Article
Pharmacology & Pharmacy
Yong Zhang, Haibo Zhang, Yan Li, Muqun Wang, Feng Qian
Summary: The study shows that BCP significantly alleviates LPS-induced ALI by reducing neutrophil infiltration and cytokine production. In vitro, BCP was found to reduce the expression of IL-6, IL-1β, and TNF-α, and suppress the MAPK signaling pathway in BMDMs.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Virology
Tuchakorn Lertwanakarn, Matepiya Khemthong, Puntanut Tattiyapong, Win Surachetpong
Summary: This study investigated the involvement of the MAPK/ERK pathway in the early stages of TiLV infection and found that TiLV infection led to distinct patterns of ERK phosphorylation in two different fish cell lines. The infected E-11 cells showed a substantial decrease in p-ERK levels and exhibited cytopathic effects, while the infected TiB cells had constant p-ERK levels and no cytopathic effects. Suppressing p-ERK significantly reduced TiLV load and gene expression levels in TiB cells. These findings provide new insights into the cellular mechanisms of TiLV infection and may contribute to the development of strategies to control this virus.
Review
Plant Sciences
Mrinalini Manna, Balakrishnan Rengasamy, Alok Krishna Sinha
Summary: The mitogen-activated protein kinase (MAPK) pathway is crucial for plant growth, development, and stress adaptation. This review summarizes recent advancements in understanding the roles of MAPK signaling in plant stress tolerance, architecture, and yield. MAPK signaling interacts with reactive oxygen species (ROS) and abscisic acid (ABA) signaling to modulate abiotic stress responses. Additionally, MAPK pathway plays an important role in plant pathogen defense and shaping plant architecture and yield. This makes MAPK pathway a valuable target for crop improvement, and various strategies to manipulate MAPK signaling components are discussed for designing future crops with enhanced physiology and phenotypes.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Hong-Beom Park, Kwang-Hyun Baek
Summary: This review summarizes the role and mechanisms of MAPK signaling pathways in cancer, as well as the functions of E3 ligases and DUBs targeting MAPK signaling components.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Immunology
Kamala Sundararaj, Jessalyn Rodgers, Peggi Angel, Bethany Wolf, Tamara K. Nowling
Summary: The study demonstrates how NEU activity and NEU1 specifically mediate the release of IL-6 and other cytokines from lupus-prone MCs, shedding light on the mechanisms involved in kidney inflammation in lupus. These findings suggest a potential therapeutic target for mitigating tissue damage in lupus nephritis.
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Oncology
Junpeng Cui, Yang Ge, Wei Sun, Baolin Liu, Chaoliu Dai
Summary: This study investigated the expression and function of CgB in colonic neuroendocrine carcinoma (NEC). It was found that the expression of CgB was significantly upregulated in colonic NEC tissues and promoted cell invasion, migration, as well as epithelial mesenchymal transition (EMT) and stemness. Mechanistically, CgB overexpression activated p38 MAPK and ERK pathways. Overall, CgB contributes to the development of colonic NEC by activating p38 MAPK and ERK pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Plant Sciences
Zahra Ayatollahi, Vaiva Kazanaviciute, Volodymyr Shubchynskyy, Kotryna Kvederaviciute, Manfred Schwanninger, Wilfried Rozhon, Michael Stumpe, Felix Mauch, Sebastian Bartels, Roman Ulm, Salma Balazadeh, Bernd Mueller-Roeber, Irute Meskiene, Alois Schweighofer
Summary: This study reveals the crucial role of different types of MAPK phosphatases in plant stress responses and the tight control of MAPK activities.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Multidisciplinary Sciences
Lei Huang, Xiao-Ou Zhang, Esteban J. Rozen, Xiaomei Sun, Benjamin Sallis, Odette Verdejo-Torres, Kim Wigglesworth, Daniel Moon, Tingting Huang, John P. Cavaretta, Gang Wang, Lei Zhang, Jason M. Shohet, Mary M. Lee, Qiong Wu
Summary: The protein arginine methyltransferase 5 (PRMT5) regulates the expression of metastasis-related genes by methylating Akt protein, which is required for its phosphorylation and activation, leading to the upregulation of pro-metastatic transcription factors. Moreover, inhibiting PRMT5 can attenuate primary tumor growth and block metastasis in multiple organs, suggesting it may be a potential therapeutic target for high-risk metastatic cancers.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Atsuko Shiraki, Satoshi Shimizu
Summary: Through the study, it is found that beta-arrestin 1 and 2 are essential for the efficient activation of Gi/o-mediated MAPK signaling at MOP. The magnitude of beta-arrestin-mediated signals is not correlated with the phosphorylation of the carboxyl-terminal of MOP, but with the molecular association with beta 2-adaptin and clathrin heavy chain in the formation of clathrin-coated pits. The findings deepen our understanding of G protein-coupled receptor-mediated signaling and highlight the critical role of the accumulation of molecules required for endocytosis in activating intracellular signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Fumio Otsuka
Summary: The study examined the roles of Clock genes and BMP system in regulating gonadotropin secretion by GnRH using mouse L beta T2 cells. The results showed that LH beta mRNA expression in L beta T2 cells changed over time and was influenced by Bmal1 and Clock. ERK and BMPs were found to be involved in the regulation of LH beta mRNA expression at different stages after GnRH stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Agriculture, Dairy & Animal Science
Meijuan Meng, Xuerui Li, Ran Huo, Nana Ma, Guangjun Chang, Xiangzhen Shen
Summary: This experiment investigated the effects of a high-concentrate diet on mammary gland inflammation and mitochondrial damage in dairy cows. The results showed that the high-concentrate diet induced inflammation in the mammary gland, increased the concentration of Ca2+, upregulated the expression of inflammatory factors, and caused mitochondrial dysfunction via activation of the mitochondrial-associated signaling pathway.
JOURNAL OF DAIRY SCIENCE
(2023)