Article
Multidisciplinary Sciences
Ya-jing Liu, Yu Ding, Yan-qing Yin, Hui Xiao, Gang Hu, Jia-wei Zhou
Summary: Cspg4high microglia, characterized by unique transcriptomic signature, are one of the origins of microgliosis during neurodegeneration. They can proliferate in response to pathological alpha-synuclein stimulation, and show higher survival rates in transplantation therapy. Additionally, these cells are detected in the brain of AD patients, suggesting their involvement in AD pathogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Delsuz Rezaee, Fatemeh Saadatpour, Nayyereh Akbari, Anahita Zoghi, Sajad Najafi, Parisa Beyranvand, Fahimeh Zamani-Rarani, Mohammad Amin Rashidi, Saeid Bagheri-Mohammadi, Mohammad Bakhtiari
Summary: MicroRNAs (miRNAs) have been found to play significant roles in regulating the development and functions of the central nervous system (CNS). Dysregulation of miRNAs has been associated with various neurodegenerative diseases and CNS tumors. They affect the expression of key genes and proteins involved in the pathogenesis of these diseases.
AGEING RESEARCH REVIEWS
(2023)
Review
Immunology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Antonio H. Iglesias, Jean Pierre Schatzmann Peron
Summary: Neuroinflammatory and neurodegenerative diseases are major public health issues worldwide, with mitochondrial dysfunction playing a significant role. Regulation of mitochondrial dynamics is essential for CNS health maintenance, impacting the development and progression of neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Michael F. McDermott
Summary: The prevalence of neurodegenerative diseases is increasing, characterized by progressive neuronal loss, protein aggregation, metabolic abnormalities, and immune dysregulation. Research has shown that low-grade systemic inflammation may impact the development and progression of these diseases, and inflammation may also be a causative factor.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Youngpyo Nam, Gyeong Joon Moon, Sang Ryong Kim
Summary: Neurotrophic factors play a crucial role in neurodegenerative diseases, and Rheb, as a regulator of NTFs expression, is an important therapeutic target for treating these diseases. AAV transduction can effectively promote neuroprotection by upregulating NTFs in conditions like AD and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sai S. Pradhan, Sai M. Thota, Saiswaroop Rajaratnam, Sai K. S. Bhagavatham, Sujith K. Pulukool, Sriram Rathnakumar, Kanikaram S. Phalguna, Rajesh B. Dandamudi, Ashish Pargaonkar, Prasanth Joseph, E. Joshy, Venketesh Sivaramakrishnan
Summary: This study analyzed metabolomics data from HD patients and a yeast model of HD, and found a considerable overlap of deregulated metabolic pathways. The multiomics analysis also revealed common and unique deregulated pathways in human, mice, and yeast model systems. The modulation of these deregulated pathways was shown to influence protein aggregation in HD through the addition of certain metabolites and gene knockouts in the yeast model system. These findings highlight the importance of regulating deregulated pathways in HD for protein aggregation, disease progression, and prognosis.
DISEASE MODELS & MECHANISMS
(2022)
Review
Neurosciences
Juan S. Jimenez
Summary: The molecular events leading to the appearance of filamentous forms of phosphorylated tau protein in neurodegenerative diseases (tauopathies) are still unknown, as well as the causal relationship between these events and initial symptoms. The main function of tau protein in neurons is controversial, but it appears to have multiple functions. It interacts with various macromolecules and proteins, participating in the regulation of microtubules, nuclear localization and DNA, synaptic activity, RNA metabolism, fats transport, proteostasis, amyloid cascade hypothesis, mitochondria, phosphorylation, and more. The interactome studies reveal numerous partners of tau, indicating its involvement in a complex network of regulatory interactions.
Review
Biochemistry & Molecular Biology
Tapan Behl, Gagandeep Kaur, Aayush Sehgal, Shaveta Bhardwaj, Sukhbir Singh, Camelia Buhas, Claudia Judea-Pusta, Diana Uivarosan, Mihai Alexandru Munteanu, Simona Bungau
Summary: Neurodegeneration is a pathological condition where the nervous system or neuron loses structure and function, with no known treatment yet, and matrix metalloproteinases (MMPs) play a crucial role in the progression of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shang-Der Chen, Yao-Chung Chuang, Tsu-Kung Lin, Jenq-Lin Yang
Summary: Aging is a crucial risk factor for neurodegenerative diseases, and GLP-1R agonists may have beneficial effects in treating these diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Mariano Catanesi, Giulia Caioni, Vanessa Castelli, Elisabetta Benedetti, Michele d'Angelo, Annamaria Cimini
Summary: Marine habitats contain diverse bioactive compounds with pharmaceutical potential, synthesized by marine organisms to survive extreme environmental conditions. Compounds like xanthines, bryostatin, and 11-dehydrosinulariolide show promising neuroprotective effects in neurodegenerative diseases. Studies suggest these marine compounds can serve as potential adjuvant therapies for neurodegenerative disorders due to their antioxidant, anti-inflammatory, and anti-apoptotic properties.
Review
Medicine, Research & Experimental
Zizhen Si, Linlin Sun, Xidi Wang
Summary: With increasing life expectancies, there has been a significant rise in the number of individuals suffering from geriatric neurodegenerative diseases such as AD and PD, leading to overwhelming financial and societal costs. Recent high-profile clinical trials for these diseases have largely failed, emphasizing the urgent need for novel treatment approaches.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Fauzia Nazam, Sibhghatulla Shaikh, Nazia Nazam, Abdulaziz Saad Alshahrani, Gulam Mustafa Hasan, Md Imtaiyaz Hassan
Summary: Neurodegeneration is a significant contributor to morbidity, mortality, and cognitive impairment in aging populations. This review focuses on the biological and psychosocial risk factors associated with Alzheimer's and Parkinson's diseases, and highlights the importance of current therapeutic strategies in improving quality of life for patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Chemistry, Medicinal
Nuria Acero, Teresa Ortega, Victoria Villagrasa, Gemma Leon, Dolores Munoz-Mingarro, Encarna Castillo, M. Eugenia Gonzalez-Rosende, Silvia Borras, Jose Luis Rios, Francisco Bosch-Morell, Isabel Martinez-Solis
Summary: The incidence and prevalence of age-related neurodegenerative dementias are increasing. Medicinal plants traditionally used for aging-related problems have potential therapeutic effects, but more research is needed to find better treatments. Current clinical and preclinical scientific information is available on 49 species used in traditional medicine for neurodegenerative dementias, but more studies are required.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cell Biology
Elena Possemato, Livia La Barbera, Annalisa Nobili, Paraskevi Krashia, Marcello D'Amelio
Summary: Neuroinflammation in the CNS is an innate immune response involving microglia and astrocytes to counteract insults. The NLRP3 inflammasome plays a key role in the neuroinflammatory response, and its persistent activation is implicated in neurodegenerative diseases like PD and AD. The neurotransmitter dopamine negatively modulates NLRP3 activation, and understanding the relationship between dopamine, glial receptors, and neuroinflammation can lead to novel diagnostic strategies and therapeutic approaches.
AGEING RESEARCH REVIEWS
(2023)
Editorial Material
Cell Biology
Rayan Fakih, Veronique Sauve, Kalle Gehring
Summary: Parkinson's disease is a neurodegenerative disorder caused by the loss of dopaminergic neurons. Mutations in PRKN and PINK1 genes are responsible for early onset Parkinson's. Our research shows that PINK1 can activate PRKN to promote mitophagy. This signaling pathway offers potential for the development of therapeutics.
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)