Article
Immunology
Jian Song, Zhigang He, Muqing Yang, Tianyu Yu, Xiaodong Wang, Bin Liu, Jiyu Li
Summary: In hepatic ischemia reperfusion injury, tryptase is accumulated in the circulation and positively correlated with liver injury. Tryptase inhibition can down-regulate adhesion molecules expression and reduce neutrophil infiltration in the liver. The activation of tryptase/PAR-2 axis participates in liver injury through the regulation of neutrophil adhesion and inflammatory factor secretion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Hematology
Imam Manggalya Adhikara, Keiko Yagi, Dyah Samti Mayasari, Yoko Suzuki, Koji Ikeda, Gusty Rizky Teguh Ryanto, Naoto Sasaki, Yoshiyuki Rikitake, Satomi Nadanaka, Hiroshi Kitagawa, Okiko Miyata, Michihiro Igarashi, Ken-ichi Hirata, Noriaki Emoto
Summary: The study demonstrated the significant role of chondroitin sulfate proteoglycans in macrophage foam cell formation and atherogenesis, particularly through the ChGn-2 gene. ChGn-2 deficiency led to reduced glycosaminoglycans and decreased atherosclerotic plaque formation in mice fed with a Western diet. The upregulation of ChGn-2 expression in the presence of oxLDL enhanced oxLDL binding on macrophage surfaces and altered foam cell formation, suggesting ChGn-2 as a potential therapeutic target for atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Pooja Agarwal, Siamon Gordon, Fernando O. Martinez
Summary: Mycobacterium tuberculosis primarily infects macrophages in the lungs, forming granulomata. In response to TB, foam cell macrophages, filled with lipid droplets, are generated. Lipid droplets play an important role in Tuberculosis, with differences from atherosclerosis foam cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jian-Jun Lv, Hao Wang, Hong-Yong Cui, Ze-Kun Liu, Ren-Yu Zhang, Meng Lu, Can Li, Yu-Le Yong, Man Liu, Hai Zhang, Tian-Jiao Zhang, Kun Zhang, Gang Li, Gang Nan, Cong Zhang, Shuang-Ping Guo, Ling Wang, Zhi-Nan Chen, Huijie Bian
Summary: The study discovered that CD147 plays a crucial role in atherosclerosis development, as its expression is upregulated in atherosclerotic lesions rich in macrophages and can be induced by ox-LDL. CD147 promotes foam cell formation through the PI3K/Akt/mTOR signaling pathway, while genetic deletion of macrophage CD147 protects against foam cell formation by impeding cholesterol uptake.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Ben Li, Chufan Wang, Peng Lu, Yumeng Ji, Xufeng Wang, Chaoyang Liu, Xiaohu Lu, Xiaohan Xu, Xiaowei Wang
Summary: In our study, we investigated the role of IDH1 in atherosclerotic foam cells. We found that inhibiting IDH1 can reduce macrophage ferroptosis and foam cell formation, which may provide insights into the occurrence and progression of atherosclerosis and potential treatment targets. The study also revealed the importance of ferroptosis and IDH1 in foam cell production.
Article
Medicine, Research & Experimental
Bo Hui, Xuwei Hou, Ruhui Liu, Xiao-Hong Liu, Zhaohui Hu
Summary: The study demonstrated that Gypenoside inhibits ox-LDL uptake and foam cell formation by enhancing the autophagy flux mediated by Sirt1-FOXO1, suggesting therapeutic potential for atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Yutian Li, Shan Deng, Xiaohong Wang, Wei Huang, Jing Chen, Nathan Robbins, Xingjiang Mu, Kobina Essandoh, Tianqing Peng, Anil G. Jegga, Jack Rubinstein, David E. Adams, Yigang Wang, Jiangtong Peng, Guo-Chang Fan
Summary: This study utilizing a global Sectm1a-knockout mouse model revealed that Sectm1a deficiency leads to increased accumulation of inflammatory macrophages in the heart, worsening cardiac injury in response to inflammatory stimuli. By modulating LXR alpha signaling in macrophages, Sectm1a was identified as a novel regulator of inflammation-induced cardiac dysfunction, suggesting its potential as a therapeutic target for resolving inflammation and associated cardiac dysfunction.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Soraya Jativa, Priscila Calle, Selene Torrico, Angeles Munoz, Miriam Garcia, Ivet Martinez, Anna Sola, Georgina Hotter
Summary: A study has shown that transplanting healthy mitochondria into cholesterol-loaded macrophages can restore phagocytosis and reduce lipid accumulation, leading to a decrease in foam cell formation.
Article
Environmental Sciences
Caixia Guo, Xinying Zhao, Ru Ma, Lingnan Zhu, Yueyue Chen, Zhu Yang, Zongwei Cai, Zhiwei Sun, Yanbo Li
Summary: This study demonstrates that silica nanoparticles (SiNPs) can promote pro-inflammatory macrophages and foam cell transformation through the ROS/PPAR7/NF-xB signaling pathway. SiNPs enhance macrophage adhesion to endothelial cells and induce the upregulation of Vcam1 and Mcp1. Furthermore, SiNPs stimulate macrophages to exhibit enhanced phagocytic activity, a pro-inflammatory phenotype, and an increase in lipid accumulation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Xuanjing Chen, Dezhi Zou, Xiaoling Chen, Huanlin Wu, Danping Xu
Summary: We found that hesperetin can reduce foam cell formation, cholesterol levels, and esterification rate in THP-1 macrophages, while increasing cholesterol efflux. Hesperetin activates AMPK, which upregulates LXRα and its target genes, ultimately inhibiting foam cell formation and promoting cholesterol efflux. This new mechanism might contribute to the anti-atherogenic effects of hesperetin.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Oncology
Yanyan Qiu, Jinyi Xu, Lihong Yang, Guihua Zhao, Jing Ding, Qiong Chen, Na Zhang, Ruike Yang, Jijing Wang, Shuaibing Li, Luming Zhang
Summary: MiR-375 plays a crucial role in atherosclerosis development by inhibiting foam cell formation, increasing cholesterol efflux gene expression, reducing cholesterol influx gene expression, promoting resolving M2 macrophages, and decreasing proinflammatory M1 macrophage markers expression. These effects are partially mediated through the activation of the KLF4-dependent mechanism in macrophages.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza
Summary: This study aimed to investigate whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can reduce cholesterol accumulation in foam cells derived from THP-1 macrophages, and to explore the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Fengjiao Yuan, Jianmei Wei, Yan Cheng, Feifei Wang, Mingliang Gu, Yanhui Li, Xin Zhao, Hao Sun, Ru Ban, Jing Zhou, Zhangyong Xia
Summary: The study suggests that SLAMF7 plays a contributing role in the pro-atherogenic effects by regulating NR4A1-RUNX3, which is important for the initiation and progression of atherosclerosis.
Article
Cell Biology
Yu Cai, Zhengchao Wang, Lun Li, Li He, Xinying Wu, Mingjing Zhang, Pengfei Zhu
Summary: This study found that NPY enhances the formation of macrophage-derived foam cells by regulating cholesterol uptake and efflux. NPY binding to Y1 and Y5 receptors increases cholesterol uptake and intracellular cholesterol content through the PKC/PPAR gamma pathway. Additionally, NPY decreases cholesterol efflux by inhibiting the JAK/STAT3 pathway and downregulating the expression of ABCA1, ABCG1, and SR-BI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)