Article
Biochemistry & Molecular Biology
Michel Rasmussen, Jiaming Zhou, Frank Schwede, Per Ekstrom
Summary: Retinitis pigmentosa (RP) leads to photoreceptor degeneration, and the interaction between cGMP and EPAC2 may play a role in this process. In RP mouse models, elevated cGMP levels and increased interactions with EPAC2 were observed in photoreceptors. Inhibition of EPAC2 activity may contribute to RP progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Cemal Demirlek, Emre Bora
Summary: Sleep disturbances and cognitive impairment are common features of schizophrenia. Sleep-dependent memory consolidation appears to be impaired in patients with schizophrenia compared to healthy controls. This systematic review analyzed 14 studies and found that sleep-dependent procedural memory consolidation has a small effect size in schizophrenia, a large effect size in healthy controls, and a moderate effect size in the comparison between healthy controls and schizophrenia. Further research using polysomnography is needed to investigate sleep-dependent consolidation of different memory subtypes in different stages of psychotic disorders.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychology, Biological
K. Landreth, M. Burgess, L. Watson, J. M. Lorusso, B. Grayson, M. K. Harte, J. C. Neill
Summary: Treatments for cognitive deficits in schizophrenia are ineffective. Through the use of scPCP, a rat model for cognitive impairments associated with schizophrenia, researchers have found that handling and enrichment can prevent and reverse these deficits.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Psychology, Clinical
Erin K. Moran, James M. Gold, Cameron S. Carter, Angus W. MacDonald, J. Daniel Ragland, Steven M. Silverstein, Steven J. Luck, Deanna M. Barch
Summary: This study examined the extent of cognitive impairment among individuals with schizophrenia not currently on antipsychotic medications using a wide range of cognitive and reinforcement learning measures derived from cognitive neuroscience. The findings suggest that cognitive deficits are pervasive in schizophrenia and are present in both medicated and unmedicated individuals, affecting cognitive domains such as reinforcement learning, processing speed, cognitive control, working memory, verbal learning, and relational encoding and retrieval.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Kyna-Anne Conn, Simin Zou, Joyosmita Das, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: In this study, the cognitive symptoms of schizophrenia, including impaired goal-directed action, were found to be associated with altered dopamine signaling in the brain. The differential roles of the dorsomedial and ventral inputs into the striatum in goal-directed action were identified, providing insights into the cognitive problems in schizophrenia.
Article
Psychiatry
Breno Fiuza Cruz, Salvina Maria de Campos-Carli, Amanda Margarida de Oliveira, Camila Bernardo de Brito, Zelia Menezes Garcia, Raquel Duque do Nascimento Arifa, Daniele da Gloria de Souza, Antonio Lucio Teixeira, Joao Vinicius Salgado
Summary: The study found deficits in neurocognition and social cognition in schizophrenia patients, with changes in oxidative stress biomarkers in serum being associated with impairments in neurocognitive functions.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Elizabeth Kody, Vaibhav A. Diwadkar
Summary: Memory deficits are core features of schizophrenia. This study suggests that impairments in sensory information accuracy may contribute to these deficits. By examining the network bases of these effects, a more comprehensive assessment of dysfunction in schizophrenia can be achieved.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Courtney Glavis-Bloom, Casey R. Vanderlip, John H. Reynolds
Summary: Research on aging marmosets has shown that aged animals exhibit delayed onset of learning, slowed learning rate after onset, and decreased asymptotic working memory performance, which are not accounted for by age-related impairments in motor speed and motivation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
James Gilleen, Yakub Farah, Cate Davison, Sarah Kerins, Lorena Valdearenas, Tolga Uz, Gez Lahu, Max Tsai, Frank Ogrinc, Avi Reichenberg, Steve C. Williams, Mitul A. Mehta, Sukhi S. Shergill
Summary: The study investigated the potential of using roflumilast to improve cognitive functioning in schizophrenia patients. Results showed that higher doses of roflumilast significantly improved verbal memory, but had no significant impact on working memory.
PSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Clinical
Deepak K. Sarpal, Goda Tarcijonas, Finnegan J. Calabro, William Foran, Gretchen L. Haas, Beatriz Luna, Vishnu P. Murty
Summary: This study examined the background connectivity in individuals with first-episode psychosis during executive processing and found that there were impairments in connectivity, potentially undermining cognitive control capacities in these patients.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Behavioral Sciences
Kyna-Anne Conn, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: This study examines the role of D1 and D2 receptors in learning induced by amphetamine. The results suggest that overall D1 receptor availability is crucial for learning, while modifying D2 receptor function can ameliorate learning deficits in a state of elevated dopamine.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Clinical Neurology
Nathaniel C. C. Noyes, Ronald L. L. Davis
Summary: The brain has molecules and cellular processes for both forming and suppressing memories. Understanding the processes and molecules involved in memory suppression is necessary for comprehending memory formation, stabilization, retrieval, and the impact of brain disorders on memory.
Article
Psychology, Multidisciplinary
Kimberly E. Marble, Jessica S. Caporaso, Kathleen M. Bettencourt, Janet J. Boseovski, Thanujeni Pathman, Stuart Marcovitch, Margaret L. Scales
Summary: In laboratory-based research, children show a preference for positive information over expertise, but may have stronger memory for neutral information in naturalistic settings. These social judgments can impact learning outcomes and understanding of children's learning from others.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Francesca Manago, Diego Scheggia, Maria Pontillo, Maddalena Mereu, Rosa Mastrogiacomo, Gayatri Udayan, Paola Valentini, Maria Cristina Tata, Daniel R. Weinberger, Cynthia S. Weickert, Pier Paolo Pompa, Maria A. De Luca, Stefano Vicari, Francesco Papaleo
Summary: This study discovered a genetic interaction between the Comt and Dtnbp1 genes, which modulate dopaminergic signaling in the brain and lead to specific cognitive disturbances. The researchers also developed an easy and inexpensive genetic screening kit for clinical application.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wiktor Bilecki, Agnieszka Wawrzczak-Bargiela, Iwona Majcher-Maslanka, Magdalena Chmelova, Marzena Mackowiak
Summary: The study revealed that schizophrenia-like abnormalities induced by MAM were only observed in males, while adolescent JQ1 treatment affected memory recognition and altered the molecular and proteomic landscape in the mPFC of both sexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Philipp Mews, Erin S. Calipari, Jeremy Day, Mary Kay Lobo, Timothy Bredy, Ted Abel
Summary: The central goal of neuroscience research is to understand how experiences modify brain circuits for future adaptive behavior, involving complex interactions between circuit activity and gene regulation. Disruptions in this interplay are linked to debilitating psychiatric conditions, emphasizing the importance of studying how neural circuits and the epigenome cooperate to produce behavioral adaptation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
David M. Steffen, Sarah L. Ferri, Charles G. Marcucci, Kelsey L. Blocklinger, Michael J. Molumby, Ted Abel, Joshua A. Weiner
Summary: Cell adhesion molecules play a key role in neural circuit formation, with gamma-protocadherins negatively regulating neuroligins to limit synapse density. Loss of gamma-Pcdhs results in increased inhibitory synapse density and abnormal behavior phenotypes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Mathieu E. Wimmer, Rosa Cui, Jennifer M. Blackwell, Ted Abel
Summary: The study demonstrates that CREB is required in forebrain neurons but not noradrenergic locus coeruleus cells to drive and sustain wakefulness.
Article
Neurosciences
Sina Radke, Kathrin Jankowiak, Sanne Tops, Ted Abel, Ute Habel, Birgit Derntl
Summary: The study found that social rejection leads to a lower willingness to cooperate with others, and increased brain activity when receiving negative feedback. Intranasal oxytocin did not seem to alter responses to social rejection.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Sarah L. Ferri, Holly C. Dow, Hannah Schoch, Ji Youn Lee, Edward S. Brodkin, Ted Abel
Summary: Pcdh10(+/-) mice exhibit male-specific social deficits and dark phase hypoactivity. Fear conditioning deficits were observed in males at both ages and in both assays, while females only showed impairment in the cued condition as adults. These findings suggest that Pcdh10(+/-) mice may serve as a useful model for studying male specific brain and behavioral phenotypes related to social and emotional behaviors.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Correction
Neurosciences
Alan Jung Park, Mahesh Shivarama Shetty, Jay M. Baraban, Ted Abel
Article
Immunology
Latarsha Porcher, Sophie Bruckmeier, Steven D. Burbano, Julie E. Finnell, Nicole Gorny, Jennifer Klett, Susan K. Wood, Michy P. Kelly
Summary: Despite the wide acceptance of neuroinflammation contributing to age-related cognitive decline, studies on cytokine protein expression in young versus old brains are limited. Age-related increases in cytokines are more pronounced in the hippocampus, especially in females, with a shift in glycosylated forms of IL-10 and IL-1 beta in this brain region. Age-related increases in IL-6 expression are also seen in extra-hippocampal regions but are more discreet.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Youri G. Bolsius, Peter Meerlo, Martien J. Kas, Ted Abel, Robbert Havekes
Summary: Sleep deprivation can reduce the density of different types of dendritic spines in the hippocampus, with specific effects on certain branches. Specifically, sleep deprivation results in a decrease in the number of mushroom and branched spines on branch 5, while there are no significant changes on branches 1 and 2.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Abigail J. Smith, Reagan Farmer, Katy Pilarzyk, Latarsha Porcher, Michy P. Kelly
Summary: Despite the known benefits of friendships, the neurobiological mechanisms driving mutual social preferences are not well understood. Through controlled experiments with mice, it was discovered that Pde11a homophily can dictate mutual social preferences and the regulatory mechanisms involved were identified.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Marie E. Gaine, Ethan Bahl, Snehajyoti Chatterjee, Jacob J. Michaelson, Ted Abel, Lisa C. Lyons
Summary: Widespread sleep deprivation poses a significant public health issue globally, impacting both adolescents and adults. Acute sleep deprivation affects hippocampal gene expression, leading to changes in various biological processes. Recovery sleep following acute sleep deprivation partially normalizes gene expression levels in the hippocampus, demonstrating the complex and differential regulation of genes by sleep deprivation.
Review
Behavioral Sciences
Jill L. Silverman, Audrey Thurm, Sarah B. Ethridge, Makayla M. Soller, Stela P. Petkova, Ted Abel, Melissa D. Bauman, Edward S. Brodkin, Hala Harony-Nicolas, Markus Woehr, Alycia Halladay
Summary: Neurodevelopmental disorders (NDDs) are prevalent and lifelong disorders without evidence-based interventions. Optimal utilization of preclinical animal models is crucial. A workshop in the field of behavioral neuroscience reviewed current studies and proposed solutions, including re-evaluating animal model links to NDDs.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Cell Biology
Katy Pilarzyk, Latarsha Porcher, William R. Capell, Steven D. Burbano, Jeff Davis, Janet L. Fisher, Nicole Gorny, Siena Petrolle, Michy P. Kelly
Summary: In both humans and mice, aging and traumatic brain injury-associated dementia increase the expression of the cAMP/cGMP-degrading enzyme PDE11A in the hippocampus, leading to decreased signaling and increased vulnerability of associative memories to age-related cognitive decline. PDE11A4 protein accumulates abnormally in the aged hippocampus, causing impairments in cognitive function. Preventing age-related increases in PDE11 expression protects against age-related cognitive decline in mice.
Article
Neurosciences
Emily Nicole Walsh, Mahesh Shivarama Shetty, Kamran Diba, Ted Abel
Summary: Sleep is important for memory storage and sleep loss can impair memory, especially hippocampus-dependent memory. Previous studies have shown that deficits in synaptic plasticity and reduced levels of cAMP in the hippocampus are associated with sleep deprivation. In this study, the researchers found that increasing cAMP levels during sleep deprivation prevented deficits in long-term potentiation (LTP) in the hippocampus. Targeting cAMP-dependent signaling pathways may be beneficial in preventing the negative effects of sleep loss.
Review
Biochemistry & Molecular Biology
Lisa C. Lyons, Yann Vanrobaeys, Ted Abel
Summary: Sleep deprivation has negative impacts on health, affecting memory, cognition, and increasing disease risks. It alters molecular signaling, gene expression, dendritic structure, and protein translation processes. Understanding the multiple levels of gene regulation impacted by sleep deprivation is crucial for developing effective therapeutics.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Clinical Neurology
Arjun Sengupta, Jennifer C. Tudor, Danielle Cusmano, Joseph A. Baur, Ted Abel, Aalim M. Weljie
Summary: This study examines the common molecular underpinnings of sleep deprivation and aging by analyzing metabolic features in young and aged mice after acute sleep deprivation. The results show that sleep deprivation primarily impacts peripheral plasma and liver metabolism, while the hippocampus is more affected by aging. Additionally, aged animals exhibit similar metabolic features to sleep deprivation even at baseline.