Article
Multidisciplinary Sciences
Hye-Jin Ahn, Hae Jin Kim, Hyein Ham, Ji Hwoon Baek, Young Lee, Mahin Alamgir, Babar Rao, Min Kyung Shin
Summary: Objective assessments to evaluate sensitive skin do not well correlate with symptoms. Reflectance confocal microscopy (RCM) was used to compare transepidermal application of zinc in sensitive and non-sensitive skin, showing deeper and higher zinc reflectance in sensitive skin with visualized structural differences. RCM is suggested as a useful tool for evaluating skin barrier integrity.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lorretta E. Uche, Gerrit S. Gooris, Joke A. Bouwstra, Charlotte M. Beddoes
Summary: The presence of CER EOS is crucial for skin barrier lipid organization, with its concentration affecting lipid phase transitions and permeability. Increasing CER EOS concentration results in more lipids transitioning to the orthorhombic phase at physiological temperature, leading to higher permeability in skin models.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Chemistry, Medicinal
Hiroki Ohnari, Eiji Naru, Taku Ogura, Osamu Sakata, Yasuko Obata
Summary: Intercellular lipids in the stratum corneum play a crucial role in protecting the body and regulating water evaporation. This study investigates how differences in lipid composition affect the microstructure of intercellular lipids. By adjusting packing structure characteristics in different lipid composition models, the study reveals insights into the barrier function of bilayers.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Allergy
Evgeny Berdyshev, Jihyun Kim, Byung Eui Kim, Elena Goleva, Taras Lyubchenko, Irina Bronova, Anna Sofia Bronoff, Olivia Xiao, Jiwon Kim, Sukyung Kim, Mijeong Kwon, Sungjoo Lee, Yu Jeong Seo, Kyunga Kim, Suk-Joo Choi, Soo-Young Oh, Seung Hwan Kim, So Yeon Yu, Seung Yong Hwang, Kangmo Ahn, Donald Y. M. Leung
Summary: A study found that the risk of developing atopic dermatitis in the future can be predicted by analyzing the skin surface of infants at the age of two months, and identified potential biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Engineering, Chemical
Suzuko Terayama, Yutaka Goto, Toshiro Fukami
Summary: This study aims to investigate the changes in the packing structure caused by surfactant-induced lipid effluence. By reducing a component in the lipid model, it was found that the decrease in cholesterol disrupts the lipid structure, and the amount of cholesterol is strongly inversely correlated with the hexagonal structure ratio in the packing structure. Furthermore, the hexagonal structure ratio values are highly correlated with the amount of lipids eluted by surfactants.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Andrej Kovacik, Petra Pullmannova, Lukas Opalka, Michaela Silarova, Jaroslav Maixner, Katerina Vavrova
Summary: The study shows that different types of ceramides play distinct roles in the structural organization and function of the skin lipid barrier, with their effects on lipid models varying depending on the sphingoid base chain and configuration at the alpha-carbon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Rivero, Martha C. Daza, Markus Doerr
Summary: In some dermal diseases, skin dehydration and desquamation occur due to alterations in the natural ratio of CER[NP] and CER[AP] in the extracellular matrix of the stratum corneum. Molecular dynamics simulations revealed that despite the minor chemical difference, differences in the structural influence of CER[NP] and CER[AP] were observed.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Article
Chemistry, Medicinal
Hiroki Ohnari, Masatoshi Sekiya, Eiji Naru, Taku Ogura, Osamu Sakata, Yasuko Obata
Summary: The study found that V-acetyl-L-hydroxyproline (AHYP) can maintain skin barrier function by preserving the hydrocarbon-chain packing structure of intercellular lipids through electrostatic repulsion. This suggests that AHYP could be used in skincare formulations to help maintain the skin's barrier function.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Tomonobu Uchino, Daichi Kamiya, Hiroaki Yagi, Hiyori Fujino-Shimaya, Ichiro Hatta, Shun Fujimori, Yasunori Miyazaki, Yukako Kirishita, Yuko Sano, Hajime Mizuno, Kenichiro Todoroki, Yoshiyuki Kagawa
Summary: This study compared the lipid composition and organization of the stratum corneum (SC) in patients with psoriasis and healthy subjects. The results showed that the SC lipids and their compositions were different in psoriatic patients compared to healthy subjects. These differences led to a lower structural transformation temperature and reduced barrier function in psoriatic SC.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Review
Dermatology
Takeshi Kono, Yoshiki Miyachi, Makoto Kawashima
Summary: This literature review evaluates the clinical effectiveness of preparations containing natural or synthetic ceramides for water retention and barrier function. Studies show that these preparations can improve dry skin and barrier function in patients with atopic dermatitis, but further large sample double-blinded comparative studies are needed for appropriate clinical use.
JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Charlotte M. Beddoes, Denise E. Rensen, Gert S. Gooris, Marc Malfois, Joke A. Bouwstra
Summary: The study found that the effects of FFA chain lengths on lamellar phases and lateral packing vary, with a threshold for water permeability at FFA C16.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
Lars Norlen, Magnus Lundborg, Christian Wennberg, Ali Narangifard, Bertil Daneholt
Summary: The skin's barrier, composed of a lipid structure in the stratum corneum, plays a crucial role in protecting the body from the environment. Recent advancements in cryo-EM have allowed for a better understanding of the architecture and formation process of this barrier.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Endocrinology & Metabolism
Anna Nicolaou, Alexandra C. Kendall
Summary: Cutaneous lipids are essential for skin health and play a role in maintaining the skin microbiome and epidermal barrier. Recent studies have expanded our understanding of lipid production and its involvement in inflammation and immune regulation. Skin lipids offer potential therapeutic targets for various conditions.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Pharmacology & Pharmacy
Aneta Vovesna, Alexander Zhigunov, Martin Balouch, Jarmila Zbytovska
Summary: The study indicated that stable liposomal systems containing ceramides and other skin barrier lipids are effective in repairing a disrupted skin barrier, and non-homogenized liposomes are more effective than their homogenized counterparts.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Joke A. Bouwstra, Andreea Nadaban, Wim Bras, Clare McCabe, Annette Bunge, Gerrit S. Gooris
Summary: The barrier function of the skin is primarily located in the outermost layer called stratum corneum (SC), which contains lipid lamellae that play a crucial role in permeation of compounds. Analyzing the lipid composition is essential in understanding the skin barrier function and its impairment in inflammatory skin diseases.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Biophysics
Enamul H. Mojumdar, Gert S. Gooris, David J. Barlow, M. Jayne Lawrence, Bruno Deme, Joke A. Bouwstra
BIOPHYSICAL JOURNAL
(2015)
Article
Chemistry, Physical
E. H. Mojumdar, G. S. Gooris, J. A. Bouwstra
Article
Biochemistry & Molecular Biology
Masayuki Uchiyama, Masashi Oguri, Enamul H. Mojumdar, Gert S. Gooris, Joke A. Bouwstra
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2016)
Article
Biochemistry & Molecular Biology
E. H. Mojumdar, G. S. Gooris, D. Groen, D. J. Barlow, M. J. Lawrence, B. Deme, J. A. Bouwstra
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2016)
Article
Multidisciplinary Sciences
Enamul Haque Mojumdar, Quoc Dat Pham, Daniel Topgaard, Emma Sparr
SCIENTIFIC REPORTS
(2017)
Review
Biophysics
Quoc Dat Pham, Enamul H. Mojumdar, Gert S. Gooris, Joke A. Bouwstra, Emma Sparr, Daniel Topgaard
QUARTERLY REVIEWS OF BIOPHYSICS
(2018)
Article
Biochemistry & Molecular Biology
Enamul H. Mojumdar, Alexander P. Lyubartsev
BIOPHYSICAL CHEMISTRY
(2010)
Article
Biophysics
E. H. Mojumdar, D. Groen, G. S. Gooris, D. J. Barlow, M. J. Lawrence, B. Deme, J. A. Bouwstra
BIOPHYSICAL JOURNAL
(2013)
Article
Chemistry, Multidisciplinary
Enamul H. Mojumdar, Richard W. J. Helder, Gert S. Gooris, Joke A. Bouwstra
Article
Biochemistry & Molecular Biology
Enamul Haque Mojumdar, Carl Grey, Emma Sparr
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biophysics
Enamul Haque Mojumdar, Emma Sparr
Summary: The study investigates how variations in pH, ionic strength, and salt composition influence the structure and dynamics of the stratum corneum (SC) lipid and protein components. The highest molecular mobility in both lipid and protein components is observed at the lowest pH of 4.0. The study results provide new insights on how SC molecular properties respond to solution conditions, which can be beneficial in developing topical drug delivery and cosmetic formulations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Enamul Haque Mojumdar, Lone Bruhn Madsen, Henri Hansson, Ida Taavoniku, Klaus Kristensen, Christina Persson, Anna Karin Moren, Rajmund Mokso, Artur Schmidtchen, Tautgirdas Ruzgas, Johan Engblom
Summary: Proper skin barrier function is crucial for survival, and restoring the lost barrier to prevent chronic wounds is of acute importance. While rapid wound closure may be more important than immediate perfection of the barrier, specific treatments can help to improve it. Molecular investigations revealed patterns of keratin organization and lipid formations in the stratum corneum that may impact barrier recovery and fluidity in regenerated tissue. This molecular approach could be valuable for future development of wound healing products.
Article
Chemistry, Physical
Maria Gunnarsson, Enamul Haque Mojumdar, Daniel Topgaard, Emma Sparr
Summary: The study investigates the impact of NMF on skin molecular dynamics and the reversal of its effects by adding specific NMF components. It was found that removing NMF reduces molecular mobility in the skin, but replacing it with single NMF components restores molecular dynamics.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)