Article
Nutrition & Dietetics
Jahangir Iqbal, Abeer Al Otaibi, Sindiyan Alshaikh Mubarak, Ali Alqarni, Ahmed Bakillah
Summary: ABCC10 is involved in the synthesis and efflux of GlcCer, with its inhibition affecting both processes.
Article
Biochemical Research Methods
Hemi Luan, Shuailong Chen, Longshan Zhao, Shijia Liu, Tiangang Luan
Summary: This study utilized precise lipidomic technology to investigate the relationship between lipid metabolism and rheumatoid arthritis (RA). The findings suggest that the accumulation of circulating ceramides is associated with disrupted ceramide/SM cycles during RA progression. Certain ceramides were found to be positively correlated with RA activity, especially in patients with serum antibody-negative RA. Additionally, the enzyme SMPD3 was identified as a factor that accelerates RA progression, and its activity can be inhibited by methotrexate, leading to a potential therapeutic option for RA by targeting the SM cycle.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Cell Biology
Makoto Taniguchi, Toshiro Okazaki
Summary: Sphingomyelin synthase plays a crucial role in regulating cell functions through the generation of sphingomyelin and the sphingomyelin cycle; Sphingomyelin and ceramide have distinct physiological roles on the cell membrane; The regulation of ceramide/SM balance by enzymes like SMS and SMase is important for cell functions and cancer progression.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Shinji Yamashita, Mikio Kinoshita, Teruo Miyazawa
Summary: Sphingolipids, as constituents of cell and vacuole membranes in eukaryotic cells, play a critical role acquired from daily diets, especially affecting intestinal health. Animal- and plant-derived foods contain different types of sphingolipids, influencing intestinal health, lipid metabolism, and skin disorders. Despite low absorption ratios, dietary sphingolipids have various functions and structures that contribute to health benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew N. Hoofnagle, Amanda M. Fretts, William T. Longstreth, Michael G. Shlipak, David S. Siscovick, Jason G. Umans, Rozenn N. Lemaitre
Summary: The study found that circulating sphingolipids partially mediate the associations between eGFR and cardiovascular events. Altered sphingolipid metabolism may be a novel mechanism for heart failure in patients with CKD.
Article
Food Science & Technology
Philippe Guerre, Caroline Gilleron, Maria Matard-Mann, Pi Nyvall Collen
Summary: Fumonisins have significant effects on sphingolipids in the heart and gizzard of chickens, but no significant effects were observed in breast muscle. There are significant differences in sphingolipid composition between the heart and gizzard.
Article
Multidisciplinary Sciences
Xiupeng Chen, Jie Li, Zhongbao Gao, Yang Yang, Wenqing Kuang, Yue Dong, Gek Huey Chua, Xiahe Huang, Binhua Jiang, He Tian, Yingchun Wang, Xun Huang, Yan Li, Sin Man Lam, Guanghou Shui
Summary: By studying the CPE synthase in Drosophila, we found that membrane CPE plays a crucial role in maintaining circadian behavior and lifespan. Deficiency in CPE leads to arrhythmic locomotor behavior and shortened lifespan, while increasing CPE has the opposite effect. Furthermore, dysregulated synaptic glutamate utilization and transport were found to be associated with CPE deficiency.
NATIONAL SCIENCE REVIEW
(2022)
Article
Food Science & Technology
Didier Tardieu, Maria Matard-Mann, Pi Nyvall Collen, Philippe Guerre
Summary: The study analyzed the effects of FB on hepatic and plasma sphingolipidome in chickens, showing that alterations in sphingolipids can lead to toxic manifestations and can potentially serve as a biomarker of exposure to FB.
Article
Nutrition & Dietetics
Jahangir Iqbal, Meghan T. Walsh, M. Mahmood Hussain
Summary: In addition to ABCA1, ABCC10 is also involved in the transport and efflux of HexCer to HDL, affecting the synthesis and egress of HexCer in liver cells.
Article
Neurosciences
Liubov S. Kalinichenko, Laila Abdel-Hafiz, An-Li Wang, Christiane Muehle, Nadine Roesel, Fabian Schumacher, Burkhard Kleuser, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Gerd Schaller, Tanja Richter-Schmidinger, Bernd Lenz, Erich Gulbins, Johannes Kornhuber, Andre W. C. Oliveira, Marilia Barros, Joseph P. Huston, Christian P. Mueller
Summary: The study found that sphingolipids play a crucial role in appetitively motivated learning and memory, with regionally enhanced neutral sphingomyelinase (NSM) activity being associated with superior performance. An opposite interaction was observed in aversively motivated tasks. NSM was confirmed to have a role in learning through its control of N-methyl-D-aspartate receptor subunit expression.
Article
Biochemistry & Molecular Biology
Makoto Taniguchi, Shingo Nagaya, Kohei Yuyama, Ai Kotani, Yasuyuki Igarashi, Toshiro Okazaki
Summary: Ceramide metabolism through receptor-mediated exosome release plays a crucial role in drug resistance and cell proliferation in leukemia cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jorge Eduardo Rico, Eveline C. Sandri, Andrea Celemin Sarmiento, Janie Levesque, Akos Kenez, Daniel E. Rico
Summary: Dietary conditions high in starch may reduce sphingolipid synthesis in milk, even without impacting circulating sphingolipids. Discriminant analysis revealed distinct metabolic differences between the high starch and control groups, with specific sphingolipids being predictive of dietary treatment.
Article
Biochemistry & Molecular Biology
Sara C. Di Rienzi, Elizabeth L. Johnson, Jillian L. Waters, Elizabeth A. Kennedy, Juliet Jacobson, Peter Lawrence, Dong Hao Wang, Tilla S. Worgall, J. Thomas Brenna, Ruth E. Ley
Summary: Studies using germfree animals as controls have shown that the gut microbiome mediates diet-induced obesity. The microbial colonization status affects fatty acid levels and liver sphingolipid pools, regardless of the diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Immunology
Samar M. M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates
Summary: SLE is a chronic autoimmune disease with African American SLE patients showing higher levels of certain sphingolipids, which are correlated with the severity of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paula A. Gonzalez, Judith Simcox, Hershel Raff, Gina Wade, Helaina Von Bank, Steven Weisman, Keri Hainsworth
Summary: The study showed that there is a distinct lipid signature associated with chronic pain and its co-occurrence with obesity in adolescents, indicating that specific lipid metabolites may play a role in the inflammation mechanism related to chronic pain and obesity.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Biophysics
Koushik Choudhury, Marina A. Kasimova, Sarah McComas, Rebecca J. Howard, Lucie Delemotte
Summary: This study used molecular modeling and simulations to test possible open-state models of NavMs channels from the bacterium Magnetococcus marinus, finding that the experimental structure was unable to conduct ions at the activation gate. By observing a spontaneous transition and comparing with other Nav channels, an alternative stable open-state model was built, showing consistent pore hydration, ion permeation, and drug binding with the functional open state.
BIOPHYSICAL JOURNAL
(2022)
Article
Biology
Lea Rems, Xinru Tang, Fangwei Zhao, Sergio Perez-Conesa, Ilaria Testa, Lucie Delemotte
Summary: The study investigates the molecular mechanisms of electroporation on the plasma membrane of biological cells. By combining molecular dynamics simulations, machine learning, and Bayesian survival analysis, the study identifies that the formation of pores depends on the local lipid organization and specific features of membrane domains. The study also reveals the importance of membrane mechanical properties and the polarity of the electric field in pore formation. The findings provide valuable insights for the design of future experiments and the development of accurate descriptions of plasma membrane electroporation.
Article
Biology
Damon J. A. Frampton, Koushik Choudhury, Johan Nikesjo, Lucie Delemotte, Sara Liin
Summary: The study reveals that polyunsaturated fatty acids (PUFAs) can facilitate the activation of one subtype of potassium channels while inhibiting the activation of another subtype. The response to PUFAs is dependent on the charge of the fatty acids and shows subtype-specific effects.
Article
Materials Science, Multidisciplinary
Meng Luo, Konstantin Shaitan, Xiaoyan Qu, Anton P. Bonartsev, Bo Lei
Summary: Rare earth-based biomaterials possess representative optical/magnetic properties and special biological properties, which make them potential candidates for wound healing and skin tissue regeneration. Inorganic-organic hybrid rare earth-based biomaterials demonstrate promising applications in wound healing and repair.
APPLIED MATERIALS TODAY
(2022)
Correction
Biophysics
Yu. M. Efremov, D. V. Bagrov, M. P. Kirpichnikov, K. V. Shaitan
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Oncology
Anton P. Bonartsev, Bo Lei, Margarita S. Kholina, Ksenia A. Menshikh, Dmitriy S. Svyatoslavov, Svetlana I. Samoylova, Mikhail Y. Sinelnikov, Vera V. Voinova, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Igor V. Reshetov
Summary: The use of bioengineering methods for experimental modeling of cancer, particularly head and neck squamous cell carcinomas (HNSCC), shows great promise for testing novel anticancer drugs and diagnostics. Various bioengineering techniques have been developed to model HNSCC tumors, including genetic engineering, exposure experiments, cell culture methods, microfluidics, and cell co-culture. These models can contribute to the development of new approaches for the diagnosis, prevention, and treatment of HNSCC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Polymer Science
Roman Chernozem, Igor O. Pariy, Artem Pryadko, Anton P. Bonartsev, Vera V. Voinova, Vsevolod A. Zhuikov, Tatiana K. Makhina, Garina A. Bonartseva, Konstantin Shaitan, Vladimir V. Shvartsman, Doru C. Lupascu, Konstantin N. Romanyuk, Andrei L. Kholkin, Roman A. Surmenev, Maria A. Surmeneva
Summary: Comprehensive research has revealed that the thermal behavior, molecular structure, and crystalline structure of PHB and PHB-HV films are influenced by their thickness, molecular weight, and 3-HV content. Increasing film thickness leads to increased isotropic crystal orientation, while decreasing PHB molecular weight results in a reduced number of piezoactive domains. The addition of 3-HV in PHB-HV causes anisotropy in the crystalline structure and decreases melting temperature and degree of crystallinity. Furthermore, increasing 3-HV content improves the smoothness of PHB-HV films.
Review
Virology
Aleksandr V. Kudriavtsev, Anna V. Vakhrusheva, Valery N. Novoseletsky, Marine E. Bozdaganyan, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova
Summary: The evolution and emergence of new mutations in viruses, such as the Omicron strain of SARS-CoV-2, impact their transmissibility and pathogenicity. This evolution may be influenced by the virus adapting to therapeutic agents and escaping vaccine-induced and natural immunity. Understanding and monitoring the key mutations that contribute to immune escape and high receptor affinity in Omicron can inform vaccine and therapeutic development to control the direction of the COVID-19 pandemic.
Article
Polymer Science
Viktoryia Kulikouskaya, Viktoryia V. Nikalaichuk, Anton P. Bonartsev, Elizaveta A. Akoulina, Nikita Belishev, Irina Demianova, Dariana Chesnokova, Tatiana K. Makhina, Garina A. Bonartseva, Konstantin Shaitan, Kseniya S. Hileuskaya, Vera V. Voinova
Summary: Surface morphology plays a crucial role in cell attachment and proliferation. Different films with microstructured surfaces made of biodegradable polymers, poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-co-HV), of varying molecular weights were investigated. The study found that stem cells exhibit different behaviors depending on the surface morphology of the films.
Article
Biochemical Research Methods
Annie M. Westerlund, Akshay Sridhar, Leo Dahl, Alma Andersson, Anna-Yaroslava Bodnar, Lucie Delemotte
Summary: Calmodulin (CaM) is a calcium-sensing protein that regulates other proteins by binding them in a calcium-dependent manner. Trifluoperazine (TFP), an antipsychotic drug, inhibits the ability of CaM to bind and regulate other proteins. In this study, we used molecular dynamics simulations, Markov state modeling, and machine learning to understand how TFP binding to one domain of CaM prevents its association with other proteins. We found that TFP promotes the adoption of a conformation similar to the calcium-unbound form of CaM, affecting different structural and dynamic features depending on its binding orientation. Understanding TFP binding is a crucial step towards developing improved drugs that target CaM.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrey Moiseenko, Dmitry Bagrov, Mikhail F. Vorovitch, Victoria Uvarova, Maxim M. Veselov, Anastasia Kashchenko, Alla L. Ivanova, Dmitry Osolodkin, Alexey M. Egorov, Aydar A. Ishmukhametov, Konstantin Shaitan, Olga S. Sokolova
Summary: This article provides a detailed analysis of the size and structure of the inactivated TBEV vaccine strain, using multiple analytical methods. The results show the monodispersity of the particles and their similarity in size, as well as the presence of specific protein molecules and RNA.
Article
Biochemistry & Molecular Biology
Irina I. Zharkova, Aleksey V. Volkov, Aleksandr A. Muraev, Tatiana K. Makhina, Vera V. Voinova, Valentina M. Ryabova, Yulia V. Gazhva, Alena S. Kashirina, Aleksandra V. Kashina, Garina A. Bonartseva, Vsevolod A. Zhuikov, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Sergey Yu. Ivanov, Anton P. Bonartsev
Summary: The biocompatibility of scaffolds in tissue engineering is still an urgent problem. A porous scaffold with a special design was used to guide cell growth and tissue development. Two types of structures were obtained from poly(3-hydroxybutyrate) (PHB) using a salt leaching technique. These scaffolds were suitable for the cultivation of rat mesenchymal stem cells and 3T3 fibroblasts in vitro, and they caused moderate inflammation and the formation of a fibrous capsule when implanted in older rats. A conduit made from PHB/PHBV tube with the scaffold-2 as a filler allowed soft connective tissue sprouting without any visible inflammatory processes when implanted in older rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Darko Mitrovic, Sarah E. McComas, Claudia Alleva, Marta Bonaccorsi, David Drew, Lucie Delemotte
Summary: In this study, we predicted the structures of the entire sugar porter superfamily in each state of the transport cycle using coevolution analysis and comparative modeling, and identified the molecular determinants of the transport cycle. This research is of great significance for understanding the functional mechanism of transport proteins.
Article
Biology
Sarah E. McComas, Tom Reichenbach, Darko Mitrovic, Claudia Alleva, Marta Bonaccorsi, Lucie Delemotte, David Drew, Randy B. Stockbridge
Summary: Glucose transporters (GLUT) play a crucial role in maintaining blood glucose homeostasis in mammals. In humans, there are 14 different GLUT isoforms that transport glucose and other monosaccharides with varying preferences and kinetics. Recent research on the malarial transporter PfHT1 and the fructose transporter GLUT5 suggests that the extracellular gate consisting of the TM7b helix is responsible for substrate promiscuity in these proteins. The findings challenge the traditional view of substrate specificity in GLUT proteins and suggest that allosteric coupling between sugar binding and the extracellular gate enables fast sugar flux at physiological blood glucose concentrations.
Article
Nanoscience & Nanotechnology
Artyom S. A. Pryadko, Yulia R. Mukhortova, Roman V. Chernozem, Igor Pariy, Svetlana I. Alipkina, Irina I. Zharkova, Andrey A. Dudun, Vsevolod A. Zhuikov, Anastasia M. Moisenovich, Garina A. Bonartseva, Vera V. Voinova, Dariana V. Chesnokova, Alexey A. Ivanov, Daria Yu. Travnikova, Konstantin V. Shaitan, Anton P. Bonartsev, Dmitry V. Wagner, Lada E. Shlapakova, Roman A. Surmenev, Maria A. Surmeneva
Summary: Magnetically responsive composite polymer scaffolds have great potential for various biomedical applications. In this study, electrospun composite scaffolds made of polyhydroxybutyrate (PHB) and magnetite (Fe3O4) particles were investigated for their degradation properties and mechanical characteristics. The results showed that particle size and surface functionalization affected the mechanical properties of the scaffolds, and the composite scaffolds exhibited biocompatibility and promoted cell proliferation.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)