Article
Biotechnology & Applied Microbiology
Norhayati Mohamed Noor, Sana Umar, Azila Abdul-Aziz, Khalid Sheikh, Satyanarayana Somavarapu
Summary: Male pattern baldness is a common condition that affects the psycho-social health of many men. This study developed an alcohol-free formulation for the topical treatment of this condition. By using a lipid-based nanoparticle system, it was found that including oleic acid in the formulation improved dermal permeation compared to a formulation without oleic acid.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Li Ming Lim, Kunn Hadinoto
Summary: This study found that hydroxypropyl starch is a suitable mucoadhesive polysaccharide for high-payload buccal film applications, with excellent CUR release characteristics and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Ramya Rajan, Kaushik Pal, D. Jayadev, Jitha S. Jayan, U. Aathira, Saritha Appukuttan, Fernando Gomes de Souza, Kuruvilla Joseph, Saran S. Kumar
Summary: In recent years, new life-threatening diseases have emerged in the form of epidemics and pandemics, requiring the introduction of novel drug delivery systems to save lives. Polymer-based drug delivery systems and nanoparticles-based systems are two developing areas in this field. The application of polymer-lipid hybrid nanoparticles and bioorthogonal catalytic reactions have shown promise in releasing drugs at target sites.
TOPICS IN CATALYSIS
(2022)
Review
Polymer Science
Maritza Fernandez, Jahir Orozco
Summary: Research on light-responsive nanocarriers has been conducted for controlled cargo release and targeted therapy, with the ability to release cargo upon light stimulation. Modifying these carriers with different moieties and ligands allows for specific cargo delivery.
Review
Biotechnology & Applied Microbiology
Sean Swetledge, Jangwook P. Jung, Renee Carter, Cristina Sabliov
Summary: Polymeric nanoparticles as drug delivery systems offer advantages such as controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. However, their properties, administration route, and suspension media can impact their distribution and effectiveness in the eye, requiring careful design for specific target tissues and ocular diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Engineering, Environmental
Xinyu Wang, Yeli Fan, Junjie Yan, Min Yang
Summary: Polyphenols, compounds found in natural plants, have various beneficial effects such as anti-tumor, anti-inflammatory, and antibacterial capacities. Polyphenol-based polymeric nanoparticles have emerged as promising drug carriers in biomedical engineering.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Athanasios Skandalis, Dimitrios Selianitis, David R. Sory, Sara M. Rankin, Julian R. Jones, Stergios Pispas
Summary: This study investigates the ability of PDMAEMA-b-PLMA-b-POEGMA amphiphilic triblock terpolymers to encapsulate curcumin. The terpolymers self-assemble into spherical micelles in aqueous solutions. The encapsulation of curcumin within the polymeric micelles is confirmed and quantified using FTIR and UV-Vis spectroscopy. The micelles exhibit spherical morphology as observed by transmission electron microscopy. Furthermore, the curcumin-loaded micelles show no cytotoxicity in vitro.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Abdul Rahim Ferhan, Soohyun Park, Hyeonjin Park, Hyunhyuk Tae, Joshua A. Jackman, Nam-Joon Cho
Summary: This article focuses on the development of next-generation lipid-based nanoparticles from a nanoarchitectonics perspective, analyzing the design, nucleic acid encapsulation methods, scalable production, and application prospects. It also compares and contrasts different nanoarchitectures, such as traditional lipid nanoparticles, lipoplexes, and bicelles, and evaluates the current development status and possible future directions in overcoming clinical translation challenges and exploring new application opportunities.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Xiangjie Di, Xiao Liang, Chao Shen, Yuwen Pei, Bin Wu, Zhiyao He
Summary: This review surveys carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy. Polymeric carbohydrates have advantages of nontoxicity, biocompatibility, and biodegradability, making them an ideal choice for drug targeting, sustained drug release, immune antigens, and adjuvants.
Article
Biochemistry & Molecular Biology
Maria Isabel Quiros-Fallas, Krissia Wilhelm-Romero, Silvia Quesada-Mora, Gabriela Azofeifa-Cordero, Luis Felipe Vargas-Huertas, Diego Alvarado-Corella, Juan Jose Mora-Roman, Jose Roberto Vega-Baudrit, Mirtha Navarro-Hoyos, Andrea Mariela Araya-Sibaja
Summary: This study focused on the issues of poor solubility and short biological half-life of curcumin (CUR). By characterizing the properties of CUR-loaded nanoparticles and conducting in vitro and in vivo experiments, it was found that CUR-loaded nanoparticles exhibited significant improvements in solubility, immune activity, and antioxidant activity. Moreover, these nanoparticles showed significant cytotoxic effects on gastric adenocarcinoma and colon adenocarcinoma cell lines, indicating their potential for phytotherapeutic applications.
Article
Polymer Science
Krissia Wilhelm Romero, Maria Isabel Quiros, Felipe Vargas Huertas, Jose Roberto Vega-Baudrit, Mirtha Navarro-Hoyos, Andrea Mariela Araya-Sibaja
Summary: The PLHNs are developed as drug delivery systems with improved bioactivity by successfully encapsulating different curcuminoids and molecules using a simple method, showing increased release and enhanced antioxidant activity compared to free compounds.
Article
Biophysics
Eva Abramov, Nissim Garti
Summary: This study aims to develop a dermal delivery system based on embedding liquid nanovehicles into polymeric films to achieve controlled release of nanodroplets. The technology results in the formation of homogeneous, transparent, and elastic films with high loading capacity of nanodomains, which spontaneously reform during dermal application. Ex-vivo release studies demonstrate significant permeation of curcumin through pig skin, highlighting the potential of this novel film technology as a solid platform reservoir for liquid nanovehicles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
O. Sreekanth Reddy, M. C. S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao
Summary: The aim of this study was to fabricate dual cross linked sodium alginate/montmorillonite microbeads as a potential drug carrier for extended release of curcumin. Characterization of the microbeads was done using FTIR, DSC, TGA, X-RD, and SEM. The swelling and in vitro release studies of the microbeads were influenced by the pH of test media, indicating their potential for intestinal drug delivery.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Review
Biotechnology & Applied Microbiology
Xiao Xiao, Fei Teng, Changkuo Shi, Junyu Chen, Shuqing Wu, Bao Wang, Xiang Meng, Aniekan Essiet Imeh, Wenliang Li
Summary: This research reviews the current state of cancer drug-loading systems, showcasing the novelty and functions of various architectures, such as micelles, liposomes, dendrimers, polymersomes, hydrogels, and metal-organic frameworks, which may contribute to the development of useful polymeric NPs for different therapeutic purposes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Mohammad F. Bayan, Saeed M. Marji, Mutaz S. Salem, M. Yasmin Begum, Kumarappan Chidambaram, Balakumar Chandrasekaran
Summary: The study aims to develop a smart drug delivery system based on pH-sensitive polymeric formulations. The system can delay the release of drugs in the stomach and small intestine, while releasing them in the colon, showing promising potential for application.
Review
Cell Biology
Naresh Kumar Rajendran, Sathish Sundar Dhilip Kumar, Nicolette Nadene Houreld, Heidi Abrahamse
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2019)
Article
Biotechnology & Applied Microbiology
Leelaram Santharam, Sivanesh Nanjan Easwaran, Anusha Subramanian Mohanakrishnan, Surianarayanan Mahadevan
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2019)
Article
Thermodynamics
Harisivasri K. Phanindra, S. P. Sivapirakasam, Pramod Soni, M. Surianarayanan, K. R. Balasubramanian
THERMOCHIMICA ACTA
(2019)
Article
Environmental Sciences
Bhuvanesh Kumar Shanmugam, Sivanesh Nanjan Easwaran, Anusha Subramanian Mohanakrishnan, Chitra Kalyanaraman, Surianarayanan Mahadevan
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2019)
Article
Biotechnology & Applied Microbiology
Anusha Subramanian Mohanakrishnan, Sivanesh Nanjan Easwaran, Deepa Perinkulam Ravi, Surianarayanan Mahadevan
BIOCHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Karolina Matuszek, R. Vijayaraghavan, Craig M. Forsyth, Surianarayanan Mahadevan, Mega Kar, Douglas R. MacFarlane
Article
Biotechnology & Applied Microbiology
Anusha Mohanakrishnan Subramanian, Sivanesh Easwaran Nanjan, Hariram Prakash, Leelaram Santharam, Ankitha Ramachandran, Vignesh Sathyaseelan, Deepa Perinkulum Ravi, Surianarayanan Mahadevan
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Dermatology
Dimakatso R. Mokoena, Nicolette N. Houreld, Sathish S. Dhilip Kumar, Heidi Abrahamse
LASERS IN SURGERY AND MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Sathish Sundar Dhilip Kumar, Heidi Abrahamse
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Materials Science, Multidisciplinary
L. Mohan, Srabani Kar, B. Nandhini, Sathish Sundar Dhilip Kumar, Moeto Nagai, Tuhin Subhra Santra
MATERIALS TODAY COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Karolina Matuszek, R. Vijayaraghavan, Mega Kar, Surianarayanan Mahadevan, Douglas R. MacFarlane
Summary: Guanidinium mesylate demonstrates excellent performance in terms of thermal energy storage, with good thermal stability and cost-effectiveness. It proves to be a promising phase-change material for inexpensive energy storage in renewable energy applications.
Article
Biochemistry & Molecular Biology
Sivanesh Nanjan Easwaran, Anusha Subramanian Mohanakrishnan, Leelaram Santharam, Saravana Raj Adimoolam, Surianarayanan Mahadevan
Summary: Comparing Kluyveromyces marxianus and Saccharomyces cerevisiae yeasts for Carboxypeptidase Y production, using Bio calorimetry and Respirometric devices, led to optimized production medium components. The increased yields of 14 IU/mL and 8 IU/mL, three times higher than shake flask experiments, were directly linked to the rate of heat evolution and respiration rate, as indicated by calorespirometric data fitting well with experimental results.
PROCESS BIOCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Sathish Sundar Dhilip Kumar, Heidi Abrahamse
Summary: Nanotechnology plays a crucial role in drug delivery, especially in cancer treatment. Biocompatible nanocarriers are easy to synthesize and can be used for targeted photodynamic therapy effectively.
Review
Chemistry, Multidisciplinary
Sathish Sundar Dhilip Kumar, Heidi Abrahamse
Summary: The use of biocompatible nanocarriers in cancer treatment offers potential benefits in terms of targeted drug delivery. These nanoparticles are safe and biodegradable, allowing for the delivery of cancer drugs and photosensitizers. By modifying their surface chemistry, biocompatible nanocarriers can be conjugated with specific ligands or antibodies to achieve targeted drug delivery to cancer cells. This review highlights the various types and properties of biocompatible nanocarriers, as well as their advantages in drug delivery systems and targeting efficiency in cancer therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
R. Vijayaraghavan, Mega Kar, N. E. Sivanesh, V. J. Samuel, M. Surianarayanan, Seth Olsen, D. R. MacFarlane
CHEMICAL COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)