Article
Oncology
Oemer Guelluelue, Stephanie Hehlgans, Benjamin E. Mayer, Ines Goessner, Chrysi Petraki, Melanie Hoffmann, Maximilian J. Dombrowsky, Patrick Kunzmann, Kay Hamacher, Klaus Strebhardt, Emmanouil Fokas, Claus Roedel, Christian Muench, Franz Roedel
Summary: Survivin overexpression in tumors is significantly associated with treatment resistance and poor prognosis, affecting DNA damage response through interaction with DNA-PKcs. The BIR domain of Survivin is directly involved in regulating radiation survival and DNA repair by interacting with the PI3K domain of DNA-PKcs. Formation of a Survivin-DNA-PKcs heterotetrameric complex alters the substrate specificity of DNA-PKcs, influencing radiation survival and DNA double-strand break repair.
Article
Chemistry, Multidisciplinary
Junbo Li, Zhijun Xu, Mei Zhu, Chunyu Zhao, Xiaoliang Wang, Haixu Chen, Xiaoman Liu, Lei Wang, Xin Huang
Summary: Spatial organization of various biomacromolecules can be achieved through heterogeneous LLPS, including nesting, partial engulfing, and petal-like multicompartmental models. Reversible programmable reconstitution between sub-microcompartments can be realized, providing a technological platform for the spatial modulation of biological reactions.
Article
Chemistry, Multidisciplinary
Fariza Zhorabek, Manisha Sandupama Abesekara, Jianhui Liu, Xin Dai, Jinqing Huang, Ying Chau
Summary: A biomimetic platform for building synthetic multiphasic condensates using engineered multivalent polymer-oligopeptide hybrids is presented. This platform enables the replication of the hierarchical multicompartment organization found in intracellular membraneless organelles, allowing for the enrichment and segregation of functional biomolecules.
Article
Chemistry, Physical
Qianqian Wang, Qinggao Zhang, Elaine Lai Han Leung, Yingqing Chen, Xiaojun Yao
Summary: This study applied integrated molecular dynamics techniques to investigate the characteristics of 5-iTU and its derivatives targeting haspin, revealing the crucial role of 5-iTU in binding with haspin and the importance of gatekeeper Phe605.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Review
Chemistry, Medicinal
Tathagata Pradhan, Ojasvi Gupta, Gurpreet Singh, Vikramdeep Monga
Summary: Aurora kinases, a family of regulatory proteins playing a crucial role in cell proliferation, have emerged as validated drug targets for anticancer drug discovery. The design and development of Aurora kinase inhibitors have been widely explored as potential anticancer agents, showing promising results in growth inhibition and apoptosis in tumor cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Physical
Priya, Shalini Jaswal, Ghanshyam Das Gupta, Sant Kumar Verma
Summary: Aurora kinase family plays a critical role in cell division and the cell cycle, and overexpression of AURKA and AURKB has been linked to the development of various carcinomas. The synthesis and development of Aurora Kinase inhibitors offer new opportunities for anticancer therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Oncology
Benson Chellakkan Selvanesan, Sheelu Varghese, Justyna Andrys-Olek, Ricardo Hernandez Arriaza, Rahul Prakash, Purushottam Babu Tiwari, Daniel Hupalo, Yuriy Gusev, Megha Nitin Patel, Sara Contente, Miloslav Sanda, Aykut Uren, Matthew D. Wilkerson, Clifton Lee Dalgard, Linda S. Shimizu, Maksymilian Chruszcz, Tomasz Borowski, Geeta Upadhyay
Summary: LY6K is a small GPI-linked protein expressed in testes and its increased expression is associated with poor survival outcomes in various solid cancers. This report reveals a novel role of LY6K in mitosis and cytokinesis through aurora B kinase and histone H3 signaling axis. The interaction of small molecule NSC243928 with LY6K disrupts LY6K-aurora B signaling, resulting in failed cytokinesis, DNA damage, senescence, and apoptosis of cancer cells. Inhibition of LY6K signaling could be a potential therapeutic approach for hard-to-treat cancers.
Review
Chemistry, Medicinal
Naga Rajiv Lakkaniga, Zhengyu Wang, Yao Xiao, Anupreet Kharbanda, Li Lan, Hong-yu Li
Summary: Aurora Kinase B, as a therapeutic target for cancer treatment, has been studied for more than two decades. Inhibitors of Aurora Kinase B show promising biological results in vitro and in vivo experiments. Although no approved inhibitors for clinical use are available due to associated side effects, they exhibit excellent synergy with other treatment methods, making them a potential adjuvant therapy for difficult-to-treat cancers.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Xianghua Zhang, Ji Eun Park, Eun Ho Kim, Jihee Hong, Ki-Tae Hwang, Young A. Kim, Chang-Young Jang
Summary: The timely and temporal phosphorylation of proteins during mitosis is critical, with mitotic kinases activating and phosphatases repressing the process. The mitotic exit, or transition from mitosis to interphase, involves removal of mitotic phosphorylation by protein phosphatases, including PP1 and PP2A. A new mitotic phosphatase relay, involving Wip1/PPM1D phosphatase activity, is essential for CPC translocation in anaphase, demonstrating spatiotemporal regulation of mitotic exit to prevent tumor initiation and progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Roberto Maggio, Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Marampon, Mario Rossi, Marco Scarselli
Summary: The passage discusses the importance of information exchange and interpretation in biology, particularly in how cells integrate signals from various molecules. G protein-coupled receptors (GPCRs) play a crucial role in signal recognition and transduction within cells, and their formation of higher order oligomers helps organize cell compartments along the membrane. This structural basis allows for cells to perceive and discriminate localized increases in second messengers, contributing to the understanding of physiological roles played by receptor homo- and hetero-oligomerization in cell biology.
Review
Biochemistry & Molecular Biology
Antal H. Kovacs, Dong Zhao, Jinqiang Hou
Summary: This paper presents a comprehensive review of the preclinical and clinical candidates of Aurora B inhibitors as potential anticancer drugs. The recent advances in the field of Aurora B inhibitor development will be highlighted, and the binding interactions between Aurora B and inhibitors based on crystal structures will be presented and discussed to provide insights for the future design of more selective Aurora B inhibitors.
Article
Biochemistry & Molecular Biology
Matthew N. Clarke, Theodor Marsoner, Manuel Alonso Y. Adell, Madhwesh C. Ravichandran, Christopher S. Campbell
Summary: Both an increased frequency of chromosome missegregation (chromosomal instability, CIN) and the presence of an abnormal complement of chromosomes (aneuploidy) are hallmarks of cancer. We previously studied yeast cells lacking the gene BIR1, a member of the chromosomal passenger complex (CPC), and found that they quickly adapted to high levels of CIN by acquiring specific combinations of beneficial aneuploidies. In this study, we monitored these yeast strains over a longer period of time and identified suppressor mutations that reduce chromosomal instability but not the negative effects of aneuploidy.
Review
Biochemistry & Molecular Biology
Dalila Boi, Elisabetta Rubini, Sara Breccia, Giulia Guarguaglini, Alessandro Paiardini
Summary: Myc transcription factors play crucial roles in many cellular processes and its overexpression is frequently associated with cancer. The interplay between Myc and kinases is essential for tumor cell proliferation, with kinase inhibitors showing potential for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Su-Jin Baek, Haeseung Lee, Sang-Min Park, Musun Park, Jin-Mu Yi, No Soo Kim, Aeyung Kim, Seongwon Cha
Summary: By analyzing the changes in gene expression at the genome-wide level, this study investigated the effects of Paeoniae Radix (PR) on molecular pathways in lung cancer cells. The results showed that PR has anticancer effects by regulating multiple pathways, particularly the downregulation of the Aurora B pathway by PR ethanol extracts and two compounds, hederagenin (HG) and oleanolic acid (OA). These findings suggest that inhibiting Aurora kinase activity could be a potential therapeutic target for lung cancer, providing novel mechanisms of action for PR and its components.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Dietmar Krex, Paula Bartmann, Doris Lachmann, Alexander Hagstotz, Willi Jugel, Rosa S. Schneiderman, Karnit Gotlib, Yaara Porat, Katja Robel, Achim Temme, Moshe Giladi, Susanne Michen
Summary: Tumor Treating Fields (TTFields) have shown positive effects on the treatment of glioblastoma in a phase III clinical trial. In this study, the combination of TTFields and the Aurora B kinase inhibitor AZD1152 was tested in primary cultures of newly diagnosed and recurrent glioblastoma. The combined treatment demonstrated significant cytotoxic effects and morphological changes, suggesting its potential as a treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Wangfei Chi, Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang
Summary: In this study, it was discovered that NEDD1 facilitates the initiation of cartwheel assembly and daughter centriole biogenesis by binding to SAS-6 and recruiting SAS-6 to the centrosome. The phosphorylation of NEDD1 by PLK4 plays a crucial role in this process.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Yuan Tian, Chenxi Wei, Jianfeng He, Yuxuan Yan, Nan Pang, Xiaomin Fang, Xin Liang, Jingyan Fu
Summary: This study provides a direct view of Drosophila centriolar proteins at approximately 50-nm resolution, revealing the arrangement of key proteins at the centriole core and discovering new symmetrical patterns. The findings shed light on the organization and construction process of the centriole.
JOURNAL OF CELL BIOLOGY
(2021)
Editorial Material
Cell Biology
Gang Wang, Haiying Zhang, David Lyden
Summary: The study found that tumor-derived humoral factors induce anorexia earlier than cachexia by dysregulating neuropeptides in the brain.
NATURE CELL BIOLOGY
(2021)
Article
Environmental Sciences
Yuyin Yang, Jianfei Chen, Xiuli Chen, Qingsong Jiang, Yong Liu, Shuguang Xie
Summary: This study investigated the temporal patterns of sedimentary archaea and bacteria during cyanobacterial blooms in a eutrophic lake, revealing significant differences in structures and functions among different phases. Microbial communities in different phases showed distinct metabolic activities and diversity, playing important roles in the transformation of cyanobacteria-derived organic matter.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Bin Yu, Qiaoyu Lin, Chao Huang, Boyan Zhang, Ying Wang, Qing Jiang, Chuanmao Zhang, Jing Yi
Summary: Research has shown that conjugation of SUMO2 with AurA at K258 in early mitosis promotes the kinase activity of AurA, while inhibition of deSUMOylation leads to increased kinase activity and abnormalities in spindle assembly and chromosome segregation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Tenghan Zhuang, Boyan Zhang, Yihong Song, Fan Huang, Wangfei Chi, Guangwei Xin, Ziyu Zhang, Steven Y. Cheng, Qing Jiang, Chuanmao Zhang
Summary: Sufu, as a negative regulator, plays a critical role in both centrosome and nuclear localization, regulating centrosome duplication and DNA replication by facilitating CP110 phosphorylation and Cdt1 degradation. Serum stimulation leads to the removal of Sufu from the centrosome and nucleus, promoting cell cycle progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Yuan Tian, Yuxuan Yan, Jingyan Fu
Summary: This article reviews the current understanding of the nine-fold symmetrical centriole structure, focusing on recent discoveries of its high-resolution structure, assembly pathways, and distributed components. A model is proposed that suggests the assembly of the nine-fold symmetrical centriole relies on the concerted efforts of its core proteins.
Article
Nutrition & Dietetics
Jiaqiang Deng, Lili Zhao, Xieyong Yuan, Yan Li, Junyang Shi, Hua Zhang, Yuxuan Zhao, Liping Han, Huani Wang, Yan Yan, Hong Zhao, Haojie Wang, Fangdong Zou
Summary: BBR has preventive effects in colon carcinogenesis by inhibiting inflammation and tumor proliferation, and maintaining intestinal homeostasis.
Article
Geosciences, Multidisciplinary
Zhen Wu, Jincheng Li, Yanxin Sun, Josep Penuelas, Jilin Huang, Jordi Sardans, Qingsong Jiang, Jacques C. Finlay, Gregory L. Britten, Michael J. Follows, Wei Gao, Boqiang Qin, Jinren Ni, Shouliang Huo, Yong Liu
Summary: Analyzing over 5000 lakes globally, researchers have found that lakes preferentially retain phosphorous over nitrogen, exacerbating the imbalance of nutrient cycles caused by human activities. The greater retention of phosphorous leads to an elevation in the nitrogen to phosphorous ratio in lake outflows, further worsening the global ecosystem's nitrogen-phosphorous imbalance.
Article
Biochemistry & Molecular Biology
Tao Zhang, Lili Zhao, Liping Han, Yan Li, Lanlin Hu, Huani Wang, Fangdong Zou
Summary: This study uncovered the interaction between mitochondrial thioredoxin 2 (TRX2) and Rab35, revealing a new role for TRX2 in the regulation of exosome secretion and cell migration. These findings also provide new molecular evidence for communication between mitochondria and vesicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Civil
Qingsong Jiang, Yanxin Sun, Mingying Chuo, Feifei Dong, Ningning Ji, Xiaoyan Ji, Jincheng Li, Zhiyun Wang, Yong Liu
Summary: This study proposes a Natural Language Understanding-Based Deep Clustering (NLU-DC) approach for global meta-analysis of lake topics. By analyzing a large literature dataset, it is found that lake topics have become more abundant and concentrated towards central ones over the century. Six evolution patterns are identified, and it is observed that emerging topics in the past twenty years attract less attention while the dependency between topics is receiving more attention.
JOURNAL OF HYDROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fan Huang, Xiaowei Xu, Guangwei Xin, Boyan Zhang, Qing Jiang, Chuanmao Zhang
Summary: Persistent assembly of the cartwheel component maintains centriole engagement, which is relieved through phosphorylation of Sas-6.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden
Summary: Cancer can affect multiple organs beyond those targeted by metastasis. In this study, we found that inflammation, fatty liver, and dysregulated metabolism are characteristics of systemically affected livers in both mouse models and patients with extrahepatic metastasis. Tumour-derived extracellular vesicles and particles (EVPs) play a crucial role in cancer-induced hepatic reprogramming by dysregulating hepatic function. The fatty acid cargo of tumour EVPs, particularly palmitic acid, induces the secretion of TNF by Kupffer cells, leading to a pro-inflammatory microenvironment, suppressing fatty acid metabolism and oxidative phosphorylation, and promoting fatty liver formation.
Article
Oncology
Lanlin Hu, Yutong Liang, Kelv Wu, Caixia Wang, Tao Zhang, Rui Peng, Fangdong Zou
Summary: The study revealed that high expression of ABCG2 in CRC cells leads to resistance to 5-FU, and upregulation of ABCG2 is achieved through repression of PDCD4 and activation of the JNK pathway. Furthermore, inhibition of the JNK pathway was shown to overcome acquired 5-FU resistance.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
