Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic

(2011) James H. Hurley et al.   Annual Review of Biophysics

The Cullin-RING Ubiquitin-Protein Ligases

(2011) Zhihua Hua et al.   Annual Review of Plant Biology

NEDD8 Pathways in Cancer, Sine Quibus Non

(2011) Ian R. Watson et al.   CANCER CELL

UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction

(2011) Min Jung Jang et al.   CANCER LETTERS

Ubiquitin editing enzyme UCH L1 and microtubule dynamics: Implication in mitosis

(2011) Anjali Bheda et al.   CELL CYCLE

Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

(2011) Wei-Jie Zhou et al.   CELL RESEARCH

The E3 Ubiquitin-Ligase HACE1 Catalyzes the Ubiquitylation of Active Rac1

(2011) Stéphanie Torrino et al.   DEVELOPMENTAL CELL

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin

(2011) David Kaluza et al.   EMBO JOURNAL

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation

(2011) Tripat Kaur Oberoi et al.   EMBO JOURNAL

Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1

(2011) Cécile Polge et al.   FASEB JOURNAL

Functional and Structural Insights into ASB2α, a Novel Regulator of Integrin-dependent Adhesion of Hematopoietic Cells

(2011) Isabelle Lamsoul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDZ-RhoGEF ubiquitination by Cullin3–KLHL20 controls neurotrophin-induced neurite outgrowth

(2011) Mei-Yao Lin et al.   JOURNAL OF CELL BIOLOGY

A novel role for BRCA1 in regulating breast cancer cell spreading and motility

(2011) Elisabeth D. Coene et al.   JOURNAL OF CELL BIOLOGY

The E3 ubiquitin ligase specificity subunit ASB2  targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain

(2011) Z. Razinia et al.   JOURNAL OF CELL SCIENCE

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

(2011) Mingjin Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

The spatial and temporal organization of ubiquitin networks

(2011) Caroline Grabbe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development

(2011) Pei-lin Cheng et al.   NEURON

Rack1 promotes epithelial cell–cell adhesion by regulating E-cadherin endocytosis

(2011) G Swaminathan et al.   ONCOGENE

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

(2011) A. T. Sasaki et al.   Science Signaling

Staying in touch: the molecular era of organelle contact sites

(2011) Yael Elbaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility

(2011) Michelle de la Vega et al.   Nature Communications

The filamins

(2011) Fumihiko Nakamura et al.   Cell Adhesion & Migration

Quality control autophagy: A joint effort of ubiquitin, protein deacetylase and actin cytoskeleton

(2010) Joo-Yong Lee et al.   Autophagy

CYLD regulates angiogenesis by mediating vascular endothelial cell migration

(2010) J. Gao et al.   BLOOD

Dynamic and Static Interactions between p120 Catenin and E-Cadherin Regulate the Stability of Cell-Cell Adhesion

(2010) Noboru Ishiyama et al.   CELL

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

(2010) Markus Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratin Hypersumoylation Alters Filament Dynamics and Is a Marker for Human Liver Disease and Keratin Mutation

(2010) Natasha T. Snider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DrosophilaKelch functions with Cullin-3 to organize the ring canal actin cytoskeleton

(2010) Andrew M. Hudson et al.   JOURNAL OF CELL BIOLOGY

The role of ubiquitylation and degradation in RhoGTPase signalling

(2010) Micha Nethe et al.   JOURNAL OF CELL SCIENCE

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNF-121 Is an Endoplasmic Reticulum-Membrane E3 Ubiquitin Ligase Involved in the Regulation of β-Integrin

(2010) Amir Darom et al.   MOLECULAR BIOLOGY OF THE CELL

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

(2010) Hiroshi Kawabe et al.   NEURON

Siah Regulation of Pard3A Controls Neuronal Cell Adhesion During Germinal Zone Exit

(2010) J. K. Famulski et al.   SCIENCE

Roles of E3 ubiquitin ligases in cell adhesion and migration

(2010) Cai Huang   Cell Adhesion & Migration

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl

(2009) Yuichi Sekine et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane remodeling during reticulocyte maturation

(2009) J. Liu et al.   BLOOD

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation

(2009) N F Bello et al.   CELL DEATH AND DIFFERENTIATION

Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells

(2009) Richard Buus et al.   CURRENT BIOLOGY

Restriction of Src Activity by Cullin-5

(2009) George S. Laszlo et al.   CURRENT BIOLOGY

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

(2009) Sara A Wickström et al.   EMBO JOURNAL

Tumor suppressor KAI1 affects integrin αvβ3-mediated ovarian cancer cell adhesion, motility, and proliferation

(2009) Zlatna Ruseva et al.   EXPERIMENTAL CELL RESEARCH

Regulation of MYPT1 stability by the E3 ubiquitin ligase SIAH2

(2009) Erin Twomey et al.   EXPERIMENTAL CELL RESEARCH

Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells

(2009) Lisa E. S. Crose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Identification of Integrin  3 as a New Substrate of the Adenovirus E4orf6/E1B 55-Kilodalton E3 Ubiquitin Ligase Complex

(2009) F. Dallaire et al.   JOURNAL OF VIROLOGY

SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination

(2009) Jean-François Trempe et al.   MOLECULAR CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Origin and function of ubiquitin-like proteins

(2009) Mark Hochstrasser   NATURE

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration

(2009) Cai Huang et al.   NATURE CELL BIOLOGY

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin–proteasome pathway

(2009) Y Yoo et al.   ONCOGENE

Filamins Regulate Cell Spreading and Initiation of Cell Migration

(2009) Massimiliano Baldassarre et al.   PLoS One

Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration

(2009) J. Yuasa-Kawada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Import of the Small GTPase Rac1 is Mediated by the Direct Interaction with Karyopherin α2

(2009) Kirstin Sandrock et al.   TRAFFIC

ASB2 targets filamins A and B to proteasomal degradation

(2008) M. L. Heuze et al.   BLOOD

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes — Evidence for an autoregulatory mechanism

(2008) Jessica Berthold et al.   EXPERIMENTAL CELL RESEARCH

Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer

(2008) J. Simoes-Correia et al.   HUMAN MOLECULAR GENETICS

The Tumor Suppressor CYLD Regulates Microtubule Dynamics and Plays a Role in Cell Migration

(2008) Jinmin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Talin at a glance

(2008) D. R. Critchley et al.   JOURNAL OF CELL SCIENCE

Ubiquitination of Fibroblast Growth Factor Receptor 1 Is Required for Its Intracellular Sorting but Not for Its Endocytosis

(2008) Ellen Margrethe Haugsten et al.   MOLECULAR BIOLOGY OF THE CELL

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

(2008) Taner Dogan et al.   NATURE CELL BIOLOGY

Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis

(2008) H J Kim et al.   ONCOGENE

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One