Article
Biochemistry & Molecular Biology
Wei Shao, Hang Zheng, Jingwen Zhu, Wenhao Li, Yifan Li, Wenjie Hu, Juanjuan Zhang, Liang Jing, Kai Wang, Xiao Jiang
Summary: Autism spectrum disorder (ASD) is a highly inherited neurodevelopmental disorder, and loss-of-function mutations in the CACNA2D3 gene are associated with ASD. Dysfunction of cortical interneurons (INs), specifically Parvalbumin-expressing (PV) INs, may underlie the abnormal social behavior observed in ASD. Knockout mouse models were used to investigate the role of Cacna2d3 insufficiency in PV neurons, and it was found that these mice exhibited deficits in core ASD behaviors, anxiety-like behavior, and improved spatial memory. On the other hand, mice with Cacna2d3 insufficiency in somatostatin-expressing (SOM) neurons did not show obvious deficits in social, cognitive, or emotional phenotypes.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Robert A. Ellingford, Martyna J. Panasiuk, Emilie Rabesahala de Meritens, Raghav Shaunak, Liam Naybour, Lorcan Browne, M. Albert Basson, Laura C. Andreae
Summary: The heterozygous mutation of CHD8 is strongly linked to autism spectrum disorder (ASD) and leads to dysregulated expression of neurodevelopmental and synaptic genes during brain development. Study on a Chd8 mouse model revealed significant alterations in both excitatory and inhibitory synaptic transmission onto deep layer projection neurons in the prefrontal cortex, resulting in an imbalance between excitatory and inhibitory signals. These disruptions were associated with impaired regulation of homeostatic plasticity mechanisms, suggesting a direct role of CHD8 mutation in the disruption of ASD-relevant cortical circuits.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Jian Meng, Linkun Han, Naizhen Zheng, Ting Wang, Hui Xu, Yiru Jiang, Zijie Wang, Zhaoji Liu, Qiuyang Zheng, Xian Zhang, Hong Luo, Dan Can, Jinsheng Lu, Huaxi Xu, Yun-wu Zhang
Summary: Synaptic abnormality is an important pathological feature of autism spectrum disorders (ASDs) and can result in ASD-like behaviors by affecting microglial synaptic refinement. This study found that the decreased expression of TMEM59 protein is associated with autistic patients. Both male and female mice with TMEM59 deficiency exhibited ASD-like behaviors. TMEM59-deficient microglia showed impaired ability for synapse engulfment, which may be caused by the degradation of CD93 protein. These findings suggest that TMEM59 plays a crucial role in regulating microglial function in synapse refinement and TMEM59 deficiency may contribute to ASDs by disrupting synapse phagocytosis and distorting the excitatory-inhibitory (E/I) neuronal activity balance.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Lichao Xu, Yue Zheng, Xuejing Li, Andi Wang, Dawei Huo, Qinglan Li, Shikang Wang, Zhiyuan Luo, Ying Liu, Fuqiang Xu, Xudong Wu, Min Wu, Yan Zhou
Summary: This study highlights the importance of SETD2 in epigenetic mechanisms underlying cortical arealization and the pathogenesis of Sotos-like syndrome. Loss of SETD2 leads to defects in cortical arealization and cognitive functions, similar to patients with SETD2 mutations.
Article
Clinical Neurology
Matthias Koenning, Xianlong Wang, Menuka Karki, Rahul Kumar Jangid, Sarah Kearns, Durga Nand Tripathi, Michael Cianfrocco, Kristen J. Verhey, Sung Yun Jung, Cristian Coarfa, Christopher Scott Ward, Brian Thomas Kalish, Sandra L. Grimm, W. Kimryn Rathmell, Ricardo Mostany, Ruhee Dere, Matthew Neil Rasband, Cheryl Lyn Walker, In Young Park
Summary: Research has found that defects in chromatin remodeller genes play a major role in autism spectrum disorder, causing methylation of microtubules and resulting in functional and structural deficits in neurons.
Article
Biochemistry & Molecular Biology
Hannes Steinkellner, Prakasha Kempaiah, Alexander Beribisky, Sandra Pferschy, Julia Etzler, Anna Huber, Victoria Sarne, Winfried Neuhaus, Mario Kuttke, Jan Bauer, Jayamuruga P. Arunachalam, John Christodoulou, Ralf Dressel, Alexander Mildner, Marco Prinz, Franco Laccone
Summary: This study demonstrates the therapeutic potential of recombinant TAT-MeCP2 in treating Rett syndrome. The findings show that TAT-MeCP2 can reverse the pathological changes of the disease and extend the lifespan of mice. This research lays the foundation for the development of a new therapy for Rett syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Donghyun D. Lee, Martin Komosa, Sumedha Sudhaman, Ricardo Leao, Cindy H. Zhang, Joana D. Apolonio, Thomas Hermanns, Peter J. Wild, Helmut Klocker, Farshad Nassiri, Gelareh Zadeh, Bill H. Diplas, Hai Yan, Steven Gallinger, Trevor J. Pugh, Vijay Ramaswamy, Michael D. Taylor, Pedro Castelo-Branco, Nuno Miguel Nunes, Uri Tabori
Summary: The research found that allele-specific DNA methylation within the TERT promoter plays a significant regulatory role in cancer, especially more common in adult cancers and enriched in tumors with TERT promoter mutations. This allele-specific DNA methylation is essential for the regulation of TERT expression in cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Neurosciences
Peng Chen, Ziyang Liu, Qian Zhang, Dong Lin, Lu Song, Jianghong Liu, Hui-Feng Jiao, Xinsheng Lai, Suqi Zou, Shunqi Wang, Tian Zhou, Bao-Ming Li, Li Zhu, Bing-Xing Pan, Erkang Fei
Summary: Mutations in cell adhesion molecules (CAMs) can lead to abnormal synapse formation and maturation, possibly contributing to autism spectrum disorders (ASDs). This study discovered that the DSCAM gene, a high-risk gene for autism, plays a role in preventing premature spine maturation and excessive glutamatergic transmission. Deficiency of DSCAM led to accelerated dendritic spine maturation and autism-like behaviors in mice.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fen Ji, Chao Feng, Jie Qin, Chong Wang, Dongming Zhang, Libo Su, Wenwen Wang, Mengtian Zhang, Hong Li, Longbing Ma, Weicheng Lu, Changmei Liu, Zhaoqian Teng, Baoyang Hu, Fengzeng Jian, Jingdun Xie, Jianwei Jiao
Summary: The deletion of Pd1 in the brain leads to abnormal cortical neurogenesis and depressive-like behaviors. Pd1 regulates neurogenesis by targeting Pax3 through the β-catenin signaling pathway. Furthermore, Pd1 also plays a similar role in the proliferation and differentiation of human neural progenitor cells (hNPCs).
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Rubal Singla, Abhishek Mishra, Hao Lin, Ethan Lorsung, Nam Le, Su Tin, Victor X. Jin, Ruifeng Cao
Summary: Approximately 50-80% of children with autism spectrum disorders (ASDs) experience sleep problems, and the role of circadian clock dysfunction in ASD development is still unclear. This study found that the clock gene Bmal1 is associated with ASD, and its deletion in mice leads to autism-like behaviors. By partially deleting the Bmal1 gene, the study showed that mice exhibited similar autism-like behavioral changes. This research provides further evidence of disrupted clock gene expression in the development of ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Ryan H. Miller, Chad A. Pollard, Kristin R. Brogaard, Andrew C. Olson, Ryan C. Barney, Larry I. Lipshultz, Erica B. Johnstone, Yetunde O. Ibrahim, James M. Hotaling, Enrique F. Schisterman, Sunni L. Mumford, Kenneth I. Aston, Tim G. Jenkins
Summary: Complex diseases are challenging to diagnose due to their multifactorial etiologies. This study developed a diagnostic tool that analyzes a comprehensive network of epigenetic profiles to identify global shifts associated with complex diseases. The tool was validated by assessing tissue-specific epigenetic variability, differences between diseased and normal tissue, and its utility in male infertility, showing potential for clinical use. This approach expands diagnostic research beyond single genetic targets and provides insights into the role of epigenetic variability in complex diseases.
FRONTIERS IN GENETICS
(2023)
Article
Neurosciences
Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen, Lan Xiao
Summary: This research indicates that DNA hypermethylation in oligodendroglial cells contributes to anxious behavior, impaired sociability, and sensorimotor gating deficits in mice. It also leads to dysregulation of oligodendroglia-specific transcription factors and reduction of oligodendroglial lineage cells and myelin integrity in the frontal white matter. These findings suggest that DNA hypermethylation may play a role in the pathogenesis of schizophrenia-like behaviors in mice and provide insights into potential therapeutic strategies for white matter pathology in schizophrenia.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Morten Dall, Anna S. Hassing, Lili Niu, Thomas S. Nielsen, Lars R. Ingerslev, Karolina Sulek, Samuel A. J. Trammell, Matthew P. Gillum, Romain Barres, Steen Larsen, Steen S. Poulsen, Matthias Mann, Cathrine Orskov, Jonas T. Treebak
Summary: The knockout of hepatic Nampt gene resulted in increased susceptibility to liver injury under diet-induced metabolic stress, characterized by disrupted lipid metabolism and reduced respiratory capacity. Supplementation with NAD(+) precursors could prevent liver injury and halt the progression of nonalcoholic fatty liver disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Hansi Pathak, Anton Borchert, Sara Garaali, Alexandra Burkert, Helge Frieling
Summary: This study investigates the interaction and mechanisms between BDNF exon IV promoter methylation and antidepressant treatment. The results show that antidepressant treatment increases promoter methylation and specific CpG methylation affects transcriptional activity. Furthermore, overexpression of DNMT3a also enhances transcription of BDNF exon IV.
CLINICAL EPIGENETICS
(2022)
Article
Cell Biology
Wei Yang, Junjun Cao, David G. McVey, Shu Ye
Summary: Genome-wide association studies have identified a link between the genetic variant rs17514846 in the FURIN gene and coronary artery disease. Our study demonstrates that rs17514846 modulates FURIN expression through DNA methylation inhibition, which is mediated by the MeCP2 protein. Knockdown of MeCP2 increases FURIN expression, affecting monocyte migration and proliferation.
Article
Computer Science, Artificial Intelligence
Zhiqiang Pu, Huimu Wang, Zhen Liu, Jianqiang Yi, Shiguang Wu
Summary: In this article, a novel method called AERL is proposed to address complex interaction and communication issues in multi agent cooperation. The method utilizes attention mechanism and parameter sharing to achieve effective and robust performance, as demonstrated in simulation experiments in three representative scenarios.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Public, Environmental & Occupational Health
Zheng Xu, Ru Liu, Liping Guo, Ziyi Gao, Zicheng Gao, Xiaowei Liu, Jieyun Li, Bin Li, Kehu Yang
Summary: This scientometric investigation provides a comprehensive analysis of the development and emerging research trends in bibliotherapy. The study identifies the leading countries and institutions in the field and highlights the hot topics of research, such as depression and anxiety. The findings of this study serve as a valuable reference for researchers in the field of bibliotherapy.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Environmental Sciences
Yu Qin, Meixuan Li, Jiani Han, Gecheng Cui, Weiping Du, Kehu Yang
Summary: This study explored the research hotspots and trends of Kinesio Taping in the past decade through bibliometric analysis. The results revealed that pain relief, sports injury prevention and treatment, and proprioception enhancement for improved postural control were important research areas in the field of Kinesio Taping.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Junjie Cao, Renzhi Pei, Ying Lu, Zhongzheng Zheng, Zhiyang Yuan, Daiyang Li, Pisheng Zhang, Xuhui Liu, Dong Chen, Xiaohong Du, Lieguang Chen, Shuangyue Li, Peipei Ye, Tiantian Wang
Summary: The study found that the modified antithymocyte globulin-post-transplant cyclophosphamide combination can decrease the risk of acute and chronic graft-versus-host disease and improve graft-versus-host disease and relapse-free survival in high-risk acute myeloid leukemia and myelodysplastic syndrome patients after allogeneic hematopoietic stem cell transplantation.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wenlin Lu, Xuhui Liu, Linghui Zhao, Shirong Yan, Qingyun Song, Cao Zou, Xun Li
Summary: This study investigated the role and mechanism of miR-22-3p in heart failure, and found that its overexpression inhibits cell activity and promotes cell apoptosis. MiR-22-3p increases the risk of heart failure damage by negatively regulating FURIN.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Plant Sciences
Hongling Zhang, Guiqiong Li, Min Jiang, Changling Zhao, Pengyu Zhao, Chen Wang, Guosong Wen, Feng Zhou, Wenhua Dongchen, Shaozhong Xu, Ting Mu, Fanlai Meng, Xinglei Xiao, Di Yang, Zhengjie Liu, Ya Zhou, Qin Xiong
Summary: The expression of flavonoid synthesis-related genes in Panax notoginseng stems shows multi-peak curves, and the distribution of total flavonoid and anthocyanin content in the stems is asymmetric, mainly concentrated in the upper parts. The correlations between gene expression and flavonoid accumulation are highly diverse.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Article
Physics, Multidisciplinary
Xingxing Yang, Yang Li, Xin Guo, Meiling Ding, Jingxuan Yang
Summary: This paper proposes a strategy to reduce energy consumption by storing and transmitting regenerative energy of trains through multi-agent simulation. By optimizing the train operation time and dwell time, the traction energy consumption is reduced, and the accuracy of the simulation model is validated in a practical case study.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Review
Obstetrics & Gynecology
Liu Yang, Lufang Feng, Lijuan Huang, Xuejiao Li, Wenwen Qiu, Kehu Yang, Jie Qiu, Haihong Li
Summary: This study conducted a meta-analysis to identify the association between maternal factors and intrauterine growth retardation (IUGR), and found that smoking, primiparity, prepregnancy BMI < 18.5, poor gestational weight gain, pregnancy-induced hypertension, anemia, and hypoproteinemia were associated with IUGR. These findings could contribute to the development of risk prediction models and improve management and education for child-bearing or early pregnant women.
REPRODUCTIVE SCIENCES
(2023)
Review
Clinical Neurology
Ying Che, Tingting Lu, Tianming Wang, Hairong Zhao, Xulin Song, Qing Zhan, Chengzu Zhang, Haibang Pan, Kehu Yang, Bo Wang
Summary: This study evaluated the effects of head-of-bed elevation on patients with acquired brain injury (ABI). The results showed that elevating the head of the bed by 30 degrees can significantly reduce intracranial pressure (ICP), but did not have statistical differences on cerebral perfusion pressure (CPP) and disability at 90 days. Therefore, head-of-bed elevation of 30 degrees may be an effective noninvasive nursing practice for the prognosis and rehabilitation of ABI patients.
JOURNAL OF NEUROSCIENCE NURSING
(2023)
Review
Sport Sciences
Meng Xu, Chen Tian, Yong Wang, Shanshan Liang, Yiyun Wang, Xiuxia Li, Kehu Yang
Summary: This study conducted an umbrella review to summarize the evidence of associations between Pilates and multiple health outcomes, and evaluated the strength and validity of these associations. It found that Pilates can reduce body mass index and body fat percentage, relieve pain and disability, and improve sleep quality and balance. However, the certainty of the evidence was mostly low, and further high quality randomized controlled trials are needed to support these promising findings.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Chemistry, Physical
Ye Ji, Xi-Lian Guo, Jia-Yu Yang, Hai-Han Zhang, Xu-Hui Liu, Ming-Xing Song, Zheng-Kun Qin, Jia Wang, Fu-Quan Bai
Summary: In this article, six novel heterocyclic Ir(III) complexes were designed and calculated using DFT and TD-DFT. The bands of the lowest-lying absorptions and lowest energy emissions, as well as the spectral properties, frontier molecular orbitals, and spin-orbital coupling values, were studied. These complexes exhibit low efficiency roll-off properties, which is significant for the development of OLEDs.
Article
Biochemistry & Molecular Biology
Guoshun Liu, Xuhui Liu, Xingdong Ma, Xiaoqi Tang, Xiaobin Zhang, Jianxia Dong, Yunfei Ma, Xiaobei Zang, Ning Cao, Qingguo Shao
Summary: Dual-ion batteries (DIBs) are a new type of energy storage device that store both anions and cations. Combining graphite cathodes with high-capacity silicon anodes can improve the energy density of DIBs.
Review
Integrative & Complementary Medicine
Meng Xu, Chaoqun Yang, Tao Nian, Chen Tian, Liying Zhou, Yanan Wu, Yanfei Li, Xinxin Deng, Xiuxia Li, Kehu Yang
Summary: This study examines the adverse effects of acupuncture and finds that there are various types of adverse reactions, but the symptoms are mild. However, most of the included studies have low quality, indicating a need for further randomized controlled trials and systematic reviews to comprehensively analyze acupuncture-related adverse events.
Review
Emergency Medicine
Qi Zhou, Wenbo Meng, Yanhan Ren, Qinyuan Li, Marja A. Boermeester, Peter Muli Nthumba, Jennifer Rickard, Bobo Zheng, Hui Liu, Qianling Shi, Siya Zhao, Zijun Wang, Xiao Liu, Zhengxiu Luo, Kehu Yang, Yaolong Chen, Robert G. Sawyer
Summary: This study reviewed the effectiveness of intraoperative peritoneal lavage (IOPL) with saline in patients with intra-abdominal infections (IAIs). The findings suggest that IOPL with saline does not significantly reduce the risk of mortality, intra-abdominal abscess, incisional surgical site infection, postoperative complication, reoperation, and readmission when compared to non-IOPL. Therefore, routine use of IOPL with saline in patients with IAIs is not supported.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Materials Science, Multidisciplinary
Lingjie Meng, Xuhui Liu, Qingxiang Hong, Yan Ji, Lingtao Wang, Qiuyang Zhang, Jie Chen, Changjiang Pan
Summary: In this study, a Zn2+-loaded polydopamine (PDA/Zn2+) coating was prepared on an alkali-heat-treated magnesium alloy surface inspired by mussel adhesion protein. The coating showed excellent wettability and selective promotion of albumin adsorption. Furthermore, the corrosion resistance, hemocompatibility, and endothelialization of the modified magnesium alloys were significantly improved with the increase of Zn2+ content in the coating.