Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

Biophysical Implications of Sphingosine Accumulation in Membrane Properties at Neutral and Acidic pH

(2014) Eva Zupancic et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes

(2013) M Hafner Česen et al.   Cell Death & Disease

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

(2012) Chiara Ullio et al.   JOURNAL OF LIPID RESEARCH

Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation

(2011) Hanna Appelqvist et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Lysosomal membrane proteins: life between acid and neutral conditions: Figure 1

(2010) Paul Saftig et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lysosome Dysfunction Triggers Atg7-dependent Neural Apoptosis

(2010) Ken C. Walls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteome of lysosomes

(2010) Bernd A. Schröder et al.   PROTEOMICS

A high content screening assay for identifying lysosomotropic compounds

(2010) Sashi Nadanaciva et al.   TOXICOLOGY IN VITRO

pH Dependence of Sphingosine Aggregation

(2009) Hirotaka Sasaki et al.   BIOPHYSICAL JOURNAL

Principles of lysosomal membrane degradation

(2008) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY