Article
Biochemistry & Molecular Biology
Xiaowen Mao, Seta Stanbouly, Jacob Holley, Michael Pecaut, James Crapo
Summary: The aim of this study was to investigate the acute oxidative damage in ocular structure and retinal function after exposure to spaceflight, and evaluate the effectiveness of an antioxidant in mitigating spaceflight-induced changes in the retina. Results showed that spaceflight conditions induced retinal oxidative stress, leading to photoreceptor cell damage and impaired retinal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Di Liu, Rukhsanda Aziz, Md Jahidul Islam Shohag, Lingli Lu, Yuyan Wang, Ying Feng, Tingqiang Li, Mei Wang, Shengke Tian, Xiaoe Yang, Siyu Chen, Mingguang Tu, Zhiqiang Wang
Summary: Tetracycline has cytotoxic effects on human liver cells and extracellular ALT activity can be used as an indicator for monitoring soil TC contamination.
Article
Biochemistry & Molecular Biology
Cassie L. L. Rayner, Steven E. E. Bottle, Alexander P. P. Martyn, Nigel L. L. Barnett
Summary: Oxidative stress plays a major role in progressive neurodegenerative diseases and could be a key target for novel preventative and therapeutic strategies. The antioxidant DCTEIO has shown efficacy in protecting retinal neurocells and reducing inflammation and oxidative stress. These findings suggest that DCTEIO has potential as a neuroprotectant for degenerative diseases of the central nervous system.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lorena Fuentes-Broto, Lorena Perdices, Francisco Segura, Elvira Orduna-Hospital, Gema Insa-Sanchez, Ana Sanchez-Cano, Nicolas Cuenca, Isabel Pinilla
Summary: Retinitis pigmentosa (RP) is characterized by progressive loss of visual function, primarily affecting photoreceptors. Melatonin treatment showed beneficial effects on visual function, circadian rhythm, and oxidative stress in RP animal models and wild-type rats, suggesting its potential therapeutic value in age-related visual damage.
Article
Environmental Sciences
Fan Mo, Haibo Li, Yinghua Li, Chuanxin Ma, Mingshuai Wang, Zhe Li, Ningcan Deng, Chenxi Zhang, Baoshan Xing, Jianing Xu, Geng Li, Lixin Wang, Yaqin Zheng, Yue Yang
Summary: This study investigated the detoxification mechanisms of red clover seedlings exposed to silver ions (Ag+) and found that the growth and physiological metabolism of the plants were disturbed. The research revealed that red clover seedlings initially transformed and immobilized Ag+ in the culture medium, and then transported and fixed them inside the cells, mainly in the form of unreduced Ag+ bound to biological molecules. Additionally, some Ag+ was reduced and formed crystalline silver nanoparticles. The results of this study provide valuable insights into the defense and tolerance mechanisms of red clover to Ag+ and the existing forms of Ag+ in vivo and in vitro.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Xin Shi, Panpan Li, Hanhan Liu, Verena Prokosch
Summary: This article reviews the impact of oxidative stress (OS) on endothelial dysfunction (ED) in the retina and explores the mechanistic links between the two and their role in different retinal neurodegenerative diseases. Understanding the role of endothelial function may lead to new therapeutic approaches.
Article
Multidisciplinary Sciences
Ang Lu, Shi-meng Yuan, Huai Xiao, Da-song Yang, Zhi-qiong Ai, Qi-Yan Li, Yu Zhao, Zhuang-zhi Chen, Xiu-mei Wu
Summary: This study used QSAR to investigate the relationship between molecular descriptors, physicochemical properties, and antioxidant activity of polyphenol analogues, providing guidance for the design and discovery of highly-potent antioxidants.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Asad Rehman, Jinyang Weng, Pengli Li, Jing Yu, Saeed Ur Rahman, Muhammad Khalid, Iftikhar Hussain Shah, Shazma Gulzar, Liying Chang, Qingliang Niu
Summary: The aim of this study was to investigate the response mechanisms of drought stress tolerance in two melon genotypes. Drought stress led to significant effects on the drought-sensitive genotype, while the drought-resistant genotype exhibited a robust response. Antioxidant enzyme genes and activities were upregulated in the drought-resistant genotype, resulting in decreased oxidative damage and improved growth and photosynthetic functions. The findings provide insights into coping strategies for drought stress tolerance and have implications for melon breeding and molecular studies.
JOURNAL OF PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anuradha Dhingra, Rachel C. Sharp, Taewan Kim, Anatoliy V. Popov, Gui-Shuang Ying, Ralph A. Pietrofesa, Kyewon Park, Melpo Christofidou-Solomidou, Kathleen Boesze-Battaglia
Summary: The interaction between retinal pigment epithelium (RPE) and neural retina is crucial for visual function. LGM2605 shows potential as a therapeutic agent to protect RPE against inflammation and restore its metabolic capacity under lipid overload.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Vy Ngo, Martin L. L. Duennwald
Summary: Oxidative stress is associated with major human diseases, and the transcription factor Nrf2 plays a key role in the antioxidant defense system and has been extensively studied in disease contexts.
Review
Nutrition & Dietetics
Beata Olas
Summary: English Summary: Graviola, a plant found in tropical regions, has various ethnomedicinal uses such as treating insomnia, diabetes, cystitis, and headaches. It contains active components called annonaceous acetogenins, with over 100 compounds isolated from it. Graviola is also a source of phenolic compounds, essential oils, alkaloids, flavonol triglycosides, and megastigmanes, as well as several minerals. This paper provides an overview of the antioxidant properties of graviola and its major constituents, based on a review of electronic databases, but more research is needed to determine its antioxidant potential and safety.
Article
Environmental Sciences
Xueying Ma, Yizhe Dai, Tiantong Qiu, Xin Chen, Peng Xiao, Wenhua Li
Summary: The purpose of this study was to evaluate the adverse effects of amisulbrom on retinal development in zebrafish. Zebrafish embryos were treated with different concentrations of amisulbrom and showed phenotypic abnormalities, dysregulation of gene transcription levels related to retinal cell layer differentiation, increased retinal apoptosis, and changes in glutathione and malondialdehyde content. These findings demonstrate the toxicity of amisulbrom to eye development and its potential ecotoxicological impacts on aquatic species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Enzo M. Vingolo, Lorenzo Casillo, Laura Contento, Francesca Toja, Antonio Florido
Summary: The study aimed to evaluate the relationship between circulating free radicals in blood and cystoid macular edema (CME) in Retinitis Pigmentosa (RP) patients. The results showed a significant increase in free oxygen radicals levels in RP patients with CME, suggesting that oxidative stress may accelerate cone cell damage.
Article
Immunology
Hui-Yi Lin, Qiufan Fu, Yu-Hsiang Kao, Tung-Sung Tseng, Krzysztof Reiss, Jennifer E. Cameron, Martin J. Ronis, Joseph Su, Navya Nair, Hsiao-Man Chang, Michael E. Hagensee
Summary: This study identified serum albumin and 4 dietary antioxidants (vitamin A, B2, E, and folate) inversely associated with high-risk HPV infection in women. Low serum albumin level and inadequate intake of antioxidants may increase the risk of HPV infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Plant Sciences
Shakeel Ahmad, Ihsan Muhammad, Guo Yun Wang, Muhammad Zeeshan, Li Yang, Izhar Ali, Xun Bo Zhou
Summary: The study demonstrated that under drought stress conditions, melatonin application can promote the growth of maize seedlings, alleviate oxidative damage, and enhance plant resistance to stress.
Review
Biochemistry & Molecular Biology
Darya V. Telegina, Oyuna S. Kozhevnikova, Anna K. Antonenko, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is a complex neurodegenerative disease that often leads to irreversible blindness in the elderly. The pathogenesis of AMD, particularly its dry type, is not fully understood. In recent years, AMD has been increasingly detected in younger individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia A. Muraleva, Nataliya G. Kolosova, Natalia A. Stefanova
Summary: SkQ1 alleviates AD pathology by suppressing MEK1/2-ERK1/2 signaling pathway activity in the OXYS rat hippocampus, making it a promising candidate drug for human AD treatment.
Article
Biochemistry & Molecular Biology
Ekaterina A. Rudnitskaya, Tatiana A. Kozlova, Alena O. Burnyasheva, Natalia A. Stefanova, Nataliya G. Kolosova
Summary: Studies suggest that immaturity during early brain development, especially inadequate glial support, may be a primary factor leading to neurodegenerative processes and the manifestation of AD pathology later in life.
Article
Biochemistry & Molecular Biology
Ekaterina A. Rudnitskaya, Alena O. Burnyasheva, Tatiana A. Kozlova, Daniil A. Peunov, Nataliya G. Kolosova, Natalia A. Stefanova
Summary: Astrocytes and microglia are more vulnerable to neurodegenerative damage in Alzheimer's disease, especially in the CA3 area. Prolonged supplementation with a mitochondria-targeted antioxidant, SkQ1, can reduce inflammation in glial cells and may be a promising approach for preventing and treating Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dmitry Oshchepkov, Irina Chadaeva, Rimma Kozhemyakina, Karina Zolotareva, Bato Khandaev, Ekaterina Sharypova, Petr Ponomarenko, Anton Bogomolov, Natalya Klimova, Svetlana Shikhevich, Olga Redina, Nataliya G. Kolosova, Maria Nazarenko, Nikolay A. Kolchanov, Arcady Markel, Mikhail Ponomarenko
Summary: In this study, the researchers focused on differentially expressed genes (DEGs) in hypertensive patients and compared them with DEGs related to stress reactivity in rats. They found significant correlations between stress reactivity-related and hypertension-related gene expression changes and identified potential molecular markers for hypertension treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Darya Telegina, Anna K. Antonenko, Anzhela Zh Fursova, Nataliya G. Kolosova
Summary: Glutamate and GABA, the most abundant amino acids in the retina, are involved in the pathogenesis of neurodegenerative disorders. This study analyzed the expression changes of enzymes, transporters, and receptors related to glutamate and GABA synthesis in the aging retina of Wistar rats and senescence-accelerated OXYS rats with AMD-like retinopathy. The results showed age-dependent expression changes of GABAergic-system proteins in both rat strains. Late-stage AMD-like retinopathy in OXYS rats was associated with the upregulation of glutaminase and downregulation of glutamine synthetase, indicating an increase in glutamate levels. Supplementation with melatonin and SkQ1 suppressed the progression of AMD-like pathology in OXYS rats but worsened the condition of the Wistar rat's retina during normal aging.
Article
Biochemistry & Molecular Biology
Oyuna S. Kozhevnikova, Anzhella Zh Fursova, Anna S. Derbeneva, Ida F. Nikulich, Mikhail S. Tarasov, Vasiliy A. Devyatkin, Yulia Rumyantseva, Darya Telegina, Nataliya G. Kolosova
Summary: The study evaluated the association between polymorphisms in genes related to the complement system and neovascular age-related macular degeneration (nAMD) and its treatment response biomarkers. The results showed that certain gene polymorphisms were associated with the risk of nAMD and treatment response.
Article
Biochemistry & Molecular Biology
Olga Snytnikova, Yuri Tsentalovich, Renad Sagdeev, Nataliya Kolosova, Oyuna Kozhevnikova
Summary: This study investigated the effects of autophagy modulation on serum metabolites. The results showed that fasting for 48 hours and CQ treatment significantly altered the serum metabolome, primarily affecting fatty acid metabolism and metabolism of several amino acids. The metabolic responses to autophagy modulation were different in OXYS rats and Wistar rats, and altered metabolites in OXYS rats may serve as potential biomarkers of accelerated aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia S. A. Stefanova, Nataliya G. G. Kolosova
Summary: Previous studies suggest that functional traits of the adult brain can affect susceptibility to Alzheimer's disease. This study analyzed transcriptomes of the prefrontal cortex and hippocampus in senescence-accelerated OXYS rats and control rats during brain maturation. Over 1000 differentially expressed genes were found, indicating reduced efficiency of neuronal contact formation, possibly due to deficits in mitochondrial functions. Three genes showed overexpression in both brain regions of OXYS rats throughout their lifespan, suggesting a contribution to the development of AD-like pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadezda V. Andrianova, Ljubava D. Zorova, Irina B. Pevzner, Nataliya G. Kolosova, Egor Y. Plotnikov, Dmitry B. Zorov
Summary: Kidney diseases are common among elderly people due to age-related changes in renal tissue. The lack of targeted pharmacotherapies for acute kidney injury (AKI) results in high mortality rates. This study investigated the protective effects of calorie restriction (CR) on ischemic AKI in OXYS rats and found that CR provided significant nephroprotection. Improvements in mitochondrial functioning may be one of the mechanisms for the beneficial effects of CR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna A. Zhdankina, Dmitry I. Tikhonov, Sergey V. Logvinov, Mark B. Plotnikov, Andrei I. Khlebnikov, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. JNK inhibitor IQ-1S shows potential in preventing and treating AMD, as it improves histological abnormalities associated with retinopathy in the OXYS rat model, including improved blood circulation, increased functional activity of the retinal pigment epithelium, reduced VEGF expression, and increased PEDF expression.
Article
Biochemistry & Molecular Biology
Tatiana Kozlova, Ekaterina Rudnitskaya, Alena Burnyasheva, Natalia Stefanova, Daniil Peunov, Nataliya Kolosova
Summary: Postnatal brain development is highly plastic and can be influenced by maternal care. Poor maternal care can lead to delayed physical and behavioral development in pups, which may contribute to neurodegeneration and Alzheimer's disease-like pathology later in life.
Article
Biochemistry & Molecular Biology
Natalia A. Muraleva, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is a major cause of irreversible visual impairment. Dysregulation of the p38 MAPK signaling pathway (SP) is linked to aging and neurodegenerative diseases. This study found that the activity of the p38 MAPK SP increased with age in healthy rats, and that AMD-like retinopathy in OXYS rats was accompanied by hyperphosphorylation of p38 MAPK and MK2. The progression of retinopathy also coincided with enhanced p38 MAPK-dependent phosphorylation of CryaB in the retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Oyuna S. Kozhevnikova, Anzhella Zh. Fursova, Anna S. Derbeneva, Ida F. Nikulich, Vasiliy A. Devyatkin, Nataliya G. Kolosova
Summary: This study aimed to evaluate the association between polymorphic markers of MTOR, SQSTM1, ULK1, MAP1LC3A, and ATG5 genes and the development of nAMD and the response to anti-VEGF therapy. The study found that MTOR gene polymorphisms are associated with the risk of nAMD, and SQSTM1-rs10277 and ULK1-rs3088051 may influence the short-term response to anti-VEGF treatment.
Article
Biochemistry & Molecular Biology
Ekaterina Rudnitskaya, Tatiana Kozlova, Alena Burnyasheva, Daniil Peunov, Michail Tyumentsev, Natalia Stefanova, Nataliya Kolosova
Summary: This study investigated the possible influence of early-life vascular dysfunction on Alzheimer's disease (AD) development using OXYS rats as a model. The expression of blood-brain barrier (BBB)-associated genes was found to be altered in the hippocampus and frontal cortex of OXYS rats during the first and second weeks of life. Delayed vascularization and pericyte coating of blood vessels were also observed in OXYS rats. These features may have long-term consequences and contribute to the neurovascular dysfunction observed in OXYS rats late in life, thereby promoting the early development of AD signs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
