☆ 4.4 Article Proceedings Paper

Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleases

BIOCHEMICAL SOCIETY TRANSACTIONS (2011)

期刊

BIOCHEMICAL SOCIETY TRANSACTIONS

卷 39, 期 -, 页码 589-594

出版社

PORTLAND PRESS LTD

DOI: 10.1042/BST0390589

关键词

ATP-binding cassette transporter (ABC transporter); DNA sliding; gyrase; heat-shock protein 90; histidine kinase and MULLATPase (GHKL ATPase); helicase; molecular switch

类别

Biochemistry & Molecular Biology

资金

Wellcome Trust Funding Source: Medline

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Protocol

Reagent

摘要

To cleave DNA, the Type III RM (restriction-modification) enzymes must communicate the relative orientation of two recognition sequences, which may be separated by many thousands of base pairs. This long-range interaction requires ATP hydrolysis by a helicase domain, and both active (DNA translocation) and passive (DNA sliding) modes of motion along DNA have been proposed. Potential roles for ATP binding and hydrolysis by the helicase domains are discussed, with a focus on bipartite ATPases that act as molecular switches.

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