期刊
BIOSENSORS & BIOELECTRONICS
卷 176, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112898
关键词
Metal nanoclusters; Templates; Biosensing; Bioimaging; Theranostics
类别
资金
- National Natural Science Foundation of China [21722505, 22076087, 22004077]
- Special Funds of the Taishan Scholar Program of Shandong Province [tsqn20161028]
- Youth Innovation Technology Program of Shandong Province [2019KJC029]
- Collaborative Innovation Program of Jinan [2018GXRC033]
- Open Project of Chemistry Department of Qingdao University of Science and Technology [QUSTHX201928]
Metal nanoclusters (MNCs) are a promising nanomaterial composed of several to hundreds of metal atoms, with unique physical and chemical properties. Template-assisted synthesis of MNCs has gained extensive attention in the biological field due to its advantages of facile preparation, controllable size, water-solubility, and biocompatibility.
As a kind of promising nanomaterials, metal nanoclusters (MNCs) generally composed of several to hundreds of metal atoms have received increasing interest owing to their unique properties, such as ultrasmall size (<2 nm), fascinating physical and chemical properties, and so on. Recently, template-assisted synthesis of MNCs (e.g., Au, Ag, Cu, Pt and Cd) has attracted extensive attention in biological fields. Up to now, various templates (e.g., dendrimers, polymers, DNAs, proteins and peptides) with different configurations and spaces have been applied to prepare MNCs with the advantages of facile preparation, controllable size, good water-solubility and biocompatibility. Herein, we focus on the recent advances in the template-assisted synthesis of MNCs, including the templates used to synthesize MNCs, and their applications in biosensing, bioimaging, and disease theranostics. Finally, the challenges and future perspectives of template-assisted synthesized MNCs are highlighted. We believe that this review could not only arouse more interest in MNCs but also promote their further development and applications by presenting the recent advances in this area to researchers from various fields, such as chemistry, material science, physiology, biomedicine, and so on.
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