance, and impaired insulin secretion.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Food Science & Technology
Yueting Ge, Yuhui Yang, Yuge Jiang, Chuanxing Feng, Bowen Li, Jin Sun, Xue Tang, Yonghui Shi, Guowei Le
Summary: Recent studies have found that high oxidative injury pork and Dityr intake induce oxidative stress and inflammation, impairing thyroid function and peripheral metabolism, leading to a decrease in circulating and liver thyroid hormones and induced hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maria Kaare, Kaie Mikheim, Kersti Lillevali, Kalle Kilk, Toomas Jagomae, Este Leidmaa, Maria Piirsalu, Rando Porosk, Katyayani Singh, Riin Reimets, Egon Taalberg, Michael K. E. Schaefer, Mario Plaas, Eero Vasar, Mari-Anne Philips
Summary: The NEGR1 gene plays a crucial role in maintaining systemic metabolism, particularly in glucose homeostasis, as revealed in studies with Negr1(-/-) mice under different diet conditions. The deficiency of Negr1 seems to affect energy storage efficiency and metabolism, leading to alterations in glucose tolerance and other metabolic pathways. Functional Negr1 appears to protect male mice from developing glucose intolerance, liver steatosis, and excessive weight gain in the presence of a high-fat diet.
Article
Pediatrics
Luis E. Simental-Mendia, Cesar Javier Ortega-Pacheco, Elvira Garcia-Guerrero, Maria Alejandra Sicsik-Aragon, Fernando Guerrero-Romero, Gerardo Martinez-Aguilar
Summary: This study found that the TyG index is highly associated with hepatic steatosis in children with overweight or obesity. Compared to other biochemical markers, the TyG index may be a more effective indicator for detecting fatty liver in this population.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Substance Abuse
Keungmo Yang, Sung Eun Choi, Won-Il Jeong
Summary: The endocannabinoid system plays a crucial role in the pathophysiology of ALD, but pharmacological applications are hindered by psychoactive side effects. Further elucidation of the mechanism linking the endocannabinoid system and ALD is essential for potential therapeutic implications.
ALCOHOL RESEARCH-CURRENT REVIEWS
(2021)
Article
Endocrinology & Metabolism
Henriette Kirchner, Indranil Sinha, Hui Gao, Maxwell A. Ruby, Milena Schonke, Jessica M. Lindvall, Romain Barres, Anna Krook, Erik Naslund, Karin Dahlman-Wright, Juleen R. Zierath
MOLECULAR METABOLISM
(2016)
Article
Cell Biology
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schonke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Naslund, Daniel K. Nomura, Juleen R. Zierath
Article
Endocrinology & Metabolism
Matthew D. Bruss, Cyrus F. Khambatta, Maxwell A. Ruby, Ishita Aggarwal, Marc K. Hellerstein
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2010)
Article
Biochemistry & Molecular Biology
Maxwell A. Ruby, Benjamin Goldenson, Gabriela Orasanu, Thomas P. Johnston, Jorge Plutzky, Ronald M. Krauss
JOURNAL OF LIPID RESEARCH
(2010)
Article
Endocrinology & Metabolism
Paul J. Arciero, Michael J. Ormsbee, Christopher L. Gentile, Bradley C. Nindl, Jonathan R. Brestoff, Maxwell Ruby
Article
Multidisciplinary Sciences
Maxwell A. Ruby, Daniel K. Nomura, Carolyn S. S. Hudak, Lara M. Mangravite, Sally Chiu, John E. Casida, Ronald M. Krauss
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2008)
Article
Endocrinology & Metabolism
Maxwell A. Ruby, Isabelle Riedl, Julie Massart, Marcus Ahlin, Juleen R. Zierath
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Public, Environmental & Occupational Health
Maxwell Ruby, Chris P. Repka, Paul J. Arciero
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2016)