PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

(2014) C. M. Taniguchi et al.   Science Translational Medicine

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

EGLN3 Inhibition of NF- B Is Mediated by Prolyl Hydroxylase-Independent Inhibition of I B Kinase   Ubiquitination

(2013) J. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

(2013) Mary M. Buschmann et al.   MOLECULAR BIOLOGY OF THE CELL

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

(2012) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

(2011) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor

(2011) Melanie L. Hart et al.   JOURNAL OF IMMUNOLOGY

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway

(2010) Jian Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Occludin is required for cytokine-induced regulation of tight junction barriers

(2010) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Advances in the pathogenesis and treatment of IBD

(2009) Nicholas A. Braus et al.   CLINICAL IMMUNOLOGY

Biological Therapies for Inflammatory Bowel Diseases

(2009) Paul Rutgeerts et al.   GASTROENTEROLOGY

Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity

(2009) Jing Xue et al.   GASTROENTEROLOGY

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxygen-Regulated  2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL

(2009) L. Xie et al.   Science Signaling

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY