Cyclic diGMP Regulates Production of Sortase Substrates ofClostridium difficileand Their Surface Exposure through ZmpI Protease-mediated Cleavage

Clostridium difficile Infection

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Structure and function of a Clostridium difficile sortase enzyme

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Engineering of Bacillus subtilis Strains To Allow Rapid Characterization of Heterologous Diguanylate Cyclases and Phosphodiesterases

(2014) Xiaohui Gao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Clostridium difficilehas a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

(2014) Elizabeth H Donahue et al.   BMC MICROBIOLOGY

The Clostridium difficile PCR ribotype 027 lineage: a pathogen on the move

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Clostridium difficilesortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation

(2014) Hans C. van Leeuwen et al.   FEBS LETTERS

Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile

(2014) Eric Bordeleau et al.   JOURNAL OF BACTERIOLOGY

A Novel Secreted Metalloprotease (CD2830) fromClostridium difficileCleaves Specific Proline Sequences in LPXTG Cell Surface Proteins

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Community-associated Clostridium difficile infection and antibiotics: a meta-analysis

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The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of sigD

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Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

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Identification of a Novel Zinc Metalloprotease through a Global Analysis of Clostridium difficile Extracellular Proteins

(2013) Valeria Cafardi et al.   PLoS One

Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

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Precise Manipulation of the Clostridium difficile Chromosome Reveals a Lack of Association between thetcdCGenotype and Toxin Production

(2012) Stephen T. Cartman et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Spatial positioning of cell wall-anchored virulence factors in Gram-positive bacteria

(2012) Hélène Bierne et al.   CURRENT OPINION IN MICROBIOLOGY

You’ve come a long way: c-di-GMP signaling

(2012) Holger Sondermann et al.   CURRENT OPINION IN MICROBIOLOGY

TheClostridium difficile spo0AGene Is a Persistence and Transmission Factor

(2012) Laura J. Deakin et al.   INFECTION AND IMMUNITY

Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile

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Multiple Factors Modulate Biofilm Formation by the Anaerobic Pathogen Clostridium difficile

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Protein secretion and surface display in Gram-positive bacteria

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Cyclic Dimeric GMP Signaling Regulates Intracellular Aggregation, Sessility, and Growth of Ehrlichia chaffeensis

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Regulated Shift from Helical to Polar Localization of Listeria monocytogenesCell Wall-Anchored Proteins

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Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

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Clostridium difficileHas Two Parallel and Essential Sec Secretion Systems

(2011) Robert P. Fagan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clostridium difficileHas an Original Peptidoglycan Structure with a High Level ofN-Acetylglucosamine Deacetylation and Mainly 3-3 Cross-links

(2011) Johann Peltier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortase enzymes in Gram-positive bacteria

(2011) Thomas Spirig et al.   MOLECULAR MICROBIOLOGY

Mechanism for gene control by a natural allosteric group I ribozyme

(2011) A. G. Y. Chen et al.   RNA

Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis

(2011) Marcos V. A. S. Navarro et al.   PLOS BIOLOGY

A c-di-GMP Effector System Controls Cell Adhesion by Inside-Out Signaling and Surface Protein Cleavage

(2011) Peter D. Newell et al.   PLOS BIOLOGY

c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and Phosphodiesterases

(2011) Eric Bordeleau et al.   PLoS Genetics

Cyclic di-GMP Signaling Regulates Invasion by Ehrlichia chaffeensis of Human Monocytes

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An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

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Intramolecular isopeptide bonds: protein crosslinks built for stress?

(2010) Hae Joo Kang et al.   TRENDS IN BIOCHEMICAL SCIENCES

A mariner-Based Transposon System for In Vivo Random Mutagenesis of Clostridium difficile

(2009) S. T. Cartman et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterial Adhesins in Host-Microbe Interactions

(2009) Kimberly A. Kline et al.   Cell Host & Microbe

New trends in Clostridium difficile virulence and pathogenesis

(2009) C. Denève et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The effect of c-di-GMP (3′–5′-cyclic diguanylic acid) on the biofilm formation and adherence of Streptococcus mutans

(2009) Wenjuan Yan et al.   MICROBIOLOGICAL RESEARCH

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Molecular Characterization of a Clostridium difficile Bacteriophage and Its Cloned Biologically Active Endolysin

(2008) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY