Review
Medicine, General & Internal
Eric Hajduch, Floriane Lachkar, Pascal Ferre, Fabienne Foufelle
Summary: Non-alcoholic fatty liver disease is a common chronic liver disease, with increasing prevalence in Western countries due to the obesity epidemic. Liver fat accumulation and the synthesis of specific lipid species, particularly ceramides, have deleterious effects on hepatic metabolism, a phenomenon known as lipotoxicity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Mohammad Zarei, David Aguilar-Recarte, Xavier Palomer, Manuel Vazquez-Carrera
Summary: NAFLD is a chronic liver disease characterized by lipid deposits in hepatocytes, with peroxisome proliferator-activated receptor (PPAR) beta/delta playing a crucial role in controlling liver carbohydrate and lipid metabolism to potentially hinder NAFLD progression. Activation of hepatic PPAR beta/delta through synthetic or natural ligands shows promise as a therapeutic option for managing NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Oncology
Yuqiu Han, Lanjuan Li, Baohong Wang
Summary: This article summarizes the role of Akkermansia muciniphila (A. muciniphila) in the progression of nonalcoholic fatty liver disease (NAFLD). The study found that the abundance of A. muciniphila is decreased in NAFLD patients, and its recovery can prevent hepatic fat accumulation and inflammation. Furthermore, the article discusses how microbes regulate hepatic immunity and lipid accumulation in NAFLD. The study suggests that A. muciniphila improves hepatic inflammation by modulating inflammatory cytokines and LPS signals, as well as innate immune cells related to gut microbiota.
FRONTIERS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Andrea Moran-Costoya, Ana M. Proenza, Magdalena Gianotti, Isabel Llado, Adamo Valle
Summary: Gender differences play a significant role in the pathogenesis of NAFLD, with new research providing interesting clues for the development of new therapeutic strategies, pointing to the higher protection females have against NAFLD.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Medicine, General & Internal
Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Dan L. Dumitrascu
Summary: After analyzing the role of visfatin in nonalcoholic fatty liver disease, it was found that visfatin levels are not associated with NAFLD, presence or severity of hepatic steatosis, liver fibrosis, lobar inflammation, NASH, and gender.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Archibold Mposhi, Fabian Cortes-Mancera, Janette Heegsma, Vincent E. de Meijer, Bart van de Sluis, Svenja Sydor, Lars P. Bechmann, Claudia Theys, Peter de Rijk, Tim De Pooter, Wim Vanden Berghe, Ikbal Agah Ince, Klaas Nico Faber, Marianne G. Rots
Summary: This study investigates the association between mtDNA methylation and hepatic lipid accumulation in metabolic associated fatty liver disease (MAFLD). The results show that excessive mtDNA methylation impairs mitochondrial gene expression and metabolic activity, leading to increased lipid accumulation. However, lipid accumulation does not directly cause changes in mtDNA methylation. This study provides evidence for further exploration of the role of mtDNA methylation in promoting mitochondrial dysfunction and impaired lipid metabolism in MAFLD.
FRONTIERS IN NUTRITION
(2023)
Letter
Gastroenterology & Hepatology
Amandeep Singh, Rajat Garg, Rocio Lopez, Naim Alkhouri
Summary: This study aims to develop a simple noninvasive fibrosis score to detect advanced fibrosis in patients with diabetes and compare its performance with other fibrosis scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Giuseppina Di Pasqua, Marta Cagna, Clarissa Berardo, Mariapia Vairetti, Andrea Ferrigno
Summary: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are global public health challenges. Drug-induced hepatic steatosis (DIHS) is a major cause of NAFLD/NASH, primarily through interfering with mitochondrial activity and inhibiting fatty acid oxidation.
Article
Multidisciplinary Sciences
Partho Sen, Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jorn M. Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K. Daly, Tuulia Hyotylainen, Quentin M. Anstee, Matej Oresic
Summary: This study investigated the metabolic pathways of nonalcoholic fatty liver disease (NAFLD) and identified metabolic signatures in the liver and blood that are associated with its progression.
Article
Gastroenterology & Hepatology
Stefania Grimaudo, Paola Dongiovanni, Jussi Pihlajamaki, Mohammed Eslam, Hannele Yki-Jarvinen, Rosaria Maria Pipitone, Guido Baselli, Calogero Camma, Vito Di Marco, Marco Enea, Miriam Longo, Grazia Pennisi, Daniele Prati, Rossella Zito, Anna Ludovica Fracanzani, Antonio Craxi, Jacob George, Stefano Romeo, Luca Valenti, Salvatore Petta
Summary: The NR1H4 gene rs35724 C allele is protective against severity of steatosis, steatohepatitis, and liver fibrosis, but is associated with higher total circulating cholesterol levels. Patients carrying the NR1H4 rs35724 C allele show increased hepatic mRNA levels of FXR and genes involved in bile acid synthesis. This suggests that increased hepatic FXR expression due to the NR1H4 rs35724 C allele may have potential therapeutic implications for NAFLD.
LIVER INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Patrice Marques, Vera Francisco, Laura Martinez-Arenas, Angela Carvalho-Gomes, Elena Domingo, Laura Piqueras, Marina Berenguer, Maria-Jesus Sanz
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, affecting about 25% of adults. It encompasses a range of liver diseases characterized by abnormal fat accumulation in the liver tissue, which can progress to inflammation and damage. This can ultimately lead to irreversible conditions like cirrhosis and hepatocarcinoma, resulting in high mortality rates and economic burden. Understanding the immune status of NAFLD patients is crucial for therapeutic approaches, early diagnosis, and prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue
Summary: This study aimed to examine the prognostic accuracy of noninvasive tests (NITs) for liver-related mortality (LRM) and events (LREs) in patients with nonalcoholic fatty liver disease (NAFLD). The results showed that NITs can accurately predict LRM and LREs, and can be an alternative method for the prognosis assessment of NAFLD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Eveline Bruinstroop, Jin Zhou, Madhulika Tripathi, Winifred W. Yau, Anita Boelen, Brijesh Kumar Singh, Paul M. Yen
Summary: The study found that in the early stages of nonalcoholic fatty liver disease, Dio1 gene expression and activity increased, which was associated with an increased T(3)/T-4 ratio. The results suggest that Dio1 regulates hepatic triglyceride content during hepatosteatosis and early nonalcoholic steatohepatitis.
MOLECULAR METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Rosaria Maria Pipitone, Daniela Cabibi, Marco Enea, Manuel Romero-Gomez, Mauro Vigano, Elisabetta Bugianesi, Vincent Wai-Sun Wong, Anna Ludovica Fracanzani, Giada Sebastiani, Annalisa Berzigotti, Francesca Di Salvo, Antonino Giulio Giannone, Claudia La Mantia, Giulia Lupo, Rossana Porcasi, Federica Vernuccio, Rossella Zito, Vito Di Marco, Calogero Camma, Antonio Craxi, Victor de Ledinghen, Stefania Grimaudo, Salvatore Petta
Summary: The presence of a cholestatic pattern in patients with NAFLD predicts a higher risk of major liver-related outcomes independently from other features of liver disease.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Nikolaos Perakakis, Pavlina Chrysafi, Michael Feigh, Sanne Skovgard Veidal, Christos S. Mantzoros
Summary: Empagliflozin has shown beneficial metabolic and hepatic effects (mainly anti-inflammatory) in non-diabetic DIO-NASH mice, improving glucose homeostasis and inflammation without affecting body weight, composition, or insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Sarra Smati, Arnaud Polizzi, Anne Fougerat, Sandrine Ellero-Simatos, Yuna Blum, Yannick Lippi, Marion Regnier, Alexia Laroyenne, Marine Huillet, Muhammad Arif, Cheng Zhang, Frederic Lasserre, Alain Marrot, Talal Al Saati, JingHong Wan, Caroline Sommer, Claire Naylies, Aurelie Batut, Celine Lukowicz, Tiffany Fougeray, Blandine Tramunt, Patricia Dubot, Lorraine Smith, Justine Bertrand-Michel, Nathalie Hennuyer, Jean-Philippe Pradere, Bart Staels, Remy Burcelin, Francoise Lenfant, Jean-Francois Arnal, Thierry Levade, Laurence Gamet-Payrastre, Sandrine Lagarrigue, Nicolas Loiseau, Sophie Lotersztajn, Catherine Postic, Walter Wahli, Christophe Bureau, Maeva Guillaume, Adil Mardinoglu, Alexandra Montagner, Pierre Gourdy, Herve Guillou
Summary: The study found that different diets induced more severe NAFLD in male mice, characterized by lipid accumulation and inflammation/fibrosis. Sex-biased hepatic gene signatures showed different responses to various dietary challenges, with Peroxisome proliferator-activated receptor alpha (PPAR alpha) playing a key role in gender-specific and NAFLD pathophysiology.
Article
Chemistry, Applied
Nathalie Bodin, Aurelien Amiel, Edwin Fouche, Fany Sardenne, Emmanuel Chassot, Laurent Debrauwer, Herve Guillou, Marie Tremblay-Franco, Cecile Canlet
Summary: High-resolution proton nuclear magnetic resonance combined with multivariate data analysis can efficiently discriminate specific metabolic profiles among wild tuna species, raw muscle tissues, fish storage conditions, and tuna geographical origin.
Article
Biochemistry & Molecular Biology
Selma Ben Fradj, Emmanuelle Nedelec, Juliette Salvi, Melanie Fouesnard, Marine Huillet, Gaetan Pallot, Celine Cansell, Clara Sanchez, Catherine Philippe, Vincent Gigot, Aleth Lemoine, Doriane Trompier, Thomas Henry, Virginie Petrilli, Benedicte F. Py, Herve Guillou, Nicolas Loiseau, Sandrine Ellero-Simatos, Jean-Louis Nahon, Carole Rovere, Jacques Grober, Gaelle Boudry, Veronique Douard, Alexandre Benani
Summary: The gut microbiota plays a role in regulating food intake at the time scale of a meal, especially with high-fat food.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Gastroenterology & Hepatology
Marine Baptissart, Christine M. Bradish, Brie S. Jones, Evan Walsh, Jesse Tehrani, Vicmarie Marrero-Colon, Sanya Mehta, Dereje D. Jima, Seh Hoon Oh, Anna Mae Diehl, Tiffany Fougeray, Herve Guillou, Michael Cowley
Article
Biochemistry & Molecular Biology
Laurent Ferrier, Helene Eutamene, Lea Siegwald, Andrea M. Marquard, Valerie Tondereau, Julien Chevalier, Guillaume E. Jacot, Laurent Favre, Vassilia Theodorou, Maria Vicario, Andreas Rytz, Gabriela Bergonzelli, Clara L. Garcia-Rodenas
Summary: The study found that human milk oligosaccharides (HMOs) can impact visceral hypersensitivity (VHS) and alleviate abdominal pain. HMOs have the ability to modulate the microbiota, gut, and brain, playing a role in regulating pain-related functional gastrointestinal disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Leonie Dopavogui, Arnaud Polizzi, Anne Fougerat, Pascal Gourbeyre, Chloe Terciolo, Wendy Klement, Philippe Pinton, Joelle Laffite, Anne-Marie Cossalter, Jean-Denis Bailly, Olivier Puel, Yannick Lippi, Claire Naylies, Herve Guillou, Isabelle P. Oswald, Nicolas Loiseau
Summary: Fumonisin B1 (FB1) is a widespread mycotoxin produced mainly in maize, and pigs and horses are most susceptible to it. FB1 exposure can cause diverse clinical symptoms. By analyzing the transcriptomes of four organs, common biological processes and tissue-specific processes related to lipid outcomes were identified in response to FB1 exposure.
Article
Environmental Sciences
Pauline Rebouillat, Rodolphe Vidal, Jean-Pierre Cravedi, Bruno Taupier-Letage, Laurent Debrauwer, Laurence Gamet-Payrastre, Herve Guillou, Mathilde Touvier, Leopold K. Fezeu, Serge Hercberg, Denis Lairon, Julia Baudry, Emmanuelle Kesse-Guyot
Summary: The study revealed associations between dietary pesticide exposure and Type 2 Diabetes risk, with different effects depending on the types of pesticide mixture, and individuals with high dietary quality may have a lower risk.
ENVIRONMENTAL HEALTH
(2022)
Article
Cell Biology
Tiffany Fougeray, Arnaud Polizzi, Marion Regnier, Anne Fougerat, Sandrine Ellero-Simatos, Yannick Lippi, Sarra Smati, Frederic Lasserre, Blandine Tramunt, Marine Huillet, Leonie Dopavogui, Juliette Salvi, Emmanuelle Nedelec, Vincent Gigot, Lorraine Smith, Claire Naylies, Caroline Sommer, Joel T. Haas, Walter Wahli, Helene Duez, Pierre Gourdy, Laurence Gamet-Payrastre, Alexandre Benani, Anne-Francoise Burnol, Nicolas Loiseau, Catherine Postic, Alexandra Montagner, Herve Guillou
Summary: Feeding and insulin play a role in regulating the liver clock and rhythmic gene expression. This study shows that the intact hepatocyte insulin receptor is required for programming the liver clock and associated rhythmic gene expression.
Article
Multidisciplinary Sciences
Jean Personnaz, Enzo Piccolo, Alizee Dortignac, Jason S. Iacovoni, Jerome Mariette, Vincent Rocher, Arnaud Polizzi, Aurelie Batut, Simon Deleruyelle, Lucas Bourdens, Oceane Delos, Lucie Combes-Soia, Romain Paccoud, Elsa Moreau, Frederic Martins, Thomas Clouaire, Fadila Benhamed, Alexandra Montagner, Walter Wahli, Robert F. Schwabe, Armelle Yart, Isabelle Castan-Laurell, Justine Bertrand-Michel, Odile Burlet-Schiltz, Catherine Postic, Pierre-Damien Denechaud, Cedric Moro, Gaelle Legube, Chih-Hao Lee, Herve Guillou, Philippe Valet, Cedric Dray, Jean-Philippe Pradere
Summary: Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as NAFLDs. Here, researchers identify the nuclear factor HMGB1 as a strong repressor of liver lipogenesis and suggest that targeting HMGB1 could be a new therapeutic option for NAFLD.
Article
Cell Biology
Anne Fougerat, Gabriele Schoiswohl, Arnaud Polizzi, Marion Regnier, Carina Wagner, Sarra Smati, Tiffany Fougeray, Yannick Lippi, Frederic Lasserre, Ilyes Raho, Valentine Melin, Blandine Tramunt, Raphael Metivier, Caroline Sommer, Fadila Benhamed, Chantal Alkhoury, Franziska Greulich, Celine Jouffe, Anthony Emile, Michael Schupp, Pierre Gourdy, Patricia Dubot, Thierry Levade, Delphine Meynard, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Ganna Panasyuk, Henriette Uhlenhaut, Ez-Zoubir Amri, Celine Cruciani-Guglielmacci, Catherine Postic, Walter Wahli, Nicolas Loiseau, Alexandra Montagner, Dominique Langin, Achim Lass, Herve Guillou
Summary: In hepatocytes, PPAR alpha is important for maintaining homeostasis during fasting, and the absence of ATGL in adipocytes impairs the production of ketone bodies and FGF21 during fasting. Liver gene expression analysis reveals that these fasting-induced genes are sensitive to both ATGL deletion in adipocytes and PPAR alpha deletion in hepatocytes. Activation of the beta(3)-adrenergic receptor induces PPAR alpha-dependent responses not only in the liver but also in BAT. Intact PPAR alpha activity in hepatocytes is necessary for the interplay between adipose tissues and the liver during fat mobilization.
Article
Anthropology
Reid Ferring, Oriol Oms, Sebastien Nomade, John D. Humphrey, Martha Tappen, Reed Coil, Teona Shelia, Peter Crislip, Rusudan Chagelishvili, Gocha Kiladze, Herve Guillou, David Lordkipanidze
Summary: The Early Pleistocene site of Dmanisi has a significant importance in understanding the activities and environmental contexts during the first colonization of Eurasia. The geological record at Dmanisi reveals distinct sedimentary environments and provides a rich collection of in situ deposits and occupation remains.
JOURNAL OF HUMAN EVOLUTION
(2022)
Article
Oncology
Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Ismael Boussaid, Mael Heiblig, Emeline Boet, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernandez-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Celine Mazzotti, Herve Avet-Loiseau, Oceane Delos, Justine Bertrand-Michel, Amelie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Remy Castellano, Yves Collette, Francois Vergez, Veronique Mansat-De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Recher, Nathalie Bourges-Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoit Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Herve Guillou, Gael Roue, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clement Larrue, Didier Bouscary, Jerome Tamburini, Jean-Emmanuel Sarry
Summary: Although the role of CCAAT-enhancer binding protein α (C/EBPα) in cancer cell and metabolic homeostasis is largely unknown, this study reveals its coordination with FLT3 in lipid anabolism and its regulation of fatty acid biosynthesis and desaturation. Furthermore, FLT3 or C/EBPα inactivation decreases monounsaturated fatty acid incorporation and renders FLT3-mutant AML cells vulnerable to ferroptosis. This finding suggests a promising therapeutic potential for targeting FLT3-mutant AML cells.
Article
Gastroenterology & Hepatology
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caer, Mathilde Cadoux, Jinghong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Herve Guillou, Catherine Postic, Valerie Paradis, Sophie Lotersztajn, Helene Gilgenkrantz
Summary: This study investigates the role of monoacylglycerol lipase (MAGL) in liver regeneration. Using in vitro and in vivo models, the researchers found that MAGL expression in hepatocytes and macrophages has a significant impact on the liver regeneration process. Inhibition of MAGL leads to reduced hepatocyte proliferation and delays liver regeneration.
Article
Environmental Sciences
Leonie Dopavogui, Marion Regnier, Arnaud Polizzi, Quentin Ponchon, Sarra Smati, Wendy Klement, Frederic Lasserre, Celine Lukowicz, Yannick Lippi, Anne Fougerat, Justine Bertrand-Michel, Claire Naylies, Cecile Canlet, Laurent Debrauwer, Elodie Rousseau-Bacquie, Laurence Gamet-Payrastre, Charlene Dauriat, Josefina Casas, Siska Croubels, Siegrid De Baere, Hester M. Burger, Benoit Chassaing, Sandrine Ellero-Simatos, Herve Guillou, Isabelle P. Oswald, Nicolas Loiseau
Summary: Obesity is associated with chronic inflammation and can lead to various long-term complications. This study explored whether obesity influences sensitivity to the food contaminant FB1, particularly in relation to gut health and hepatotoxicity. The results showed that combined exposure to a high-fat diet and FB1 in obese mice resulted in weight loss, decreased blood glucose levels, gut dysbiosis, increased plasma FB1 levels, decreased liver weight, hepatic steatosis, and liver inflammation. These findings suggest that FB1 exposure promotes gut dysbiosis and severe liver inflammation in the context of obesity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Gastroenterology & Hepatology
Simon Ducheix, Elena Piccinin, Claudia Peres, Oihane Garcia-Irigoyen, Justine Bertrand-Michel, Allan Fouache, Marica Cariello, Jean-Marc Lobaccaro, Herve Guillou, Carlo Sabba, James M. Ntambi, Antonio Moschetta
Summary: This study reveals the important role of mono-unsaturated fatty acids (MUFAs) in intestinal metabolism in maintaining liver function and preventing the development of nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
