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Function of SIRT1 in physiology

BIOCHEMISTRY-MOSCOW (2009)

期刊

BIOCHEMISTRY-MOSCOW

卷 74, 期 7, 页码 703-708

出版社

MAIK NAUKA/INTERPERIODICA/SPRINGER

DOI: 10.1134/S0006297909070013

关键词

SIRT1; metabolism; calorie restriction; apoptosis

类别

Biochemistry & Molecular Biology

资金

National High Technology Research and Development Program [2006AA02Z192]
National Natural Sciences Foundation of China [30700386]

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Protocol

Reagent

摘要

Sirtuins were originally defined as a family of oxidized nicotinamide adenine nucleotide (NAD(+))-dependent enzymes that deacetylate lysine residues on various proteins. The sirtuins are remarkably conserved throughout evolution from archae to eukaryotes. They were named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). The mammalian sirtuins, SIRT1-7, are implicated in a variety of cellular functions ranging from gene silencing, control of the cell cycle and apoptosis, and energy homeostasis. As SIRT1 is a nuclear protein and is the mammalian homolog most highly related to Sir2, it has been the focus of a large number of recent studies. Here we review some of the current data related to SIRT1 and discuss its mode of action and biological role in cellular and organismal models.

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