Article
Geochemistry & Geophysics
Chadlin M. Ostrander, Sune G. Nielsen, Hayley J. Gadol, Luciana Villarroel, Scott D. Wankel, Tristan J. Horner, Jerzy Blusztajn, Colleen M. Hansel
Summary: Thallium (Tl) isotopes serve as a valuable tool for studying the history of molecular oxygen in seawater. Understanding the modern Tl isotope cycle is crucial for its application, especially in anoxic environments. This study found significant variability in Tl isotopes in short timeframes and observed the association of Tl with sulfide and other metals. The sediment data revealed limited isotopic variability, indicating the ability of sediments to capture the Tl isotope composition of contemporary waters.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2023)
Article
Engineering, Environmental
Guochen Wang, Adam C. Hambly, Guan Wang, Kai Tang, Henrik R. Andersen
Summary: In this study, an engineered cycle of manganese reduction followed by oxidation was successfully implemented in a two-stage moving bed biofilm reactor for continuous micropollutant removal. The mass balance assessment showed that the manganese redox cycling functioned well and biogenic manganese oxides were continuously regenerated. Specific micropollutants were efficiently removed by the staged MBBR.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Engineering, Environmental
Yue Wang, Yihan Bai, Junfeng Su, Amjad Ali, Zhihong Gao, Tinglin Huang, Meng Cao, Miqi Ren
Summary: Nitrogen pollution is a major threat to global sustainable development and has recently gained increased attention. The combination of microbially mediated Mn redox cycling and N removal shows promise as an economical, efficient, and environmentally friendly alternative. This review explores the key factors, theories, and mechanisms of Mn species in driving the biogeochemical cycle, and summarizes the application and development trends of Mn redox cycling in water treatment, particularly in simultaneous N and micropollutant removal. Bibliometric analysis identifies research hotspots, gaps, challenges, and future directions for Mn redox-mediated biological N removal. Overall, this review aims to guide the further development and optimization of Mn redox-mediated microbial N removal processes to establish cost-effective N removal techniques for contaminated water.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Ke Zhang, Shaojian Zhang, Peng Liao, Yuanxin Zhao, Min Gan, Jianyu Zhu
Summary: This study investigates the impact of natural microbial communities under fluctuating redox conditions on the cycling of sulfur and iron and their transformation. The results demonstrate the importance of bio-mediated sulfur and iron cycling for pollutant transformation in sulfur-rich aquatic environments.
Article
Geosciences, Multidisciplinary
Jing Liu, Qingze Chen, Yixuan Yang, Hongyan Wei, Minwang Laipan, Runliang Zhu, Hongping He, Michael F. Hochella
Summary: The chemistry of Fe and Mn in natural geochemical systems are closely coupled, and the coupled redox reactions between Fe and Mn play important roles in environmental system dynamics. The crystallization and transformation of FeOx and MnOx are bilaterally affected by the coupled redox between Fe and Mn. The coupled redox cycling of Fe and Mn exerts more complex and significant influences on biogeochemical processes compared to individual Fe or Mn.
EARTH-SCIENCE REVIEWS
(2022)
Article
Engineering, Environmental
Yingying You, Shaobin Huang, Moshan Chen, Kimberly M. Parker, Zhen He
Summary: The study demonstrates that a hybrid catalyst composed of alpha-Fe2O3 and SeS2 can effectively promote the regeneration of Fe(II), leading to a significant improvement in pollutant removal efficiency. Hydroxyl radicals are identified as the dominant active species in the H2O2 system, while sulfate radicals are identified as the dominant active species in the PS system.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Hermano M. Queiroz, Samantha C. Ying, Macon Abernathy, Diego Barcellos, Fabricio A. Gabriel, Xose L. Otero, Gabriel N. Nobrega, Angelo F. Bernardino, Tiago O. Ferreira
Summary: The study assessed manganese contamination in the Rio Doce estuary after the collapse of the world's largest mine tailings dam, finding a significant increase in dissolved manganese and decrease in total manganese content in soils over the following two years. The dynamic interaction between Fe and Mn in the impacted estuary poses a high risk to estuarine biota and human health, indicating a possible chronic contamination scenario.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Lihu Liu, Qi Qiao, Wenfeng Tan, Xuecheng Sun, Chengshuai Liu, Zhi Dang, Guohong Qiu
Summary: This study utilized electrochemical redox to enhance the As removal efficiency of iron-manganese nodules and explored their potential application in treating arsenic-contaminated wastewater.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Neurosciences
Praneet Kaur Marwah, Gijong Paik, Christopher J. Issa, Christopher C. Jemison, Muhammad B. Qureshi, Tareq M. Hanna, Eduardo Palomino, Krishna Rao Maddipati, David Njus
Summary: Chronic exposure to high levels of manganese causes a condition called manganism, which selectively affects the dopamine-rich basal ganglia and leads to movement disorders similar to Parkinson's disease. The specific targeting mechanism is not yet known, but it is hypothesized that complexation of manganese with dopamine derivatives may play a role.
Article
Engineering, Environmental
Yongsheng Lu, Hui Liu, Xueer Huang, Lu Xu, Jizhi Zhou, Guangren Qian, Jupei Shen, Xueping Chen
Summary: Fe(III) bio-reduction offers potential for nitrate remediation in aquatic environments. This study demonstrated multiple nitrate removal using Shewanella oneidensis MR-1 and either ferrihydrite or magnetite, showing that nitrate reduction is primarily achieved through a combination of biological reduction and iron oxidation-reduction processes, resulting in significant nitrogen gas production.
WATER SCIENCE AND TECHNOLOGY
(2021)
Article
Agricultural Engineering
Ru Sun, Mengxin Fu, Liangcai Ma, Yucheng Zhou, Qunliang Li
Summary: The aim of this study was to investigate the impact of Fe (III) on humification and free radicals in composting. The experimental group (CT) with Fe-2(SO4)(3) exhibited a higher degree of humification compared to the control group (CK). Fe (III) significantly contributed to the formation of free radicals in humic substances, as evidenced by increased H2O2 content and semiquinone free radical concentration in CT.
BIORESOURCE TECHNOLOGY
(2023)
Article
Environmental Sciences
Zhe Zhou, Susann Henkel, Sabine Kasten, Moritz Holtappels
Summary: Permeable sandy sediments on the global continental shelf play a crucial role in regulating organic matter and nutrient cycling in the coastal ocean. This study investigated the biogeochemical processes in North Sea sands under porewater advection and changing redox conditions. The results showed that Fe(III) oxyhydroxides served as the major electron acceptors during anoxic incubation, and Fe(II) in the solid phase acted as a rechargeable redox battery. Furthermore, excessive phosphorus release occurred after the release of Fe(II), potentially increasing net benthic phosphorus efflux under variable redox conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Geochemistry & Geophysics
Valeria Boyko, Khoren Avetisyan, Alyssa Findlay, Qingjun Guo, Xi Yang, Andre Pellerin, Alexey Kamyshny
Summary: The research investigates the cycling of redox-sensitive elements in a seasonally stratified lake in China and suggests that the biogeochemical cycles in the lake may be analogous to those in the Archean ocean. The study found that the lake's hypolimnion becomes anoxic and contains iron, manganese, and low concentrations of hydrogen sulfide, similar to conditions suggested in the ancient ocean.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2021)
Article
Electrochemistry
Erin Lyle, Ron Vaeli, Animesh Dutta, Michael Metzger
Summary: This study synthesized dense LMFP materials using the melt synthesis method, which showed higher electrical conductivity and crystallinity compared to reference samples. The crystallite size of melt LMFP is larger, but its performance is worse with higher Mn content.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Geochemistry & Geophysics
Delphine Tisserand, Stephane Guedron, Eric Viollier, Didier Jezequel, Sylvain Rigaud, Sylvain Campillo, Geraldine Sarret, Laurent Charlet, Daniel Cossa
Summary: This study investigated the speciation and distribution of mercury (Hg) in Lake Pavin, France. The results showed that the cycling of Hg in the lake is controlled by biological activity, organic matter, iron, and sulfur. The study provides important insights into the understanding of Hg cycling in lakes.
APPLIED GEOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Theo Battista, Gianmarco Pascarella, David Sasah Staid, Gianni Colotti, Jessica Rosati, Annarita Fiorillo, Alessia Casamassa, Angelo Luigi Vescovi, Barbara Giabbai, Marta Stefania Semrau, Sergio Fanelli, Paola Storici, Ferdinando Squitieri, Veronica Morea, Andrea Ilari
Summary: The study utilized a drug repositioning strategy to identify six drugs that can directly bind sigma 1R and improve the growth of cells from Huntington disease patients. These drugs have shown efficacy in providing new therapeutic tools against HD, offering hope for future treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Valerio Chiarini, Annarita Fiorillo, Serena Camerini, Marco Crescenzi, Shin Nakamura, Theo Battista, Leonardo Guidoni, Gianni Colotti, Andrea Ilari
Summary: The study revealed that zinc ion can activate the protein splicing of BIL2, leading to ubiquitination through the formation of a covalent isopeptide bond. Additionally, ubiquitination of T.thRas-GTPase was found to stabilize the protein's active state.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Pharmacology & Pharmacy
Luana di Leandro, Francesco Giansanti, Sabrina Mei, Sara Ponziani, Martina Colasante, Matteo Ardini, Francesco Angelucci, Giuseppina Pitari, Michele d'Angelo, Annamaria Cimini, Maria Serena Fabbrini, Rodolfo Ippoliti
Summary: A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells, utilizing a G-rich double-stranded DNA aptamer and glioma-specific aptamer to effectively kill target cells. The main findings support the proof-of-concept for local delivery in rat glioblastoma models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Francesca Fata, Ilaria Silvestri, Matteo Ardini, Rodolfo Ippoliti, Luana Di Leandro, Nicola Demitri, Maurizio Polentarutti, Adele Di Matteo, Haining Lyu, Gregory R. J. Thatcher, Pavel A. Petukhov, David L. Williams, Francesco Angelucci
Summary: Fragment screening is a powerful drug discovery approach, and in this study, fragments selected from a large screen against SmTGR were probed by X-ray crystallography to identify three binding sites, one of which stabilizes the crucial C-terminus through allosteric effects. This demonstrates the value of fragments as small molecule probes for investigating target protein function and provides fundamental chemical information for drug discovery.
ACS INFECTIOUS DISEASES
(2021)
Article
Chemistry, Analytical
Ramanand Bisauriya, Simonetta Antonaroli, Matteo Ardini, Francesco Angelucci, Antonella Ricci, Roberto Pizzoferrato
Summary: In this study, nitrogen and sulfur co-doped carbon dots (NS-CDs) were used for colorimetric detection of heavy metals in water, specifically focusing on the detection of copper with potential for dual-species sensitivity. By increasing the pH of the NS-CD solution to 9.5, interference from other metals was reduced, allowing for enhanced response to copper. The method offers a low-cost and promising option for on-site monitoring of copper by unskilled personnel, without the need for additional reagents or prior treatment.
Article
Multidisciplinary Sciences
Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boffi
Summary: Numerous studies have shown a strong correlation between the number of neurofibrillary tangles of the tau protein and Alzheimer's disease progression, making the quantitative detection of tau very promising from a clinical point of view. However, the lack of highly reliable fluorescent probes for selective imaging of tau neurofibrillary tangles is a major challenge. In this study, a small-size library of fluorescent probes was designed and evaluated in silico. The synthesized probe BT1 showed excellent photophysical properties and high selectivity for imaging hyperphosphorylated tau protein filaments in vitro.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S. J. Arner, Francesco Angelucci
Summary: This study characterized the thioredoxin reductase (TrxR) selenoproteins from two filarial nematode parasites, providing insights on drug targets for lymphatic filariasis and onchocerciasis treatment.
Article
Chemistry, Medicinal
Theo Battista, Stefano Federico, Simone Brogi, Luca Pozzetti, Tuhina Khan, Stefania Butini, Anna Ramunno, Eleonora Fiorentino, Stefania Orsini, Trentina Di Muccio, Annarita Fiorillo, Cecile Exertier, Daniel Di Risola, Andrea Ilari, Giuseppe Campiani, Gianni Colotti, Sandra Gemma
Summary: Leishmania spp. is a significant public health issue, and developing better therapeutic drugs is urgently needed. This study optimized a novel class of Leishmania inhibitors through various approaches and identified potent and selective compounds that could be used for treating leishmaniasis and related diseases.
ACS INFECTIOUS DISEASES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Matteo Ardini, Paola Baiocco, Adele Di Matteo, Giorgio Giardina, Adriana Erica Miele
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Annarita Fiorillo, Gianni Colotti, Cecile Exertier, Anastasia Liuzzi, Francesca Seghetti, Alessandra Salerno, Jessica Caciolla, Andrea Ilari
Summary: Trypanothione reductase (TR) plays a key role in the redox homeostasis of trypanosomatid parasites and is essential for their survival in the oxidative environment. We conducted a fragment-based crystal screening and identified 12 new ligands binding to five different sites, including an allosteric pocket named the doorstop pocket, which hampers TR activity. Another site, known as the Z-site, located within the trypanothione cavity, has not yet been explored for inhibition.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Food Science & Technology
Matteo Ardini, Riccardo Vago, Maria Serena Fabbrini, Rodolfo Ippoliti
Summary: Suicide gene therapy is a promising approach in cancer treatment, in which genes coding for enzymes or protein toxins are delivered to cells to induce cell death. This review provides an overview of bacterial and plant enzymes studied for their delivery and controlled expression in tumor models.
Article
Chemistry, Multidisciplinary
Marco Ambrosetti, Maria Cristina Mozzati, Alberto Cini, Maria Fittipaldi, Daniele Spada, Michela Sturini, Irene Quinzeni, Marcella Bini
Summary: This study synthesized undoped and Cu- or Fe-doped Na0.67MnO2 (NMO) samples via the sol-gel route and analyzed the samples using spectroscopic techniques, cyclic voltammetry, and galvanostatic cycling. The results revealed the impact of doping on the performance of the samples.
APPLIED SCIENCES-BASEL
(2022)
Review
Chemistry, Analytical
Francesca Fata, Federica Gabriele, Francesco Angelucci, Rodolfo Ippoliti, Luana Di Leandro, Francesco Giansanti, Matteo Ardini
Summary: The publication of the first enzyme-based electrode for glucose detection in 1967 prompted significant efforts in developing sensors that utilize biomolecules either in their native form or modified to achieve improved sensing performances. Bionanotechnology has emerged as a prominent field, demonstrating how nanomaterials can be tailored into responsive nanostructures using biomolecules and integrated into sensors for high sensitivity detection of various analytes, including biomarkers, antibiotics, toxins, organic compounds, cells, and microorganisms. The natural affinity between biomolecules and almost all types of nanomaterials, along with well-established crosslinking strategies to stabilize hybrid nanostructures, has enabled the realization of biosensors with broad applications and unprecedented low detection limits. This review provides a comprehensive overview of recent biochemical and biophysical strategies for building hybrid devices based on bioconjugated nanomaterials, along with their applications in label-free detection in diagnostics, food, and environmental analysis.
Review
Biochemistry & Molecular Biology
Federica Gabriele, Marta Palerma, Rodolfo Ippoliti, Francesco Angelucci, Giuseppina Pitari, Matteo Ardini
Summary: Affibodies and designed ankyrin repeat proteins (DARPins) are synthetic proteins with biochemical and biophysical features ideal for targeting and fighting diseases. They have a strong binding affinity, solubility, small size, multiple functionalization sites, biocompatibility, and are easy to produce. This review highlights their use in conjugation with zero-dimensional nanomaterials for targeted cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Daniele Spada, Marco Ambrosetti, Maria Cristina Mozzati, Benedetta Albini, Pietro Galinetto, Alberto Cini, Maria Fittipaldi, Marcella Bini
Summary: ZnFe2O4 has been prepared using different methods and its physico-chemical properties have been analyzed. The electrochemical behavior of ZnFe2O4 has been studied through various techniques, showing the relationship between electrochemical features and physico-chemical properties.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)