Review
Biochemistry & Molecular Biology
Sarah Vascellari, Aldo Manzin
Summary: This review discusses the shared pathological mechanism between Parkinson's disease and other neurological disorders, mainly related to the aggregation of alpha-synuclein, which progresses in a prion-like manner in the host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Songzhe He, Fushun Wang, Ken Kin Lam Yung, Shiqing Zhang, Shaogang Qu
Summary: This review summarizes the structure, physiological function, and effects of post-translational modifications on alpha-syn aggregation, which may elucidate mechanisms for Parkinson's disease pathogenesis and lay a theoretical foundation for clinical treatment.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Maksym Galkin, Anastasiia Priss, Yevhenii Kyriukha, Volodymyr Shvadchak
Summary: This article reviews small molecule, peptide, and protein inhibitors of alpha-synuclein fibrillization reported so far and discusses the specificity of inhibitors, their action mechanisms, and the strengths and weaknesses of different approaches to testing the inhibitors.
Review
Clinical Neurology
David G. Coughlin, David J. Irwin
Summary: Several advances have been made in fluid and tissue-based biomarkers for Parkinson's disease (PD) and other synucleinopathies in the last few years. Immunohistochemistry, immunofluorescence, and alpha-synuclein seeding amplification assays now offer a crucial advancement in identifying different species of alpha-synuclein in PD patients. Co-pathology of Alzheimer's disease (AD) is commonly found in PD and dementia with Lewy bodies (DLB), and biofluid biomarkers for tau and amyloid beta species can detect this co-pathology.
Review
Neurosciences
Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wang
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the progressive death of dopamine neurons, with mutations in PD-related genes playing a role in neuronal pathogenesis. Molecular chaperones/co-chaperones interact with PD-related proteins to modulate their function and potentially provide new therapeutic targets for the disease progression.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Michele Perni, Annemieke van der Goot, Ryan Limbocker, Tjakko J. van Ham, Francesco A. Aprile, Catherine K. Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W. Chen, Pavan K. Challa, Julius B. Kirkegaard, Romain F. Laine, Kai Yu Ma, Martin B. D. Muller, Tessa Sinnige, Janet R. Kumita, Samuel I. A. Cohen, Renee Seinstra, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Denise Barbut, Alfonso De Simone, Tuomas P. J. Knowles, Michael Zasloff, Ellen A. A. Nollen, Michele Vendruscolo, Christopher M. Dobson
Summary: The aggregation of alpha-synuclein is a key feature of Parkinson's disease, and mutations in this protein are associated with familial forms of the disease. Two C. elegans models expressing mutational variants were studied, showing different behavioral manifestations and levels of aggregation. Squalamine was found to reduce aggregation and toxicity of alpha-synuclein in certain models. Targeting specific regions of alpha-synuclein with antibodies also showed suppression of toxicity in the models. These findings demonstrate the utility of these models in Parkinson's disease research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francisco J. Padilla-Godinez, Rodrigo Ramos-Acevedo, Hilda Angelica Martinez-Becerril, Luis D. Bernal-Conde, Jeronimo F. Garrido-Figueroa, Marcia Hiriart, Adriana Hernandez-Lopez, Ruben Arguero-Sanchez, Francesco Callea, Magdalena Guerra-Crespo
Summary: Dysfunction of cellular homeostasis can lead to misfolding and aggregation of proteins, causing various diseases such as PD, AATD, and HHHS. Understanding the common principles of protein misfolding and aggregation in these diseases could lead to potential mutual treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Abbie T. Rodger, Maryam A. L. Nasser, Wayne G. Carter
Summary: Currently, there are no pharmacological treatments that can completely stop or reverse the progression of Parkinson's Disease (PD). Therefore, there is a need for neuroprotective therapies. This systematic review examines the effectiveness of anti-a-synuclein (a-syn) therapies in preventing PD progression in preclinical models and human clinical trials. The review found that novel preclinical anti-a-syn therapeutics reduced a-syn aggregations and protected against dopaminergic neuronal loss. Completed clinical trials showed significant tolerability and efficacy in reducing a-syn and minimal adverse effects. Overall, this review highlights the potential of anti-a-syn therapies in both preclinical and clinical settings to reduce a-syn accumulation and potentially slow down PD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Johan Willem Smit, Peter Basile, Maria Key Prato, Laurent Detalle, Francois-Xavier Mathy, Astrid Schmidt, Marianna Lalla, Massimiliano Germani, Coralie Domange, Anja-Leona Biere, Massimo Bani, Stan Carson, Just Genius
Summary: This study investigated the safety, tolerability, and pharmacokinetics of UCB0599 in both healthy participants and participants with Parkinson's disease (PD). The results demonstrated that UCB0599 had rapid absorption and predictable pharmacokinetic properties, with no significant food effect observed. Co-administration with itraconazole affected the disposition of UCB0599, but did not impact its safety profile. Treatment-related adverse events were more common in PD patients receiving UCB0599, but were mostly mild to moderate in intensity and unrelated to dosage.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Minal Chaturvedi, Ritu Raj, Sanjeev Kumar Yadav, Tulika Srivastava, Shweta Devi, Durga Dharmadana, Celine Valery, Sandeep K. Sharma, Dinesh Kumar, Smriti Priya
Summary: Post-translational modifications play a crucial role in determining the function and characteristics of proteins. In this study, the phosphorylation of α-synuclein (α-syn) and its impact on aggregation, seeding capacity, and cytotoxicity were investigated. It was found that α-syn can undergo multi-serine phosphorylation, which exacerbates its aggregation potential and toxicity.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Robert I. Horne, Michael A. Metrick, Wing Man, Dillon J. Rinauro, Z. Faidon Brotzakis, Sean Chia, Georg Meisl, Michele Vendruscolo
Summary: The accurate recapitulation of a-synuclein aggregation process in an in vitro assay for Parkinson's disease has been challenging. This study investigated assay conditions that enable spontaneous primary and secondary nucleation of a-synuclein at pH 7.4 using 400 mM sodium phosphate. The presence of potassium ions enhanced the reproducibility of a-synuclein aggregation. This work provides a framework for studying spontaneous a-synuclein aggregation at physiological pH.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
G. Pagano, K. I. Taylor, J. Anzures-Cabrera, M. Marchesi, T. Simuni, K. Marek, R. B. Postuma, N. Pavese, F. Stocchi, J. -P. Azulay, B. Mollenhauer, L. Lopez-Manzanares, D. S. Russell, J. T. Boyd, A. P. Nicholas, M. R. Luquin, R. A. Hauser, T. Gasser, W. Poewe, B. Ricci, A. Boulay, A. Vogt, F. G. Boess, J. Dukart, G. D'Urso, R. Finch, S. Zanigni, A. Monnet, N. Pross, A. Hahn, H. Svoboda, M. Britschgi, F. Lipsmeier, E. Volkova-Volkmar, M. Lindemann, S. Dziadek, S. Holiga, D. Rukina, T. Kustermann, G. A. Kerchner, P. Fontoura, D. Umbricht, R. Doody, T. Nikolcheva, A. Bonni
Summary: The study found that prasinezumab had no meaningful effect on global or imaging measures of Parkinson's disease progression and was associated with infusion reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Ramil Gabdulkhaev, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, Norihito Uemura, Noriko Matsui, Sachiko Hirokawa, Maki Yoshihama, Aki Shimozawa, Shin-ichiro Kubo, Kenji Iwasaki, Masato Hasegawa, Ryosuke Takahashi, Keisuke Hirai, Akiyoshi Kakita, Osamu Onodera
Summary: This study found that phosphorylation of a-Synuclein at T64 was increased in both Parkinson's disease models and human PD brains. The T64D phosphomimetic mutation led to the formation of a-Synuclein oligomers with a similar structure to those with the A53T mutation, and it induced mitochondrial dysfunction, lysosomal disorder, cell death, and neurodegeneration. These findings suggest a pathogenic role of a-Synuclein phosphorylation at T64 in Parkinson's disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Aitor Franco, Pablo Gracia, Adai Colom, Jose D. Camino, Jose Angel Fernandez-Higuero, Natalia Orozco, Alexander Dulebo, Leonor Saiz, Nunilo Cremades, Jose M. G. Vilar, Adelina Prado, Arturo Muga
Summary: Research shows that the Hsc70-based disaggregase system preferentially breaks down toxic oligomers and short fibrils, while its activity against larger, less toxic amyloids is severely impaired. This behavior is the result of an all-or-none abrupt solubilization of individual aggregates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, In-Su Kim, Yuxi Lin, Young-Ho Lee, Dong-Kug Choi
Summary: In Parkinson's disease, the aggregated alpha-synuclein in Lewy bodies and mitochondrial dysfunction play crucial roles in neurodegeneration, with interactions between aggregated alpha-synuclein and mitochondria potentially leading to neuronal loss, making it an emerging drug target for Parkinson's disease treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Clinical Neurology
Wolfgang H. Jost, Carsten Buhmann, Joseph Classen, Karla Eggert, Zacharias Kohl, Tiago Outeiro, Lars Tonges, Dirk Woitalla, Heinz Reichmann
Summary: COMT inhibitors have been established for over 20 years in the treatment of motor fluctuations in Parkinson's disease. However, the available inhibitors differ in pharmacokinetics, indication requirements, and side effects, leading to many patients not receiving optimized drug treatment.
Article
Multidisciplinary Sciences
Laura Torres-Garcia, Joana M. P. Domingues, Edoardo Brandi, Caroline Haikal, Janitha M. Mudannayake, Ines C. Bras, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F. Outeiro, Gunnar K. Gouras, Jia-Yi Li
Summary: This study demonstrates the interaction between alpha-synuclein and Tau proteins using bimolecular fluorescence complementation technique. The findings suggest the importance of studying the interaction between these proteins in the pathogenesis of Parkinson's disease and Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mohammed Al-Azzani, Annekatrin Koenig, Tiago Fleming Outeiro
Summary: Synucleinopathies are neurodegenerative diseases characterized by abnormal accumulation of alpha-synuclein protein. Understanding the transitions between different aggregation states of alpha-synuclein is crucial for deciphering the molecular basis of these diseases. Standardizing protocols for the production and purification of alpha-synuclein is important to ensure reproducibility and reliability in studies.
Review
Biology
Rita Flores, Angela Carneiro, Sandra Tenreiro, Miguel C. Seabra
Summary: Early and intermediate AMD patients have varying risks of disease progression, highlighting the importance of predictive biomarkers. Traditional clinical parameters have been replaced by multimodal retinal assessment, which provides more accurate image biomarkers.
Article
Biochemistry & Molecular Biology
Samantha L. Schaffner, Zinah Wassouf, Diana F. Lazaro, Mary Xylaki, Nicole Gladish, David T. S. Lin, Julia MacIsaac, Katia Ramadori, Thomas Hentrich, Julia M. Schulze-Hentrich, Tiago F. Outeiro, Michael S. Kobor
Summary: This study identified the association between alpha-synuclein variants and epigenetic regulation of PD, impacting DNA methylation at thousands of CpGs and DNA hydroxymethylation at hundreds of CpGs, primarily involving genes related to locomotor behavior and glutamate signaling pathways.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Samuel Pena-Diaz, Jordi Pujols, Eftychia Vasili, Francisca Pinheiro, Jaime Santos, Zoe Manglano-Artunedo, Tiago F. Outeiro, Salvador Ventura
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons and the accumulation of proteinaceous inclusions. The intrinsically disordered protein alpha-synuclein (alpha-Syn) plays a major role in the formation of these inclusions. In this study, researchers generated different alpha-Syn amyloid conformations and found that a compound called SC-D can reduce aggregation and fibril formation of alpha-Syn. Additionally, SC-D showed activity in disaggregating fibrils and reducing strain-specific intracellular accumulation of phosphorylated alpha-Syn. These findings suggest that SC-D may be a promising compound for inhibiting polymorphic alpha-Syn aggregation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Cleonice Creusa Santos, Thyago R. Cardim-Pires, Liana Shvachiy, Luis Arturo Fonseca-Fonseca, Patricia Munoz, Aurea Maria A. N. Almeida, Ana Carla S. Costa, Jessica Teles-Souza, Estael Ochoa-Rodriguez, Maria de Fatima Dias Costa, Fernando L. Palhano, Juan Segura-Aguilar, Deyse B. Barbosa, Mayra R. do Bomfim, Manoelito C. dos Santos Junior, Franco Henrique A. Leite, Samuel Silva da Rocha Pita, Silvia Lima Costa, Yanier Nunez-Figueredo, Tiago Fleming Outeiro, Debora Foguel, Victor Diogenes Amaral Silva
Summary: Studies have shown that JM-20 can protect against neurotoxicity related to Parkinson's disease. It inhibits the aggregation of alpha-synuclein and induces the formation of harmless amyloid fibrils. JM-20 also reduces the size of Parkinson's disease-related protein inclusions. It offers neuroprotective effects by interacting with alpha-synuclein.
NEUROTOXICITY RESEARCH
(2022)
Article
Neurosciences
Ines C. Bras, Mohammad H. Khani, Eftychia Vasili, Wiebke Moebius, Dietmar Riedel, Iwan Parfentev, Ellen Gerhardt, Christiane Fahlbusch, Henning Urlaub, Markus Zweckstetter, Tim Gollisch, Tiago F. Outeiro
Summary: This study systematically compares the molecular mechanisms involved in the release of alpha-synuclein, Tau, and huntingtin proteins and evaluates their effects on cellular activity and inflammation. The results demonstrate that the released proteins can have detrimental effects on surrounding cells and suggest that protein release pathways could be targeted for therapeutic interventions in various neurodegenerative diseases.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Aisha M. Swaih, Carlo Breda, Korrapati Sathyasaikumar, Natalie Allcock, Mary E. W. Collier, Robert P. Mason, Adam Feasby, Federico Herrera, Tiago F. Outeiro, Robert Schwarcz, Mariaelena Repici, Flaviano Giorgini
Summary: Kynurenine 3-monooxygenase (KMO) localizes to the outer mitochondrial membrane and interacts with huntingtin (HTT) protein, which is associated with Huntington's disease (HD). The interaction between KMO and HTT is localized to the outer mitochondrial membrane, suggesting a potential physiological role for mitochondrial HTT in HD pathogenesis.
Article
Cell Biology
Kambiz Hassanzadeh, Castrese Morrone, Keivan Akhtari, Ellen Gerhardt, Ludovica Zaccagnini, Tiago Fleming Outeiro, Marco Feligioni
Summary: This study aims to investigate the SUMOylation of alpha-Syn isoforms and its impact on cell death and alpha-Syn aggregation. The results suggest that boosting SUMOylation can prevent alpha-Syn aggregation and promote autophagy, and that alpha-Syn 140 and alpha-Syn 126 undergo SUMOylation while alpha-Syn 112 and 98 do not. Overexpression of the non-SUMOylated isoforms leads to increased toxicity and alpha-Syn aggregation. These findings highlight the importance of SUMOylation in modulating alpha-Syn aggregation and the behavior of alpha-Syn isoforms.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Review
Clinical Neurology
Patrick W. Cullinane, Eduardo de Pablo Fernandez, Annekatrin Konig, Tiago Fleming Outeiro, Zane Jaunmuktane, Thomas T. Warner
Summary: Highly reproducible epidemiological evidence suggests that type 2 diabetes (T2D) increases the risk and progression of Parkinson's disease (PD) and repurposing certain antidiabetic medications for PD treatment shows promise. The high prevalence of T2D highlights the need for personalized antidiabetic treatment in PD patients. However, understanding the mechanistic relation and molecular pathways affected by T2D in the brain is essential. The review focuses on the evidence of T2D-associated dysregulation in peripheral and brain pathways, its impact on neurodegeneration in PD, and the challenges in unraveling the complex relationship between T2D, insulin resistance, and PD.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Tiago Fleming Outeiro, Omar M. El-Agnaf
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Louise Berkhoudt Lassen, Maj Schneider Thomsen, Elisa Basso, Ernst-Martin Fuchtbauer, Annette Fuchtbauer, Tiago Fleming Outeiro, Poul Henning Jensen, Torben Moos
Summary: Mutations of tyrosine to phenylalanine at positions 125, 133, and 136 in alpha-synuclein lead to severe motor impairment and neuropathology in mice. The phosphorylation of serine 129 does not seem to be the cause of the toxicity.
Article
Oncology
Agathe Quesnel, Nathan Coles, Claudio Angione, Priyanka Dey, Tuomo M. Polvikoski, Tiago F. Outeiro, Meez Islam, Ahmad A. Khundakar, Panagiota S. Filippou
Summary: Raman spectroscopy combined with machine learning can discriminate different grades of gliomas and understand their molecular changes, particularly in glycosylation. This technique holds promise as a tool for assisting glioma diagnosis and evaluation.
Review
Biochemistry & Molecular Biology
Luca Marsili, Jennifer Sharma, Tiago Fleming Outeiro, Carlo Colosimo
Summary: Stem cell-based therapies (SCT) have potential in treating neurodegenerative disorders, but clinical trials are just starting and results may take several years. SCTs can provide both symptomatic and disease-modifying effects, and may complement molecular therapies in precision medicine.
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)