Review
Multidisciplinary Sciences
Weiguo Qiao, Zhong'an Li
Summary: This review summarizes the recent progress of SQ-based fluorescent materials and their biomedical applications. The synthetic routes and design principles of SQ-based fluorescent materials, as well as their aggregation-induced luminescence behaviors, are discussed. The biomedical applications of SQ-based fluorescent materials in cell imaging, fluorescent sensors, and therapeutic agents are introduced.
Review
Chemistry, Organic
Kilian Colas, Susanne Doloczki, Mauricio Posada Urrutia, Christine Dyrager
Summary: This minireview discusses the synthesis, structure-photophysical properties relationship, and bioimaging applications of fluorescent coumarins, xanthenes, BODIPYs, and cyanines. Advantages and disadvantages of the emissive units are also explored, along with general practical considerations when using fluorophores in a biological context.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Seokhwan Chung, Richard A. Revia, Miqin Zhang
Summary: Graphene quantum dots (GQDs) have excellent properties for various applications in nanomedicine. Recent research focuses on their physicochemical, electronic, magnetic, and biological properties, discussing their use in bioimaging and therapy, as well as technical progress in GQDs synthesis.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Frederik Brondsted, Cliff Stains
Summary: The study focused on the influence of electron-withdrawing groups on tetramethylrhodamine (TMR) structure using computational methods, successfully extending the emission wavelength of TMR fluorophore to the shortwave-infrared region, providing a new approach for generating fluorogenic reporters.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Biophysics
Zhenjie Qiao, Jian Zhang, Xin Hai, Yongcun Yan, Weiling Song, Sai Bi
Summary: Metal nanoclusters (MNCs) are a promising nanomaterial composed of several to hundreds of metal atoms, with unique physical and chemical properties. Template-assisted synthesis of MNCs has gained extensive attention in the biological field due to its advantages of facile preparation, controllable size, water-solubility, and biocompatibility.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Spectroscopy
Chenlu Liang, Wei Shu, Rubing Han, Hao Kang, Xiaoli Zhang, Jing Jing, Rubo Zhang, Xiaoling Zhang
Summary: The turn-on fluorescent probe DMX has been developed for monitoring and tracking the reactive oxygen species peroxynitrite (ONOO-) in biological systems. DMX exhibits high sensitivity and selectivity towards ONOO- and can be visualized using confocal laser scanning microscopy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Yan Liu, Bingya Wang, Ji-Ting Hou, Peng Xie, Weiyi Li, Shan Wang
Summary: In this study, a series of dyes based on C2-alkenyl indole skeleton, called AI dyes, were synthesized. These dyes exhibited wide ranges of emission wavelengths and large Stokes shifts. The optical and structural dissimilarities between C2- and C3-alkenyl AI dyes were discussed and theoretical calculations were conducted to gain insights into the structure-activity relationship. Additionally, a fluorescent probe, AI-Py-B, capable of imaging endogenous ONOO- was presented, demonstrating the bioimaging potentials of these alkenyl indole dyes.
BIOORGANIC CHEMISTRY
(2023)
Review
Materials Science, Multidisciplinary
Jiaxing Wu, Zhenxiong Shi, Linlin Zhu, Jie Li, Xu Han, Man Xu, Shiping Hao, Yibo Fan, Tao Shao, Hua Bai, Bo Peng, Wenbo Hu, Xiaowang Liu, Chuanhao Yao, Lin Li, Wei Huang
Summary: The near-infrared region is crucial in biomedicine due to reduced photon attenuation, autofluorescence, and scattering. This review focuses on the structure-property relationship of fluorescent dyes, strategies for maintaining high brightness with redshifted absorption/emission wavelengths, and recent advances in highly fluorescent NIR dyes. The authors aim to provide design guidelines and insights that may inspire new ideas and applications.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Biophysics
Legha Ansari, Shahin Hallaj, Tooba Hallaj, Mohammad Amjadi
Summary: This review summarizes the recent developments in the use of doped-CDs for pharmaceutical and medical applications, including their applications in biological imaging, nanomedicine, and biosensing. The review also discusses the advantages, disadvantages, and limitations of doped-CD technologies in biomedical research.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Zayakhuu Gerelkhuu, Yong-Ill Lee, Tae Hyun Yoon
Summary: This review describes the potential applications of upconversion nanomaterials (UCNMs) in biomedical fields, including drug delivery, bioimaging, biosensing, and photodynamic therapy. The mechanisms, synthesis methods, and biological toxicity of UCNMs are discussed, and the prospects for clinical applications are explored.
Article
Chemistry, Multidisciplinary
Arindam Mukhopadhyay, Kaixuan Liu, Victor Paulino, Jean-Hubert Olivier
Summary: This study reveals the close correlation between the aggregation state of pi-conjugated chromophore precursors and the semiconductor properties of n-type monolayers. By stabilizing the maximum anodic potential during oxidative cycles, the conduction band energies of hybrid monolayers can be modulated, enabling electron injection. These findings hold promising opportunities for developing switchable nonvolatile electronic memory devices.
Article
Chemistry, Applied
Rumeng Tian, Xiaojie Ren, Peixin Niu, Lei Yang, Ailing Sun, Yuhan Li, Xingjiang Liu, Liuhe Wei
Summary: In this study, a series of new dyes, CQ-Cou, were designed and synthesized for the first time, which have high fluorescence quantum yield, high photostability and molar absorption coefficient. The mechanisms of intramolecular charge transfer related to donor and acceptor in these dyes were investigated through theoretical calculations. Importantly, these new dyes were successfully applied in biological imaging for living cells and zebrafish.
Review
Biochemistry & Molecular Biology
Oksana Krupka, Pietrick Hudhomme
Summary: The emblematic PDI structure has seen incredible development in recent decades, with the power of synthetic organic chemistry allowing for highly functional dye derivatives. These derivatives have been widely studied in materials science, particularly in photovoltaics, due to their combination of thermal, chemical, and photostability, as well as high absorption coefficient and near-unity fluorescence quantum yield.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Serkan Erdemir, Sait Malkondu
Summary: A novel colorimetric and fluorescent switch-on probe based on xanthene-triphenylamine was developed for highly selective and sensitive detection of Hg2+. The probe exhibited significant enhancement in fluorescence intensity upon binding with Hg2+ and successfully detected Hg2+ in food and water samples, as well as in live cells for cell imaging studies.
Article
Engineering, Environmental
Xiao-Fan Zhang, Lin Shen, Sheng Wang, Qian Chen, Xiao-Qun Cao, Shi-Li Shen, Xiaohua Li
Summary: Fluorescence imaging is widely studied for its unique advantages, especially near-infrared (NIR, 650-900 nm) probes which can minimize interference and photodamage. Rhodamine B, a xanthene dye, is commonly used but its short wavelengths hinder bioapplication in living mice. In this study, a novel fluorophore F3 with high NIR quantum yield and tunable fluorescence off-on switch is presented, enabling fluorescence imaging of peroxynitrite fluctuations in hepatotoxicity and nitroreductase changes in tumor mice.
CHEMICAL ENGINEERING JOURNAL
(2023)