Article
Endocrinology & Metabolism
Cecilia Bjornfot, Anders Garpebring, Sara Qvarlander, Jan Malm, Anders Eklund, Anders Wahlin
Summary: Intracranial arterial stiffening could be an early marker of cerebrovascular dysfunction and may be involved in detrimental disease processes to brain function. A novel 4D flow MRI method utilizing the intracranial vascular tree structure is shown to be stable and sensitive in estimating pulse wave velocity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Ines Alexandra Marques, Carolina Fernandes, Nuno Tiago Tavares, Ana Salome Pires, Ana Margarida Abrantes, Maria Filomena Botelho
Summary: Cell-based assays on monolayer cultured cells are valuable, but 3D cell culture models have gained relevance for better mimicry of in vivo microenvironment. Magnetic-based 3D cell culture systems have been developed to promote cell aggregation into 3D structures. This systematic review summarizes studies using magnetic 3D culture to mimic human tissues and explores methodological differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
JoEllen Welsh, Min Ji Bak, Carmen J. Narvaez
Summary: Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) play essential roles in the post-translational gamma-carboxylation process of a small number of proteins, which have been implicated in cancer. Observational studies have shown an inverse association between vitamin K intake and cancer incidence and mortality. In cancer cells, vitamin K has newly discovered functions including activation of signaling pathways and regulation of oxidative stress.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Konstantina Flouda, John Mercer, Michael J. Davies, Clare L. Hawkins
Summary: This study demonstrates that HOCl reacts rapidly with cells, causing cell death, while HOSCN reacts more slowly, with cell death occurring only after prolonged incubation. HOCl also influences mitochondrial respiration, decreases glycolysis, lactate release, ATP production, cellular thiols, and glutathione levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Tingrui Zhao, Qingsong Jiang, Wenming Li, Yin Wang, Yao Zou, Xinyu Chai, Zhiyi Yuan, Limei Ma, Ruihong Yu, Tao Deng, Chao Yu, Tingting Wang
Summary: A unique subset of neutrophils with antigen-presenting cell-like characteristics was found in atherosclerotic patients and mice. These neutrophils, when activated, promoted the proliferation and interferon-gamma production of CD3(+) T cells through HLA-DR/CD80/CD86. This finding suggests that targeting this neutrophil subset could be a new immunotherapeutic strategy for atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hui Wang, Xiaoting Zhang, Ping Li, Fang Huang, Tiancong Xiu, Hongtong Wang, Wei Zhang, Wen Zhang, Bo Tang
Summary: Atherosclerosis, a disease driven by lipoproteins, lacks effective therapy for reversal. Therefore, there is an urgent need for a noninvasive and reliable early detection approach to prevent plaque formation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Qiu-Hua Gao, Baiqing Wen, Yani Kang, Wen-Ming Zhang
Summary: Magnetic levitation (MagLev) is a simple and promising method for density-based analysis and detection of individual cells. However, the existing MagLev configurations have low sample utilization due to limited knowledge about the sample cells outside the microscope's vision. This study proposes a pump-free microfluidic MagLev approach for sensitive and effective cellular density measurement on small sample volumes.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Cell Biology
Wanlin Zhan, Wei Tian, Wenlu Zhang, Hua Tian, Ting Sun
Summary: In this study, the researchers found that ANGPTL4 promotes endothelial cell proliferation and protects against palmitic acid-induced endothelial injury by increasing autophagy, which may have a protective effect on the development of atherosclerosis.
CELLULAR SIGNALLING
(2022)
Article
Cardiac & Cardiovascular Systems
Katrin Nitz, Michael Lacy, Mariaelvy Bianchini, Kanin Wichapong, Irem Avcilar Kuecuekgoeze, Cecilia A. Bonfiglio, Roberta Migheli, Yuting Wu, Carina Burger, Yuanfang Li, Ignasi Forne, Constantin Ammar, Aleksandar Janjic, Sarajo Mohanta, Johan Duchene, Johan W. M. Heemskerk, Remco T. A. Megens, Edzard Schwedhelm, Stephan Huveneers, Craig A. Lygate, Donato Santovito, Ralf Zimmer, Axel Imhof, Christian Weber, Esther Lutgens, Dorothee Atzler
Summary: Amino acid homoarginine reduces atherosclerosis by modulating the T-cell cytoskeleton and inhibiting T-cell functions. This finding provides a molecular explanation for the beneficial effects of homoarginine in atherosclerotic cardiovascular disease.
CIRCULATION RESEARCH
(2022)
Article
Materials Science, Biomaterials
Deniz Yagmur Urey, Hsi-Min Chan, Naside Gozde Durmus
Summary: A label-free method has been developed for real-time interrogation, monitoring, detection, and sorting of biological rare cells in magnetically suspended heterogeneous samples. This technique allows for efficient and accurate isolation of cell populations, as well as forensic evidence processing in crime scene samples.
Article
Engineering, Environmental
Valquiria Campos, Diego Gouveia Marques, Joao Nogueira, Carlos O. Amorim, Ana Luisa Daniel-da-Silva, Tito Trindade
Summary: Metoprolol, a commonly used beta-blocker for treating hypertension, has been found in significant amounts in surface waters, causing negative impacts on the environment and human health. Current water treatment procedures are ineffective in removing metoprolol, highlighting the need for more efficient water treatments. This study investigates the use of magnetic nanoparticles coated with silica and.-polyglutamic acid as sorbents to capture metoprolol dissolved in water.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Minghua Zhang, Jing Liu, Rong Gao, Yazhuo Hu, Li Lu, Chuanbin Liu, Lunna Ai, Jingkun Pan, Lei Tian, Jiao Fan
Summary: IL-36γ plays a role in regulating inflammatory responses and lipoprotein metabolism in macrophages, promoting foam cell formation and uptake of oxidized low-density lipoproteins, and thereby advancing atherosclerosis progression.
Article
Cardiac & Cardiovascular Systems
Umar R. Rekhi, Mohamed Omar, Maria Alexiou, Cole Delyea, Linnet Immaraj, Shokrollah Elahi, Maria Febbraio
Summary: Research indicates that endothelial cell CD36 plays a significant role in systemic metabolism and has a sex-specific impact on atherosclerosis and energy substrate use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Dan Mu, Wenshen Wang, Jianhui Li, Pin Lv, Renyuan Liu, Ying Tan, Chongxia Zhong, Yu Qi, Xuan Sun, Yihai Liu, Song Shen, Yuyu Li, Biao Xu, Bing Zhang
Summary: The HFTNPs nanoparticles manufactured in this study can specifically accumulate in inflammatory macrophages in atherosclerotic plaques, provide brighter magnetic resonance images, promote reactive oxygen species generation, induce the death of inflammatory macrophages, without damaging normal cells and tissues.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Oncology
Lili Tan, Jie Lu, Limin Liu, Lu Li
Summary: Silencing of FABP3 promotes cholesterol efflux, inhibits macrophage foam cell formation, and prevents atherosclerosis. Mechanistic studies reveal the involvement of PPAR gamma signaling in balancing cholesterol metabolism.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Divya Ramchandani, Seung Koo Lee, Shira Yomtoubian, Myung Shin Han, Ching-Hsuan Tung, Vivek Mittall
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Seung Koo Lee, Myung Shin Han, Weiqi Zhang, Ching-Hsuan Tung
MACROMOLECULAR BIOSCIENCE
(2019)
Review
Materials Science, Biomaterials
Baoji Du, Ching-Hsuan Tung
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Oncology
Vanessa Bellat, Yago Alcaina, Ching-Hsuan Tung, Richard Ting, Adam O. Michel, Mark Souweidane, Benedict Law
Article
Oncology
Zihua Zeng, Ching-Hsuan Tung, Youli Zu
Article
Chemistry, Multidisciplinary
Ching-Hsuan Tung, Myung Shin Han, Zhenhua Shen, Brian D. Gray, Koon Y. Pak, Jianguang Wang
Summary: CypH-11 is a pH-responsive fluorogenic dye designed for highlighting cancerous tissues during surgery, with fast absorption and bright fluorescence in acidic environments. Its spray-and-see concept enables real-time identification of small cancerous lesions for optimal resection without systemic toxicity.
Article
Chemistry, Multidisciplinary
Weiqi Zhang, Baoji Du, Menghan Gao, Ching-Hsuan Tung
Summary: In this study, long-term lysosome tracking with minimized photodamage was achieved by using a multifunctional nanoprobe. The platinum nanoparticle scavenged light-induced reactive oxygen species, protecting lysosomal membranes from damage and enabling long-term quinacrine fluorescence imaging of lysosomes.
Article
Chemistry, Multidisciplinary
Seung Koo Lee, Zhenhua Shen, Myung Shin Han, Ching-Hsuan Tung
Summary: A methylene blue-based beta-galactosidase activatable molecule, Gal-MB, has been developed for senescence imaging and light-triggered senolysis. Gal-MB becomes fluorescent when in contact with LacZ beta-gal or senescence-associated beta-gal (SA-beta-gal). It also selectively induces phototoxicity in LacZ beta-gal expressing cells and drug-induced senescent cells, which express SA-beta-gal, after light illumination at 665 nm.
Article
Oncology
Xiang Chen, Seung Koo Lee, Mei Song, Tiantian Zhang, Myung Shin Han, Yao-Tseng Chen, Zhengming Chen, Xiaojing Ma, Ching-Hsuan Tung, Yi-Chieh Nancy Du
Summary: Researchers developed a RHAMMB-targeting nanoparticle to deliver siRNA and KLA peptide into PNET cells, achieving a synergistic killing effect and significantly reducing tumor burden in mice with RHAMMB-positive PNETs.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Chemistry, Medicinal
Jianjun Qi, Zihua Zeng, Zhenghu Chen, Cole Nipper, Xiaohui Liu, Quanyuan Wan, Jian Chen, Ching-Hsuan Tung, Youli Zu
Summary: Gemcitabine is a chemotherapeutic drug that may have adverse effects on patients due to lack of tumor cell specificity. To improve its therapeutic efficacy, researchers synthesized a novel aptamer-drug conjugate that carries a high drug payload and allows controlled drug release. This approach achieved higher therapeutic efficacy and reduced off-target effects compared to free-drug chemotherapy.
Meeting Abstract
Oncology
Xiang Chen, Tiantian Zhang, Seung Koo Lee, Dunrui Wang, Zhengming Chen, Ching-Hsuan Tung, Yao-Tseng Chen, Yi-Chieh Nancy Du
Meeting Abstract
Oncology
Seung Koo Lee, Xiang Chen, Yi-Chieh Nancy Du, Ching-Hsuan Tung
Article
Chemistry, Multidisciplinary
Zhenhua Shen, Ching-Hsuan Tung
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Baoji Du, Weiqi Zhang, Ching-Hsuan Tung
CHEMICAL COMMUNICATIONS
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Seung Koo Lee, Divya Ramchandani, Shira Yomtoubian, Myung Shin Han, Vivek Mittal, Ching-Hsuan Tung
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)