Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation

Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells

(2013) Michael J. MacDonald et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

P4 ATPases: Flippases in Health and Disease

(2013) Vincent van der Mark et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

(2013) Matthew A. Lorenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation

(2013) Uwe Panten et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

MARCKS-ED Peptide as a Curvature and Lipid Sensor

(2012) Leslie A. Morton et al.   ACS Chemical Biology

Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells

(2012) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

(2012) Eunjin Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb’s cycle flux independent of ATP synthesis

(2011) Gary W. Cline et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

(2011) J. K. Kruit et al.   DIABETES

Differences between Human and Rodent Pancreatic Islets

(2011) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

(2011) Marc Prentki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Flippin' lipids

(2011) Marcus R Clark   NATURE IMMUNOLOGY

Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles

(2011) Gary W. Cline   Diabetes & Metabolism Journal

Metabolic amplifying pathway increases both phases of insulin secretion independently of β-cell actin microfilaments

(2010) Nizar I. Mourad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: Knockdown of SCOT inhibits insulin release in rat insulinoma cells

(2010) Noaman M. Hasan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Docking and Fast Fusion of Synaptobrevin Vesicles Depends on the Lipid Compositions of the Vesicle and the Acceptor SNARE Complex-Containing Target Membrane

(2010) Marta K. Domanska et al.   BIOPHYSICAL JOURNAL

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

Ionization Properties of Phosphatidylinositol Polyphosphates in Mixed Model Membranes

(2009) Edgar E. Kooijman et al.   BIOCHEMISTRY

Lipid Mixing and Content Release in Single-Vesicle, SNARE-Driven Fusion Assay with 1–5 ms Resolution

(2009) Tingting Wang et al.   BIOPHYSICAL JOURNAL

Differential Phosphorylation of RhoGDI Mediates the Distinct Cycling of Cdc42 and Rac1 to Regulate Second-phase Insulin Secretion

(2009) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

Phosphatidylserine Regulation of Ca2+-triggered Exocytosis and Fusion Pores in PC12 Cells

(2009) Zhen Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence that Electrostatic Interactions between Vesicle-associated Membrane Protein 2 and Acidic Phospholipids May Modulate the Fusion of Transport Vesicles with the Plasma Membrane

(2009) Dumaine Williams et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolic cycling in control of glucose-stimulated insulin secretion

(2008) Mette V. Jensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

How lipid flippases can modulate membrane structure

(2008) Philippe F. Devaux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion

(2008) M MACDONALD et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

(2008) J. Xu et al.   DIABETOLOGIA

Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase

(2008) Noaman M. Hasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anaplerosis from glucose, α-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria

(2008) Michael J. MacDonald et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

Acetoacetate and β-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion

(2007) Michael J. MacDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells

(2007) Michael J. MacDonald et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

SNARE-catalyzed Fusion Events Are Regulated by Syntaxin1A–Lipid Interactions

(2007) Alice D. Lam et al.   MOLECULAR BIOLOGY OF THE CELL