Article
Medicine, General & Internal
Dandan Mao, Huanyi Cao, Mai Shi, Chi Chiu Wang, Joseph Kwong, Joshua Jing Xi Li, Yong Hou, Xing Ming, Heung Man Lee, Xiao Yu Tian, Chun Kwok Wong, Elaine Chow, Alice Pik Shan Kong, Vivian Wai Yan Lui, Paul Kay Sheung Chan, Juliana Chung Ngor Chan
Summary: Our study revealed that the expression of PSMA2 and GLP-1R was increased and positively correlated in T2D-related cervical cancer specimens, suggesting hyperglycemia might promote cancer growth by increasing PSMA2 expression, which could be attenuated by Exendin-4.
Article
Endocrinology & Metabolism
Neil Tanday, Andrew English, Ryan A. Lafferty, Peter R. Flatt, Nigel Irwin
Summary: The combined activation of GLP-1 and CCK1 receptors through [Lys(12)Pal]Ex-4/CCK showed enhanced beneficial effects on pancreatic beta-cells, leading to improved insulin secretion and glucose homeostasis in vitro and in mice models. This hybrid peptide therapy also resulted in reductions in energy intake and body weight, as well as improvements in glucose tolerance, insulin responsiveness, and pancreatic islet morphology, highlighting its potential for treating obesity-related diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sundararajan Mahalingam, Ramesh Bellamkonda, Madan Kumar Arumugam, Sathish Kumar Perumal, Jessica Yoon, Carol Casey, Kusum Kharbanda, Karuna Rasineni
Summary: The GLP-1 receptor agonist exendin-4 has been found to effectively mitigate alcohol-induced hepatic steatosis by regulating fat metabolism, according to an experimental rat model.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Shimpei Iikuni, Ichiro Kamei, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono
Summary: A GLP-1R imaging probe [In-111]In-E4DA1 has been developed, which can detect the location of insulinomas in vivo and has reduced renal accumulation.
MOLECULAR PHARMACEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Ravi Retnakaran, Jiajie Pu, Chang Ye, Alexandra Emery, Caroline K. Kramer, Bernard Zinman
Summary: This study evaluated the effects of adding GLP1-RA exenatide or meal insulin lispro to basal glargine therapy on vascular function in early type 2 diabetes. The findings suggest that adding exenatide or lispro does not affect fasting endothelial function in patients with early type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Abigayle B. Simon, Cassandra C. Derella, Marsha Blackburn, Jeffrey Thomas, Lawrence C. Layman, Matthew S. Nicholson, Jennifer Waller, Ahmed Elmarakby, Karim M. Saad, Ryan A. Harris
Summary: The study found that women with type 1 diabetes have higher levels of estradiol in the late follicular phase, leading to increased oxidative stress and endothelial dysfunction. The use of oral contraceptive pills appears to benefit endothelial function in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medicine, Research & Experimental
Shimpei Iikuni, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono
Summary: In this study, 111In-labeled exendin-4 derivatives with specific albumin binder (ALB) moieties were designed and synthesized for noninvasive detection of insulinomas. Through in vitro and in vivo experiments, it was determined that these derivatives exhibited good affinity and tumor accumulation, while showing lower renal accumulation. These results provide important guidance for the design of novel radioligands targeting GLP-1R.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Laurent Knerr, Thazha P. Prakash, Richard Lee, William J. Drury, Mehran Nikan, Wuxia Fu, Elaine Pirie, Leonardo De Maria, Eric Valeur, Ahlke Hayen, Maria Olwegard-Halvarsson, Johan Broddefalk, Carina Ammala, Michael E. Ostergaard, Johan Meuller, Linda Sundstrom, Patrik Andersson, David Janzen, Rasmus Jansson-Lofmark, Punit P. Seth, Shalini Andersson
Summary: The study demonstrates the potential of GLP1R agonist conjugation to improve the delivery efficiency of ASOs in diabetes treatment, particularly for pancreatic beta cells. Optimization of linker chemistry and exploration of GLP1R agonist ligands can effectively enhance the in vivo efficacy of ASOs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Jufen Liu, Huijing Wang, Cuiting Huang
Summary: This study found that Exendin-4 has a protective effect in inhibiting the progression of DR, and it may exert its effect by regulating the expression of TGFB2.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Karolina Nocun-Wasilewska, Danuta Zwolinska, Agnieszka Zubkiewicz-Kucharska, Dorota Polak-Jonkisz
Summary: This study found significantly higher concentrations of endothelial lesion markers in children with type 1 diabetes mellitus, which were positively correlated with disease duration, age, and BMI. Some markers showed linear correlations with the estimated glomerular filtration rate, suggesting their potential as prognostic factors for kidney dysfunction in children with type 1 diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fengwu Chen, Lina He, Jilin Li, Shuhui Yang, Bangzhou Zhang, Dan Zhu, Zezhen Wu, Shuo Zhang, Ducheng Hou, Cong Ouyang, Jianfeng Yi, Chuanxing Xiao, Kaijian Hou
Summary: This study evaluates the protective effect of GLP-1 on endothelial cells in middle-aged and elderly patients with newly diagnosed or poorly controlled type 2 diabetes. It also explores the correlation between GLP-1 and gut microbiota.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Khaoula Errafii, Olfa Khalifa, Neyla S. Al-Akl, Abdelilah Arredouani
Summary: No therapy exists for non-alcoholic fatty liver disease (NAFLD). However, glucagon-like peptide receptor agonists (GLP-1RAs) showed a beneficial effect on NAFLD. The study examined the signaling pathways involved in the protective effect of the GLP-1RA Exendin-4 (Ex-4) using comparative transcriptomics in a cell model of steatosis. It identified several key pathways, including FXR/RXR and LXR/RXR, that may contribute to the protective effect of GLP-1RAs on NAFLD.
Article
Endocrinology & Metabolism
Matthew Anson, Sizheng S. Zhao, Philip Austin, Gema H. Ibarburu, Rayaz A. Malik, Uazman Alam
Summary: The study found that in patients with type 1 diabetes, adjunctive therapy with sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can provide clinically significant reductions in blood glucose levels. Additionally, SGLT2is offer cardio-renal benefits, although there is an increased risk of diabetic ketoacidosis and urinary tract infections compared to GLP-1 RA therapy.
Article
Pharmacology & Pharmacy
Zumra Kara, Berna Guven, Arzu Onay Besikci, Nuh Yildirim, Hikmet Altunay
Summary: The study aimed to investigate the beneficial effects of Ivabradine (IVA) on vascular function in diabetes, beyond its primary mechanism of action on heart rate reduction. The study found that IVA improved vascular function in diabetic rats, potentially through the support of HCN channels against the damaging effects of diabetes. These findings suggest that IVA may be a useful intervention to prevent diabetic cardiovascular dysfunction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa, Abdelilah Arredouani
Summary: This study confirmed that Ex-4 can improve steatosis in HepG2 cells and identified 379 and 180 differentially expressed LncRNAs between untreated, steatotic, and Ex-4-treated steatotic cells. Functional enrichment analysis revealed critical pathways involved in fatty acid and pyruvate metabolism, insulin, PPAR, Wnt, TGF-beta, mTOR, VEGF, NOD-like, and Toll-like receptors signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Liselotte Fransson, Ake Sjoholm, Henrik Ortsater
CELL BIOCHEMISTRY AND FUNCTION
(2014)
Review
Endocrinology & Metabolism
Henrik Ortsater, Nina Grankvist, Richard E. Honkanen, Ake Sjoholm
JOURNAL OF ENDOCRINOLOGY
(2014)
Article
Cell Biology
Liselotte Fransson, Victoria Rosengren, Titu Kumar Saha, Nina Grankvist, Tohidul Islam, Richard E. Honkanen, Ake Sjoholm, Henrik Ortsater
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2014)
Article
Multidisciplinary Sciences
Vladimer Darsalia, Sansan Hua, Martin Larsson, Carina Mallard, David Nathanson, Thomas Nystroem, Ake Sjoeholm, Maria E. Johansson, Cesare Patrone
Article
Endocrinology & Metabolism
Vladimer Darsalia, Anna Olverling, Martin Larsson, Shiva Mansouri, David Nathanson, Thomas Nystrom, Thomas Klein, Ake Sjoholm, Cesare Patrone
REGULATORY PEPTIDES
(2014)
Review
Endocrinology & Metabolism
Vladimer Darsalia, David Nathanson, Thomas Nystrom, Thomas Klein, Ake Sjoholm, Cesare Patrone
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2014)
Article
Endocrinology & Metabolism
Ake Sjoholm
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Ake Sjoholm
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Pharmacology & Pharmacy
Ake Sjoholm
Summary: This article surveys adjuvant treatments against type 1 diabetes, with a focus on the role of SGLT inhibitors.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Editorial Material
Endocrinology & Metabolism
Ake Sjoholm, John A. Corbett, Po Sing Leung, Bernard Portha
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Agnes Kataja Knight, Peter Magnusson, Ake Sjoholm
Summary: Diabetes can lead to acute complications in the CNS during episodes of hyperglycemia. Here we report a case of hyperosmolar non-ketotic syndrome with reversible hemichoreic dyskinesia and morphological changes in the basal ganglia.
CLINICAL CASE REPORTS
(2021)
Article
Medicine, General & Internal
Ake Sjoholm
Summary: The classification of diabetes is not as clear-cut as before, with patients potentially having features of multiple types. This can impact the progression of the disease, and clinicians need to consider this when diagnosing and treating patients.
CLINICAL CASE REPORTS
(2021)
Review
Endocrinology & Metabolism
Ake Sjoholm
Summary: Different dysglycemic states can precede the onset of type 2 diabetes, with prediabetic dysglycemia carrying an increased cardiovascular risk. Prediabetic dysglycemia may include impaired fasting glycemia, impaired glucose tolerance, and intermediate hyperglycemia, often appearing in mixed forms. These abnormalities develop insidiously over many years, usually without symptoms, and can be prevented from progressing to type 2 diabetes through various interventions.
CURRENT DIABETES REVIEWS
(2021)
Article
Endocrinology & Metabolism
Ake Sjoholm, Maria Joao Pereira, Thomas Nilsson, Torbjorn Linden, Petros Katsogiannos, Jan Saaf, Jan W. Eriksson
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2020)
Article
Physiology
Qimin Zhang, Fan Zhang, Ake Sjoholm
PHYSIOLOGICAL REPORTS
(2014)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)