Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain–domain interactions

The eag domain regulates hERG channel inactivation gating via a direct interaction

(2013) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel

(2012) Carol A. Harley et al.   PLoS One

Screening for Sudden Cardiac Death in the Young

(2011) Jonathan R. Kaltman et al.   CIRCULATION

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant HumanEther-á-go-go-related Gene Potassium Channels

(2011) Elena C. Gianulis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hERG potassium channel gating is mediated by N- and C-terminal region interactions

(2011) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

(2011) Chai Ann Ng et al.   PLoS One

NMR solution structure of the N-terminal domain of hERG and its interaction with the S4–S5 linker

(2010) Qingxin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trigger-specific risk factors and response to therapy in long QT syndrome type 2

(2010) James A. Kim et al.   HEART RHYTHM

Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain

(2010) Frederick W. Muskett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp40 Chaperones Promote Degradation of the hERG Potassium Channel

(2009) Valerie E. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype

(2009) JING TING ZHAO et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

(2009) Wataru Shimizu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

(2009) A. S. Gustina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genetic framework for improving arrhythmia therapy

(2008) Björn C. Knollmann et al.   NATURE