ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

(2022) Jelena Krstic et al.   Science Advances

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

(2021) Myoung Sook Han et al.   GENES & DEVELOPMENT

Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease

(2021) Ebru S. Selen et al.   JCI Insight

Hepatic PPARα is critical in the metabolic adaptation to sepsis

(2019) Réjane Paumelle et al.   JOURNAL OF HEPATOLOGY

Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure

(2019) Magdalene Ameka et al.   Scientific Reports

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

(2019) Steven A. Kliewer et al.   Cell Metabolism

Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes

(2019) S. Smati et al.   DIABETES & METABOLISM

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

(2019) Matthieu Lacroix et al.   Molecular Metabolism

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

(2018) Markus Heine et al.   Cell Metabolism

Insights into the role of hepatocyte PPARα activity in response to fasting

(2018) Marion Régnier et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Brown adipocyte glucose metabolism: a heated subject

(2018) Mohammed K Hankir et al.   EMBO REPORTS

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine

(2018) Osamu Hashimoto et al.   Cell Reports

Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis

(2017) Andreas Prokesch et al.   FASEB JOURNAL

Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription

(2017) Cecilia Patitucci et al.   JOURNAL OF CLINICAL INVESTIGATION

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

(2017) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

(2017) Alison Iroz et al.   Cell Reports

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice

(2015) Gabriele Schoiswohl et al.   ENDOCRINOLOGY

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

(2015) Young Suk Jo et al.   HEPATOLOGY

Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids

(2015) Doris Jaeger et al.   JOURNAL OF HEPATOLOGY

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Transcriptional and Chromatin Regulation during Fasting – The Genomic Era

(2015) Ido Goldstein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling

(2015) Ivan Nemazanyy et al.   Nature Communications

Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice

(2014) Rebecca E. K. MacPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

(2014) Michal Pawlak et al.   HEPATOLOGY

Fasting of mice: a review

(2013) TL Jensen et al.   LABORATORY ANIMALS

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver

(2011) KyeongJin Kim et al.   HEPATOLOGY

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Bias in the Cq value observed with hydrolysis probe based quantitative PCR can be corrected with the estimated PCR efficiency value

(2010) Jari Michael Tuomi et al.   METHODS

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

(2009) Manu V. Chakravarthy et al.   CELL

Peroxisome Proliferator-Activated Receptor  /  (PPAR / ) but Not PPAR  Serves as a Plasma Free Fatty Acid Sensor in Liver

(2009) L. M. Sanderson et al.   MOLECULAR AND CELLULAR BIOLOGY

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH