Review
Biochemistry & Molecular Biology
Stefanie Maurer, Xiaoxuan Zhong, Betsy Deza Prada, John Mascarenhas, Lucas Ferrari de Andrade
Summary: The advancements in immunotherapy provide new hope for the treatment of AML. The development of antibodies, chimeric proteins, and immune checkpoint blockers has shown promising results in preclinical studies, and cellular therapies involving allogeneic NK cells or targeting leukemia antigens are also being explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo, Ole A. Mandrup, Ainhoa Erce-Llamazares, Rodrigo Lazaro-Gorines, Daniel Nehme-Alvarez, Carmen Dominguez-Alonso, Seandean L. Harwood, Carlos Alfonso, Belen Blanco, Laura Rubio-Perez, Anais Jimenez-Reinoso, Laura Diez-Alonso, Francisco J. Blanco, Laura Sanz, Kenneth A. Howard, Luis Alvarez-Vallina
Summary: This study introduces bispecific antibodies fused with human and mouse sequences that specifically target the tumor microenvironment to provide 4-1BB costimulation. These antibodies show specific targeting of the tumor cells and provide costimulatory activity, with prolonged circulatory half-life and tumor inhibition effects. Combining these antibodies with PD-1-blocking antibodies enhances the therapeutic effect.
Review
Health Care Sciences & Services
Sean Harrop, Chathuri Abeyakoon, Carrie Van der Weyden, H. Miles Prince
Summary: T-cell lymphomas, rare and unsatisfactorily treated, have shown progress in targeted therapies due to advancements in understanding T-cell lymphogenesis pathways and identifying therapeutic targets. New treatments include antibody-based, small molecule inhibitors, and immune-based therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jize Liu, Xiaomin Ma, Chuxuan Liu, Yang Cheng, Bingjun Li, Wenjie Zhang, Runzhi Zeng, Qishuai Chen, Yun Zhang, Sanyuan Hu
Summary: In this study, the therapeutic effect of MSCs and their improvement of sensitivity to alpha PD1 therapy in CRC were investigated. It was found that MSCs recruit and polarize macrophages to inhibit tumor growth through the secretion of CX3CL1. The combination of MSCs and alpha PD1 was more effective than monotherapy in CRC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Nathan El-ghazzi, Xavier Durando, Alexia Giro, Tressie Herrmann
Summary: Endometrial cancer is a rare but aggressive cancer with a low survival rate. Recent advancements in molecular classification have allowed for more targeted treatment options. Immune checkpoint inhibitors such as pembrolizumab have shown promising results in the second-line treatment of advanced EC. There are ongoing investigations into new combinations of pembrolizumab with other drugs that may further improve treatment outcomes.
ONCOTARGETS AND THERAPY
(2023)
Review
Oncology
Christophe Maritaz, Sophie Broutin, Nathalie Chaput, Aurelien Marabelle, Angelo Paci
Summary: Anti-CTLA-4 and anti-PD-1/PD-L1 immune checkpoint inhibitors are therapeutic monoclonal antibodies that reactivate or promote antitumor immunity. However, there are questions regarding the dosing and scheduling of these drugs, due to their high variability and cost.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Xiaohan Guo, Yi Wu, Ying Xue, Na Xie, Guobo Shen
Summary: Recent progress in immunotherapy has revolutionized cancer treatment by utilizing bispecific antibodies (BsAbs) to activate the patient's immune system for targeted elimination of cancer cells. BsAbs can identify various cancer targets and exert effector activities by redirecting cellular pathways. However, further research is needed to optimize conditions, identify appropriate combination partners, and reduce toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Adilet Beishenaliev, Yean Leng Loke, Sook Jing Goh, Hui Nee Geo, Malar Mugila, Misni Misran, Lip Yong Chung, Lik Voon Kiew, Steve Roffler, Yin Yin Teo
Summary: Monospecific antibodies have limitations in delivering drugs to tumors with multiple epitopes, while bispecific antibodies provide a promising alternative by simultaneously targeting two distinct antigens or epitopes. This review discusses the roles of bispecific antibodies in enhancing the internalization and intracellular trafficking of drug-conjugated antibodies and facilitating the delivery of drug-encapsulating nanoconstructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Anna Wrona, Rafal Dziadziuszko, Jacek Jassem
Summary: Combining radiotherapy with targeted agents in non-small cell lung cancer (NSCLC) holds promise for improving treatment outcomes, but so far, no targeted agent has shown clear clinical benefit over standard chemoradiation in locally advanced NSCLC. Well-designed clinical trials may help develop more effective combination strategies.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Lisa Nadal, Frederik Peissert, Abdullah Elsayed, Tobias Weiss, Thomas Look, Michael Weller, Geny Piro, Carmine Carbone, Giampaolo Tortora, Mattia Matasci, Nicholas Favalli, Riccardo Corbellari, Cesare Di Nitto, Eleonora Prodi, Chiara Libbra, Simone Galeazzi, Claudiopietro Carotenuto, Cornelia Halin, Emanuele Puca, Dario Neri, Roberto De Luca
Summary: In this study, a fully human monoclonal antibody targeting human fibroblast activation protein (FAP) was generated and shown to have tumor recognition properties. The antibody demonstrated potent antitumor activity in cancer mouse models and was well-tolerated in non-human primate safety evaluations. These results provide a rationale for future clinical translation of this fully human product.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cell Biology
Alireza Isazadeh, Saba Hajazimian, Hamid Garshasbi, Behrouz Shadman, Amir Baghbanzadeh, Reza Chavoshi, Sina Taefehshokr, Mahdieh Farhoudi Sefidan Jadid, Khalil Hajiasgharzadeh, Behzad Baradaran
Summary: Multiple myeloma is characterized by neoplastic proliferation of plasma cells in the bone marrow. Immune checkpoint inhibitors show anticancer activity in various solid and liquid cancers, but limited efficacy due to resistance is a common challenge for patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Alex J. McCraw, Jitesh Chauhan, Heather J. Bax, Chara Stavraka, Gabriel Osborn, Melanie Grandits, Jacobo Lopez-Abente, Debra H. Josephs, James Spicer, Gerd K. Wagner, Sophia N. Karagiannis, Alicia Chenoweth, Silvia Crescioli
Summary: The field of AllergoOncology is exploring the potential of using IgE in cancer immunotherapy, with evidence showing the significant role of IgE in tumor immunosurveillance. Epidemiological and functional data reveal a complex interplay between IgE, allergy, and cancer.
Review
Oncology
Akanksha Sharma, Lauren Singer, Priya Kumthekar
Summary: Metastatic disease to the central nervous system is a serious complication with high mortality rates. Advances in targeted therapy and immunotherapy have led to successful penetration and efficacy within the CNS, improving treatment options for patients. Identifying key targets in tumorigenesis pathway and upcoming trials continue to promise significant progress in managing CNS metastases.
Article
Chemistry, Multidisciplinary
Nihal Olcay Dogan, Hakan Ceylan, Eylul Suadiye, Devin Sheehan, Asli Aydin, Immihan Ceren Yasa, Anna-Maria Wild, Gunther Richter, Metin Sitti
Summary: Building medical microrobots from the body's own cells may have more potential in clinical applications to improve the possibility of escaping from the host defense mechanism. These microrobots can be remotely controlled with externally applied magnetic fields and have therapeutic functions. They have demonstrated anticancer activity against urinary bladder cancer cells.
Review
Pharmacology & Pharmacy
Claudia Ceci, Pedro Miguel Lacal, Grazia Graziani
Summary: Antibody-drug conjugates (ADCs) are a new group of anticancer agents that combine the selectivity of monoclonal antibodies with the cell killing properties of chemotherapeutic agents. However, the development of ADCs faces challenges such as low tumor selectivity, premature release of drugs, and tumor resistance mechanisms. The design of inert antibodies and the discovery of innovative targets and drugs have led to the development of next-generation ADCs with improved therapeutic properties.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Patrick Ebner, Arif Luqman, Sebastian Reichert, Ksenia Hauf, Peter Popella, Karl Forchhammer, Michael Otto, Friedrich Goetz
Editorial Material
Genetics & Heredity
Michael Otto
Review
Microbiology
Yue Zheng, Lei He, Titus K. Asiamah, Michael Otto
ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Kimbria J. Blake, Pankaj Baral, Tiphaine Voisin, Ashira Lubkin, Felipe Almeida Pinho-Ribeiro, Kelsey L. Adams, David P. Roberson, Yuxin C. Ma, Michael Otto, Clifford J. Woolf, Victor J. Torres, Isaac M. Chiu
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Teruaki Nakatsuji, Tiffany H. Chen, Anna M. Butcher, Lynnie L. Trzoss, Sang-Jip Nam, Karina T. Shirakawa, Wei Zhou, Julia Oh, Michael Otto, William Fenical, Richard L. Gallo
Article
Infectious Diseases
Pipat Piewngam, Mariam Quinones, Witoon Thirakittiwatthana, Thitiya Yungyuen, Michael Otto, Pattarachai Kiratisin
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Article
Immunology
Justin S. Bae, Fei Da, Ryan Liu, Lei He, Huiying Lv, Emilie L. Fisher, Govindarajan Rajagopalan, Min Li, Gordon Y. C. Cheung, Michael Otto
Summary: The study found that Staphylococcal enterotoxin B (SEB) contributes significantly to the pathogenicity of Staphylococcus aureus, suggesting the value of including SEB as a target in multipronged antistaphylococcal drug development strategies. Furthermore, it indicates that SEB contributes to fatal exacerbation of community-associated methicillin-resistant S. aureus infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Gordon Y. C. Cheung, Justin S. Bae, Ryan Liu, Rachelle L. Hunt, Yue Zheng, Michael Otto
Summary: The study found that bacterial virulence and quorum-sensing regulation play crucial roles in staphylococcal sepsis, providing important guidance for developing anti-virulence drugs. It revealed a critical early stage in the development of bacterial sepsis where the battle between bacteria and leukocytes determines the outcome of the disease. This highlights the key role of invading pathogens and their virulence mechanisms in sepsis, challenging the traditional attribution of sepsis mainly to host factors.
Article
Cell Biology
Pipat Piewngam, Janice Chiou, Joie Ling, Ryan Liu, Pawiya Pupa, Yue Zheng, Michael Otto
Summary: The use of probiotic Bacillus subtilis spores has been shown to effectively block the translocation of Enterococcus faecalis from the gut to the bloodstream, thus preventing subsequent systemic infection in mice by inhibiting the Fsr quorum-sensing system. This suggests that probiotics can play a role in controlling key aspects of Enterococcus pathogenesis through quorum sensing mechanisms.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Microbiology
Ping Miao, Yiming Jiang, Ying Jian, Jiali Shi, Yao Liu, Pipat Piewngam, Yue Zheng, Gordon Y. C. Cheung, Qian Liu, Michael Otto, Min Li
Summary: Allergic rhinitis (AR), commonly known as hay fever, is a widespread condition that greatly impacts the lives of millions of people. This study explores the role of nasal microbiota in AR and reveals distinct differences in the nasal microbiome between AR patients and healthy individuals. Specifically, the study identifies Streptococcus salivarius as a contributing factor to AR development and highlights the potential of targeted antibacterial approaches for AR therapy.
NATURE MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Seth W. Dickey, Dylan J. Burgin, Steven Huang, David Maguire, Michael Otto
Summary: Diverse organisms secrete amphipathic biomolecules for competitive gains. However, how cells cope with producing these membrane-permeabilizing molecules is unclear. We focused on the PSM family of secreted amphipathic peptides in the pathogen Staphylococcus aureus that uses two ABC transporters, PmtCD and AbcA, to export peptides across the bacterial cell membrane. We found that increased peptide hydropho-bicity favors PSM secretion through PmtCD over AbcA and that only PmtCD protected cells against amphipathic peptides. We propose a two-system model in which PmtCD and AbcA independently export PSMs from either membrane or cytosolic environments, respectively. Our model provides a rationale for the encoding of multiple transport systems on diverse biosynthetic gene clusters used to produce distinct amphipathic molecules. In addition, our data serve as a guide for selectively blocking PSM secretion to achieve antimicrobial or antivirulence approaches and to disrupt established roles of PSM-mediated virulence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biotechnology & Applied Microbiology
Lei He, Huiying Lv, Yanan Wang, Feng Jiang, Qian Liu, Feiyang Zhang, Hua Wang, Hao Shen, Michael Otto, Min Li
Summary: Quorum cheating, a mutation in cell density-sensing systems, has become a crucial factor in biofilm-associated infection. Inactivation of the quorum-sensing system in Staphylococcus aureus leads to enhanced biofilm formation and resistance to antibiotics and immune defense. Antibiotic treatment can promote quorum cheating and the development of biofilms, especially in biofilm infection models.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Infectious Diseases
Mariana Favero Bonesso, Carlos Magno Castelo Branco Fortaleza, Ricardo de Souza Cavalcante, Moises Teixeira Sobrinho, Carlos Fernando Ronchi, Ligia Maria Abraao, Hwang-Soo Joo, Michael Otto, Maria de Lourdes Ribeiro de Souza da Cunha
Summary: This study aimed to investigate the molecular epidemiology of Staphylococcus aureus in patients on mechanical ventilation and its role in the development of ventilator-associated pneumonia (VAP). Various factors, including resistance profile, virulence factors, and clonal profile, were analyzed in the S. aureus isolates. The study identified patient-related risk factors for VAP and found that the majority of strains causing VAP originated from the community.
Review
Infectious Diseases
Lauren R. Heinzinger, Aaron R. Pugh, Julie A. Wagner, Michael Otto
Summary: Antibiotic resistance is a global threat to human and animal health, especially with the increasing prevalence of antibiotic-resistant Staphylococcus aureus strains. Bacteriocins, which are antimicrobial peptides produced by bacteria, offer a potential alternative therapeutic that has shown efficacy in animal models.
Review
Biochemistry & Molecular Biology
Hoai T. T. Nguyen, Thuan H. Nguyen, Michael Otto
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2020)