Article
Biochemistry & Molecular Biology
Koichi Fujisawa, Maina Wakazaki, Aya Matsuzaki, Toshihiko Matsumoto, Naoki Yamamoto, Takafumi Noma, Taro Takami
Summary: The balance between oxidative phosphorylation and glycolysis is crucial for cancer cell growth and survival. In this study, the researchers focused on adenylate kinase 3 (AK3), an enzyme in the mitochondrial matrix that regulates adenine nucleotide metabolism. The knockout of AK3 in HeLa cells resulted in reduced proliferation and increased G1 phase cells. Metabolomic analysis showed decreased ATP levels and changes in glycolytic and TCA cycle metabolites. Additionally, AK3KO cells exhibited increased mitochondrial DNA and oxidative stress levels. The study concluded that increased expression of PCK2 may compensate for the deficiency of GDP caused by AK3 knockout.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Leenu Reinsalu, Marju Puurand, Vladimir Chekulayev, Sten Miller, Igor Shevchuk, Kersti Tepp, Egle Rebane-Klemm, Natalja Timohhina, Anton Terasmaa, Tuuli Kaambre
Summary: Metabolic plasticity is the ability of cells to adjust metabolism to environmental changes. Cancer cells exhibit increased metabolic plasticity, allowing them to have a survival advantage and higher proliferative capacity. This enhanced plasticity is characterized by changes in adenine nucleotide transport, impaired regulation of VDAC and reprogrammed energy transfer circuits like AK and CK pathways.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Koichi Fujisawa
Summary: Adenylate kinase (AK) plays a crucial role in regulating adenine nucleotide metabolism and has been found to be associated with various diseases. This review article provides a summary of the physiological roles of AK isozymes, focusing on the symptoms caused by mutated AK isozymes in humans and phenotypic changes in animal models. The authors emphasize the importance of further research on intracellular, extracellular, and intercellular energy metabolism with a focus on AK for advancing new therapeutic approaches for diseases like cancer, lifestyle-related diseases, and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Song Zhang, Satsuki Yamada, Sungjo Park, Aleksandr Klepinin, Tuuli Kaambre, Andre Terzic, Petras Dzeja
Summary: The study revealed that AK2 plays a crucial role in early embryonic development and its loss in adults can lead to sudden heart failure, which is eventually recovered with an adaptive response. The compensatory upregulation of related enzymes and genes highlights the innate plasticity of the AK2-integrated bioenergetics system in maintaining homeostasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Xingyan Zhang, Yaoyao Zhou, Zhenyu Shi, Zhenfeng Liu, Hao Chen, Xiaochen Wang, Yiming Cheng, Lishan Xi, Xuanyuan Li, Chunze Zhang, Li Bao, Chenghao Xuan
Summary: ATP-dependent chromatin remodelers (ATPCRs) play a crucial role in cancer, particularly in colorectal cancer, where several genes involved in chromatin organization and regulation are frequently mutated. One of these genes, chromodomain helicase DNA-binding protein 7 (CHD7), is shown to promote the growth of colorectal cancer cells by maintaining chromatin accessibility and facilitating transcription. Additionally, a CHD7-AK4-AMPK-p53 axis is identified, which plays an oncogenic role in colorectal cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Physiology
Sevasti Zervou, Debra J. McAndrew, Hannah J. Whittington, Hannah A. Lake, Kyung Chan Park, Kuan Minn Cha, Philip J. Ostrowski, Thomas R. Eykyn, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Summary: The study suggests that modest elevation of AK1 activity may improve functional recovery following ischemia/reperfusion injury, but has unexpected impacts on left ventricular weight, function, and metabolite levels under basal resting conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Jingtai Zhi, Linfei Hu, Yuyang Qian, Ning Kang, Xinwei Yun, Xin Wang, Xianhui Ruan, Dongmei Huang, Weiwei Yang, Xiangrui Meng, Tianze Zhu, Wei Wang, Xiangqian Zheng
Summary: This study reveals the crucial role of Aurora-A in regulating energy supply in thyroid cancer cells, and highlights the potential of combining Alisertib with Sorafenib for treating advanced thyroid carcinoma.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger
Summary: Phosphorylation plays a vital role in regulating biological processes, and protein kinases have been extensively studied for their involvement in human health and disease. Some kinases possess additional catalytic functions in addition to phosphotransferase activity, while others have lost their catalytic activity completely. In this study, we analyzed the UniProtKB database for bifunctional protein kinases and focused on those crucial for bacterial and human cellular homeostasis. These kinases have diverse functional roles in environmental sensing, metabolic regulation, immune-host defense, and cell cycle control. This article explores their dual catalytic activities and their contributions to disease pathogenesis.
Article
Infectious Diseases
Guoqing Shao, Ruiqi Hua, Hongyu Song, Yanxin Chen, Xiaowei Zhu, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang
Summary: The study demonstrates that the six recombinant proteins have significant protective efficacy in dogs against E. granulosus infection, reducing worm biomass and inhibiting growth. The vaccinated dogs also showed an increased level of IgG, indicating an enhanced immune response.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Pharmacology & Pharmacy
Gennady G. Yegutkin, Detlev Boison
Summary: Adenosine pathway plays an important role in tumor immunomodulation and cell proliferation. Tumors create an adenosine-rich microenvironment by releasing ATP and converting it into adenosine. There are multiple pathways controlling intratumoral adenosine levels that need to be considered for more effective therapeutic approaches. This review provides a comprehensive view of adenosine metabolism and its role in cancer immunosurveillance and tumor angiogenesis.
PHARMACOLOGICAL REVIEWS
(2022)
Article
Cell Biology
Ruipeng Zhuge, Chao Wang, Jie Wang, Shuyu Yu, Liming Liao, Xiaofeng Zheng
Summary: This study reveals that hCINAP is a crucial regulator of YAP1 activity and plays a vital role in stem cell lineage differentiation. The research uncovers the interaction between hCINAP and NEDD4 and their impact on YAP1 activation.
Article
Multidisciplinary Sciences
Ashley S. Williams, Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, Deborah M. Muoio
Summary: Nicotinamide riboside supplements (NRS) have been claimed to enhance health by increasing NAD(+) synthesis and improving mitochondrial function. However, this study found that NRS had some marginal benefits in a high-fat diet but did not increase tissue NAD(+) levels or improve mitochondrial function.
Article
Chemistry, Physical
Takumi Washio, Ryo Kanada, Xiaoke Cui, Jun-ichi Okada, Seiryo Sugiura, Shoji Takada, Toshiaki Hisada
Summary: The semi-implicit Hessian correction (SimHec) scheme proposed in this study allows for significantly larger time steps in molecular dynamics simulations compared to traditional implicit methods. By introducing a hybrid method (SimHec-H) that combines explicit time steps, the drawbacks of increased transition dynamics and reduced fluctuations in bonded potentials can be corrected. This scheme results in a speedup factor of 7-30, making simulations more efficient and accurate.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Pharmacology & Pharmacy
Facundo Galceran, Fabio A. Digirolamo, Marcos Rengifo, Chantal Reigada, Melisa Saye, Belen J. Maciel, Ivana G. Estecho, Andrea E. Errasti, Claudio A. Pereira, Mariana R. Miranda
Summary: In this study, potential drugs for the treatment of Chagas' disease were identified using computer-assisted drug repurposing methods. NEB and TEL showed inhibitory effects on the causative agent of Chagas' disease and performed comparably to the first-line drug BZL.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Leszek A. Kleczkowski, Abir U. Igamberdiev
Summary: Free magnesium (Mg2+) functions as a signal of adenylate (ATP+ADP+AMP) status in cells, controlled by the equilibrium of adenylate kinase (AK) and membrane-bound adenylate- and Mg2+-translocators. Changes in [Mg2+] impact enzyme activities, metabolism, and processes like photosynthesis, under normal and stress conditions. Magnesium signaling is likely widespread in all eukaryotic and prokaryotic organisms due to the ubiquitous nature of AK and its role in adenylate equilibration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Haiyang Jiang, Lei Zhao, Xiaoshen Dong, Anning He, Caiwei Zheng, Magnus Johansson, Anna Karlsson, Xinyu Zheng
Article
Multidisciplinary Sciences
Stefano Bartesaghi, Vincenzo Graziano, Sara Galavotti, Nick V. Henriquez, Joanne Betts, Jayeta Saxena, A. Deli, Anna Karlsson, L. Miguel Martins, Melania Capasso, Pierluigi Nicotera, Sebastian Brandner, Vincenzo De Laurenzi, Paolo Salomoni
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Oncology
Xiaoshan Zhou, Joao A. Paredes, Shuba Krishnan, Sophie Curbo, Anna Karlsson
Article
Oncology
Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan, Anna Karlsson
Article
Biochemistry & Molecular Biology
Sophie Curbo, Kathrin Reiser, Anna-Klara Rundlof, Anna Karlsson, Mathias Lundberg
ANTIOXIDANTS & REDOX SIGNALING
(2013)
Article
Oncology
Xiaoshen Dong, Wenzhi Qu, Shuai Ma, Zhi Zhu, Caiwei Zheng, Anning He, Anna Karlsson, Ke Xu, Xinyu Zheng
Review
Pharmacology & Pharmacy
Eva-Maria Priego, Anna Karlsson, Federico Gago, Maria-Jose Camarasa, Jan Balzarini, Maria-Jesus Perez-Perez
CURRENT PHARMACEUTICAL DESIGN
(2012)
Article
Biochemistry & Molecular Biology
Kathrin Reiser, Katrien O. Francois, Dominique Schols, Tomas Bergman, Hans Jornvall, Jan Balzarini, Anna Karlsson, Mathias Lundberg
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Marjan Amiri, Francesca Conserva, Christakis Panayiotou, Anna Karlsson, Nicola Solaroli
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Christakis Panayiotou, Nicola Solaroli, Anna Karlsson
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Shuba Krishnan, Xiaoshan Zhou, Joao A. Paredes, Raoul V. Kuiper, Sophie Curbo, Anna Karlsson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Shuba Krishnan, Joao A. Paredes, Xiaoshan Zhou, Raoul V. Kuiper, Kjell Hultenby, Sophie Curbo, Anna Karlsson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Editorial Material
Clinical Neurology
Charlotte L. Alston, Andrew M. Schaefer, Pravrutha Raman, Nicola Solaroli, Kim J. Krishnan, Emma L. Blakely, Langping He, Kate Craig, Mark Roberts, Aashish Vyas, John Nixon, Rita Horvath, Douglass M. Turnbull, Anna Karlsson, Grainne S. Gorman, Robert W. Taylor
Article
Multidisciplinary Sciences
Xiaoshan Zhou, Kristina Kannisto, Sophie Curbo, Ulrika von Dobeln, Kjell Hultenby, Sindra Isetun, Mats Gafvels, Anna Karlsson
Article
Multidisciplinary Sciences
Kathrin Reiser, Leen Mathys, Sophie Curbo, Christophe Pannecouque, Sam Noppen, Sandra Liekens, Lars Engman, Mathias Lundberg, Jan Balzarini, Anna Karlsson